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1

Targeting Radioresistant Osteosarcoma Cells With Parthenolide

Daniel Zuch, An-Hoa Giang, Yuriy Shapovalov, Edward Schwarz, Randy Rosier, Regis O'Keefe, Roman A. Eliseev

Journal:

Journal of Cellular Biochemistry

Year:

2012

Language:

english

File:

PDF, 308 KB

english, 2012

2

Determination of Responsiveness in Biological Systems Is Dependent on Highly Sensitive Quantitative Measures

REGIS J. O'KEEFE

Journal:

Annals of the New York Academy of Sciences

Year:

2002

Language:

english

File:

PDF, 80 KB

english, 2002

3

Cellular and molecular targets to enhance fracture healing and bone formation in aging

Regis J. O'Keefe

Journal:

Year:

2010

Language:

english

File:

PDF, 60 KB

english, 2010

4

The molecular pathophysiology of subacromial bursitis in rotator cuff disease

Theodore A. Blaine, Yang-Soo Kim, Ilya Voloshin, Darwin Chen, Koko Murakami, Seong-Sil Chang, Robert Winchester, Francis Y. Lee, Regis J. O’Keefe, Louis U. Bigliani

Journal:

Journal of Shoulder and Elbow Surgery

Year:

2005

Language:

english

File:

PDF, 362 KB

english, 2005

5

Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues

Susan D. Reynolds, Donghui Zhang, J.Edward Puzas, Regis J. O'Keefe, Randy N. Rosier, Paul R. Reynolds

Journal:

Year:

2000

Language:

english

File:

PDF, 669 KB

english, 2000

6

Structural Bone Allograft Combined with Genetically Engineered Mesenchymal Stem Cells as a Novel Platform for Bone Tissue Engineering

Xie, Chao, Reynolds, David, Awad, Hani, Rubery, Paul T., Pelled, Gadi, Gazit, Dan, Guldberg, Robert E., Schwarz, Edward M., O'Keefe, Regis J., Zhang, Xinping

Journal:

Tissue Engineering

Year:

2007

Language:

english

File:

PDF, 10.12 MB

english, 2007

7

Point of View

O’Keefe, Regis J., Rubery, Paul T.

Journal:

Year:

2005

Language:

english

File:

PDF, 748 KB

english, 2005

8

Articular cartilage biology.

Ulrich-Vinther, Michael, Maloney, Michael D, Schwarz, Edward M, Rosier, Randy, O'Keefe, Regis J

Journal:

Journal of the American Academy of Orthopaedic Surgeons

Year:

2003

Language:

english

File:

PDF, 852 KB

english, 2003

9

P-glycoprotein expression in cartilaginous tumors

Rosier, Randy N., O'Keefe, Regis J., Teot, Lisa A., Fox, Edward J., Nester, Theresa A., Puzas, J. Edward, Reynolds, Paul R., Hicks, David G.

Journal:

Journal of Surgical Oncology

Year:

1997

Language:

english

File:

PDF, 1.21 MB

english, 1997

10

Primary lymphoma of bone. Correlation of magnetic resonance imaging features with cytokine production by tumor cells

David G. Hicks, Regis J. O'Keefe, Randy N. Rosier, Joshua Z. Sickel, Alexander R. Judkins, Takehiko Gokan, Saara M. S. Totterman, Patrick J Fultz, Steven P. Meyers, Deborah J. Rubens

Journal:

Year:

1995

Language:

english

File:

PDF, 2.40 MB

english, 1995

11

Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles

Emily E. Carmody, Edward M. Schwarz, J. Edward Puzas, Randy N. Rosier, Regis J. O'Keefe

Journal:

Arthritis & Rheumatism

Year:

2002

Language:

english

File:

PDF, 697 KB

english, 2002

12

Light-activated gene transduction enhances adeno-associated virus vector–mediated gene expression in human articular chondrocytes

Michael Ulrich-Vinther, Michael D. Maloney, J. Jeffrey Goater, Kjeld Søballe, Mary B. Goldring, Regis J. O'Keefe, Edward M. Schwarz

Journal:

Arthritis & Rheumatism

Year:

2002

Language:

english

File:

PDF, 398 KB

english, 2002

13

Systemic tumor necrosis factor α mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor α–transgenic mice

Ping Li, Edward M. Schwarz, Regis J. O'Keefe, Lin Ma, R. John Looney, Christopher T. Ritchlin, Brendan F. Boyce, Lianping Xing

Journal:

Arthritis & Rheumatism

Year:

2004

Language:

english

File:

PDF, 224 KB

english, 2004

14

Inhibition of β-catenin signaling in articular chondrocytes results in articular cartilage destruction

Mei Zhu, Mo Chen, Michael Zuscik, Qiuqian Wu, Yong-Jun Wang, Randy N. Rosier, Regis J. O'Keefe, Di Chen

Journal:

Arthritis & Rheumatism

Year:

2008

Language:

english

File:

PDF, 1.60 MB

english, 2008

15

Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice

Qiuqian Wu, Kyung-Ok Kim, Erik R. Sampson, Di Chen, Hani Awad, Todd O'Brien, J. Edward Puzas, Hicham Drissi, Edward M. Schwarz, Regis J. O'Keefe, Michael J. Zuscik, Randy N. Rosier

Journal:

Arthritis & Rheumatism

Year:

2008

Language:

english

File:

PDF, 406 KB

english, 2008

16

Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor β–activated kinase 1/activating transcription factor 2 signaling: A potential clinical implication for osteoarthritis

Tian-Fang Li, Lin Gao, Tzong-Jen Sheu, Erik R. Sampson, Lisa M. Flick, Yrjö T. Konttinen, Di Chen, Edward M. Schwarz, Michael J. Zuscik, Jennifer H. Jonason, Regis J. O'Keefe

Journal:

Arthritis & Rheumatism

Year:

2010

Language:

english

File:

PDF, 519 KB

english, 2010

17

Physiology and pathophysiology of the growth plate

R. Tracy Ballock, Regis J. O'Keefe

Journal:

Birth Defects Research Part C: Embryo Today: Reviews

Year:

2003

Language:

english

File:

PDF, 626 KB

english, 2003

18

Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase

Mo Chen, Alexander C. Lichtler, Tzong-Jen Sheu, Chao Xie, Xinping Zhang, Regis J. O'Keefe, Di Chen

Journal:

Year:

2007

Language:

english

File:

PDF, 1.53 MB

english, 2007

19

Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering

Laura Yanoso-Scholl, Justin A. Jacobson, Gino Bradica, Amy L. Lerner, Regis J. O'Keefe, Edward M. Schwarz, Michael J. Zuscik, Hani A. Awad

Journal:

Journal of Biomedical Materials Research Part A

Year:

2010

Language:

english

File:

PDF, 2.37 MB

english, 2010

20

EP1−/− mice have enhanced osteoblast differentiation and accelerated fracture repair

Minjie Zhang, Hsin-chiu Ho, Tzong-jen Sheu, Matthew D Breyer, Lisa M Flick, Jennifer H Jonason, Hani A Awad, Edward M Schwarz, Regis J O'Keefe

Journal:

Journal of Bone and Mineral Research

Year:

2011

Language:

english

File:

PDF, 11.38 MB

english, 2011

21

The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model

Erik R Sampson, Brad A Martin, Aimee E Morris, Chao Xie, Edward M Schwarz, Regis J O'Keefe, Randy N Rosier

Journal:

Journal of Bone and Mineral Research

Year:

2011

Language:

english

File:

PDF, 5.06 MB

english, 2011

22

Delayed short-course treatment with teriparatide (PTH1–34) improves femoral allograft healing by enhancing intramembranous bone formation at the graft–host junction

Masahiko Takahata, Edward M Schwarz, Tony Chen, Regis J O'Keefe, Hani A Awad

Journal:

Journal of Bone and Mineral Research

Year:

2012

Language:

english

File:

PDF, 2.07 MB

english, 2012

23

TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways

Lea M Gunnell, Jennifer H Jonason, Alayna E Loiselle, Anat Kohn, Edward M Schwarz, Matthew J Hilton, Regis J O'Keefe

Journal:

Journal of Bone and Mineral Research

Year:

2010

Language:

english

File:

PDF, 917 KB

english, 2010

24

Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes

M. Hicham Drissi, Xufeng Li, Tzong J. Sheu, Michael J. Zuscik, Edward M. Schwarz, J. Edward Puzas, Randy N. Rosier, Regis J. O'Keefe

Journal:

Journal of Cellular Biochemistry

Year:

2003

Language:

english

File:

PDF, 305 KB

english, 2003

25

5-azacytidine alters TGF-β and BMP signaling and induces maturation in articular chondrocytes

Michael J. Zuscik, Jonathan F. Baden, Qiuqian Wu, Tzong J. Sheu, Edward M. Schwarz, Hicham Drissi, Regis J. O'Keefe, J. Edward Puzas, Randy N. Rosier

Journal:

Journal of Cellular Biochemistry

Year:

2004

Language:

english

File:

PDF, 422 KB

english, 2004

26

Wnt-mediated regulation of chondrocyte maturation: Modulation by TGF-β

Yufeng Dong, Hicham Drissi, Mo Chen, Di Chen, Michael J. Zuscik, Edward M. Schwarz, Regis J. O'Keefe

Journal:

Journal of Cellular Biochemistry

Year:

2005

Language:

english

File:

PDF, 275 KB

english, 2005

27

Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFκB: A role for c-Jun N-terminal kinase

Roman A. Eliseev, Michael J. Zuscik, Edward M. Schwarz, Regis J. O'Keefe, Hicham Drissi, Randy N. Rosier

Journal:

Journal of Cellular Biochemistry

Year:

2005

Language:

english

File:

PDF, 341 KB

english, 2005

28

Teriparatide (1-34 human PTH) regulation of osterix during fracture repair

Lee A. Kaback, Do Y. Soung, Amish Naik, Graziello Geneau, Edward M. Schwarz, Randy N. Rosier, Regis J. O'Keefe, Hicham Drissi

Journal:

Journal of Cellular Biochemistry

Year:

2008

Language:

english

File:

PDF, 373 KB

english, 2008

29

CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter

Andreia M. Ionescu, Hicham Drissi, Edward M. Schwarz, Mitsuyasu Kato, J. Edward Puzas, Dennis J. McCance, Randy N. Rosier, Michael J. Zuscik, Regis J. O'Keefe

Journal:

Journal of Cellular Physiology

Year:

2004

Language:

english

File:

PDF, 288 KB

english, 2004

30

PTHrP expression in chick sternal chondrocytes is regulated by TGF-β through Smad-mediated signaling

Dhruv B. Pateder, Cristin M. Ferguson, Andreia M. Ionescu, Edward M. Schwarz, Randy N. Rosier, J. Edward Puzas, Regis J. O'Keefe

Journal:

Journal of Cellular Physiology

Year:

2001

Language:

english

File:

PDF, 273 KB

english, 2001

31

Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development

Nathan Smith, Yufeng Dong, Jane B. Lian, Jitesh Pratap, Paul D. Kingsley, Andre J. van Wijnen, Janet L. Stein, Edward M. Schwarz, Regis J. O'Keefe, Gary S. Stein, M. Hicham Drissi

Journal:

Journal of Cellular Physiology

Year:

2005

Language:

english

File:

PDF, 600 KB

english, 2005

32

Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor

Yu-Feng Dong, Do Y. Soung, Edward M. Schwarz, Regis J. O'Keefe, Hicham Drissi

Journal:

Journal of Cellular Physiology

Year:

2006

Language:

english

File:

PDF, 428 KB

english, 2006

33

Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification

Lee A. Kaback, Do Y. Soung, Amish Naik, Nathan Smith, Edward M. Schwarz, Regis J. O'Keefe, Hicham Drissi

Journal:

Journal of Cellular Physiology

Year:

2008

Language:

english

File:

PDF, 430 KB

english, 2008

34

Aryl hydrocarbon receptor-mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(α)pyrene

Ming H. Kung, Kiminori Yukata, Regis J. O'Keefe, Michael J. Zuscik

Journal:

Journal of Cellular Physiology

Year:

2012

Language:

english

File:

PDF, 980 KB

english, 2012

35

Effects of transforming growth factor-β1 and fibroblast growth factor on DNA synthesis in growth plate chondrocytes are enhanced by insulin-like growth factor-I

Regis J. O'Keefe, Ian D. Crabb, J. Edward Puzas, Dr. Randy N. Rosier

Journal:

Journal of Orthopaedic Research

Year:

1994

Language:

english

File:

PDF, 1.07 MB

english, 1994

36

Differential regulation of type-II and type-X collagen synthesis by parathyroid hormone-related protein in chick growth-plate chondrocytes

Regis J. O'Keefe, Luke S. Loveys, David G. Hicks, Paul R. Reynolds, Ian D. Crabb, J. Edward Puzas, Randy N. Rosier

Journal:

Journal of Orthopaedic Research

Year:

1997

Language:

english

File:

PDF, 1.30 MB

english, 1997

37

Bone morphogenetic protein-7 in growth-plate chondrocytes: Regulation by retinoic acid is dependent on the stage of chondrocyte maturation

Christopher D. Grimsrud, Randy N. Rosier, J Edward Puzas, Paul R. Reynolds, Susan D. Reynolds, David G. Hicks, Regis J. O'Keefe

Journal:

Journal of Orthopaedic Research

Year:

1998

Language:

english

File:

PDF, 2.63 MB

english, 1998

38

Interleukin-10 inhibits cytokine synthesis in monocytes stimulated by titanium particles: Evidence of an anti-inflammatory regulatory pathway

Paul F. Pollice, James Hsu, David G. Hicks, Susan Bukata, Randy N. Rosier, Paul R. Reynolds, J. Edward Puzas, Regis J. O'Keefe

Journal:

Journal of Orthopaedic Research

Year:

1998

Language:

english

File:

PDF, 877 KB

english, 1998

39

Tumor necrosis factor-α/nuclear transcription factor-κB signaling in periprosthetic osteolysis

Edward M. Schwarz, Allen P. Lu, J. Jeffrey Goater, Eric B. Benz, George Kollias, Randy N. Rosier, J. Edward Puzas, Regis J. O'Keefe

Journal:

Journal of Orthopaedic Research

Year:

2000

Language:

english

File:

PDF, 1.01 MB

english, 2000

40

Quantitative small-animal surrogate to evaluate drug efficacy in preventing wear debris-induced osteolysis

Edward M. Schwarz, Eric B. Benz, Allen P. Lu, J. Jeffrey Goater, Anthony V. Mollano, Randy N. Rosier, J. Edward Puzas, Regis J. O'Keefe

Journal:

Journal of Orthopaedic Research

Year:

2000

Language:

english

File:

PDF, 856 KB

english, 2000

41

Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity

Dan Li, Kirill Gromov, Kjeld Søballe, J. Edward Puzas, Regis J. O'Keefe, Hani Awad, Hicham Drissi, Edward M. Schwarz

Journal:

Journal of Orthopaedic Research

Year:

2008

Language:

english

File:

PDF, 456 KB

english, 2008

42

Regulation of embryonic endochondral ossification by Smurf2

Qiuqian Wu, Meina Wang, Michael J. Zuscik, Di Chen, Regis J. O'Keefe, Randy N. Rosier

Journal:

Journal of Orthopaedic Research

Year:

2008

Language:

english

File:

PDF, 316 KB

english, 2008

43

Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT

Ryosuke Tsutsumi, Colleen Hock, C. Dustin Bechtold, Steven T. Proulx, Susan V. Bukata, Hiromu Ito, Hani A. Awad, Takashi Nakamura, Regis J. O'Keefe, Edward M. Schwarz

Journal:

Journal of Orthopaedic Research

Year:

2008

Language:

english

File:

PDF, 436 KB

english, 2008

44

Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression

Alayna E. Loiselle, Gwynne A. Bragdon, Justin A. Jacobson, Sys Hasslund, Zenia E. Cortes, Edward M. Schwarz, David J. Mitten, Hani A. Awad, Regis J. O'Keefe

Journal:

Journal of Orthopaedic Research

Year:

2009

Language:

english

File:

PDF, 236 KB

english, 2009

45

Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation

Christine A. Clark, Tian-Fang Li, Kyung-Ok Kim, Hicham Drissi, Michael J. Zuscik, Xinping Zhang, Regis J. O'Keefe

Journal:

Journal of Orthopaedic Research

Year:

2009

Language:

english

File:

PDF, 208 KB

english, 2009

46

Efficacy of colistin-impregnated beads to prevent multidrug-resistant A. baumannii implant-associated osteomyelitis

Daniel P. Crane, Kirill Gromov, Dan Li, Kjeld Søballe, Christian Wahnes, Hubert Büchner, Matthew J. Hilton, Regis J. O'Keefe, Clinton K. Murray, Edward M. Schwarz

Journal:

Journal of Orthopaedic Research

Year:

2009

Language:

english

File:

PDF, 331 KB

english, 2009

47

Axin2 regulates chondrocyte maturation and axial skeletal development

Debbie Y. Dao, Xue Yang, Lisa M. Flick, Di Chen, Matthew J. Hilton, Regis J. O'Keefe

Journal:

Journal of Orthopaedic Research

Year:

2010

Language:

english

File:

PDF, 413 KB

english, 2010

48

Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing

Evan B. Katzel, Matthew Wolenski, Alayna E. Loiselle, Patrick Basile, Lisa M. Flick, Howard N. Langstein, Matthew J. Hilton, Hani A. Awad, Warren C. Hammert, Regis J. O'Keefe

Journal:

Journal of Orthopaedic Research

Year:

2011

Language:

english

File:

PDF, 552 KB

english, 2011

49

The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy

Erik R. Sampson, Vinit Amin, Edward M. Schwarz, Regis J. O'Keefe, Randy N. Rosier

Journal:

Journal of Orthopaedic Research

Year:

2011

Language:

english

File:

PDF, 6.52 MB

english, 2011

50

Establishment of an index with increased sensitivity for assessing murine arthritis

Erik R. Sampson, Christopher A. Beck, John Ketz, Krista L. Canary, Matthew J. Hilton, Hani Awad, Edward M. Schwarz, Di Chen, Regis J. O'Keefe, Randy N. Rosier, Michael J. Zuscik

Journal:

Journal of Orthopaedic Research

Year:

2011

Language:

english

File:

PDF, 1.91 MB

english, 2011

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