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1

Therapeutic potential of RQ-00311651, a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain

Sekiguchi, Fumiko, Kawara, Yuma, Tsubota, Maho, Kawakami, Eri, Ozaki, Tomoka, Kawaishi, Yudai, Tomita, Shiori, Kanaoka, Daiki, Yoshida, Shigeru, Ohkubo, Tsuyako, Kawabata, Atsufumi

Journal:

Year:

2016

Language:

english

File:

PDF, 1.70 MB

english, 2016

2

Presence and possible role of the spliced isoform of the P2X1receptor in rat vascular smooth muscle cells

Tsuyako Ohkubo, Jun Yamazaki, Yoshiyuki Nakashima, Kenji Kitamura

Journal:

Pflügers Archiv European Journal of Physiology

Year:

2000

Language:

english

File:

PDF, 157 KB

english, 2000

3

Algogen-specific pain processing in mouse spinal cord: differential involvement of voltage-dependent Ca2+ channels in synaptic transmission

Akemi Kato, Tsuyako Ohkubo, Kenji Kitamura

Journal:

British Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 279 KB

english, 2002

4

Role of substance P in neurogenic inflammation in the rat incisor pulp and the lower lip

Tsuyako Ohkubo, Manabu Shibata, Yasuo Yamada, Hidehiro Kaya, Hiroshi Takahashi

Journal:

Archives of Oral Biology

Year:

1993

Language:

english

File:

PDF, 716 KB

english, 1993

5

Specific expression of salivary maxi-K channel variant is augmented in diabetic mice

Kazuhiko Okamura, Kenichi Kato, Ryuji Uchida, Tsuyako Ohkubo, Kunihisa Taniguchi, Jun Yamazaki

Journal:

Archives of Oral Biology

Year:

2010

Language:

english

File:

PDF, 538 KB

english, 2010

6

Regulation of substance P release mediated via prejunctional histamine H3 receptors

Tsuyako Ohkubo, Manabu Shibata, Masayuki Inoue, Hidehiro Kaya, Hiroshi Takahashi

Journal:

European Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 466 KB

english, 1995

7

ATP-sensitive K+ channels mediate regulation of substance P release via the prejunctional histamine H3 receptor

Tsuyako Ohkubo, Manabu Shibata

Journal:

European Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 401 KB

english, 1995

8

Molecular and immunohistochemical studies in expression of voltage-dependent Ca2+ channels in dorsal root ganglia from streptozotocin-induced diabetic mice

Mariko Umeda, Tsuyako Ohkubo, Jun Ono, Tadaoki Fukuizumi, Kenji Kitamura

Journal:

Year:

2006

Language:

english

File:

PDF, 730 KB

english, 2006

9

Spinally delivered N-, P/Q- and L-type Ca2+-channel blockers potentiate morphine analgesia in mice

Tadaoki Fukuizumi, Tsuyako Ohkubo, Kenji Kitamura

Journal:

Year:

2003

Language:

english

File:

PDF, 146 KB

english, 2003

10

Spinal sensitization mechanism in vincristine-induced hyperalgesia in mice

Tadaoki Fukuizumi, Tsuyako Ohkubo, Kenji Kitamura

Journal:

Neuroscience Letters

Year:

2003

Language:

english

File:

PDF, 112 KB

english, 2003

11

Modified formalin test: characteristic biphasic pain response

Shibata, Manabu, Ohkubo, Tsuyako, Takahashi, Hiroshi, Inoki, Reizo

Journal:

Year:

1989

Language:

english

File:

PDF, 524 KB

english, 1989

12

T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells

Ohkubo, Tsuyako

Journal:

International Journal of Oncology

Year:

2012

Language:

english

File:

PDF, 673 KB

english, 2012

13

The analgesia induced by intrathecal injection of ruthenium red

Ohkubo, Tsuyako, Shibata, Manabu, Takahashi, Hiroshi

Journal:

Year:

1993

Language:

english

File:

PDF, 290 KB

english, 1993

14

Endogenous and exogenous hydrogen sulfide facilitates T-type calcium channel currents in Cav3.2-expressing HEK293 cells

Sekiguchi, Fumiko, Miyamoto, Yosuke, Kanaoka, Daiki, Ide, Hiroki, Yoshida, Shigeru, Ohkubo, Tsuyako, Kawabata, Atsufumi

Journal:

Biochemical and Biophysical Research Communications

Year:

2014

Language:

english

File:

PDF, 553 KB

english, 2014

15

Integrin α6β4 and TRPV1 channel coordinately regulate directional keratinocyte migration

Miyazaki, Ayako, Ohkubo, Tsuyako, Hatta, Mitsutoki, Ishikawa, Hiroyuki, Yamazaki, Jun

Journal:

Biochemical and Biophysical Research Communications

Year:

2015

Language:

english

File:

PDF, 1.91 MB

english, 2015

16

Identification and Electrophysiological Characteristics of Isoforms of T-type Calcium Channel Cav3.2 Expressed in Pregnant Human Uterus

Ohkubo, Tsuyako, Inoue, Yoshihito, Kawarabayashi, Tatsuhiko, Kitamura, Kenji

Journal:

Cellular Physiology and Biochemistry

Year:

2005

Language:

english

File:

PDF, 908 KB

english, 2005

17

Differential Expression of L- and T-Type Calcium Channels between Longitudinal and Circular Muscles of the Rat Myometrium during Pregnancy

Ohkubo, Tsuyako, Kawarabayashi, Tatsuhiko, Inoue, Yoshihito, Kitamura, Kenji

Journal:

Gynecologic and Obstetric Investigation

Year:

2005

Language:

english

File:

PDF, 180 KB

english, 2005

18

Participation of the sensory nerves in the inflammatory response induced by irritants.

OHKUBO, Tsuyako, SHIBATA, Manabu, TAKAHASHI, Hiroshi

Journal:

Folia Pharmacologica Japonica

Year:

1990

File:

PDF, 7.84 MB

1990

19

Effect of prostaglandin D2 on pain and inflammation.

OHKUBO, Tsuyako, SHIBATA, Manabu, TAKAHASHI, Hiroshi, INOKI, Reizo

Journal:

The Japanese Journal of Pharmacology

Year:

1983

Language:

english

File:

PDF, 144 KB

english, 1983

20

Effect of neurotropin on hyperalgesia induced by prostaglandin E2, naloxone, melatonin and dark condition in mice.

TAKAHASHI, Hiroshi, SHIBATA, Manabu, OHKUBO, Tsuyako, SAITO, Kihachi, INOKI, Reizo

Journal:

The Japanese Journal of Pharmacology

Year:

1987

Language:

english

File:

PDF, 204 KB

english, 1987

21

Tarantula Toxin ProTx-I Differentiates Between Human T-type Voltage-Gated Ca2+ Channels Cav3.1 and Cav3.2

Ohkubo, Tsuyako, Yamazaki, Jun, Kitamura, Kenji

Journal:

Journal of Pharmacological Sciences

Year:

2010

Language:

english

File:

PDF, 357 KB

english, 2010

22

10.1254/fpj.84.353

TAKAHASHI, Hiroshi, SHIBATA, Manabu, OHKUBO, Tsuyako, NARUSE, Satoru

Journal:

Folia Pharmacologica Japonica

Year:

1984

File:

PDF, 4.16 MB

1984

23

Peripheral analgesic actions of opioid peptides and morphine analogues.

SHIBATA, Manabu, OHKUBO, Tsuyako, TAKAHASHI, Hiroshi, KUDO, Teruo, INOKI, Reizo

Journal:

Folia Pharmacologica Japonica

Year:

1986

File:

PDF, 4.90 MB

1986

24

Studies of inflammatory pain response: Related pain producing substance and endogenous opioid system.

SHIBATA, Manabu, OHKUBO, Tsuyako, TAKAHASHI, Hiroshi, KUDO, Teruo, INOKI, Reizo

Journal:

Folia Pharmacologica Japonica

Year:

1986

File:

PDF, 7.49 MB

1986

25

Interaction of bradykinin with substance P on vascular permeability and pain response.

SHIBATA, Manabu, OHKUBO, Tsuyako, TAKAHASHI, Hiroshi, INOKI, Reizo

Journal:

The Japanese Journal of Pharmacology

Year:

1986

Language:

english

File:

PDF, 185 KB

english, 1986

26

Mechanisms Mediating the Vasorelaxing Action of Eugenol, a Pungent Oil, or Rabbit Arterial Tissue.

Nishijima, Hiroaki, Uchida, Ryuji, Kameyama, Kimiko, Kawakami, Nozomi, Ohkubo, Tsuyako, Kitamura, Kenji

Journal:

The Japanese Journal of Pharmacology

Year:

1999

File:

PDF, 870 KB

1999

27

Genetic deletion of Cav3.2 T-type calcium channels abolishes H2S-dependent somatic and visceral pain signaling in C57BL/6 mice

Matsui, Kazuki, Tsubota, Maho, Fukushi, Saaya, Koike, Nene, Masuda, Hiroshi, Kasanami, Yoshihito, Miyazaki, Takaya, Sekiguchi, Fumiko, Ohkubo, Tsuyako, Yoshida, Shigeru, Mukai, Yutaro, Oita, Akira, Ta

Journal:

Journal of Pharmacological Sciences

Year:

2019

Language:

english

File:

PDF, 700 KB

english, 2019

28

Anti-inflammatory and analgesic action of indomethacin cream ointment containing drugs for stimulation of indomethacin absorption.

Inoki, Reizo, Takahashi, Hiroshi, Shibata, Manabu, Ohkubo, Tsuyako, Nakanishi, Michio

Journal:

Year:

1987

File:

PDF, 811 KB

1987

29

Anti-inflammatory and analgesic action of indomethacin cream ointment containing drugs for stimulation of indomethacin absorption.

Inoki, Reizo, Takahashi, Hiroshi, Shibata, Manabu, Ohkubo, Tsuyako, Nakanishi, Michio

Journal:

Year:

1987

File:

PDF, 811 KB

1987

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