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51

Polymorphisms in TLR4 and TLR2 genes, cytokine production and survival in rural Ghana

May, Linda, van Bodegom, David, Frölich, Marijke, van Lieshout, Lisette, Slagboom, P Eline, Westendorp, Rudi GJ, Kuningas, Maris

Journal:

European Journal of Human Genetics

Year:

2009

Language:

english

File:

PDF, 372 KB

english, 2009

52

Human longevity and 11p15.5: a study in 1321 centenarians

Lescai, Francesco, Blanché, Helene, Nebel, Almut, Beekman, Marian, Sahbatou, Mourad, Flachsbart, Friederike, Slagboom, Eline, Schreiber, Stefan, Sorbi, Sandro, Passarino, Giuseppe

Journal:

European Journal of Human Genetics

Year:

2009

Language:

english

File:

PDF, 87 KB

english, 2009

53

A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-α levels

Bos, Steffan D, Lakenberg, Nico, van der Breggen, Ruud, Houwing-Duistermaat, Jeanine J, Kloppenburg, Margreet, de Craen, Anton JM, Beekman, Marian, Meulenbelt, Ingrid, Slagboom, P Eline

Journal:

European Journal of Human Genetics

Year:

2010

Language:

english

File:

PDF, 462 KB

english, 2010

54

Mortality risk in men is associated with a common mutation in the methylenetetrahydrofolate reductase gene (MTHFR)

Heijmans, Bastiaan T, Gussekloo, Jacobijn, Kluft, Cornelis, Droog, Simone, Lagaay, A Margot, Knook, Dick L, Westendorp, Rudi GJ, Slagboom, Eline P

Journal:

European Journal of Human Genetics

Year:

1999

Language:

english

File:

PDF, 134 KB

english, 1999

55

QTLs for height: results of a full genome scan in Dutch sibling pairs

Willemsen, Gonneke, Boomsma, Dorret I, Beem, A Leo, Vink, Jacqueline M, Slagboom, P Eline, Posthuma, Danielle

Journal:

European Journal of Human Genetics

Year:

2004

Language:

english

File:

PDF, 138 KB

english, 2004

56

Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study

Schoenmaker, Manja, de Craen, Anton J M, de Meijer, Paul H E M, Beekman, Marian, Blauw, Gerard J, Slagboom, P Eline, Westendorp, Rudi G J

Journal:

European Journal of Human Genetics

Year:

2005

Language:

english

File:

PDF, 101 KB

english, 2005

57

Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes

Meulenbelt, Ingrid, Min, Josine L, van Duijn, Cornelia M, Kloppenburg, Margreet, Breedveld, Ferdinand C, Slagboom, P Eline

Journal:

European Journal of Human Genetics

Year:

2006

Language:

english

File:

PDF, 153 KB

english, 2006

58

Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age

Kuningas, Maris, Mägi, Reedik, Westendorp, Rudi G J, Slagboom, P Eline, Remm, Maido, van Heemst, Diana

Journal:

European Journal of Human Genetics

Year:

2007

Language:

english

File:

PDF, 148 KB

english, 2007

59

Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis

Min, Josine L, Meulenbelt, Ingrid, Kloppenburg, Margreet, van Duijn, Cornelia M, Slagboom, P Eline

Journal:

European Journal of Human Genetics

Year:

2007

Language:

english

File:

PDF, 139 KB

english, 2007

60

Pharmacogenetics of statins: achievements, whole-genome analyses and future perspectives

Postmus, Iris, Verschuren, Jeffrey JW, de Craen, Anton JM, Slagboom, P Eline, Westendorp, Rudi GJ, Jukema, J Wouter, Trompet, Stella

Journal:

Pharmacogenomics

Year:

2012

Language:

english

File:

PDF, 2.59 MB

english, 2012

61

Genetica: een panacee? – I

Journal:

Year:

1997

Language:

dutch

File:

PDF, 81 KB

dutch, 1997

62

Genetica: een panacee? – II

Dorret Boomsma, Eline Slagboom

Journal:

Year:

1998

Language:

dutch

File:

PDF, 77 KB

dutch, 1998

63

Parental longevity correlates with offspring’s optimism in two cohorts of community-dwelling older subjects

Nathaly Rius-Ottenheim, Daan Kromhout, Anton J. M. de Craen, Johanna M. Geleijnse, Roos C. van der Mast, Frans G. Zitman, Rudi G. Westendorp, P. Eline Slagboom, Erik J. Giltay

Journal:

Year:

2012

Language:

english

File:

PDF, 188 KB

english, 2012

64

Variation in the SHC1 gene and longevity in humans

Simon P Mooijaart, Diana van Heemst, Jeroen Schreuder, Suzan van Gerwen, Marian Beekman, Bernd W Brandt, P Eline Slagboom, Rudi G.J Westendorp, on behalf of the ‘Long Life’ study group

Journal:

Experimental Gerontology

Year:

2004

Language:

english

File:

PDF, 132 KB

english, 2004

65

Variation in the human TP53 gene affects old age survival and cancer mortality

Diana van Heemst, Simon P. Mooijaart, Marian Beekman, Jeroen Schreuder, Anton J.M. de Craen, Bernd W. Brandt, P. Eline Slagboom, Rudi G.J. Westendorp, on behalf of the ‘Long Life’ study group

Journal:

Experimental Gerontology

Year:

2005

Language:

english

File:

PDF, 131 KB

english, 2005

66

Interleukin-1 region meta-analysis with osteoarthritis phenotypes

G. Moxley, I. Meulenbelt, K. Chapman, C.M. van Diujn, P. Eline Slagboom, M.C. Neale, A.J.P. Smith, A.J. Carr, J. Loughlin

Journal:

Osteoarthritis and Cartilage

Year:

2010

Language:

english

File:

PDF, 257 KB

english, 2010

67

Impact of genetic variations in the WRN gene on age related pathologies and mortality

Maris Kuningas, P. Eline Slagboom, Rudi G.J. Westendorp, Diana van Heemst

Journal:

Mechanisms of Ageing and Development

Year:

2006

Language:

english

File:

PDF, 286 KB

english, 2006

68

Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs

Rudolf P. Talens, Kaare Christensen, Hein Putter, Gonneke Willemsen, Lene Christiansen, Dennis Kremer, H. Eka D. Suchiman, P. Eline Slagboom, Dorret I. Boomsma, Bastiaan T. Heijmans

Journal:

Year:

2012

Language:

english

File:

PDF, 283 KB

english, 2012

69

mRNA levels and methylation patterns of the tyrosine aminotransferase gene in aging inbred rats

P.Eline Slagboom, Wiljo J.F. de Leeuw, Jan Vijg

Journal:

Year:

1990

Language:

english

File:

PDF, 566 KB

english, 1990

70

No or only population-specific effect of PON1 on human longevity: A comprehensive meta-analysis

Amke Caliebe, Rabea Kleindorp, Hélène Blanché, Lene Christiansen, Annibale Alessandro Puca, Irene Maeve Rea, Eline Slagboom, Friederike Flachsbart, Kaare Christensen, Gerald Rimbach, Stefan Schreiber,

Journal:

Ageing Research Reviews

Year:

2010

Language:

english

File:

PDF, 325 KB

english, 2010

71

VDR gene variants associate with cognitive function and depressive symptoms in old age

Maris Kuningas, Simon P. Mooijaart, Jelle Jolles, P. Eline Slagboom, Rudi G.J. Westendorp, Diana van Heemst

Journal:

Neurobiology of Aging

Year:

2009

Language:

english

File:

PDF, 188 KB

english, 2009

72

Variation in the CBP gene involved in epigenetic control associates with cognitive function

Stella Trompet, Anton J.M. de Craen, J. Wouter Jukema, D. Pons, P. Eline Slagboom, D. Kremer, Eduard L.E.M. Bollen, Rudi G.J. Westendorp

Journal:

Neurobiology of Aging

Year:

2011

Language:

english

File:

PDF, 1005 KB

english, 2011

73

Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock

Rudi GJ Westendorp, Jouke-Jan Hottenga, P Eline Slagboom

Journal:

Year:

1999

Language:

english

File:

PDF, 33 KB

english, 1999

74

A Genomewide Scan for Intelligence Identifies Quantitative Trait Loci on 2q and 6p

Danielle Posthuma, Michelle Luciano, Eco J. C. de Geus, Margie J. Wright, P. Eline Slagboom, Grant W. Montgomery, Dorret I. Boomsma, Nicholas G. Martin

Journal:

The American Journal of Human Genetics

Year:

2005

Language:

english

File:

PDF, 2.43 MB

english, 2005

75

Genetic Association Analysis of RHOB and TXNDC3 in Osteoarthritis

John Loughlin, Ingrid Meulenbelt, Josine Min, Zehra Mustafa, Janet S. Sinsheimer, Andrew Carr, P. Eline Slagboom

Journal:

The American Journal of Human Genetics

Year:

2007

Language:

english

File:

PDF, 215 KB

english, 2007

76

Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study

Yingchang Lu, Edith J.M. Feskens, Jolanda M.A. Boer, Sandra Imholz, W.M. Monique Verschuren, Cisca Wijmenga, Anika Vaarhorst, Eline Slagboom, Michael Müller, Martijn E.T. Dollé

Journal:

Atherosclerosis

Year:

2010

Language:

english

File:

PDF, 204 KB

english, 2010

77

Cortisol serum levels in familial longevity and perceived age: The Leiden Longevity Study

Noordam, Raymond, Gunn, David A., Tomlin, Cyrena C., Rozing, Maarten P., Maier, Andrea B., Slagboom, P. Eline, Westendorp, Rudi G.J., van Heemst, Diana, de Craen, Anton J.M.

Journal:

Psychoneuroendocrinology

Year:

2012

Language:

english

File:

PDF, 293 KB

english, 2012

78

Genetic Variation at theTPH2Gene Influences Impulsivity in Addition to Eating Disorders

Margarita C. T. Slof-Op’t Landt, Meike Bartels, Christel M. Middeldorp, Catherina E. M. van Beijsterveldt, P. Eline Slagboom, Dorret I. Boomsma, Eric F. van Furth, Ingrid Meulenbelt

Journal:

Behavior Genetics

Year:

2013

Language:

english

File:

PDF, 236 KB

english, 2013

79

Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study

Mariette E. C. Waaijer, David A. Gunn, Sharon D. Catt, Michael van Ginkel, Anton J. M. de Craen, Nicole M. Hudson, Diana van Heemst, P. Eline Slagboom, Rudi G. J. Westendorp, Andrea B. Maier

Journal:

Year:

2012

Language:

english

File:

PDF, 313 KB

english, 2012

80

High serum glucose levels are associated with a higher perceived age

Raymond Noordam, David A. Gunn, Cyrena C. Tomlin, Andrea B. Maier, Simon P. Mooijaart, P. Eline Slagboom, Rudi G. J. Westendorp, Anton J. M. de Craen, Diana van Heemst

Journal:

Year:

2013

Language:

english

File:

PDF, 138 KB

english, 2013

81

Handgrip strength at midlife and familial longevity

Carolina H. Y. Ling, Anton J. M. de Craen, P. Eline Slagboom, Rudi G. J. Westendorp, Andrea B. Maier

Journal:

Year:

2012

Language:

english

File:

PDF, 195 KB

english, 2012

82

Messenger RNA levels and methlation patterns of GAPDH and β-actin genes in rat liver, spleen and brain in relation to aging

P.Eline Slagboom, Wiljo J.F. De Leeuw, Jan Vijg

Journal:

Mechanisms of Ageing and Development

Year:

1990

Language:

english

File:

PDF, 1.05 MB

english, 1990

83

Common paraoxonase gene variants, mortality risk and fatal cardiovascular events in elderly subjects

Bastiaan T Heijmans, Rudi G.J Westendorp, A.Margot Lagaay, Dick L Knook, Cornelis Kluft, P.Eline Slagboom

Journal:

Atherosclerosis

Year:

2000

Language:

english

File:

PDF, 92 KB

english, 2000

84

Angiotensin I–converting enzyme and plasminogen activator inhibitor-1 gene variants: risk of mortality and fatal cardiovascular disease in an elderly population-based cohort

Bastiaan T Heijmans, Rudi G.J Westendorp, Dick L Knook, Cornelis Kluft, P.Eline Slagboom

Journal:

Journal of the American College of Cardiology

Year:

1999

Language:

english

File:

PDF, 173 KB

english, 1999

85

DNA Processing, Aging, and Cancer : The Impact of New Technology

JAN VIJG, JAN A. GOSSEN, WILJO J. F. DE LEEUW, ERIK MULLAART, P. ELINE SLAGBOOM, ANDRÉ G. UITTERLINDEN

Journal:

Annals of the New York Academy of Sciences

Year:

1991

Language:

english

File:

PDF, 2.09 MB

english, 1991

86

The Dynamics of Genome Organization and Expression during the Aging Process

P. ELINE SLAGBOOM, JAN VIJG

Journal:

Annals of the New York Academy of Sciences

Year:

1992

Language:

english

File:

PDF, 901 KB

english, 1992

87

The continuing value of twin studies in the omics era

van Dongen, Jenny, Slagboom, P. Eline, Draisma, Harmen H. M., Martin, Nicholas G., Boomsma, Dorret I.

Journal:

Nature Reviews Genetics

Year:

2012

Language:

english

File:

PDF, 504 KB

english, 2012

88

Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health

Ruhaak, L. Renee, Uh, Hae-Won, Beekman, Marian, Hokke, Cornelis H., Westendorp, Rudi G. J., Houwing-Duistermaat, Jeanine, Wuhrer, Manfred, Deelder, André M., Slagboom, P. Eline

Journal:

Journal of Proteome Research

Year:

2011

Language:

english

File:

PDF, 1.71 MB

english, 2011

89

N-glycomic biomarkers of biological aging and longevity: A link with inflammaging

Dall’Olio, Fabio, Vanhooren, Valerie, Chen, Cuiying Chitty, Slagboom, P. Eline, Wuhrer, Manfred, Franceschi, Claudio

Journal:

Ageing Research Reviews

Year:

2013

Language:

english

File:

PDF, 831 KB

english, 2013

90

Identifying the genomic determinants of aging and longevity in human population studies: Progress and challenges

Deelen, Joris, Beekman, Marian, Capri, Miriam, Franceschi, Claudio, Slagboom, P. Eline

Journal:

Year:

2013

Language:

english

File:

PDF, 489 KB

english, 2013

91

The Val66Met polymorphism of the BDNF gene in anorexia nervosa: New data and a meta-analysis

Brandys, Marek K., Kas, Martien J. H., van Elburg, Annemarie A., Ophoff, Roel, Slof-Op't Landt, Margarita C. T., Middeldorp, Christel M., Boomsma, Dorret I., van Furth, Eric F., Slagboom, P. Eline, Ad

Journal:

The World Journal of Biological Psychiatry

Year:

2013

Language:

english

File:

PDF, 797 KB

english, 2013

92

Duration of breastfeeding and gender are associated with methylation of the LEPTIN gene in very young children

Obermann-Borst, Sylvia A., Eilers, Paul H.C., Tobi, Elmar W., de Jong, Frank H., Slagboom, P. Eline, Heijmans, Bastiaan T., Steegers-Theunissen, Régine P.M.

Journal:

Pediatric Research

Year:

2013

Language:

english

File:

PDF, 422 KB

english, 2013

93

The Genome of the Netherlands: design, and project goals

Boomsma, Dorret I, Wijmenga, Cisca, Slagboom, Eline P, Swertz, Morris A, Karssen, Lennart C, Abdellaoui, Abdel, Ye, Kai, Guryev, Victor, Vermaat, Martijn, van Dijk, Freerk, Francioli, Laurent C, Hotte

Journal:

European Journal of Human Genetics

Year:

2014

Language:

english

File:

PDF, 795 KB

english, 2014

94

P3-164

Lambert, Jean-Charles, Ferreira, Stéphanie, Gusselkloo, Jacobjin, Christiansen, Lene, Brysbaert, Guillaume, Slagboom, Eline, Lendon, Corinne, Petit, Thierry, Richard, Florence, Berr, Claudine, Mann, D

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 58 KB

english, 2006

95

Renal function in familial longevity: the Leiden Longevity Study

de Goeij, Moniek C.M., Halbesma, Nynke, Dekker, Friedo W., Wijsman, Carolien A., van Heemst, Diana, Maier, Andrea B., Mooijaart, Simon P., Slagboom, P. Eline, Westendorp, Rudi G.J., de Craen, Anton J.

Journal:

Experimental Gerontology

Year:

2014

Language:

english

File:

PDF, 355 KB

english, 2014

96

In search for genetic determinants of clinically meaningful differential cardiovascular event reduction by pravastatin in the PHArmacogenetic study of Statins in the Elderly at risk (PHASE)/PROSPER study

Postmus, Iris, Johnson, Paul C.D., Trompet, Stella, de Craen, Anton J.M., Slagboom, P. Eline, Devlin, James J., Shiffman, Dov, Sacks, Frank M., Kearney, Patricia M., Stott, David J., Buckley, Brendan

Journal:

Atherosclerosis

Year:

2014

Language:

english

File:

PDF, 448 KB

english, 2014

97

The aging genome: Determinant or target?

Slagboom, P.Eline

Journal:

Mutation Research/DNAging

Year:

1990

Language:

english

File:

PDF, 460 KB

english, 1990

98

Two-Dimensional DNA Fingerprinting of Human Individuals

Andre G. Uitterlinden, P. Eline Slagboom, Dick L. Knook and Jan Vijg

Journal:

Proceedings of the National Academy of Sciences

Year:

1989

Language:

english

File:

PDF, 1.74 MB

english, 1989

99

Genetic instability and aging: theories, facts, and future perspectives

Slagboom, P. Eline, Vijg, Jan

Journal:

Year:

1989

Language:

english

File:

PDF, 1.36 MB

english, 1989

100

Human in vivo longevity is reflected in vitro by differential metabolism as measured by 1H-NMR profiling of cell culture supernatants

Dekker, Pim, Meissner, Axel, Dirks, Roeland W., Eline Slagboom, P., van Heemst, Diana, Deelder, André M., Tanke, Hans J., Westendorp, Rudi G. J., Maier, Andrea B.

Journal:

Molecular BioSystems

Year:

2012

Language:

english

File:

PDF, 1.44 MB

english, 2012