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51

Talampanel, a New Antiepileptic Drug: Single and Multiple-dose Pharmacokinetics and Initial One Week Experience in Patients with Chronic Intractable Epilepsy

Yvonne M. Langan, Richard Lucas, Haley Jewell, Nathalie Toublanc, Hans Schaefer, Josemir W.A.S. Sander, Philip N. Patsalos

Journal:

Year:

2003

File:

PDF, 19 KB

2003

52

Talampanel, a New Antiepileptic Drug: Single- and Multiple-dose Pharmacokinetics and Initial 1-Week Experience in Patients with Chronic Intractable Epilepsy

Yvonne M. Langan, Richard Lucas, Haley Jewell, N. Toublanc, H. Schaefer, Jasemire W. A. S. Sander, Philip N. Patsalos

Journal:

Year:

2003

Language:

english

File:

PDF, 141 KB

english, 2003

53

Interlaboratory Variability in the Quantification of New Generation Antiepileptic Drugs Based on External Quality Assessment Data

John Williams, Meir Bialer, Svein I. Johannessen, Günther Krämer, René Levy, Richard H. Mattson, Emilio Perucca, Philip N. Patsalos, John F. Wilson

Journal:

Year:

2003

Language:

english

File:

PDF, 130 KB

english, 2003

54

Treatment of Phenytoin Toxicity by the Molecular Adsorbents Recirculating System (MARS)

Sambit Sen, Neville Ratnaraj, Nathan A. Davies, Rajeshwar P. Mookerjee, Christopher E. Cooper, Philip N. Patsalos, Roger Williams, Rajiv Jalan

Journal:

Year:

2003

Language:

english

File:

PDF, 107 KB

english, 2003

55

A microdialysis study of glycinamide, glycine and other amino acid neurotransmitters in rat frontal cortex and hippocampus after the administration of milacemide, a glycine pro-drug

Mary H. Doheny, Shigeru Nagaki, Philip N. Patsalos

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1996

Language:

english

File:

PDF, 673 KB

english, 1996

56

Dose dependent enzyme induction by oxcarbazepine?

P. N. Patsalos, J. M. Zakrzewska, A. A. Elyas

Journal:

European Journal of Clinical Pharmacology

Year:

1990

Language:

english

File:

PDF, 192 KB

english, 1990

57

Protein binding of oxcarbazepine and its primary active metabolite, 10-hydroxycarbazepine, in patients with trigeminal neuralgia

P. N. Patsalos, A. A. Elyas, J. M. Zakrzewska

Journal:

European Journal of Clinical Pharmacology

Year:

1990

Language:

english

File:

PDF, 313 KB

english, 1990

58

Blood and cerebrospinal fluid pharmacokinetics of primidone and its primary pharmacologically active metabolites, phenobarbital and phenylethylmalonamide in the rat

S. Nagaki, N. Ratnaraj, P. N. Patsalos

Journal:

European Journal of Drug Metabolism and Pharmacokinetics

Year:

1999

Language:

english

File:

PDF, 916 KB

english, 1999

59

Isobolographic analysis of interactions between loreclezole and conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model

Jarogniew J. Luszczki, Neville Ratnaraj, Philip N. Patsalos, Stanislaw J. Czuczwar

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2006

Language:

english

File:

PDF, 234 KB

english, 2006

60

The excitatory amino acid antagonist d-CPP-ene (SDZ EAA-494) in patients with epilepsy

S. Sveinbjornsdottir, J.W.A.S. Sander, D. Upton, P.J. Thompson, P.N. Patsalos, D. Hirt, M. Emre, D. Lowe, J.S. Duncan

Journal:

Epilepsy Research

Year:

1993

Language:

english

File:

PDF, 927 KB

english, 1993

61

Blood and cerebrospinal fluid pharmacokinetics of the novel anticonvulsant levetiracetam (ucb L059) in the rat

H.C Doheny, N Ratnaraj, M.A Whittington, J.G.R Jefferys, P.N Patsalos

Journal:

Epilepsy Research

Year:

1999

Language:

english

File:

PDF, 119 KB

english, 1999

62

Synergism between Topiramate and Budipine in Refractory Status Epilepticus in the Rat

Andrew Fisher, Xiaolan Wang, Hannah R. Cock, Maria Thom, Philip N. Patsalos, Matthew C. Walker

Journal:

Year:

2004

Language:

english

File:

PDF, 221 KB

english, 2004

63

Pharmacodynamic and Pharmacokinetic Interaction Studies of Loreclezole with Felbamate, Lamotrigine, Topiramate, and Oxcarbazepine in the Mouse Maximal Electroshock Seizure Model

Jarogniew J. Luszczki, Neville Ratnaraj, Philip N. Patsalos, Stanislaw J. Czuczwar

Journal:

Year:

2005

Language:

english

File:

PDF, 181 KB

english, 2005

64

A Halothane-Related Effect on Rat Brain Myelination: A Comparison of Chronic Prenatal or Postnatal Exposure

P. N. Patsalos, B. M. Rigor, R. C. Wiggins

Journal:

Journal of Neurochemistry

Year:

1980

Language:

english

File:

PDF, 486 KB

english, 1980

65

Changes in Regional Brain Levels of Amino Acid Putative Neurotransmitters After Prolonged Treatment with t he Anticonvulsant Drugs Diphenylhydantoin, Phenobarbitone, Sodium Valproate, Ethosuximide, and Sulthiame in the Rat

P. N. Patsalos, P. T. Lascelles

Journal:

Journal of Neurochemistry

Year:

1981

Language:

english

File:

PDF, 750 KB

english, 1981

66

Brain Maturation Following Administration of Phenobarbital, Phenytoin, and Sodium Valproate to Developing Rats or to Their Dams: Effects on Synthesis of Brain Myelin and Other Subcellular Membrane Proteins

Philip N. Patsalos, Richard C. Wiggins

Journal:

Journal of Neurochemistry

Year:

1982

Language:

english

File:

PDF, 884 KB

english, 1982

67

Comparison of Single- and Repeated-Dose Pharmacokinetics of Diazepam

M. C. Walker, X. Tong, S. Brown, S. D. Shorvon, P. N. Patsalos

Journal:

Year:

1998

Language:

english

File:

PDF, 574 KB

english, 1998

68

Halothane as a Neuroprotectant During Constant Stimulation of the Perforant Path

M. C. Walker, H. Perry, F. Scaravilli, P. N. Patsalos, S. D. Shorvon, J. G. R. Jefferys

Journal:

Year:

1999

Language:

english

File:

PDF, 919 KB

english, 1999

69

Selection of Antiepileptic Drug Polytherapy Based on Mechanisms of Action: The Evidence Reviewed

Charles L. P. Deckers, Stanislaw J. Czuczwar, Yechiel A. Hekster, Antoine Kewser, Hana Kubova, Harry Meinardi, Philip N. Patsalos, Willy O. Renier, Clementina M. Van Rijn

Journal:

Year:

2000

Language:

english

File:

PDF, 1.11 MB

english, 2000

70

Properties of Antiepileptic Drugs in the Treatment of Idiopathic Generalized Epilepsies

Philip N. Patsalos

Journal:

Year:

2005

Language:

english

File:

PDF, 83 KB

english, 2005

71

Pharmacodynamic and Pharmacokinetic Characterization of Interactions between Levetiracetam and Numerous Antiepileptic Drugs in the Mouse Maximal Electroshock Seizure Model: An Isobolographic Analysis

Jarogniew J. Luszczki, Marta M. Andres, Piotr Czuczwar, Anna Cioczek-Czuczwar, Neville Ratnaraj, Philip N. Patsalos, Stanislaw J. Czuczwar

Journal:

Year:

2006

Language:

english

File:

PDF, 141 KB

english, 2006

72

Characterization of the Anticonvulsant, Behavioral and Pharmacokinetic Interaction Profiles of Stiripentol in Combination with Clonazepam, Ethosuximide, Phenobarbital, and Valproate Using Isobolographic Analysis

Jarogniew J. Luszczki, Neville Ratnaraj, Philip N. Patsalos, Stanislaw J. Czuczwar

Journal:

Year:

2006

Language:

english

File:

PDF, 188 KB

english, 2006

73

In Situ Metabolism of Levetiracetam in Blood of Patients with Epilepsy

Philip N. Patsalos, Sandirup Ghattaura, Neville Ratnaraj, Josemir W. Sander

Journal:

Year:

2006

Language:

english

File:

PDF, 52 KB

english, 2006

74

Levetiracetam and Felbamate Interact Both Pharmacodynamically and Pharmacokinetically: An Isobolographic Analysis in the Mouse Maximal Electroshock Model

Jarogniew J. Luszczki, Marta M. Andres-Mach, Neville Ratnaraj, Philip N. Patsalos, Stanislaw J. Czuczwar

Journal:

Year:

2007

Language:

english

File:

PDF, 146 KB

english, 2007

75

Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies

Philip N. Patsalos, David J. Berry, Blaise F. D. Bourgeois, James C. Cloyd, Tracy A. Glauser, Svein I. Johannessen, Ilo E. Leppik, Torbjörn Tomson, Emilio Perucca

Journal:

Year:

2008

Language:

english

File:

PDF, 415 KB

english, 2008

76

Vigabatrin extracellular pharmacokinetics and concurrent γ-aminobutyric acid neurotransmitter effects in rat frontal cortex and hippocampus using microdialysis

Xin Tong, Neville Ratnaraj, Philip N. Patsalos

Journal:

Year:

2009

Language:

english

File:

PDF, 564 KB

english, 2009

77

Saliva and serum lacosamide concentrations in patients with epilepsy

Clare Greenaway, Neville Ratnaraj, Josemir W. Sander, Philip N. Patsalos

Journal:

Year:

2011

Language:

english

File:

PDF, 341 KB

english, 2011

78

Benzodiazepine Receptor Quantification In Vivo in Humans Using [11C]Flumazenil and PET: Application of the Steady-State Principle

Lassen, N. A., Bartenstein, P. A., Lammertsma, A. A., Prevett, M. C., Turton, D. R., Luthra, S. K., Osman, S., Bloomfield, P. M., Jones, T., Patsalos, P. N.

Journal:

Journal of Cerebral Blood Flow and Metabolism

Year:

1995

Language:

english

File:

PDF, 727 KB

english, 1995

79

Comparison of serum, cerebrospinal fluid and brain extracellular fluid pharmacokinetics of lamotrigine

M C Walker, X Tong, H Perry, M S Alavijeh, P N Patsalos

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 154 KB

english, 2000

80

A microdialysis study of the novel antiepileptic drug levetiracetam: extracellular pharmacokinetics and effect on taurine in rat brain

X Tong, P N Patsalos

Journal:

British Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 198 KB

english, 2001

81

A comparison of the efficacy of carbamazepine and the novel anti-epileptic drug levetiracetam in the tetanus toxin model of focal complex partial epilepsy

H C Doheny, M A Whittington, J G R Jefferys, P N Patsalos

Journal:

British Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 263 KB

english, 2002

82

Computational models explain the oligosaccharide specificity of cyanovirin-N

Yukiji K. Fujimoto, Ryan N. TerBush, Vadim Patsalo, David F. Green

Journal:

Protein Science

Year:

2008

Language:

english

File:

PDF, 345 KB

english, 2008

83

Methodologies used to identify and characterize interactions among antiepileptic drugs

Johannessen Landmark, Cecilie, Patsalos, Philip N

Journal:

Expert Review of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 696 KB

english, 2012

84

Effect of denzimol on carbamazepine and carbamazepine-10,11-epoxide concentrations in serum, liver, spleen and different brain regions of the rat: an inhibitory metabolic interaction

P. N. Patsalos, M. S. Alavijeh, W. Brownhill, P. T. Lascelles

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1988

Language:

english

File:

PDF, 401 KB

english, 1988

85

Drugs used in the management of trigeminal neuralgia

J.M. Zakrzewska, P.N. Patsalos

Journal:

Oral Surgery, Oral Medicine, Oral Pathology

Year:

1992

Language:

english

File:

PDF, 1.29 MB

english, 1992

86

Clinical pharmacokinetics of new antiepileptic drugs

M.C. Walker, P.N. Patsalos

Journal:

Pharmacology & Therapeutics

Year:

1995

Language:

english

File:

PDF, 3.21 MB

english, 1995

87

A freely moving and behaving rat model for the chronic and simultaneous study of drug pharmacokinetics (blood) and neuropharmacokinetics (cerebrospinal fluid): Hematological and biochemical characterization and kinetic evaluation using carbamazepine

Philip N. Patsalos, Mohammed S. Alavijeh, Jun'ichi Semba, Yvette I. Lolin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

1992

Language:

english

File:

PDF, 659 KB

english, 1992

88

Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy

Jarogniew J. Luszczki, Neville Ratnaraj, Philip N. Patsalos, Stanislaw J. Czuczwar

Journal:

European Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 405 KB

english, 2008

89

Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: An isobolographic analysis

Monika Dudra-Jastrzebska, Marta M. Andres-Mach, Marcin Sielski, Neville Ratnaraj, Philip N. Patsalos, Stanislaw J. Czuczwar, Jarogniew J. Luszczki

Journal:

European Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 252 KB

english, 2009

90

Effect of felbamate and its combinations with conventional antiepileptics in amygdala-kindled rats

K.K Borowicz, N Ratnaraj, P.N Patsalos, S.J Czuczwar

Journal:

Pharmacology Biochemistry and Behavior

Year:

2004

Language:

english

File:

PDF, 226 KB

english, 2004

91

Pharmacokinetic profile of levetiracetam: toward ideal characteristics

Journal:

Pharmacology & Therapeutics

Year:

2000

Language:

english

File:

PDF, 101 KB

english, 2000

92

Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs

Philip N Patsalos, Emilio Perucca

Journal:

The Lancet Neurology

Year:

2003

Language:

english

File:

PDF, 267 KB

english, 2003

93

Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs

Philip N Patsalos, Emilio Perucca

Journal:

The Lancet Neurology

Year:

2003

Language:

english

File:

PDF, 182 KB

english, 2003

94

Benzodiazepine-GABAA Receptors in Idiopathic Generalized Epilepsy Measured with [11C]Flumazenil and Positron Emission Tomography

Martin C. Prevett, Adriaan A. Lammertsma, David J. Brooks, Peter A. Bartenstein, Philip N. Patsalos, David R. Fish, John S. Duncan

Journal:

Year:

1995

Language:

english

File:

PDF, 905 KB

english, 1995

95

Microdialysis Study of the Neuropharmacokinetics of Phenytoin in Rat Hippocampus and Frontal Cortex

M. C. Walker, M. S. Alavijeh, S. D. Shorvon, P. N. Patsalos

Journal:

Year:

1996

Language:

english

File:

PDF, 597 KB

english, 1996

96

In vitro hydroxylation of diphenylhydantoin and its inhibition by other commonly used anticonvulsant drugs

Philip N. Patsalos, Peter T. Lascelles

Journal:

Biochemical Pharmacology

Year:

1977

Language:

english

File:

PDF, 470 KB

english, 1977

97

Milacemide effects on the temporal inter-relationship of amino acids and monoamine metabolites in rat cerebrospinal fluid

Jun'ichi Semba, Philip N. Patsalos

Journal:

European Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 478 KB

english, 1993

98

Chronic subanesthetic halothane exposure causes selective alterations in neurotransmitter systems in discrete brain regions

Zehava Gottesfeld, Philip N. Patsalos, Benjamin M. Rigor, Richard C. Wiggins

Journal:

Experimental Neurology

Year:

1982

Language:

english

File:

PDF, 694 KB

english, 1982

99

Efficacy and tolerability study of ucb L059 in patients with refractory epilepsy

M.K. Sharief, P. Singh, J.W.A.S. Sander, P.N. Patsalos, S.D. Shorvon

Journal:

Journal of Epilepsy

Year:

1996

Language:

english

File:

PDF, 692 KB

english, 1996

100

Sensitivity of Amyloid Formation by Human Islet Amyloid Polypeptide to Mutations at Residue 20

Ping Cao, Ling-Hsien Tu, Andisheh Abedini, Olesya Levsh, Rehana Akter, Vadim Patsalo, Ann Marie Schmidt, Daniel P. Raleigh

Journal:

Journal of Molecular Biology

Year:

2012

Language:

english

File:

PDF, 1.58 MB

english, 2012

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