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51

Design and Implementation of a Multicenter Trial of Vitamin E in Aging Individuals with Down Syndrome

Paul S. Aisen, Arthur J. Dalton, Mary Sano, Ira T. Lott, H. F. Andrews, W.-Y. Tsai, the International Down Syndrome, Alzheimer's Disease Consortium

Journal:

Journal of Policy and Practice in Intellectual Disabilities

Year:

2005

Language:

english

File:

PDF, 96 KB

english, 2005

52

Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage

Yasuji Matsuoka, Audrey J. Gray, Chiho Hirata-Fukae, S. Sakura Minami, Emily Graeme Waterhouse, Mark P. Mattson, Frank M. LaFerla, Illana Gozes, Paul S. Aisen

Journal:

Journal of Molecular Neuroscience

Year:

2007

Language:

english

File:

PDF, 202 KB

english, 2007

53

An update on huperzine A as a treatment for Alzheimer's disease

Little, John T, Walsh, Sally, Aisen, Paul S

Journal:

Expert Opinion on Investigational Drugs

Year:

2008

Language:

english

File:

PDF, 182 KB

english, 2008

54

Longitudinal stability of subsyndromal symptoms of depression in individuals with mild cognitive impairment: relationship to conversion to dementia after 3 years

R. Scott Mackin, Philip Insel, Paul S. Aisen, Yonas E. Geda, Michael W. Weiner

Journal:

International Journal of Geriatric Psychiatry

Year:

2012

Language:

english

File:

PDF, 177 KB

english, 2012

55

Longitudinal plasma amyloid beta as a biomarker of Alzheimer’s disease

Rissman, Robert A., Trojanowski, John Q., Shaw, Leslie M., Aisen, Paul S.

Journal:

Journal of Neural Transmission

Year:

2012

Language:

english

File:

PDF, 203 KB

english, 2012

56

IL-1 and anti-inflammatory drugs modulate A β cytotoxicity in PC12 cells

Mirela O. Fagarasan, Paul S. Aisen

Journal:

Year:

1996

Language:

english

File:

PDF, 349 KB

english, 1996

57

P44 Implementation of multicenter clinical trials: The Alzheimer's Disease Cooperative Study protocol implementation manual

Kimberly Schafer, Leon Thal, Jacqueline Bochenek, Mary Sano, Michael Grundman, Peter Woodbury, Melville Klauber, Paul Aisen

Journal:

Controlled Clinical Trials

Year:

1995

Language:

english

File:

PDF, 68 KB

english, 1995

58

Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman

Richard K. Gordon, Julian R. Haigh, Gregory E. Garcia, Shawn R. Feaster, Michael A. Riel, David E. Lenz, Paul S. Aisen, Bhupendra P. Doctor

Journal:

Chemico-Biological Interactions

Year:

2005

Language:

english

File:

PDF, 342 KB

english, 2005

59

Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: Next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase

Julian R. Haigh, Scott R. Johnston, Adam Peppernay, Patrick J. Mattern, Gregory E. Garcia, Bhupendra P. Doctor, Richard K. Gordon, Paul S. Aisen

Journal:

Chemico-Biological Interactions

Year:

2008

Language:

english

File:

PDF, 685 KB

english, 2008

60

NAP ameliorates Alzheimer’s pathology in ad model mouse

Y. Matsuoka, Illana Gozes, Paul S. Aisen

Journal:

Year:

2006

Language:

english

File:

PDF, 64 KB

english, 2006

61

Evaluation of Selective COX-2 Inhibitors for the Treatment of Alzheimer's Disease

Journal:

Journal of Pain and Symptom Management

Year:

2002

Language:

english

File:

PDF, 65 KB

english, 2002

62

The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease

Journal:

The Lancet Neurology

Year:

2002

Language:

english

File:

PDF, 225 KB

english, 2002

63

An aspirin a day for Alzheimer's disease?

Journal:

The Lancet Neurology

Year:

2008

Language:

english

File:

PDF, 70 KB

english, 2008

64

Tarenflurbil: a shot on goal

Journal:

The Lancet Neurology

Year:

2008

Language:

english

File:

PDF, 42 KB

english, 2008

65

Recent developments in Alzheimer's disease therapeutics

Michael S Rafii, Paul S Aisen

Journal:

Year:

2009

Language:

english

File:

PDF, 207 KB

english, 2009

66

Q & A: The Alzheimer's disease neuroimaging initiative

Journal:

Year:

2011

Language:

english

File:

PDF, 98 KB

english, 2011

67

Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivo

Chiho Hirata-Fukae, Elkhansa Hassan Sidahmed, Thomas P. Gooskens, Paul S. Aisen, Ilse Dewachter, Herman Devijver, Fred Van Leuven, Yasuji Matsuoka

Journal:

Neuroscience Letters

Year:

2008

Language:

english

File:

PDF, 322 KB

english, 2008

68

No cross-sectional influence of APOE ɛ4 dose on clinical tests in Alzheimer's disease

Rochelle E. Tractenberg, Paul S. Aisen, Gregory R. Hancock, G. William Rebeck

Journal:

Neurobiology of Aging

Year:

2009

Language:

english

File:

PDF, 73 KB

english, 2009

69

Relations between brain tissue loss, CSF biomarkers, and the ApoE genetic profile: a longitudinal MRI study

Duygu Tosun, Norbert Schuff, Diana Truran-Sacrey, Leslie M. Shaw, John Q. Trojanowski, Paul Aisen, Ronald Peterson, Michael W. Weiner

Journal:

Neurobiology of Aging

Year:

2010

Language:

english

File:

PDF, 1.76 MB

english, 2010

70

Nonlinear time course of brain volume loss in cognitively normal and impaired elders

Norbert Schuff, Duygu Tosun, Philip S. Insel, Gloria C. Chiang, Diana Truran, Paul S. Aisen, Clifford R. Jack Jr., Michael W. Weiner

Journal:

Neurobiology of Aging

Year:

2012

Language:

english

File:

PDF, 1.85 MB

english, 2012

71

Clinical trial methodologies for disease-modifying therapeutic approaches

Journal:

Neurobiology of Aging

Year:

2011

Language:

english

File:

PDF, 336 KB

english, 2011

72

Prevention trials in Alzheimer's disease: An EU-US task force report

Bruno Vellas, Paul S. Aisen, Cristina Sampaio, Maria Carrillo, Philip Scheltens, Bruno Scherrer, Giovanni B. Frisoni, Michael Weiner, Lon Schneider, Serge Gauthier, Christine C. Gispen-de Wied, Suzann

Journal:

Progress in Neurobiology

Year:

2011

Language:

english

File:

PDF, 249 KB

english, 2011

73

Biomarkers for Alzheimer's disease therapeutic trials

Harald Hampel, Gordon Wilcock, Sandrine Andrieu, Paul Aisen, Kaj Blennow, K. Broich, Maria Carrillo, Nick C. Fox, Giovanni B. Frisoni, Maria Isaac, Simon Lovestone, Agneta Nordberg, David Prvulovic, C

Journal:

Progress in Neurobiology

Year:

2011

Language:

english

File:

PDF, 1.31 MB

english, 2011

74

Potentiation of Excitotoxicity in Transgenic Mice Overexpressing Neuronal Cyclooxygenase-2

Kevin A. Kelley, Lap Ho, David Winger, Jose Freire-Moar, Cy Blanco Borelli, Paul S. Aisen, Giulio Maria Pasinetti

Journal:

The American Journal of Pathology

Year:

1999

Language:

english

File:

PDF, 517 KB

english, 1999

75

Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

Rachelle S Doody, Svetlana I Gavrilova, Mary Sano, Ronald G Thomas, Paul S Aisen, Sergey O Bachurin, Lynn Seely, David Hung

Journal:

Year:

2008

Language:

english

File:

PDF, 211 KB

english, 2008

76

Statistical treatment of withdrawal in trials of anti-dementia drugs – Authors' reply

Rachelle Doody, Lynn Seely, Ronald Thomas, Mary Sano, Paul Aisen

Journal:

Year:

2008

Language:

english

File:

PDF, 41 KB

english, 2008

77

Induction of cyclooxygenase (COX)-2 but not COX-1 gene expression in apoptotic cell death

Lap Ho, Hiroshi Osaka, Paul S Aisen, Giulio Maria Pasinetti

Journal:

Journal of Neuroimmunology

Year:

1998

Language:

english

File:

PDF, 1.17 MB

english, 1998

78

Anti-inflammatory therapy for Alzheimer’s disease

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 40 KB

english, 2000

79

Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer’s Disease neuropathology

Zhongmin Xiang, Lap Ho, Jennifer Valdellon, David Borchelt, Kevin Kelley, Lauren Spielman, Paul S. Aisen, Giulio Maria Pasinetti

Journal:

Neurobiology of Aging

Year:

2002

Language:

english

File:

PDF, 226 KB

english, 2002

80

O1-05-06 Clinical data on Alzhemed™ after 12 months of treatment in patients with mild to moderate Alzheimer's disease

Paul A. Aisen, Mariam Mehran, Ruth Poole, Isabelle Lavoie, Francine Gervais, Richard Briand, Denis Garceau

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 157 KB

english, 2004

81

P1-093 ADCS prevention instrument project: mail-in cognitive function screening instrument (MCFSI)

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 159 KB

english, 2004

82

P1-407 ADCS prevention instrument project: overview and initial results

Steven Ferris, Paul Aisen, Doug Galasko, David Salmon, Lon Schneider, Mary Sano, Peter Whitehouse

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 167 KB

english, 2004

83

Altered expression of a-type but not b-type synapsin isoform in the brain of patients at high risk for Alzheimer's disease assessed by DNA microarray technique

Lap Ho, Yujin Guo, Lauren Spielman, Oana Petrescu, Vahran Haroutunian, Dushyant Purohit, Andrew Czernik, Shrishailam Yemul, Paul S. Aisen, Richard Mohs, Giulio Maria Pasinetti

Journal:

Neuroscience Letters

Year:

2001

Language:

english

File:

PDF, 134 KB

english, 2001

84

Safety and biomarker effects of solanezumab in patients with Alzheimer’s disease

Martin Farlow, Steven E. Arnold, Christopher H. van Dyck, Paul S. Aisen, B. Joy Snider, Anton P. Porsteinsson, Stuart Friedrich, Robert A. Dean, Celedon Gonzales, Gopalan Sethuraman, Ronald B. DeMatto

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 570 KB

english, 2012

85

Commentary on “Biomarkers in Alzheimer's disease drug development.” Can't live without ‘em

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 658 KB

english, 2011

86

Biological markers of amyloid β-related mechanisms in Alzheimer's disease

Harald Hampel, Yong Shen, Dominic M. Walsh, Paul Aisen, Les M. Shaw, Henrik Zetterberg, John Q. Trojanowski, Kaj Blennow

Journal:

Experimental Neurology

Year:

2010

Language:

english

File:

PDF, 1.03 MB

english, 2010

87

Clinical trials of anti-amyloid agents

Journal:

Alzheimer's & Dementia

Year:

2005

Language:

english

File:

PDF, 47 KB

english, 2005

88

Functional GAG mimetics as an approach for the treatment of amyloid diseases

Patrick Tremblay, Paul Aisen, Denis Garceau

Journal:

Alzheimer's & Dementia

Year:

2005

Language:

english

File:

PDF, 46 KB

english, 2005

89

Developing outcome measures for therapeutic trials for dementia in aging individuals with Down Syndrome

Mary Sano, Paul Aisen, Howard Andrews, Arthur Dalton

Journal:

Alzheimer's & Dementia

Year:

2005

Language:

english

File:

PDF, 61 KB

english, 2005

90

Design and implementation of a multicenter trial of vitamin E in aging individuals with Down syndrome

Sally Walsh, Howard F. Andrews, Wei-Yann Tsai, Dalton J. Arthur, Mary Sano, Paul S. Aisen

Journal:

Alzheimer's & Dementia

Year:

2005

Language:

english

File:

PDF, 50 KB

english, 2005

91

Development of a disease-modifying treatment for Alzheimer’s disease: Alzhemed

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 61 KB

english, 2006

92

Commentary on “Challenges to demonstrating disease-modifying effects in Alzheimer’s disease clinical trials”

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 78 KB

english, 2006

93

A simple method to rule out dementia with temporal orientation

Rochelle E. Tractenberg, Myron F. Weiner, Paul S. Aisen, Jeffrey A. Kaye, Jong-Ling Fuh

Journal:

Alzheimer's & Dementia

Year:

2007

Language:

english

File:

PDF, 102 KB

english, 2007

94

Independent contributions of neural and “higher-order” deficits to symptoms in Alzheimer’s disease: A latent variable modeling approach

Rochelle E. Tractenberg, Paul S. Aisen, Myron F. Weiner, Jeffrey L. Cummings, Gregory R. Hancock

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 186 KB

english, 2006

95

S3-02-03: Results of a one-year randomized, placebo-controlled trial of dimebon for the treatment of mild to moderate Alzheimer’s disease

Rachelle S. Doody, Svetlana Gavrilova, Mary Sano, Ronald Thomas, Paul Aisen, Sergey Bachurin, Lynn Seely, David Hung

Journal:

Alzheimer's & Dementia

Year:

2007

Language:

english

File:

PDF, 54 KB

english, 2007

96

O2-05-08: A phase III study of the efficacy, safety and disease modification effect of tramiprosate in mild-to-moderate Alzheimer’s disease

Paul Aisen, Serge Gauthier, Richard Briand, Daniel Saumier, Graziella Soulban, Denis Garceau

Journal:

Alzheimer's & Dementia

Year:

2007

Language:

english

File:

PDF, 47 KB

english, 2007

97

S3-02-01: ADCS homocysteine trial

Paul S. Aisen, Shelia Jin, Ronald G. Thomas, Mary Sano, Ramon Diaz-Arrastia, Leon Thal

Journal:

Alzheimer's & Dementia

Year:

2007

Language:

english

File:

PDF, 46 KB

english, 2007

98

P-198: Huperzine A as a treatment for Alzheimer’s disease

John T. Little, Sally Walsh, Paul Aisen

Journal:

Alzheimer's & Dementia

Year:

2007

Language:

english

File:

PDF, 48 KB

english, 2007

99

Commentary on “The Third Canadian Consensus Conference on the Diagnosis and Treatment of Dementia, 2006.”—An appraisal

Journal:

Alzheimer's & Dementia

Year:

2007

Language:

english

File:

PDF, 73 KB

english, 2007

100

Leon Thal and the therapeutic age of Alzheimer’s disease

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 75 KB

english, 2008