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51

Antitumor activity of prolonged as compared with bolus administration of 2′,2′-difluorodeoxycytidine in vivo against murine colon tumors

Gijsbert Veerman, V. W. T. Ruiz van Haperen, Jan B. Vermorken, Paul Noordhuis, Boudewijn J. M. Braakhuis, Herbert M. Pinedo, G. J. Peters

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1996

Language:

english

File:

PDF, 201 KB

english, 1996

52

Tumor size and origin determine the antitumor activity of cisplatin or 5-fluorouracil and its modulation by leucovorin in murine colon carcinomas

J. A. M. Van Laar, Youcef M. Rustum, C. L. Van der Wilt, Kees Smid, Catharina M. Kuiper, Herbert M. Pinedo, G. J. Peters, J. A. M. Van Laar

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1996

Language:

english

File:

PDF, 2.05 MB

english, 1996

53

5-Fluorouracil/leucovorin-induced inhibition of thymidylate synthase in normal tissues of mouse and man

Clasina L. van der Wilt, Cornelis J. van Groeningen, Herbert M. Pinedo, Kees Smid, Klaas Hoekman, Sybren Meijer, G. J. Peters

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

1997

Language:

english

File:

PDF, 203 KB

english, 1997

54

New developments in autologous tumor cell vaccination therapy for renal cell carcinoma

Alfons JM van den Eertwegh, Herbert M. Pinedo

Journal:

Current Oncology Reports

Year:

2000

Language:

english

File:

PDF, 140 KB

english, 2000

55

Neoadjuvant chemoimmunotherapy in locally advanced breast cancer: A new avenue to be explored

Jan Buter, Herbert M. Pinedo

Journal:

Current Oncology Reports

Year:

2003

Language:

english

File:

PDF, 420 KB

english, 2003

56

Pharmacokinetics of free and total platinum species after rapid and prolonged infusions of cisplatin

Vermorken, Jan B, Vijgh, Wim J F Van Der, Gall, Ina Klein, Helen E, Groeningen, Cees J Van, Hart, Guus A M, Pinedo, Herbert M

Journal:

Clinical Pharmacology & Therapeutics

Year:

1986

Language:

english

File:

PDF, 749 KB

english, 1986

57

The drug resistance-related protein LRP is the human major vault protein

Scheffer, George L., Wijngaard, Peter L.J., Flens, Marcel J., Izquierdo, Miguel A., Slovak, Marilyn L., Pinedo, Herbert M., Meijer, Chris J.L.M., Clevers, Hans C., Scheper, Rik J.

Journal:

Nature Medicine

Year:

1995

File:

PDF, 668 KB

1995

58

Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition

Verheul, Henk. M. W., Pinedo, Herbert M.

Journal:

Nature Reviews Cancer

Year:

2007

Language:

english

File:

PDF, 531 KB

english, 2007

59

Targeting of adenoviral vectors through a bispecific single-chain antibody

Haisma, Hidde J, Grill, Jacques, Curiel, David T, Hoogeland, Susan, van Beusechem, Victor W, Pinedo, Herbert M, Gerritsen, Winald R

Journal:

Cancer Gene Therapy

Year:

2000

Language:

english

File:

PDF, 2.11 MB

english, 2000

60

Selective gene delivery toward gastric and esophageal adenocarcinoma cells via EpCAM-targeted adenoviral vectors

Heideman, Daniëlle A M, Snijders, Peter J F, Craanen, Mikael E, Bloemena, Elisabeth, Meijer, Chris J L M, Meuwissen, Stefan G M, van Beusechem, Victor W, Pinedo, Herbert M, Curiel, David T, Haisma, Hi

Journal:

Cancer Gene Therapy

Year:

2001

Language:

english

File:

PDF, 2.35 MB

english, 2001

61

Protein expression of B-cell lymphoma gene 6 (BCL-6) in invasive breast cancer is associated with cyclin D1 and hypoxia-inducible factor-1α (HIF-1α)

Bos, Reinhard, Diest, Paul J van, Groep, Petra van der, Greijer, Astrid E, Hermsen, Mario A J A, Heijnen, Ingrid, Meijer, Gerrit A, Baak, Jan P A, Pinedo, Herbert M, Wall, Elsken van der

Journal:

Year:

2003

Language:

english

File:

PDF, 152 KB

english, 2003

62

Development of a Panel of 15 Human Ovarian Cancer Xenografts for Drug Screening and Determination of the Role of the Glutathione Detoxification System

Geertruida M. Kolfschoten, Herbert M. Pinedo, Peter G. Scheffer, Hennie M.M. Schlüper, Caroline A.M. Erkelens, Epie Boven

Journal:

Gynecologic Oncology

Year:

2000

Language:

english

File:

PDF, 64 KB

english, 2000

63

Clinical and biochemical studies of high-dose thymidine treatment in patients with solid tumors

Albert Leyva, Jan H. Schornagel, Ineke Kraal, Sybe K. Wadman, Herbert M. Pinedo

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

1984

Language:

english

File:

PDF, 568 KB

english, 1984

64

European drug development and its impact on national activities: The Dutch example

Pinedo, Herbert M.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1998

Language:

english

File:

PDF, 139 KB

english, 1998

65

Determination of N-(Phosphonacetyl)-l-Aspartic acid (PALA) in plasma and urine by high pressure liquid chromatography

Jan Lankelma, Paul G.M. Penders, Albert Leyva, Herbert M. Pinedo

Journal:

European Journal of Cancer (1965)

Year:

1965

Language:

english

File:

PDF, 353 KB

english, 1965

66

Purine modulation of thymidine activity in L1210 leukemia cells in vitro

Albert Leyva, Hillie Appel, Herbert M. Pinedo

Journal:

Leukemia Research

Year:

1982

Language:

english

File:

PDF, 567 KB

english, 1982

67

Differential expression of DNA topoisomerases in non-small cell lung cancer and normal lung

Giuseppe Giaccone, Jannette van Ark-Otte, Giorgio Scagliotti, Giovanni Capranico, Paul van der Valk, Gonzalo Rubio, Otilia Dalesio, Rafael Lopez, Franco Zunino, Jan Walboomers, Herbert M. Pinedo

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1995

Language:

english

File:

PDF, 1.42 MB

english, 1995

68

A methylester of the glucuronide prodrug DOX-GA3 for improvement of tumor-selective chemotherapy

Michelle de Graaf, Tapio J. Nevalainen, Hans W. Scheeren, Herbert M. Pinedo, Hidde J. Haisma, Epie Boven

Journal:

Biochemical Pharmacology

Year:

2004

Language:

english

File:

PDF, 237 KB

english, 2004

69

Cisplatin and doxorubicin repress Vascular Endothelial Growth Factor expression and differentially down-regulate Hypoxia-inducible Factor I activity in human ovarian cancer cells

Monique C.A. Duyndam, Maria P.A. van Berkel, Josephine C. Dorsman, Davy A.P. Rockx, Herbert M. Pinedo, Epie Boven

Journal:

Biochemical Pharmacology

Year:

2007

Language:

english

File:

PDF, 976 KB

english, 2007

70

The effect of fluoropyrimidines with or without thymidine phosphorylase inhibitor on the expression of thymidine phosphorylase

Michiel De Bruin, Toni Van Capel, Kees Smid, Masakazu Fukushima, Klaas Hoekman, Herbert M Pinedo, Godefridus J Peters

Journal:

European Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 320 KB

english, 2004

71

Collateral sensitivity to gemcitabine (2′,2′-difluorodeoxycytidine) and cytosine arabinoside of daunorubicin- and VM-26-resistant variants of human small cell lung cancer cell lines

Andries M. Bergman, Birgitte Munch-Petersen, Peter Buhl Jensen, Maxwell Sehested, Gijsbert Veerman, Daphne A. Voorn, Kees Smid, Herbert M. Pinedo, Godefridus J. Peters

Journal:

Biochemical Pharmacology

Year:

2001

Language:

english

File:

PDF, 225 KB

english, 2001

72

Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis

Robert Mauritz, Godefridus J Peters, David G Priest, Yehuda G Assaraf, Stavit Drori, Ietje Kathmann, Paul Noordhuis, Marlene A Bunni, Andre Rosowsky, Jan H Schornagel, Herbert M Pinedo, Gerrit Jansen

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 176 KB

english, 2002

73

Variation in the kinetics of caspase-3 activation, Bcl-2 phosphorylation and apoptotic morphology in unselected human ovarian cancer cell lines as a response to docetaxel

Geertruida M. Kolfschoten, Theresia M. Hulscher, Monique C.A. Duyndam, Herbert M. Pinedo, Epie Boven

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 246 KB

english, 2002

74

A doxorubicin–CNGRC-peptide conjugate with prodrug properties

Yvette van Hensbergen, Henk J. Broxterman, Yvonne W. Elderkamp, Jan Lankelma, Judith C.C. Beers, Marc Heijn, Epie Boven, Klaas Hoekman, Herbert M. Pinedo

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 508 KB

english, 2002

75

The activity profile of the hexacyclic camptothecin derivative DX-8951f in experimental human colon cancer and ovarian cancer

Annemarie H van Hattum, Herbert M Pinedo, Hennie M.M Schlüper, Caroline A.M Erkelens, Akiko Tohgo, Epie Boven

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 301 KB

english, 2002

76

Cytosolic β-glycosidases for activation of glycoside prodrugs of daunorubicin

Michelle de Graaf, Herbert M. Pinedo, Razi Quadir, Hidde J. Haisma, Epie Boven

Journal:

Biochemical Pharmacology

Year:

2003

Language:

english

File:

PDF, 189 KB

english, 2003

77

Decreased resistance to gemcitabine (2′,2′-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase

Andries M. Bergman, Herbert M. Pinedo, Ans P.M. Jongsma, Marjoleine Brouwer, Veronique W.T. Ruiz van Haperen, Gijsbert Veerman, Albert Leyva, Steffan Eriksson, Godefridus J. Peters

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 263 KB

english, 1999

78

Combination chemotherapy studies with gemcitabine and etoposide in non-small cell lung and ovarian cancer cell lines

Catharina J.A van Moorsel, Herbert M Pinedo, Gijsbert Veerman, Assen Guechev, Kees Smid, Willem J.P Loves, Jan B Vermorken, Pieter E Postmus, Godefridus J Peters

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 431 KB

english, 1999

79

Distribution and pharmacokinetics of the prodrug daunorubicin-GA3 in nude mice bearing human ovarian cancer xenografts

Pieter H.J Houba, Epie Boven, Ida H van der Meulen-Muileman, Ruben G.G Leenders, Johannes W Scheeren, Herbert M Pinedo, Hidde J Haisma

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 369 KB

english, 1999

80

Steroids affect collateral sensitivity to gemcitabine of multidrug-resistant human lung cancer cells

Andries M. Bergman, Herbert M. Pinedo, Godefridus J. Peters

Journal:

European Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 277 KB

english, 2001

81

Potent expansion of human natural killer T cells using α-galactosylceramide (KRN7000)-loaded monocyte-derived dendritic cells, cultured in the presence of IL-7 and IL-15

Hans J.J van der Vliet, Nobusuke Nishi, Yasuhiko Koezuka, B.Mary E von Blomberg, Alfons J.M van den Eertwegh, Steven A Porcelli, Herbert M Pinedo, Rik J Scheper, Giuseppe Giaccone

Journal:

Journal of Immunological Methods

Year:

2001

Language:

english

File:

PDF, 297 KB

english, 2001

82

Clinical resistance to topoisomerase-targeted drugs

Anne-Marie C. Dingemans, Herbert M. Pinedo, Giuseppe Giaccone

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1998

Language:

english

File:

PDF, 204 KB

english, 1998

83

Homing and clonogenic outgrowth of CD34+ peripheral blood stem cells: A role for L-selectin?

Fransien de Boer, Floortje L Kessler, Tanja Netelenbos, Sonja Zweegman, Peter C Huijgens, Elsken van der Wall, Jan A.M van der Linden, Herbert M Pinedo, Gerrit Jan Schuurhuis, Angelika M Dräger

Journal:

Experimental Hematology

Year:

2002

Language:

english

File:

PDF, 138 KB

english, 2002

84

Effect of Pyrimidine Nucleosides on Body Temperatures of Man and Rabbit in Relation to Pharmacokinetic Data

Godefridus J. Peters, Cees J. van Groeningen, Emile Laurensse, Ineke Kraal, Albert Leyva, Jan Lankelma, Herbert M. Pinedo

Journal:

Pharmaceutical Research

Year:

1987

File:

PDF, 985 KB

1987

85

Interleukin-2 induces activation of coagulation and fibrinolysis: resemblance to the changes seen during experimental endotoxaemia

Johanna W. Baars, Jan Paul de Boer, John Wagstaff, Dorina Roem, Anke J. M. Eerenberg-Belmer, Jos Nauta, Herbert M. Pinedo, C. Erik Hack

Journal:

British Journal of Haematology

Year:

1992

Language:

english

File:

PDF, 696 KB

english, 1992

86

The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate

Ellen C. SPOELSTRA, Hans V. WESTERHOFF, Herbert M. PINEDO, Henk DEKKER, Jan LANKELMA

Journal:

Year:

1994

Language:

english

File:

PDF, 1.21 MB

english, 1994

87

Effects of the ortho-quinone and catechol of the antitumor drug VP-16-213 on the biological activity of single-stranded and double-stranded ΦX174 DNA

Johannes M.S. van Maanen, M.Vincent M. Lafleur, Dennis R.A. Mans, Eric van den Akker, Cor de Ruiter, Peter R. Kootstra, David Pappie, John de Vries, Jan Retèl, Herbert M. Pinedo

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 1.10 MB

english, 1988

88

Increase of daunorubicin and vincristine accumulation in multidrug resistant human ovarian carcinoma cells by a monoclonal antibody reacting with P-glycoprotein

Henricus J. Broxterman, Catharina M. Kuiper, Gerrit J. Schuurhuis, Takashi Tsuruo, Herbert M. Pinedo, Jan Lankelma

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 533 KB

english, 1988

89

The chemical reactivity of the modulating agent WR2721 (ethiofos) and its main metabolites with the antitumor agents cisplatin and carboplatin

Marco Treskes, Ulbe Holwerda, Ina Klein, Herbert M. Pinedo, Wim J.F. Van Der Vijgh

Journal:

Biochemical Pharmacology

Year:

1991

Language:

english

File:

PDF, 682 KB

english, 1991

90

Effect of folate diastereoisomers on the binding of 5-fluoro-2'-deoxyuridine-5'- monophosphate to thymidylate synthase

Clasina L. Van Der Wilt, Herbert M. Pinedo, Marion De Jong, Godefridus J. Peters

Journal:

Biochemical Pharmacology

Year:

1993

Language:

english

File:

PDF, 287 KB

english, 1993

91

Effects of temperature on the interaction of cisplatin and carboplatin with cellular DNA

Gerrit Los, Marianne J.H. Van Vugt, Leo Den Engelse, Herbert M. Pinedo

Journal:

Biochemical Pharmacology

Year:

1993

Language:

english

File:

PDF, 1001 KB

english, 1993

92

Competitive inhibition by genistein and ATP dependence of daunorubicin transport in intact MRP overexpressing human small cell lung cancer cells

Carolien H.M. Versantvoort, Henk J. Broxterman, Jan Lankelma, Nicole feller, Herbert M. Pinedo

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 1.08 MB

english, 1994

93

Antiproliferative activity of the topoisomerase I inhibitors topotecan and camptothecin, on sub- and postconfluent tumor cell cultures

Paulo E. Pizao, Evelien Smitskamp-Wilms, Jannette Van Ark-Otte, Jos H. Beijnen, Godefridus J. Peters, Herbert M. Pinedo, Giuseppe Giaccone

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 1.74 MB

english, 1994

94

Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression

Evelien Smitskamp-Wilms, Godefridus J. Peters, Herbert M. Pinedo, Jannette van Ark-Otte, Giuseppe Giaccone

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 933 KB

english, 1994

95

The P-glycoprotein-mediated relative decrease in cytosolic free drug concentration is similar for several anthracyclines with varying lipophilicity

H.Sipko Mülder, Henk Dekker, Herbert M. Pinedo, Jan Lankelma

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.01 MB

english, 1995

96

Regulation of phosphorylation of deoxycytidine and 2′,2′-difluorodeoxycytidine (gemcitabine); effects of cytidine 5′-triphosphate and uridine 5′-triphosphate in relation to chemosensitivity for 2′,2′-difluorodeoxycytidine

Veronique W.T. Ruiz van Haperen, Gijsbert Veerman, Jan B. Vermorken, Herbert M. Pinedo, Godefridus J. Peters

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.00 MB

english, 1996

97

Characterization of novel anthracycline prodrugs activated by human β-glucuronidase for use in antibody-directed enzyme prodrug therapy

Pieter H.J Houba, Ruben G.G Leenders, Epie Boven, Johannes W Scheeren, Herbert M Pinedo, Hidde J Haisma

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 740 KB

english, 1996

98

Tissue homogenization using a micro-dismembrator for the measurement of enzyme activities

Godefridus J. Peters, Emile J. Laurensse, Albert Leyva, Herbert M. Pinedo

Journal:

Clinica Chimica Acta

Year:

1986

Language:

english

File:

PDF, 429 KB

english, 1986

99

A sensitive non-radioactive assay for pyrimidine nucleoside phosphorylase using reversed-phase high performance liquid chromatography

Emile J. Laurensse, Herbert M. Pinedo, Godefridus J. Peters

Journal:

Clinica Chimica Acta

Year:

1988

Language:

english

File:

PDF, 581 KB

english, 1988

100

Glycolysis in P-glycoprotein-overexpressing human tumor cell lines Effects of resistance-modifying agents

Henricus J. Broxterman, Herbert M. Pinedo, Catharina M. Kuiper, Gerrit J. Schuurhuis, Jan Lankelma

Journal:

Year:

1989

Language:

english

File:

PDF, 549 KB

english, 1989

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