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51

Inhibition of efflux transporter ABCG2/BCRP does not restore mitoxantrone sensitivity in irinotecan-selected human leukemia CPT-K5 cells: Evidence for multifactorial multidrug resistance

Yaming Su, Sung-Hack Lee, Patrick J. Sinko

Journal:

European Journal of Pharmaceutical Sciences

Year:

2006

Language:

english

File:

PDF, 507 KB

english, 2006

52

Tumor-targeted bioconjugate based delivery of camptothecin: design, synthesis and in vitro evaluation

Pankaj V. Paranjpe, Yu Chen, Vladyslav Kholodovych, William Welsh, Stanley Stein, Patrick J. Sinko

Journal:

Journal of Controlled Release

Year:

2004

Language:

english

File:

PDF, 866 KB

english, 2004

53

Pharmacokinetic and pharmacodynamic evaluation of a novel in situ forming poly(ethylene glycol)-based hydrogel for the controlled delivery of the camptothecins

Anita Lalloo, Piyun Chao, Peidi Hu, Stanley Stein, Patrick J. Sinko

Journal:

Journal of Controlled Release

Year:

2006

Language:

english

File:

PDF, 201 KB

english, 2006

54

Design and evaluation of novel fast forming pilocarpine-loaded ocular hydrogels for sustained pharmacological response

SivaNaga S. Anumolu, Yashveer Singh, Dayuan Gao, Stanley Stein, Patrick J. Sinko

Journal:

Journal of Controlled Release

Year:

2009

Language:

english

File:

PDF, 593 KB

english, 2009

55

Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats

Hilliard L. Kutscher, Piyun Chao, Manjeet Deshmukh, Yashveer Singh, Peidi Hu, Laurie B. Joseph, David C. Reimer, Stanley Stein, Debra L. Laskin, Patrick J. Sinko

Journal:

Journal of Controlled Release

Year:

2010

Language:

english

File:

PDF, 1.05 MB

english, 2010

56

Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide

Adrienne T. Black, Laurie B. Joseph, Robert P. Casillas, Diane E. Heck, Donald R. Gerecke, Patrick J. Sinko, Debra L. Laskin, Jeffrey D. Laskin

Journal:

Toxicology and Applied Pharmacology

Year:

2010

Language:

english

File:

PDF, 841 KB

english, 2010

57

Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide

Adrienne T. Black, Patrick J. Hayden, Robert P. Casillas, Diane E. Heck, Donald R. Gerecke, Patrick J. Sinko, Debra L. Laskin, Jeffrey D. Laskin

Journal:

Toxicology and Applied Pharmacology

Year:

2010

Language:

english

File:

PDF, 1.82 MB

english, 2010

58

Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide

Adrienne T. Black, Patrick J. Hayden, Robert P. Casillas, Diane E. Heck, Donald R. Gerecke, Patrick J. Sinko, Debra L. Laskin, Jeffrey D. Laskin

Journal:

Toxicology and Applied Pharmacology

Year:

2011

Language:

english

File:

PDF, 1.28 MB

english, 2011

59

Structural changes in the skin of hairless mice following exposure to sulfur mustard correlate with inflammation and DNA damage

Laurie B. Joseph, Donald R. Gerecke, Diane E. Heck, Adrienne T. Black, Patrick J. Sinko, Jessica A. Cervelli, Robert P. Casillas, Michael C. Babin, Debra L. Laskin, Jeffrey D. Laskin

Journal:

Experimental and Molecular Pathology

Year:

2011

Language:

english

File:

PDF, 3.53 MB

english, 2011

60

Adjuvancy enhancement of muramyl dipeptide by modulating its release from a physicochemically modified matrix of ovalbumin microspheres: I. In vitro characterization

Navneet Puri, Jim H. Kou, Patrick J. Sinko

Journal:

Journal of Controlled Release

Year:

2000

Language:

english

File:

PDF, 1.49 MB

english, 2000

61

Adjuvancy enhancement of muramyl dipeptide by modulating its release from a physicochemically modified matrix of ovalbumin microspheres: II. In vivo investigation

Navneet Puri, Patrick J Sinko

Journal:

Journal of Controlled Release

Year:

2000

Language:

english

File:

PDF, 864 KB

english, 2000

62

Targeted PEG-based bioconjugates enhance the cellular uptake and transport of a HIV-1 TAT nonapeptide

Srinivasan Ramanathan, Bo Qiu, Shahriar Pooyan, Guobao Zhang, Stanley Stein, Michael J Leibowitz, Patrick.J Sinko

Journal:

Journal of Controlled Release

Year:

2001

Language:

english

File:

PDF, 318 KB

english, 2001

63

Determining the absolute surface hydrophobicity of microparticulates using thin layer wicking

Daniel A Norris, Navneet Puri, Mohamed E Labib, Patrick J Sinko

Journal:

Journal of Controlled Release

Year:

1999

Language:

english

File:

PDF, 265 KB

english, 1999

64

Oral delivery of salmon calcitonin

Yong-Hee Lee, Patrick J Sinko

Journal:

Advanced Drug Delivery Reviews

Year:

2000

Language:

english

File:

PDF, 378 KB

english, 2000

65

Physiologically-based pharmacokinetic simulation modelling

George M Grass, Patrick J Sinko

Journal:

Advanced Drug Delivery Reviews

Year:

2002

Language:

english

File:

PDF, 554 KB

english, 2002

66

The effect of physical barriers and properties on the oral absorption of particulates

Daniel A Norris, Navneet Puri, Patrick J Sinko

Journal:

Advanced Drug Delivery Reviews

Year:

1998

Language:

english

File:

PDF, 663 KB

english, 1998

67

Preface

Yong Hee Lee, Patrick J Sinko

Journal:

Advanced Drug Delivery Reviews

Year:

1999

Language:

english

File:

PDF, 45 KB

english, 1999

68

Involvement of multiple transporters in the oral absorption of nucleoside analogues

Praveen V. Balimane, Patrick J. Sinko

Journal:

Advanced Drug Delivery Reviews

Year:

1999

Language:

english

File:

PDF, 545 KB

english, 1999

69

Oral absorption of the HIV protease inhibitors: a current update

Gregory C. Williams, Patrick J. Sinko

Journal:

Advanced Drug Delivery Reviews

Year:

1999

Language:

english

File:

PDF, 352 KB

english, 1999

70

Effect of diverse datasets on the predictive capability of ADME models in drug discovery

George M. Grass, Patrick J. Sinko

Journal:

Drug Discovery Today

Year:

2001

Language:

english

File:

PDF, 100 KB

english, 2001

71

Estimating Human Oral Fraction Dose Absorbed: A Correlation Using Rat Intestinal Membrane Permeability for Passive and Carrier-Mediated Compounds

Gordon L. Amidon, Patrick J. Sinko, David Fleisher

Journal:

Pharmaceutical Research

Year:

1988

File:

PDF, 533 KB

1988

72

Characterization of the Oral Absorption of β-Lactam Antibiotics. I. Cephalosporins: Determination of Intrinsic Membrane Absorption Parameters in the Rat IntestineIn Situ

Patrick J. Sinko, Gordon L. Amidon

Journal:

Pharmaceutical Research

Year:

1988

File:

PDF, 855 KB

1988

73

Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2)

Anita K Lalloo, Feng R Luo, Ailan Guo, Pankaj V Paranjpe, Sung-Hack Lee, Viral Vyas, Eric Rubin, Patrick J Sinko

Journal:

Year:

2004

Language:

english

File:

PDF, 687 KB

english, 2004

74

Multiple-Peptide Conjugates for Binding β-Amyloid Plaques of Alzheimer's Disease

Zhang, Guobao, Leibowitz, Michael J., Sinko, Patrick J., Stein, Stanley

Journal:

Bioconjugate Chemistry

Year:

2003

Language:

english

File:

PDF, 237 KB

english, 2003

75

Microfluidic Generation of Droplets with a High Loading of Nanoparticles

Wan, Jiandi, Shi, Lei, Benson, Bryan, Bruzek, Matthew J., Anthony, John E., Sinko, Patrick J., Prudhomme, Robert K., Stone, Howard A.

Journal:

Year:

2012

Language:

english

File:

PDF, 1.13 MB

english, 2012

76

Direct Evidence for Peptide Transporter (PepT1)-Mediated Uptake of a Nonpeptide Prodrug, Valacyclovir

Praveen V. Balimane, Ikumi Tamai, Ailan Guo, Takeo Nakanishi, Hideyuki Kitada, Frederick H. Leibach, Akira Tsuji, Patrick J. Sinko

Journal:

Biochemical and Biophysical Research Communications

Year:

1998

Language:

english

File:

PDF, 123 KB

english, 1998

77

Involvement of multidrug resistance-associated proteins in regulating cellular levels of (−)-epigallocatechin-3-gallate and its methyl metabolites

Jungil Hong, Joshua D Lambert, Sung-Hack Lee, Patrick J Sinko, Chung S Yang

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 229 KB

english, 2003

78

Exploitation of drug-induced Bcl-2 overexpression for restoring normal apoptosis function: A promising new approach to the treatment of multidrug resistant cancer

Yaming Su, Xiaoping Zhang, Patrick J. Sinko

Journal:

Year:

2007

Language:

english

File:

PDF, 593 KB

english, 2007

79

Sulfur mustard-induced pulmonary injury: Therapeutic approaches to mitigating toxicity

Barry Weinberger, Jeffrey D. Laskin, Vasanthi R. Sunil, Patrick J. Sinko, Diane E. Heck, Debra L. Laskin

Journal:

Pulmonary Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 200 KB

english, 2011

80

An investigation of the intradermal route as an effective means of immunization for microparticulate vaccine delivery systems

Navneet Puri, Eric H Weyand, Susan M Abdel-Rahman, Patrick J Sinko

Journal:

Year:

2000

Language:

english

File:

PDF, 897 KB

english, 2000

81

Regional oral absorption, hepatic first-pass effect, and non-linear disposition of salmon calcitonin in beagle dogs

Yong Hee Lee, Glen D Leesman, Vijaya Makhey, Hongshi Yu, Peidi Hu, Barbara Perry, John P Sutyak, Erik J Wagner, Lisa M Falzone, William Stern, Patrick J Sinko

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2000

Language:

english

File:

PDF, 185 KB

english, 2000

82

Endocytosis and Membrane Potential Are Required for HeLa Cell Uptake of R.I.-CKTat9, a Retro-Inverso Tat Cell Penetrating Peptide

Zhang, Xiaoping, Jin, Yongjiu, Plummer, Mark R., Pooyan, Shahriar, Gunaseelan, Simi, Sinko, Patrick J.

Journal:

Molecular Pharmaceutics

Year:

2009

Language:

english

File:

PDF, 387 KB

english, 2009

83

Influence of Molecular Size on the Retention of Polymeric Nanocarrier Diagnostic Agents in Breast Ducts

Yashveer Singh, Dayuan Gao, Zichao Gu, Shike Li, Kristia A. Rivera, Stanley Stein, Susan Love, Patrick J. Sinko

Journal:

Pharmaceutical Research

Year:

2012

Language:

english

File:

PDF, 526 KB

english, 2012

84

Carrier mediated transport of amino acids, small peptides, and their drug analogs

Patrick J. Sinko, Ming Hu, Gordon L. Amidon

Journal:

Journal of Controlled Release

Year:

1987

Language:

english

File:

PDF, 634 KB

english, 1987

85

Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregates

Deshmukh, Manjeet, Kutscher, Hilliard L., Gao, Dayuan, Sunil, Vasanthi R., Malaviya, Rama, Vayas, Kinal, Stein, Stanley, Laskin, Jeffrey D., Laskin, Debra L., Sinko, Patrick J.

Journal:

Journal of Controlled Release

Year:

2012

Language:

english

File:

PDF, 1.51 MB

english, 2012

86

Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor

Rama Malaviya, Alessandro Venosa, LeRoy Hall, Andrew J. Gow, Patrick J. Sinko, Jeffrey D. Laskin, Debra L. Laskin

Journal:

Toxicology and Applied Pharmacology

Year:

2012

Language:

english

File:

PDF, 5.62 MB

english, 2012

87

Safety, Formulation and In Vitro Antiviral Activity of the Antimicrobial Peptide Subtilosin Against Herpes Simplex Virus Type 1

Torres, NicolÃ¡s I., Noll, Katia Sutyak, Xu, Shiqi, Li, Ji, Huang, Qingrong, Sinko, Patrick J., Wachsman, MÃ³nica B., Chikindas, Michael L.

Journal:

Probiotics and Antimicrobial Proteins

Year:

2013

Language:

english

File:

PDF, 470 KB

english, 2013

88

Quantitative Assessment of the Cell Penetrating Properties of RI-Tat-9: Evidence for a Cell Type-Specific Barrier at the Plasma Membrane of Epithelial Cells

Zhang, Xiaoping, Wan, Li, Pooyan, Shahriar, Su, Yaming, Gardner, Carol R., Leibowitz, Michael J., Stein, Stanley, Sinko, Patrick J.

Journal:

Molecular Pharmaceutics

Year:

2004

Language:

english

File:

PDF, 129 KB

english, 2004

89

Noninvasive Detection of Passively Targeted Poly(ethylene glycol) Nanocarriers in Tumors

Singh, Yashveer, Gao, Dayuan, Gu, Zichao, Li, Shike, Stein, Stanley, Sinko, Patrick J.

Journal:

Molecular Pharmaceutics

Year:

2012

Language:

english

File:

PDF, 2.44 MB

english, 2012

90

Novel Monodisperse PEGtide Dendrons: Design, Fabrication, and Evaluation of Mannose Receptor-Mediated Macrophage Targeting

Gao, Jieming, Chen, Peiming, Singh, Yashveer, Zhang, Xiaoping, Szekely, Zoltan, Stein, Stanley, Sinko, Patrick J.

Journal:

Bioconjugate Chemistry

Year:

2013

Language:

english

File:

PDF, 4.25 MB

english, 2013

91

Synthesis of Poly(ethylene glycol)-Based Saquinavir Prodrug Conjugates and Assessment of Release and Anti-HIV-1 Bioactivity Using a Novel Protease Inhibition Assay

Gunaseelan, Simi, Debrah, Olivia, Wan, Li, Leibowitz, Michael J., Rabson, Arnold B., Stein, Stanley, Sinko, Patrick J.

Journal:

Bioconjugate Chemistry

Year:

2004

Language:

english

File:

PDF, 257 KB

english, 2004

92

Gelation Chemistries for the Encapsulation of Nanoparticles in Composite Gel Microparticles for Lung Imaging and Drug Delivery

Pinkerton, Nathalie M., Zhang, Stacey W., Youngblood, Richard L., Gao, Dayuan, Li, Shike, Benson, Bryan R., Anthony, John, Stone, Howard A., Sinko, Patrick J., Prud’homme, Robert K.

Journal:

Biomacromolecules

Year:

2014

Language:

english

File:

PDF, 1.18 MB

english, 2014

93

Optimization of cell receptor-specific targeting through multivalent surface decoration of polymeric nanocarriers

D'Addio, Suzanne M., Baldassano, Steven, Shi, Lei, Cheung, Lila, Adamson, Douglas H., Bruzek, Matthew, Anthony, John E., Laskin, Debra L., Sinko, Patrick J., Prud'homme, Robert K.

Journal:

Journal of Controlled Release

Year:

2013

Language:

english

File:

PDF, 1.68 MB

english, 2013

94

Structural changes in hair follicles and sebaceous glands of hairless mice following exposure to sulfur mustard

Joseph, Laurie B., Heck, Diane E., Cervelli, Jessica A., Composto, Gabriella M., Babin, Michael C., Casillas, Robert P., Sinko, Patrick J., Gerecke, Donald R., Laskin, Debra L., Laskin, Jeffrey D.

Journal:

Experimental and Molecular Pathology

Year:

2014

Language:

english

File:

PDF, 1.38 MB

english, 2014

95

The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard

Zheng, Ruijin, Po, Iris, Mishin, Vladimir, Black, Adrienne T., Heck, Diane E., Laskin, Debra L., Sinko, Patrick J., Gerecke, Donald R., Gordon, Marion K., Laskin, Jeffrey D.

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.73 MB

english, 2013

96

Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard

Chang, Yoke-Chen, Wang, James D., Hahn, Rita A., Gordon, Marion K., Joseph, Laurie B., Heck, Diane E., Heindel, Ned D., Young, Sherri C., Sinko, Patrick J., Casillas, Robert P., Laskin, Jeffrey D., La

Journal:

Toxicology and Applied Pharmacology

Year:

2014

Language:

english

File:

PDF, 466 KB

english, 2014

97

Conjugates Bearing Multiple Formyl-Methionyl Peptides Display Enhanced Binding to but Not Activation of Phagocytic Cells

Pooyan, Shahriar, Qiu, Bo, Chan, Marion M., Fong, Dunne, Sinko, Patrick J., Leibowitz, Michael J., Stein, Stanley

Journal:

Bioconjugate Chemistry

Year:

2002

Language:

english

File:

PDF, 86 KB

english, 2002

98

Human Organic Anion-Transporting Polypeptide OATP-A (SLC21A3) Acts in Concert with P-Glycoprotein and Multidrug Resistance Protein 2 in the Vectorial Transport of Saquinavir in Hep G2 Cells

Su, Yaming, Zhang, Xiaoping, Sinko, Patrick J.

Journal:

Molecular Pharmaceutics

Year:

2004

Language:

english

File:

PDF, 121 KB

english, 2004

99

Poly(ethylene glycol) (PEG)-lactic acid nanocarrier-based degradable hydrogels for restoring the vaginal microenvironment

Sundara Rajan, Sujata, Turovskiy, Yevgeniy, Singh, Yashveer, Chikindas, Michael L., Sinko, Patrick J.

Journal:

Journal of Controlled Release

Year:

2014

Language:

english

File:

PDF, 1.31 MB

english, 2014

100

Optimizing Size and Copy Number For PEG-fMLF ( N -Formyl-methionyl-leucyl-phenylalanine) Nanocarrier Uptake by Macrophages

Wan, Li, Zhang, Xiaoping, Pooyan, Shahriar, Palombo, Matthew S., Leibowitz, Michael J., Stein, Stanley, Sinko, Patrick J.

Journal:

Bioconjugate Chemistry

Year:

2008

Language:

english

File:

PDF, 585 KB

english, 2008