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51

Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice

Heppner, Kristy M., Marks, Sarah, Holland, Jenna, Ottaway, Nickki, Smiley, David, Dimarchi, Richard, Perez-Tilve, Diego

Journal:

Year:

2015

Language:

english

File:

PDF, 441 KB

english, 2015

52

Bsx, a Novel Hypothalamic Factor Linking Feeding with Locomotor Activity, Is Regulated by Energy Availability

Nogueiras, Ruben, López, Miguel, Lage, Ricardo, Perez-Tilve, Diego, Pfluger, Paul, Mendieta-Zerón, Hugo, Sakkou, Maria, Wiedmer, Petra, Benoit, Stephen C., Datta, Rakesh, Dong, Jesse Z., Culler, Micha

Journal:

Year:

2008

Language:

english

File:

PDF, 239 KB

english, 2008

53

The Melanocortin-4 Receptor Integrates Circadian Light Cues and Metabolism

Arble, Deanna M., Holland, Jenna, Ottaway, Nickki, Sorrell, Joyce, Pressler, Joshua W., Morano, Rachel, Woods, Stephen C., Seeley, Randy J., Herman, James P., Sandoval, Darleen A., Perez-Tilve, Diego

Journal:

Year:

2015

Language:

english

File:

PDF, 1.17 MB

english, 2015

54

Role of adipose and hepatic atypical protein kinase C lambda (PKCλ) in the development of obesity and glucose intolerance

Habegger, Kirk M., Matzke, Daniela, Ottaway, Nickki, Hembree, Jazzminn, Holland, Jenna, Raver, Christine, Mansfeld, Johannes, Müller, Timo D., Perez-Tilve, Diego, Pfluger, Paul T., Lee, Sang Jun, Diaz

Journal:

Year:

2012

Language:

english

File:

PDF, 2.18 MB

english, 2012

55

The Brain and the Metabolic Syndrome: Not a Wireless Connection

Perez-Tilve, Diego, Stern, Javier E., Tschöp, Matthias

Journal:

Year:

2006

Language:

english

File:

PDF, 117 KB

english, 2006

56

CNS Opioid Signaling Separates Cannabinoid Receptor 1-Mediated Effects on Body Weight and Mood-Related Behavior in Mice

Lockie, Sarah Haas, Czyzyk, Traci A., Chaudhary, Nilika, Perez-Tilve, Diego, Woods, Stephen C., Oldfield, Brian J., Statnick, Michael A., Tschöp, Matthias H.

Journal:

Year:

2011

Language:

english

File:

PDF, 186 KB

english, 2011

57

Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity

Tamas L. Horvath, Beatrix Sarman, Cristina García-Cáceres, Pablo J. Enriori, Peter Sotonyi, Marya Shanabrough, Erzsebet Borok, Jesus Argente, Julie A. Chowen, Diego Perez-Tilve, Paul T. Pfluger, Hella

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.57 MB

english, 2010

58

Growth Hormone Secretagogue (Ghrelin-) Receptors - A Complex Drug Target for the Regulation of Body Weight

Nogueiras, R., Perez-Tilve, D., Wortley, K., Tschop, M.

Journal:

CNS & Neurological Disorders - Drug Targets (Formerly Current Drug Targets - CNS & Neurological Disorders)

Year:

2006

Language:

english

File:

PDF, 160 KB

english, 2006

59

Neural regulation of cholesterol metabolism

Perez-Tilve, Diego, Habbeger, Kirk M., Tschöp, Matthias H., Hofmann, Susanna M.

Journal:

Current Opinion in Lipidology

Year:

2011

Language:

english

File:

PDF, 130 KB

english, 2011

60

Unimolecular Polypharmacy for Treatment of Diabetes and Obesity

Tschöp, Matthias H., Finan, Brian, Clemmensen, Christoffer, Gelfanov, Vasily, Perez-Tilve, Diego, Müller, Timo D., DiMarchi, Richard D.

Journal:

Cell Metabolism

Year:

2016

Language:

english

File:

PDF, 1.82 MB

english, 2016

61

Pyridyl-alanine as a Hydrophilic, Aromatic Element in Peptide Structural Optimization

Mroz, Piotr A., Perez-Tilve, Diego, Liu, Fa, Gelfanov, Vasily, DiMarchi, Richard D., Mayer, John P.

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 920 KB

english, 2016

62

Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding

Loyd, Christine, Magrisso, I. Jack, Haas, Michael, Balusu, Sowmya, Krishna, Radha, Itoh, Nobuyuki, Sandoval, Darleen A., Perez-Tilve, Diego, Obici, Silvana, Habegger, Kirk M.

Journal:

Journal of Applied Physiology

Year:

2016

Language:

english

File:

PDF, 414 KB

english, 2016

63

Fibroblast activation protein (FAP) as a novel metabolic target

Sánchez-Garrido, Miguel Angel, Habegger, Kirk M., Clemmensen, Christoffer, Holleman, Cassie, Müller, Timo D., Perez-Tilve, Diego, Li, Pengyun, Agrawal, Archita S., Finan, Brian, Drucker, Daniel J., Ts

Journal:

Molecular Metabolism

Year:

2016

Language:

english

File:

PDF, 1002 KB

english, 2016

64

Novel Hypothalamic Mechanisms in the Pathophysiological Control of Body Weight and Metabolism

Perez-Tilve, Diego

Journal:

Year:

2017

Language:

english

File:

PDF, 817 KB

english, 2017

65

Dietary manipulations that induce ketosis activate the HPA axis in male rats and mice: a potential role for fibroblast growth factor-21

Ryan, Karen K, Packard, Amy E B, Larson, Karlton R, Stout, Jayna, Fourman, Sarah M, Thompson, Abigail M K, Ludwick, Kristen, Habegger, Kirk M, Stemmer, Kerstin, Itoh, Nobuyuki, Perez-Tilve, Diego, Tsc

Journal:

Year:

2017

Language:

english

File:

PDF, 1.44 MB

english, 2017

66

Optimization of Peptide-based Polyagonists for Treatment of Diabetes and Obesity

Knerr, Patrick, Finan, Brian, Gelfanov, Vasily, Perez-Tilve, Diego, Tschöp, Matthias H., DiMarchi, Richard D.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 2.32 MB

english, 2017

67

Desacyl Ghrelin Decreases Anxiety-like Behavior in Male Mice

Mahbod, Parinaz, Smith, Eric P, Fitzgerald, Maureen E, Morano, Rachel L, Packard, Benjamin A, Ghosal, Sriparna, Scheimann, Jessie R, Perez-Tilve, Diego, Herman, James P, Tong, Jenny

Journal:

Year:

2018

Language:

english

File:

PDF, 933 KB

english, 2018

68

Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity

Agrawal, Archita, Parlee, Sebastian, Perez-Tilve, Diego, Li, Pengyun, Pan, Jia, Mroz, Piotr A., Kruse Hansen, Ann Maria, Andersen, Birgitte, Finan, Brian, Kharitonenkov, Alexei, DiMarchi, Richard D.

Journal:

Molecular Metabolism

Year:

2018

Language:

english

File:

PDF, 3.75 MB

english, 2018

69

GLP-1 based therapeutics: simultaneously combating T2DM and obesity

Heppner, Kristy M., Perez-Tilve, Diego

Journal:

Frontiers in Neuroscience

Year:

2015

Language:

english

File:

PDF, 723 KB

english, 2015

70

Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia

Rivero-Gutierrez, Belen, Haller, April, Holland, Jenna, Yates, Emily, Khrisna, Radha, Habegger, Kirk, Dimarchi, Richard, D'Alessio, David, Perez-Tilve, Diego

Journal:

Molecular Metabolism

Year:

2018

Language:

english

File:

PDF, 1.03 MB

english, 2018

71

Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

Mroz, Piotr A., Finan, Brian, Gelfanov, Vasily, Yang, Bin, Tschöp, Matthias H., DiMarchi, Richard D., Perez-Tilve, Diego

Journal:

Molecular Metabolism

Year:

2018

Language:

english

File:

PDF, 2.30 MB

english, 2018

72

‘Et Tu, Leptin?’

Perez-Tilve, Diego

Journal:

Trends in Endocrinology & Metabolism

Year:

2019

File:

PDF, 262 KB

2019

73

Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice

Nomiyama, Takashi, Perez-Tilve, Diego, Ogawa, Daisuke, Gizard, Florence, Zhao, Yue, Heywood, Elizabeth B., Jones, Karrie L., Kawamori, Ryuzo, Cassis, Lisa A., Tschöp, Matthias H., Bruemmer, Dennis

Journal:

Journal of Clinical Investigation

Year:

2007

Language:

english

File:

PDF, 767 KB

english, 2007

74

‘Et Tu, Leptin?’

Perez-Tilve, Diego

Journal:

Trends in Endocrinology & Metabolism

Year:

2019

Language:

english

File:

PDF, 262 KB

english, 2019

75

Stereochemical inversion as a route to improved biophysical properties of therapeutic peptides exemplified by glucagon

Mroz, Piotr A., Perez-Tilve, Diego, Mayer, John P., DiMarchi, Richard D.

Journal:

Communications Chemistry

Year:

2019

File:

PDF, 955 KB

2019

76

A disulfide-scan of insulin by [3+1] methodology exhibits site-specific influence on bioactivity

Brunel, Florence M, Mayer, John P, Gelfanov, Vasily M., Zaykov, Alexander N., Finan, Brian, Perez-Tilve, Diego, DiMarchi, Richard D.

Journal:

ACS Chemical Biology

Year:

2019

Language:

english

File:

PDF, 546 KB

english, 2019

77

Selection and progression of unimolecular agonists at the GIP, GLP-1, and glucagon receptors as drug candidates

Knerr, Patrick J., Mowery, Stephanie A., Finan, Brian, Perez-Tilve, Diego, Tschöp, Matthias H., DiMarchi, Richard D.

Journal:

Year:

2019

Language:

english

File:

PDF, 2.33 MB

english, 2019

78

Glucagon Peptide Family and Adipose Tissue: not that Intimate, just Acquaintances

Perez-Tilve, Diego

Journal:

Year:

2020

Language:

english

File:

PDF, 357 KB

english, 2020

79

Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence

Kabotso, Daniel, Smiley, David, Mayer, John Philip, Gelfanov, Vasily M., Perez-Tilve, Diego, DiMarchi, Richard D., Pohl, Nicola L. B., Liu, Fa

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 781 KB

2020

80

The central melanocortin system mediates the benefits of time-restricted feeding on energy balance

Sorrell, Joyce, Yates, Emily, Rivir, Marita, Woods, Stephen C., Hogenesch, John B., Perez-Tilve, Diego

Journal:

Physiology & Behavior

Year:

2020

File:

PDF, 873 KB

2020

81

Optimization of Peptide Inhibitors of Î²-Klotho as Antagonists of Fibroblast Growth Factors 19 and 21

Pan, Jia, Parlee, Sebastian D., Brunel, Florence M., Li, Pengyun, Lu, Wei, Perez-Tilve, Diego, Liu, Fa, Finan, Brian, Kharitonenkov, Alexei, DiMarchi, Richard D.

Journal:

ACS Pharmacology & Translational Science

Year:

2020

File:

PDF, 2.47 MB

2020