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1

Gene therapy: Targeting β-thalassaemia

Persons, Derek A.

Journal:

Year:

2010

Language:

english

File:

PDF, 305 KB

english, 2010

2

Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia

Md Nasimuzzaman, Eugene Khandros, Xiaomei Wang, Yi Kong, Huifen Zhao, David Weiss, Stefano Rivella, Mitchell J. Weiss, Derek A. Persons

Journal:

American Journal of Hematology

Year:

2010

Language:

english

File:

PDF, 1.04 MB

english, 2010

3

Transgenic mice with pancellular enhanced green fluorescent protein expression in primitive hematopoietic cells and all blood cell progeny

Massimo Dominici, Merhdad Tadjali, Steven Kepes, Esther R. Allay, Kelli Boyd, Paul A. Ney, Edwin Horwitz, Derek A. Persons

Journal:

Year:

2005

Language:

english

File:

PDF, 323 KB

english, 2005

4

Increased expression of glycolysis-associated genes in oncogene-transformed and growth-accelerated states

Derek A. Persons, Nancy Schek, Bruce Lee Hall, Olivera J. Finn

Journal:

Molecular Carcinogenesis

Year:

1989

Language:

english

File:

PDF, 681 KB

english, 1989

5

Development of Gene Therapy for Hemoglobin Disorders

ARTHUR W. NIENHUIS, HIDEKI HANAWA, NOBUKUNI SAWAI, BRIAN P. SORRENTINO, DEREK A. PERSONS

Journal:

Annals of the New York Academy of Sciences

Year:

2003

File:

PDF, 5.07 MB

2003

6

The challenge of obtaining therapeutic levels of genetically modified hematopoietic stem cells in β-thalassemia patients

Derek A. Persons

Journal:

Annals of the New York Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 126 KB

english, 2010

7

10.1038/13787

Ney, Paul A., Persons, Derek A., Paulson, Robert F., Loyd, Melanie R., Herley, Mark T., Bodner, Sara M., Bernstein, Alan, Correll, Pamela H.

Journal:

Nature Genetics

Year:

1999

Language:

english

File:

PDF, 1.37 MB

english, 1999

8

In vivo selection of retrovirally transduced hematopoietic stem cells

Allay, James A., Persons, Derek A., Galipeau, Jacques, Riberdy, Janice M., Ashmun, Richard A., Blakley, Raymond L., Sorrentino, Brian P.

Journal:

Nature Medicine

Year:

1998

Language:

english

File:

PDF, 261 KB

english, 1998

9

Use of the green fluorescent protein as a marker to identify and track genetically modified hematopoietic cells

Persons, Derek A, Allay, James A, Riberdy, Janice M, Wersto, Robert P, Donahue, Robert E, Sorrentino, Brian P, Nienhuis, Arthur W

Journal:

Nature Medicine

Year:

1998

Language:

english

File:

PDF, 264 KB

english, 1998

10

Control of nucleic acid and protein synthesis in developing brain, kidney, and heart of the neonatal rat: Effects of α-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase

Theodore A. Slotkin, Derek Persons, Ruta J. Slepetis, Donald Taylor, Jorge Bartolome

Journal:

Birth Defects Research Part A: Clinical and Molecular Teratology

Year:

1984

Language:

english

File:

PDF, 1006 KB

english, 1984

11

Therapeutic in vivo selection of thymic-derived natural T regulatory cells following non-myeloablative hematopoietic stem cell transplant for IPEX

Kimberly A. Kasow, Vanessa M. Morales-Tirado, David Wichlan, Sheila A. Shurtleff, Allistair Abraham, Derek A. Persons, Janice M. Riberdy

Journal:

Clinical Immunology

Year:

2011

Language:

english

File:

PDF, 813 KB

english, 2011

12

An Improved Method for Generating Retroviral Producer Clones for Vectors Lacking a Selectable Marker Gene

Derek A. Persons, Michele G. Mehaffey, Michael Kaleko, Arthur W. Nienhuis, Elio F. Vanin

Journal:

Blood Cells, Molecules, and Diseases

Year:

1998

Language:

english

File:

PDF, 271 KB

english, 1998

13

A chromatin insulator blocks interactions between globin regulatory elements and cellular promoters in erythroid cells

Byoung Y. Ryu, Derek A. Persons, Marguerite V. Evans-Galea, John T. Gray, Arthur W. Nienhuis

Journal:

Blood Cells, Molecules, and Diseases

Year:

2007

Language:

english

File:

PDF, 734 KB

english, 2007

14

Gamma-globin lentiviral vector-mediated stem cell gene therapy of beta-thalassemia and sickle cell disease

Huifen Zhao, Tamara Pestina, Phillip Hargrove, Yoon Sang Kim, Robert Throm, Arthur W. Nienhuis, John Gray, Derek A. Persons

Journal:

Blood Cells, Molecules, and Diseases

Year:

2008

Language:

english

File:

PDF, 58 KB

english, 2008

15

Gene therapy for the hemoglobin disorders

Derek A. Persons, John F. Tisdale

Journal:

Seminars in Hematology

Year:

2004

Language:

english

File:

PDF, 272 KB

english, 2004

16

Genetically Modified CD34+ Hematopoietic Stem Cells Contribute to Turnover of Brain Perivascular Macrophages in Long-Term Repopulated Primates

Caroline Soulas, Robert E. Donahue, Cynthia E. Dunbar, Derek A. Persons, Xavier Alvarez, Kenneth C. Williams

Journal:

The American Journal of Pathology

Year:

2009

Language:

english

File:

PDF, 1.53 MB

english, 2009

17

Polyamines in brain and heart of the neontal rat: Effects of inhibitors of ornithine decarboxylase and spermidine synthase

Theodore A. Slotkin, Jorge Bartolome, Derek Persons, William L. Whitmore

Journal:

Year:

1984

Language:

english

File:

PDF, 393 KB

english, 1984

18

Identification of Hlx homeobox transcription factor downstream targets in Hlx knockout mesenchymal cell lines using retroviral vectors and microarrays

Michael D. Bates, Derek A. Persons, Lynn C. Schatzman, Richard P. Harvey, S Steven Potter

Journal:

Gastroenterology

Year:

2001

Language:

english

File:

PDF, 189 KB

english, 2001

19

Optimized Lentiviral Vector Design Improves Titer and Transgene Expression of Vectors Containing the Chicken β-Globin Locus HS4 Insulator Element

Hanawa, Hideki, Yamamoto, Motoko, Zhao, Huifen, Shimada, Takashi, Persons, Derek A

Journal:

Molecular Therapy

Year:

2009

Language:

english

File:

PDF, 1.05 MB

english, 2009

20

Using Latent Semantic Analysis to Evaluate the Contributions of Students in AutoTutor

Graesser, Arthur C., Wiemer-Hastings, Peter, Wiemer-Hastings, Katja, Harter, Derek, Tutoring Research Group, Tutoring Research Group, Person, Natalie

Journal:

Interactive Learning Environments

Year:

2000

Language:

english

File:

PDF, 88 KB

english, 2000

21

Genomic Analyses of Pneumococci from Children with Sickle Cell Disease Expose Host-Specific Bacterial Adaptations and Deficits in Current Interventions

Carter, Robert, Wolf, Joshua, van Opijnen, Tim, Muller, Martha, Obert, Caroline, Burnham, Corinna, Mann, Beth, Li, Yimei, Hayden, Randall T., Pestina, Tamara, Persons, Derek, Camilli, Andrew, Flynn, P

Journal:

Cell Host & Microbe

Year:

2014

Language:

english

File:

PDF, 2.47 MB

english, 2014

22

Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA

Persons, Derek A., Wilkison, William O., Bell, Robert M., Finn, Olivera J.

Journal:

Year:

1988

Language:

english

File:

PDF, 3.75 MB

english, 1988

23

Gene Therapy for Canine Leukocyte Adhesion Deficiency with Lentiviral Vectors Using the Murine Stem Cell Virus and Human Phosphoglycerate Kinase Promoters

Hunter, Michael J., Zhao, Huifen, Tuschong, Laura M., Bauer, Thomas R., Burkholder, Tanya H., Persons, Derek A., Hickstein, Dennis D.

Journal:

Human Gene Therapy

Year:

2011

Language:

english

File:

PDF, 677 KB

english, 2011

24

High-Efficiency Transduction and Long-Term Gene Expression with a Murine Stem Cell Retroviral Vector Encoding the Green Fluorescent Protein in Human Marrow Stromal Cells

Marx, Jeffrey C., Allay, James A., Persons, Derek A., Nooner, Sharon A., Hargrove, Phillip W., Kelly, Patrick F., Vanin, Elio F., Horwitz, Edwin M.

Journal:

Human Gene Therapy

Year:

1999

Language:

english

File:

PDF, 493 KB

english, 1999

25

High-Level Erythroid Lineage-Directed Gene Expression Using Globin Gene Regulatory Elements After Lentiviral Vector-Mediated Gene Transfer into Primitive Human and Murine Hematopoietic Cells

Hanawa, Hideki, Persons, Derek A., Nienhuis, Arthur W.

Journal:

Human Gene Therapy

Year:

2002

Language:

english

File:

PDF, 582 KB

english, 2002

26

1059. The Influence of a Chromatin Insulator on Interactions between Globin Regulatory Elements and Cellular Promoters in Erythroid Cells

Ryu, Byoung Y., Persons, Derek A., Nienhuis, Arthur W.

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 82 KB

english, 2006

27

69. Selection of Hematopoietic Progenitor and Stem Cells in Transplanted Rhesus Macaques Using MGMT and HOXB4 Lentiviral Vectors

Shou, Yan, Gray, John, Agricola, Brian, Ma, Zhijun, Nair, Geeta K., Stewart, Clinton F., Persons, Derek A., Sorrentino, Brian P.

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 83 KB

english, 2006

28

MURINE PGK PROMOTER IN A LENTIVIRAL VECTOR IN CANINE LEUKOCYTE ADHESION DEFICIENCY AND IN HUMAN LAD-1 CD34 + CELLS IN NSG MICE

HUNTER, MICHAEL J., CHOI, UIMOOK, TUSCHONG, LAURA M., ZHAO, HUIFEN, KOONTZ, SHERRY, KAPOOR, VEENA, PERSONS, DEREK A., MALECH, HARRY L., HICKSTEIN, DENNIS D.

Journal:

Gene Therapy and Regulation

Year:

2012

Language:

english

File:

PDF, 1.05 MB

english, 2012

29

Potentially therapeutic levels of anti-sickling globin gene expression following lentivirus-mediated gene transfer in sickle cell disease bone marrow CD34+ cells

Urbinati, Fabrizia, Hargrove, Phillip W., Geiger, Sabine, Romero, Zulema, Wherley, Jennifer, Kaufman, Michael L., Hollis, Roger P., Chambers, Christopher B., Persons, Derek A., Kohn, Donald B., Wilber

Journal:

Experimental Hematology

Year:

2015

Language:

english

File:

PDF, 491 KB

english, 2015

30

Hypersusceptibility to Invasive Pneumococcal Infection in Experimental Sickle Cell Disease Involves Platelet‐Activating Factor Receptor

Miller, Martha L., Gao, Geli, Pestina, Tamara, Persons, Derek, Tuomanen, Elaine

Journal:

The Journal of Infectious Diseases

Year:

2007

Language:

english

File:

PDF, 960 KB

english, 2007

31

Low-level GATA2 overexpression promotes myeloid progenitor self-renewal and blocks lymphoid differentiation in mice

Nandakumar, Satish K., Johnson, Kyle, Throm, Stacy L., Pestina, Tamara I., Neale, Geoffrey, Persons, Derek A.

Journal:

Experimental Hematology

Year:

2015

Language:

english

File:

PDF, 3.84 MB

english, 2015

32

Lentiviral Vector Gene Therapy: Effective and Safe?

Persons, Derek A

Journal:

Molecular Therapy

Year:

2010

Language:

english

File:

PDF, 211 KB

english, 2010

33

Correction of Murine Sickle Cell Disease Using γ-Globin Lentiviral Vectors to Mediate High-level Expression of Fetal Hemoglobin

Pestina, Tamara I, Hargrove, Phillip W, Jay, Dennis, Gray, John T, Boyd, Kelli M, Persons, Derek A

Journal:

Molecular Therapy

Year:

2009

Language:

english

File:

PDF, 2.30 MB

english, 2009

34

Solving the Problem of γ-Retroviral Vectors Containing Long Terminal Repeats

Persons, Derek A, Baum, Christopher

Journal:

Molecular Therapy

Year:

2011

Language:

english

File:

PDF, 222 KB

english, 2011

35

Globin Lentiviral Vector Insertions Can Perturb the Expression of Endogenous Genes in β-thalassemic Hematopoietic Cells

Hargrove, Phillip W, Kepes, Steven, Hanawa, Hideki, Obenauer, John C, Pei, Deiqing, Cheng, Cheng, Gray, John T, Neale, Geoffrey, Persons, Derek A

Journal:

Molecular Therapy

Year:

2008

Language:

english

File:

PDF, 373 KB

english, 2008

36

Transduction of Human Primitive Repopulating Hematopoietic Cells With Lentiviral Vectors Pseudotyped With Various Envelope Proteins

Kim, Yoon-Sang, Wielgosz, Matthew M, Hargrove, Phillip, Kepes, Steven, Gray, John, Persons, Derek A, Nienhuis, Arthur W

Journal:

Molecular Therapy

Year:

2010

Language:

english

File:

PDF, 250 KB

english, 2010

37

Cell Membrane–associated Heparan Sulfate Is a Receptor for Prototype Foamy Virus in Human, Monkey, and Rodent Cells

Nasimuzzaman, Md, Persons, Derek A

Journal:

Molecular Therapy

Year:

2012

Language:

english

File:

PDF, 392 KB

english, 2012

38

Fas-antisense long noncoding RNA is differentially expressed during maturation of human erythrocytes and confers resistance to fas-mediated cell death

Villamizar, Olga, Chambers, Christopher B., Mo, Yin-Yuan, Torry, Donald S., Hofstrand, Reese, Riberdy, Janice M., Persons, Derek A., Wilber, Andrew

Journal:

Blood Cells, Molecules, and Diseases

Year:

2016

Language:

english

File:

PDF, 955 KB

english, 2016

39

Data in support of transcriptional regulation and function of Fas-antisense long noncoding RNA during human erythropoiesis

Villamizar, Olga, Chambers, Christopher B., Mo, Yin-Yuan, Torry, Donald S., Hofstrand, Reese, Riberdy, Janice M., Persons, Derek A., Wilber, Andrew

Journal:

Year:

2016

Language:

english

File:

PDF, 731 KB

english, 2016

40

Neogenesis of Cerebellar Purkinje Neurons from Gene-Marked Bone Marrow Cells in vivo

Josef Priller, Derek A. Persons, Francisco F. Klett, Gerd Kempermann, Georg W. Kreutzberg and Ulrich Dirnagl

Journal:

The Journal of Cell Biology

Year:

2001

Language:

english

File:

PDF, 2.25 MB

english, 2001

41

High-titer foamy virus vector transduction and integration sites of human CD34+ cell–derived SCID-repopulating cells

Nasimuzzaman, Md, Kim, Yoon-Sang, Wang, Yong-Dong, Persons, Derek A.

Journal:

Molecular Therapy — Methods & Clinical Development

Year:

2014

Language:

english

File:

PDF, 972 KB

english, 2014

42

Amelioration of murine sickle cell disease by nonablative conditioning and γ-globin gene-corrected bone marrow cells

Pestina, Tamara I, Hargrove, Phillip W, Zhao, Huifen, Mead, Paul E, Smeltzer, Matthew P, Weiss, Mitchell J, Wilber, Andrew, Persons, Derek A

Journal:

Molecular Therapy — Methods & Clinical Development

Year:

2015

Language:

english

File:

PDF, 2.34 MB

english, 2015

43

Lentiviral Transfer of γ-Globin with Fusion Gene NUP98-HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates Murine β-Thalassemia

Zhao, Hui Fen, Abraham, Allistair, Kim, Yoon-Sang, Wang, Yong-Dong, Pestina, Tamara, Zhan, Jun, Humphries, Keith, Nienhuis, Arthur W., Persons, Derek A.

Journal:

Molecular Therapy

Year:

2017

Language:

english

File:

PDF, 2.17 MB

english, 2017

44

Encyclopedia of Life Sciences || Hemoglobin Disorders: Gene Therapy

Persons, Derek A

Year:

2001

Language:

english

File:

PDF, 118 KB

english, 2001

45

Retroviral-Mediated Transfer of the Green Fluorescent Protein Gene Into Murine Hematopoietic Cells Facilitates Scoring and Selection of Transduced Progenitors In Vitro and Identification of Genetically Modified Cells In Vivo

Persons, Derek A., Allay, James A., Allay, Esther R., Smeyne, Richard J., Ashmun, Richard A., Sorrentino, Brian P., Nienhuis, Arthur W.

Journal:

Year:

1997

Language:

english

File:

PDF, 759 KB

english, 1997

46

Enforced Expression of the GATA-2 Transcription Factor Blocks Normal Hematopoiesis

Persons, Derek A., Allay, James A., Allay, Esther R., Ashmun, Richard A., Orlic, Donald, Jane, Stephen M., Cunningham, John M., Nienhuis, Arthur W.

Journal:

Year:

1999

File:

PDF, 407 KB

1999

47

High levels of lymphoid expression of enhanced green fluorescent protein in nonhuman primates transplanted with cytokine-mobilized peripheral blood CD34+ cells

Donahue, Robert E., Wersto, Robert P., Allay, James A., Agricola, Brian A., Metzger, Mark E., Nienhuis, Arthur W., Persons, Derek A., Sorrentino, Brian P.

Journal:

Year:

2000

File:

PDF, 255 KB

2000