R. Olavi Pelkonen: search on Z-Library

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51

Prediction of Drug Metabolism and Interactions on the Basis of in vitro Investigations

Olavi Pelkonen, Miia Turpeinen, Jouko Uusitalo, Arja Rautio, Hannu Raunio

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2005

Language:

english

File:

PDF, 90 KB

english, 2005

52

Effects of Selective Serotonin Reuptake Inhibitors on Timolol Metabolism in Human Liver Microsomes and Cryo-Preserved Hepatocytes

Marjo Volotinen, Timo Korjamo, Ari Tolonen, Miia Turpeinen, Olavi Pelkonen, Jukka Hakkola, Jukka Mäenpää

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2010

Language:

english

File:

PDF, 209 KB

english, 2010

53

Metabolism of Ophthalmic Timolol: New Aspects of an Old Drug

Marjo Volotinen, Jukka Hakkola, Olavi Pelkonen, Heikki Vapaatalo, Jukka Mäenpää

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2011

Language:

english

File:

PDF, 199 KB

english, 2011

54

Cigarette smoking and drug metabolism

Vähäkangas, Kirsi, Pelkonen, Olavi, Sotaniemi, Eero

Journal:

Clinical Pharmacology & Therapeutics

Year:

1983

Language:

english

File:

PDF, 383 KB

english, 1983

55

Fibrotic process and drug metabolism in alcoholic liver disease

Sotaniemi, Eero A, Niemelä, Onni, Risteli, Leila, Stenbäck, Frej, Pelkonen, R Olavi, Lahtela, Jorma T, Risteli, Juha

Journal:

Clinical Pharmacology & Therapeutics

Year:

1986

Language:

english

File:

PDF, 1.05 MB

english, 1986

56

Independent Induction and Inhibition of Ornithine Decarboxylase and Aryl Hydrocarbon Hydroxylase Activities in Rat Epidermis.

Raunio, Hannu, Pelkonen, Olavi

Journal:

The Journal of Investigative Dermatology

Year:

1982

File:

PDF, 2.25 MB

1982

57

The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue

Mumtaz Iscan, Tuula Klaavuniemi, Tulay Çoban, Nilgun Kapucuoğlu, Olavi Pelkonen, Hannu Raunio

Journal:

Breast Cancer Research and Treatment

Year:

2001

Language:

english

File:

PDF, 181 KB

english, 2001

58

Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver

Pirkko Salonpää, Kai Krause, Olavi Pelkonen, Hannu Raunio

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1995

Language:

english

File:

PDF, 661 KB

english, 1995

59

Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases

Pertti Pellinen, Frej Stenbäck, Arja Rautio, Olavi Pelkonen, Matti Lang, Markku Pasanen

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1993

Language:

english

File:

PDF, 2.34 MB

english, 1993

60

Relationship between in vivo and in vitro drug metabolism in man

Eero A. Sotaniemi, R. Olavi Pelkonen, Jorma T. Ahokas, Heikki I. Pirttiaho, Johan Ahlqvist

Journal:

European Journal of Drug Metabolism and Pharmacokinetics

Year:

1978

Language:

english

File:

PDF, 687 KB

english, 1978

61

Influence of liver size on the relationship between in vivo and in vitro studies of drug metabolism

Heikki I. Pirttiaho, Eero A. Sotaniemi, R. Olavi Pelkonen, Uolevi Pitkänen

Journal:

European Journal of Drug Metabolism and Pharmacokinetics

Year:

1978

Language:

english

File:

PDF, 570 KB

english, 1978

62

In vitro prediction of gastrointestinal absorption and bioavailability: an experts' meeting report

Pelkonen, Olavi, Boobis, Alan, Gundert-Remy, Ursula

Journal:

European Journal of Clinical Pharmacology

Year:

2001

Language:

english

File:

PDF, 119 KB

english, 2001

63

The in vitro oxidative metabolism of benzo(a)pyrene in human liver measured by different assays

Olavi Pelkonen, Eero Sotaniemi, Risto Mokka

Journal:

Chemico-Biological Interactions

Year:

1977

Language:

english

File:

PDF, 589 KB

english, 1977

64

The DNA binding of benzo[a]pyrene metabolites catalysed by rat lung microsomes in vitro and in isolated perfused rat lung

Kirsi' Vähäkangas, Daniel W. Nebert, Olavi Pelkonen

Journal:

Chemico-Biological Interactions

Year:

1979

Language:

english

File:

PDF, 899 KB

english, 1979

65

The in vitro metabolism and covalent binding of benzo[a]pyrene to dna catalysed by trout liver microsomes

Jorma T. Ahokas, Hannu Saarni, Daniel W. Nebert, Olavi Pelkonen

Journal:

Chemico-Biological Interactions

Year:

1979

Language:

english

File:

PDF, 749 KB

english, 1979

66

Unusual patterns of benzo[a]pyrene metabolites and DNA-benzo[a]pyrene adducts produced by human placental microsomes in vitro

Olavi Pelkonen, Hannu Saarni

Journal:

Chemico-Biological Interactions

Year:

1980

Language:

english

File:

PDF, 576 KB

english, 1980

67

Cytochrome P450 isozyme induction by methyl ethyl ketone and m-xylene in rat liver

Hannu Raunio, Juha Liira, Eivor Elovaara, Vesa Riihimäki, Olavi Pelkonen

Journal:

Toxicology and Applied Pharmacology

Year:

1990

Language:

english

File:

PDF, 729 KB

english, 1990

68

Comparison of the immunochemical properties of human placental and bovine adrenal cholesterol side-chain cleavage enzyme complex

Sergei A. Usanov, Paavo Honkakoski, Matti A. Lang, Markku Pasanen, Olavi Pelkonen, Hannu Raunio

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1989

Language:

english

File:

PDF, 1.04 MB

english, 1989

69

Regulation of CYP3A genes in the human respiratory tract

Hannu Raunio, Jukka Hakkola, Olavi Pelkonen

Journal:

Chemico-Biological Interactions

Year:

2005

Language:

english

File:

PDF, 310 KB

english, 2005

70

Metabolism of carbosulfan. I. Species differences in the in vitro biotransformation by mammalian hepatic microsomes including human

Khaled Abass, Petri Reponen, Sampo Mattila, Olavi Pelkonen

Journal:

Chemico-Biological Interactions

Year:

2009

Language:

english

File:

PDF, 643 KB

english, 2009

71

Metabolism of carbosulfan II. Human interindividual variability in its in vitro hepatic biotransformation and the identification of the cytochrome P450 isoforms involved

Khaled Abass, Petri Reponen, Sampo Mattila, Olavi Pelkonen

Journal:

Chemico-Biological Interactions

Year:

2010

Language:

english

File:

PDF, 757 KB

english, 2010

72

Liquid chromatography–mass spectrometry in in vitro drug metabolite screening

Ari Tolonen, Miia Turpeinen, Olavi Pelkonen

Journal:

Drug Discovery Today

Year:

2009

Language:

english

File:

PDF, 1.13 MB

english, 2009

73

Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay

Miia Turpeinen, Uusitalo Jouko, Jalonen Jorma, Pelkonen Olavi

Journal:

European Journal of Pharmaceutical Sciences

Year:

2005

Language:

english

File:

PDF, 274 KB

english, 2005

74

A simple method for differentiation of monoisotopic drug metabolites with hydrogen–deuterium exchange liquid chromatography/electrospray mass spectrometry

Ari Tolonen, Miia Turpeinen, Jouko Uusitalo, Olavi Pelkonen

Journal:

European Journal of Pharmaceutical Sciences

Year:

2005

Language:

english

File:

PDF, 328 KB

english, 2005

75

Corrigendum to “Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay” [Eur. J. Pharm. Sci. 24 (2005) 123–132]

Miia Turpeinen, Jouko Uusitalo, Jorma Jalonen, Olavi Pelkonen

Journal:

European Journal of Pharmaceutical Sciences

Year:

2005

File:

PDF, 32 KB

2005

76

In vitro metabolism and interaction of profenofos by human, mouse and rat liver preparations

Khaled Abass, Petri Reponen, Jorma Jalonen, Olavi Pelkonen

Journal:

Pesticide Biochemistry and Physiology

Year:

2007

Language:

english

File:

PDF, 315 KB

english, 2007

77

Coactivator PGC-1α regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes

Satu Arpiainen, Sanna-Mari Järvenpää, Aki Manninen, Pirkko Viitala, Matti A. Lang, Olavi Pelkonen, Jukka Hakkola

Journal:

Toxicology and Applied Pharmacology

Year:

2008

Language:

english

File:

PDF, 578 KB

english, 2008

78

Characterization of human cytochrome P450 induction by pesticides

Khaled Abass, Virpi Lämsä, Petri Reponen, Jenni Küblbeck, Paavo Honkakoski, Sampo Mattila, Olavi Pelkonen, Jukka Hakkola

Journal:

Year:

2012

Language:

english

File:

PDF, 1.81 MB

english, 2012

79

Lack of association between CYP2A5 induction and apoptosis in mouse primary hepatocytes

Sami Tetri, Minna Ruhanen, Pirkko Viitala, Olavi Pelkonen, Markku Pasanen, Hannu Raunio

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 373 KB

english, 2002

80

Cytochrome P-450-linked monooxygenase system and drug-induced spectral interactions in human liver microsomes

Olavi Pelkonen, Eero H. Kaltiala, Teuvo K.I. Larmi, Niilo T. Kärki

Journal:

Chemico-Biological Interactions

Year:

1974

Language:

english

File:

PDF, 794 KB

english, 1974

81

Synthesis of new potent and selective aromatase inhibitors based on long-chained diarylalkylimidazole and diarylalkyltriazole molecule skeletons

Arto Karjalainen, Arja Kalapudas, Marja Södervall, Olavi Pelkonen, Risto Lammintausta

Journal:

European Journal of Pharmaceutical Sciences

Year:

2000

Language:

english

File:

PDF, 584 KB

english, 2000

82

In silico prediction of ADME and pharmacokinetics: Report of an expert meeting organised by COST B15

Alan Boobis, Ursula Gundert-Remy, Pierre Kremers, Panos Macheras, Olavi Pelkonen

Journal:

European Journal of Pharmaceutical Sciences

Year:

2002

Language:

english

File:

PDF, 108 KB

english, 2002

83

Stability of sufentanil and levobupivacaine solutions and a mixture in a 0.9% sodium chloride infusion stored in polypropylene syringes

Annaliisa Jäppinen, Miia Turpeinen, Hannu Kokki, Anu Rasi, Tarja Ojanen, Olavi Pelkonen, Toivo Naaranlahti

Journal:

European Journal of Pharmaceutical Sciences

Year:

2003

Language:

english

File:

PDF, 119 KB

english, 2003

84

Modulation of murine phenobarbital-inducible CYP2A5, CYP2B10 and CYP1A enzymes by inhibitors of protein kinases and phosphatases

Katja Posti, Susanna Leinonen, Sami Tetri, Sami Kottari, Pirkko Viitala, Olavi Pelkonen, Hannu Raunio

Journal:

Year:

1999

Language:

english

File:

PDF, 664 KB

english, 1999

85

Liver Injury in Subjects Occupationally Exposed to Chemicals in Low Doses

Eero A. Sotaniemi, Seppo Sutinen, Sirkka Sutinen, Arno J. Arranto, R. Olavi Pelkonen

Journal:

Journal of Internal Medicine

Year:

1982

Language:

english

File:

PDF, 984 KB

english, 1982

86

Liver Damage in Nurses Handling Cytostatic Agents

EERO A. SOTANIEMI, SEPPO SUTINEN, ARNO J. ARRANTO, SIRKKA SUTINEN, KYÖSTI A. SOTANIEMI, JUHANI LEHTOLA, R. OLAVI PELKONEN

Journal:

Journal of Internal Medicine

Year:

1983

Language:

english

File:

PDF, 2.60 MB

english, 1983

87

Impairment of drug metabolism in patients with liver cancer

EERO A. SOTANIEMI, R. OLAVI PELKONEN, RISTO E. MOKKA, RISTO HUTTUNEN, EILA VILJAKAINEN

Journal:

European Journal of Clinical Investigation

Year:

1977

Language:

english

File:

PDF, 486 KB

english, 1977

88

Liver Enzyme Induction and Serum Lipid Levels After Replacement of Carbamazepine with Oxcarbazepine

Jouko I. T. Isojärvi, Arto J. Pakarinen, Arja Rautio, Olavi Pelkonen, Vilho V. Myllylä

Journal:

Year:

1994

Language:

english

File:

PDF, 420 KB

english, 1994

89

Thyroid and Myocardial Function After Replacement of Carbamazepine by Oxcarbazepine

Jouko I. T. Isojärvi, K. E. Juhani Airaksinen, Juha N. Mustonen, Arto J. Pakarinen, Arja Rautio, Olavi Pelkonen, Vilho V. Myllylä

Journal:

Year:

1995

Language:

english

File:

PDF, 591 KB

english, 1995

90

Metabolism of Chlorpromazine and p-Nitrobenzoic Acid in the Liver, Intestine and Kidney of the Human Foetus

Olavi Pelkonen, Martti Vorne, Pentti Jouppila, Niilo T. Käarki

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1971

Language:

english

File:

PDF, 546 KB

english, 1971

91

Demonstration of Cytochrome P-450 in Human Foetal Liver Microsomes in Early Pregnancy

Olavi Pelkonen, Niilo T. Kärki

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1971

Language:

english

File:

PDF, 161 KB

english, 1971

92

3,4-Benzpyrene and N-Methylaniline Metabolizing Enzymes in the Immature Human Foetus and Placenta

Olavi Pelkonen, Pentti Arvela, Niilo T. Kärki

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1972

Language:

english

File:

PDF, 529 KB

english, 1972

93

Cytochrome P-450 and Drug-induced Spectral Interactions in the Hepatic Microsomes of Trout, Salmo trutta lacustris

Jorma T. Ahokas, Olavi Pelkonen, Niilo T. Kärki

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1976

Language:

english

File:

PDF, 423 KB

english, 1976

94

The Metabolism of Benzo(a)pyrene in Isolated Perfused Lungs from Variously-treated Rats

Kirsi Vähäkangas, Kaisu Nevasaari, Olavi Pelkonen, Niilo T. Kärki

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1977

Language:

english

File:

PDF, 635 KB

english, 1977

95

Differential Inhibition of Aryl Hydrocarbon Hydroxylase in Human Foetal Liver, Adrenal Gland and Placenta

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1977

Language:

english

File:

PDF, 592 KB

english, 1977

96

Effects of Various in Vitro - inhibitors of Benzo(a)pyrene Metabolism in Isolated Rat Lung Perfusion

Kirsi Vähäkangas, Kaisu Nevasaari, Olavi Pelkonen, Niilo T. Kärki

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1979

Language:

english

File:

PDF, 553 KB

english, 1979

97

Effects of Cigarette Smoke on Rat Lung and Liver Ornithine Decarboxylase and Aryl Hydrocarbon Hydroxylase Activities and Lung Benzo(a)pyrene Metabolism

Hannu Raunio, Kirsi Vähäkangas, Hannu Saarni, Olavi Pelkonen

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1983

Language:

english

File:

PDF, 468 KB

english, 1983

98

Inhibition of Hepatic Microsomal Drug Metabolism in Rats by Five Calcium Antagonists

Jukka Mäenpää, Heikki Ruskoaho, Olavi Pelkonen

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1989

Language:

english

File:

PDF, 465 KB

english, 1989

99

Preferential Inhibition of Mouse Hepatic Coumarin 7-Hydroxylase by Inhibitors of Steroid Metabolizing Monooxygenases

Anneli Kojo, Paavo Honkakoski, Päivi Järvinen, Olavi Pelkonen, Matti Lang

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1989

Language:

english

File:

PDF, 540 KB

english, 1989

100

Comparative Effects of Medetomidine Enantiomers on in vitro and in vivo Microsomal Drug Metabolism

Olavi Pelkonen, Juhani Puurunen, Pentti Arvela, Risto Lammintausta

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1991

Language:

english

File:

PDF, 543 KB

english, 1991