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51

Virokines in the Pathogenesis of Cancer: Focus on Human Herpesvirus 8

MARIAM KLOUCHE, GIUSEPPE CARRUBA, LUIGI CASTAGNETTA, STEFAN ROSE-JOHN

Journal:

Annals of the New York Academy of Sciences

Year:

2004

Language:

english

File:

PDF, 9.13 MB

english, 2004

52

Letter to the Editor:1H,15N and13C Backbone Assignment of the Carboxyl Terminal Domain of the Cytokine Binding Module of the Interleukin-6 Receptor

Andreas Schwantner, Andrew J. Dingley, Suat Özbek, Oliver Hecht, Stefan Rose-John, Joachim Grötzinger

Journal:

Journal of Biomolecular NMR

Year:

2004

Language:

english

File:

PDF, 74 KB

english, 2004

53

Expression of a fusion protein of human ciliary neurotrophic factor and soluble CNTF-Receptor and identification of its activity

Yi Sun, März Pia, Otten Uwe, Ji-guang Ge, Rose-John Stefan

Journal:

Journal of Zhejiang University SCIENCE A

Year:

2003

Language:

english

File:

PDF, 631 KB

english, 2003

54

Ligand/Receptor Signaling Threshold (LIST) Model Accounts for gp130-Mediated Embryonic Stem Cell Self-Renewal Responses to LIF and HIL-6

Sowmya Viswanathan, Tania Benatar, Stefan Rose-John, Doug A. Lauffenburger, Peter W. Zandstra

Journal:

Year:

2002

Language:

english

File:

PDF, 826 KB

english, 2002

55

Multilevel Regulation of IL-6R by IL-6–sIL-6R Fusion Protein According to the Primitiveness of Peripheral Blood-Derived CD133+ Cells

David Campard, Marc Vasse, Stefan Rose-John, Florent Poyer, Marek Lamacz, Jean-Pierre Vannier

Journal:

Year:

2006

Language:

english

File:

PDF, 1.19 MB

english, 2006

56

Maintenance of Pluripotency in Human Embryonic Stem Cells Is STAT3 Independent

Rohan K. Humphrey, Gillian M. Beattie, Ana D. Lopez, Nathan Bucay, Charles C. King, Meri T. Firpo, Stefan Rose-John, Alberto Hayek

Journal:

Year:

2004

Language:

english

File:

PDF, 206 KB

english, 2004

57

Human Interleukin-6 Facilitates Hepatitis B Virus Infection in Vitro and in Vivo

Eithan Galun, Orit Nahor, Ahmed Eid, Oded Jurim, Stefan Rose-John, Hubert E. Blum, Ofer Nussbaum, Ehud Ilan, Nili Daudi, Daniel Shouval, Yair Reisner, Shlomo Dagan

Journal:

Year:

2000

Language:

english

File:

PDF, 969 KB

english, 2000

58

Alternative assay procedures for cytokines and soluble receptors of the IL-6 family

Birgit Oppmann, Tanja Stoyan, Martina Fischer, Nicole Voltz, Pia März, Stefan Rose-John

Journal:

Journal of Immunological Methods

Year:

1996

Language:

english

File:

PDF, 676 KB

english, 1996

59

ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by γ-secretase

Athena Chalaris, Jessica Gewiese, Krzysztof Paliga, Lina Fleig, Alex Schneede, Karsten Krieger, Stefan Rose-John, Jürgen Scheller

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2010

Language:

english

File:

PDF, 1.31 MB

english, 2010

60

The pro- and anti-inflammatory properties of the cytokine interleukin-6

Jürgen Scheller, Athena Chalaris, Dirk Schmidt-Arras, Stefan Rose-John

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2011

Language:

english

File:

PDF, 788 KB

english, 2011

61

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

Sergei Grivennikov, Eliad Karin, Janos Terzic, Daniel Mucida, Guann-Yi Yu, Sivakumar Vallabhapurapu, Jürgen Scheller, Stefan Rose-John, Hilde Cheroutre, Lars Eckmann, Michael Karin

Journal:

Year:

2009

Language:

english

File:

PDF, 1.25 MB

english, 2009

62

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

Sergei Grivennikov, Eliad Karin, Janos Terzic, Daniel Mucida, Guann-Yi Yu, Sivakumar Vallabhapurapu, Jürgen Scheller, Stefan Rose-John, Hilde Cheroutre, Lars Eckmann, Michael Karin

Journal:

Year:

2009

Language:

english

File:

PDF, 38 KB

english, 2009

63

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

Marina Lesina, Magdalena U. Kurkowski, Katharina Ludes, Stefan Rose-John, Matthias Treiber, Günter Klöppel, Akihiko Yoshimura, Wolfgang Reindl, Bence Sipos, Shizuo Akira, Roland M. Schmid, Hana Algül

Journal:

Year:

2011

Language:

english

File:

PDF, 2.46 MB

english, 2011

64

The Transcription Factor NFATc2 Controls Apoptosis and Activation of T Cells by IL-6 in Colitis

Benno Weigmann, Hans-Anton Lehr, Stefan Rose-John, Markus Neurath

Journal:

Clinical Immunology

Year:

2010

Language:

english

File:

PDF, 55 KB

english, 2010

65

Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization

Jan Suthaus, Nina Adam, Joachim Grötzinger, Jürgen Scheller, Stefan Rose-John

Journal:

European Journal of Cell Biology

Year:

2011

Language:

english

File:

PDF, 1.33 MB

english, 2011

66

The soluble Interleukin 6 receptor: Generation and role in inflammation and cancer

Athena Chalaris, Christoph Garbers, Björn Rabe, Stefan Rose-John, Jürgen Scheller

Journal:

European Journal of Cell Biology

Year:

2011

Language:

english

File:

PDF, 933 KB

english, 2011

67

The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution

Inken Lorenzen, Weifeng Shang, Markus Perbandt, Maxim V. Petoukhov, Dmitri I. Svergun, Georg H. Waetzig, Stefan Rose-John, Rolf Hilgenfeld, Joachim Grötzinger

Journal:

European Journal of Cell Biology

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

68

Dendritic cell lineage commitment is instructed by distinct cytokine signals

Kristin M. Seré, Qiong Lin, Piritta Felker, Nina Rehage, Theresa Klisch, Inga Ortseifer, Thomas Hieronymus, Stefan Rose-John, Martin Zenke

Journal:

European Journal of Cell Biology

Year:

2012

Language:

english

File:

PDF, 1.12 MB

english, 2012

69

IL-6-trans-signalling increases rapid-eye-movement sleep in rats

Ulrike May, Thomas Schiffelholz, Paul Christian Baier, James M. Krueger, Stefan Rose-John, Jürgen Scheller

Journal:

European Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 275 KB

english, 2009

70

The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II

Inken Lorenzen, Juliane Lokau, Stefan Düsterhöft, Ahmad Trad, Christoph Garbers, Jürgen Scheller, Stefan Rose-John, Joachim Grötzinger

Journal:

Year:

2012

Language:

english

File:

PDF, 943 KB

english, 2012

71

Development of a monoclonal antibody-based enzyme-linked immunoabsorbent assay for the binding of gp130 to the IL-6/IL-6R complex and its competitive inhibition

Jürgen Scheller, Marina Kovaleva, Björn Rabe, Jutta Eichler, Karl-Josef Kallen, Stefan Rose-John

Journal:

Journal of Immunological Methods

Year:

2004

Language:

english

File:

PDF, 327 KB

english, 2004

72

IL-6 regulates MCP-1, ICAM-1 and IL-6 expression in human myoblasts

Mariapaola Marino, Flavia Scuderi, Carlo Provenzano, Jürgen Scheller, Stefan Rose-John, Emanuela Bartoccioni

Journal:

Journal of Neuroimmunology

Year:

2008

Language:

english

File:

PDF, 657 KB

english, 2008

73

IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier

Ralf A. Linker, Fred Lühder, Karl-Josef Kallen, De-Hyung Lee, Britta Engelhardt, Stefan Rose-John, Ralf Gold

Journal:

Journal of Neuroimmunology

Year:

2008

Language:

english

File:

PDF, 2.07 MB

english, 2008

74

Elastin-like polypeptides revolutionize recombinant protein expression and their biomedical application

Doreen M. Floss, Kai Schallau, Stefan Rose-John, Udo Conrad, Jürgen Scheller

Journal:

Trends in Biotechnology

Year:

2010

Language:

english

File:

PDF, 404 KB

english, 2010

75

Yeast expression of the cytokine receptor domain of the soluble interleukin-6 receptor

Petra Vollmer, Malte Peters, Marc Ehlers, Harutaka Yagame, Takao Matsuba, Masahide Kondo, Kiyoshi Yasukawa, Karl-Hermann Meyer zum Büschenfelde, Stefan Rose-John

Journal:

Journal of Immunological Methods

Year:

1996

Language:

english

File:

PDF, 766 KB

english, 1996

76

Immunoadhesins of interleukin-6 and the IL-6/soluble IL-6R fusion protein hyper-IL-6

Thomas Jostock, Guido Blinn, Christoph Renné, Karl-Josef Kallen, Stefan Rose-John, Jürgen Müllberg

Journal:

Journal of Immunological Methods

Year:

1999

Language:

english

File:

PDF, 397 KB

english, 1999

77

The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex

Simon A Jones, Stefan Rose-John

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2002

Language:

english

File:

PDF, 535 KB

english, 2002

78

CYTOKINES COME OF AGE

Stefan Rose-John

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2002

Language:

english

File:

PDF, 48 KB

english, 2002

79

New perspectives on the design of cytokines and growth factors

Karl-Josef Kallen, Joachim Grötzinger, Stefan Rose-John

Journal:

Trends in Biotechnology

Year:

2000

Language:

english

File:

PDF, 488 KB

english, 2000

80

GP130 stimulation and the maintenance of stem cells

Stefan Rose-John

Journal:

Trends in Biotechnology

Year:

2002

Language:

english

File:

PDF, 614 KB

english, 2002

81

The gp130-stimulating designer cytokine hyper-IL-6 promotes the expansion of human hematopoietic progenitor cells capable to differentiate into functional dendritic cells

Helga Bernhard, Matthias Lohmann, Wendy Y. Batten, Jochen Metzger, Hanns F. Löhr, Christian Peschel, Karl-Hermann Meyer zum Büschenfelde, Stefan Rose-John

Journal:

Experimental Hematology

Year:

2000

Language:

english

File:

PDF, 159 KB

english, 2000

82

Interleukin-6 and the soluble interleukin-6 receptor induce stem cell factor and Flt-3L expression in vivo and in vitro

Malte Peters, Fian Solem, Jutta Goldschmidt, Peter Schirmacher, Stefan Rose-John

Journal:

Experimental Hematology

Year:

2001

Language:

english

File:

PDF, 3.42 MB

english, 2001

83

gp130-Stimulating designer cytokine Hyper-interleukin-6 synergizes with murine stroma for long-term survival of primitive human hematopoietic progenitor cells

Katharina S Götze, Ulrich Keller, Stefan Rose-John, Christian Peschel

Journal:

Experimental Hematology

Year:

2001

Language:

english

File:

PDF, 188 KB

english, 2001

84

Optimization of retroviral-mediated gene transfer to human NOD/SCID mouse repopulating cord blood cells through a systematic analysis of protocol variables

Burkhard Hennemann, Eibhlin Conneally, Robert Pawliuk, Philippe Leboulch, Stefan Rose-John, Dianne Reid, Jean Y Chuo, R.Keith Humphries, Connie J Eaves

Journal:

Experimental Hematology

Year:

1999

Language:

english

File:

PDF, 318 KB

english, 1999

85

A role for the immunoglobulin-like domain of the human IL-6 receptor : Intracellular protein transport and shedding

Petra Vollmer, Birgit Oppmann, Nicole Voltz, Martina Fischer, Stefan Rose-John

Journal:

Year:

1999

Language:

english

File:

PDF, 670 KB

english, 1999

86

Towards determining the differentiation program of antigen-presenting dendritic cells by transcriptional profiling

Xin-Sheng Ju, Christine Hacker, Jaime Madruga, Steffen M. Kurz, Siegne Knespel, Gitta Blendinger, Stefan Rose-John, Martin Zenke

Journal:

European Journal of Cell Biology

Year:

2003

Language:

english

File:

PDF, 323 KB

english, 2003

87

Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC cocultures

Harald Loppnow, Li Zhang, Michael Buerke, Michael Lautenschläger, Li Chen, Adrian Frister, Axel Schlitt, Tanja Luther, Nan Song, Britt Hofmann, Stefan Rose-John, Rolf-Edgar Silber, Ursula Müller-Werda

Journal:

Journal of Cellular and Molecular Medicine

Year:

2011

Language:

english

File:

PDF, 708 KB

english, 2011

88

Contribution of vascular cell-derived cytokines to innate and inflammatory pathways in atherogenesis

Harald Loppnow, Michael Buerke, Karl Werdan, Stefan Rose-John

Journal:

Journal of Cellular and Molecular Medicine

Year:

2011

Language:

english

File:

PDF, 823 KB

english, 2011

89

Studies on the structure and regulation of the human hepatic interleukin-6 receptor

Stefan ROSE-JOHN, Heidi SCHOOLTINK, Dorothée LENZ, Erich HIPP, Gabi DUFHUES, Hildegard SCHMITZ, Xaver SCHIEL, Toshio HIRANO, Tadamitsu KISHIMOTO, Peter C. HEINRICH

Journal:

Year:

1990

Language:

english

File:

PDF, 559 KB

english, 1990

90

Recombinant soluble human interleukin-6 receptor : Expression in Escherichia coli, renaturation and purification

Tanja STOYAN, Uwe MICHAELIS, Heidi SCHOOLTINK, Marc VAN DAM, Rainer RUDOLPH, Peter C. HEINRICH, Stefan ROSE-JOHN

Journal:

Year:

1993

Language:

english

File:

PDF, 859 KB

english, 1993

91

Biosynthesis and half-life of the interleukin-6 receptor and its signal transducer gp130

Claudia GERHARTZ, Elke DITTRICH, Tanja STOYAN, Stefan ROSE-JOHN, Kiyoshi YASUKAWA, Peter C. HEINRICH, Lutz GRAEVE

Journal:

Year:

1994

Language:

english

File:

PDF, 1.20 MB

english, 1994

92

Expression of a Biologically Active Murine Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) in Baculovirus-Infected Insect Cells : Purification and Tissue Distribution in the Rat

Peter Kurschat, Lutz Graeve, Andrea Erren, Petros Gatsios, Stefan Rose-John, Elke Roeb, Harald Tschesche, Aleksander Koj, Peter C. Heinrich

Journal:

Year:

1995

Language:

english

File:

PDF, 816 KB

english, 1995

93

Soluble Human Interleukin-6 Receptor : Expression in Insect Cells, Purification and Characterization

Oliver Weiergräber, Ulrike Hemmann, Andrea Küster, Gerhard Müller-Newen, Johannes Schneider, Stefan Rose-John, Peter Kurschat, Just P. J. Brakenhoff, Margreet H. L. Hart, Silvia Stabel, Peter C. Heinr

Journal:

Year:

1995

Language:

english

File:

PDF, 970 KB

english, 1995

94

Participation of Two Ser-Ser-Phe-Tyr Repeats in Interleukin-6 (IL-6)-Binding Sites of the Human IL-6 Receptor

Michael Kalai, Felix A. Montero-Julian, Joachim Grötzinger, Axel Wollmer, Danielle Morelle, Jean Brochier, Stefan Rose-John, Peter C. Heinrich, Hervé Brailly, Jean Content

Journal:

Year:

1996

Language:

english

File:

PDF, 1.25 MB

english, 1996

95

Long-term survival of high-risk melanoma patients immunized with a Hyper-IL-6-modified allogeneic whole-cell vaccine after complete resection

Mackiewicz, Andrzej, Mackiewicz, Jacek, Wysocki, Piotr J., Wiznerowicz, Maciej, Kapcinska, Malgorzata, Laciak, Maria, Rose-John, Stefan, Izycki, Dariusz, Burzykowski, Tomasz, Karczewska-Dzionk, Aldona

Journal:

Expert Opinion on Investigational Drugs

Year:

2012

Language:

english

File:

PDF, 497 KB

english, 2012

96

Effect of Soluble Interleukin-6 Receptor on Interleukin-6 Synthesis in Human Skin Fibroblasts

Joanna Cichy, Stefan Rose-John, Juliusz Pryjma, James Travis

Journal:

Biochemical and Biophysical Research Communications

Year:

1996

Language:

english

File:

PDF, 266 KB

english, 1996

97

Functional distinction of two regions of human interleukin 6 important for signal transduction via gp130

Floris D. de Hon, Edwin ten Boekel, Jean Herrman, Claude Clement, Marc Ehlers, Tetsuya Taga, Kiyoshi Yasukawa, Yoshiyuki Ohsugi, Tadamitsu Kishimoto, Stefan Rose-John, John Wijdenes, Rob Kastelein, Lu

Journal:

Year:

1995

Language:

english

File:

PDF, 130 KB

english, 1995

98

Soluble Interleukin 6 Receptor is Biologically Active In Vivo

Andrzej Mackiewicz, Maciej Wiznerowicz, Elke Roeb, Aldona Karczewska, Jerzy Nowak, Peter C. Heinrich, Stefan Rose-John

Journal:

Year:

1995

File:

PDF, 476 KB

1995

99

SOLUBLE INTERLEUKIN 6 (IL-6) RECEPTOR INFLUENCES THE EXPRESSION OF THE PROTOONCOGENE junB AND THE PRODUCTION OF FIBRINOGEN IN THE HepG2 HUMAN HEPATOMA CELL LINE AND PRIMARY RAT HEPATOCYTES

Peter Igaz, Sara Tóth, Stefan Rose-John, Ildikó Madurka, György Fejér, Csaba Szalai, Andras Falus

Journal:

Year:

1998

Language:

english

File:

PDF, 206 KB

english, 1998

100

AN IL-6/IL-6 SOLUBLE RECEPTOR (IL-6R) HYBRID PROTEIN (H-IL-6) INDUCES EPO-INDEPENDENT ERYTHROID DIFFERENTIATION IN HUMAN CD34+CELLS

Marta Baiocchi, Isabella Marcucci, Stefan Rose-John, Ottaviano Serlupi-Crescenzi, Mauro Biffoni

Journal:

Year:

2000

Language:

english

File:

PDF, 111 KB

english, 2000