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51

Hydrazones and new Oximes of 4-Aminobicyclo[2.2.2]octanones and their Antiprotozoal Activities

Robert Weis, Marcel Kaiser, Reto Brun, Robert Saf, Werner Seebacher

Journal:

Monatshefte für Chemie - Chemical Monthly

Year:

2006

Language:

english

File:

PDF, 152 KB

english, 2006

52

ChemInform Abstract: Diarylcyclohexanones: Synthons for New Bicyclic Compounds.

Sarfraz Ahmad, Robert Weis, Johanna Faist, Volker Wolkinger, Robert Saf, Ferdinand Belaj, Reto Brun, Marcel Kaiser, Werner Seebacher

Journal:

Year:

2012

File:

PDF, 28 KB

2012

53

Okundoperoxide, a Bicyclic Cyclofarnesylsesquiterpene Endoperoxide from Scleria striatinux with Antiplasmodial Activity

Efange, Simon M. N., Brun, Reto, Wittlin, Sergio, Connolly, Joseph D., Hoye, Thomas R., McAkam, Thomas, Makolo, Felix L., Mbah, James A., Nelson, Dorian P., Nyongbela, Kennedy D., Wirmum, Clare K.

Journal:

Journal of Natural Products

Year:

2009

Language:

english

File:

PDF, 85 KB

english, 2009

54

Ancient Chinese Methods Are Remarkably Effective for the Preparation of Artemisinin-Rich Extracts of Qing Hao with Potent Antimalarial Activity

Wright, Colin W., Linley, Peter A., Brun, Reto, Wittlin, Sergio, Hsu, Elisabeth

Journal:

Year:

2010

Language:

english

File:

PDF, 123 KB

english, 2010

55

Novel Spiroanellated 1,2,4-Trioxanes with High in vitro Antimalarial Activities.

Axel G. Griesbeck, Tamer T. El-Idressy, Lars-Oliver Hoeinck, Johann Lex, Reto Brun

Journal:

Year:

2005

File:

PDF, 14 KB

2005

56

Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase

Andrea Cavalli, Federica Lizzi, Salvatore Bongarzone, Reto Brun, R. Luise Krauth-Siegel, Maria Laura Bolognesi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 362 KB

english, 2009

57

Potent and selective antiplasmodial activity of the cyanobacterial alkaloid nostocarboline and its dimers

Damien Barbaras, Marcel Kaiser, Reto Brun, Karl Gademann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 179 KB

english, 2008

58

Alkyl and dialkylaminoethyl derivatives of 5-amino-2-azabicyclo[3.2.2]nonanes and their antiplasmodial and antitrypanosomal activities

Johanna Faist, Werner Seebacher, Marcel Kaiser, Reto Brun, Robert Saf, Robert Weis

Journal:

European Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 221 KB

english, 2010

59

Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes

Donald A. Patrick, Stanislav A. Bakunov, Svetlana M. Bakunova, E.V.K. Suresh Kumar, Heidi Chen, Susan Kilgore Jones, Tanja Wenzler, Todd Barzcz, Karl A. Werbovetz, Reto Brun, Richard R. Tidwell

Journal:

European Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 260 KB

english, 2009

60

Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents

Reem K. Arafa, Tanja Wenzler, Reto Brun, Yun Chai, W. David Wilson

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 633 KB

english, 2011

61

Conjugation of Quinones with Natural Polyamines: Toward an Expanded Antitrypanosomatid Profile

Lizzi, Federica, Veronesi, Giacomo, Belluti, Federica, Bergamini, Christian, López-Sánchez, Almudena, Kaiser, Marcel, Brun, Reto, Krauth-Siegel, R. Luise, Hall, Dennis G., Rivas, Luis, Bolognesi, Mari

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.55 MB

english, 2012

62

Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius

Bringmann, Gerhard, Zhang, Guoliang, Ölschläger, Tobias, Stich, August, Wu, Jun, Chatterjee, Manik, Brun, Reto

Journal:

Year:

2013

Language:

english

File:

PDF, 533 KB

english, 2013

63

Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei

Hwang, Jong Yeon, Smithson, David C., Holbrook, Gloria, Zhu, Fangyi, Connelly, Michele C., Kaiser, Marcel, Brun, Reto, Kiplin Guy, R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.98 MB

english, 2013

64

Antitrypanosomal isoflavan quinones from Abrus precatorius

Hata, Yoshie, Ebrahimi, Samad Nejad, De Mieri, Maria, Zimmermann, Stefanie, Mokoka, Tsholofelo, Naidoo, Dashnie, Fouche, Gerda, Maharaj, Vinesh, Kaiser, Marcel, Brun, Reto, Potterat, Olivier, Hamburge

Journal:

Year:

2014

Language:

english

File:

PDF, 544 KB

english, 2014

65

Ancistrocongolines A−D, New Naphthylisoquinoline Alkaloids from Ancistrocladus c ongolensis 1

Bringmann, Gerhard, Messer, Kim, Brun, Reto, Mudogo, Virima

Journal:

Journal of Natural Products

Year:

2002

Language:

english

File:

PDF, 122 KB

english, 2002

66

In Vitro Activity of Aurones against Plasmodium falciparum Strains K1 and NF54

Kayser, Oliver, Kiderlen, Albrecht, Brun, Reto

Journal:

Year:

2001

Language:

english

File:

PDF, 245 KB

english, 2001

67

Ancistectorine D, a naphthylisoquinoline alkaloid with antiprotozoal and antileukemic activities, and further 5,8'- and 7,1'-linked metabolites from the Chinese liana Ancistrocladus tectorius

Bringmann, Gerhard, Seupel, Raina, Feineis, Doris, Zhang, Guoliang, Xu, Minjuan, Wu, Jun, Kaiser, Marcel, Brun, Reto, Seo, Ean-Jeong, Efferth, Thomas

Journal:

Year:

2016

Language:

english

File:

PDF, 957 KB

english, 2016

68

Antiplasmodial Ealapasamines A-C,‘Mixed’ Naphthylisoquinoline Dimers from the Central African Liana Ancistrocladus ealaensis

Tshitenge, Dieudonné Tshitenge, Feineis, Doris, Mudogo, Virima, Kaiser, Marcel, Brun, Reto, Bringmann, Gerhard

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 3.12 MB

english, 2017

69

Herpes Simplex Virus Type 1 Infects Enteric Neurons and Triggers Gut Dysfunction via Macrophage Recruitment

Brun, Paola, Qesari, Marsela, Marconi, Peggy C., Kotsafti, Andromachi, Porzionato, Andrea, Macchi, Veronica, Schwendener, Reto A., Scarpa, Marco, Giron, Maria C., Palù, Giorgio, Calistri, Arianna, Cas

Journal:

Frontiers in Cellular and Infection Microbiology

Year:

2018

Language:

english

File:

PDF, 3.53 MB

english, 2018

70

Biosynthetic Capacities of Actinomycetes. Part 29. Diversity and Biosynthesis of Secondary Metabolites. Part 8. Pyrocoll (I), an Antibiotic, Antiparasitic and Antitumor Compound Produced by a Novel Alkaliphilic Streptomyces Strain.

Anke Dieter, Andreas Hamm, Hans-Peter Fiedler, Michael Goodfellow, Werner E. G. Mueller, Reto Brun, Winfried Beil, Gerhard Bringmann

Journal:

Year:

2003

File:

PDF, 73 KB

2003

71

Synthesis and Evaluation of the Antitrypanosomal and Antiplasmodial Activities of New 4-Aminobicyclo[2.2.2]octane Derivatives.

Werner Seebacher, Reto Brun, Marcel Kaiser, Robert Saf, Robert Weis

Journal:

Year:

2006

File:

PDF, 12 KB

2006

72

ChemInform Abstract: Chloropupukeanolides C—E: Cytotoxic Pupukeanane Chlorides with a Spiroketal Skeleton from Pestalotiopsis fici.

Ling Liu, Torsten Bruhn, Liangdong Guo, Daniel C. G. Goetz, Reto Brun, August Stich, Yongsheng Che, Gerhard Bringmann

Journal:

Year:

2011

File:

PDF, 25 KB

2011

73

Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines

Romina J. Pagliero, Sabrina Lusvarghi, Adriana B. Pierini, Reto Brun, María R. Mazzieri

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 400 KB

english, 2010

74

Synthesis of a series of N6-substituted adenosines with activity against trypanosomatid parasites

Andreas Link, Philipp Heidler, Marcel Kaiser, Reto Brun

Journal:

European Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 217 KB

english, 2009

75

Isolation and propagation of Trypanosoma brucei gambiense from sleeping sickness patients in south Sudan

Naomi W.N. Maina, Michael Oberle, Charles Otieno, Christina Kunz, Pascal Maeser, Joseph M. Ndung’u, Reto Brun

Journal:

Transactions of the Royal Society of Tropical Medicine and Hygiene

Year:

2007

Language:

english

File:

PDF, 328 KB

english, 2007

76

Dioncophylline E from Dioncophyllum thollonii, the first 7,3′-coupled dioncophyllaceous naphthylisoquinoline alkaloid

Gerhard Bringmann, Kim Messer, Kristina Wolf, Jörg Mühlbacher, Matthias Grüne, Reto Brun, Adriaan M. Louis

Journal:

Year:

2002

Language:

english

File:

PDF, 222 KB

english, 2002

77

Novel inhibitors of leishmanial dihydrofolate reductase

Shafinaz F Chowdhury, Raffaella Di Lucrezia, Ramon Hurtado Guerrero, Reto Brun, Jonathan Goodman, Luis M Ruiz-Perez, Dolores Gonzalez Pacanowska, Ian H Gilbert

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 110 KB

english, 2001

78

Synthesis of bicyclic amines and their activities againstTrypanosoma brucei rhodesienseandPlasmodium falciparum K1

Robert Weis, Heinrich Berger, Marcel Kaiser, Reto Brun, Robert Saf, Werner Seebacher

Journal:

Archives of Pharmacal Research

Year:

2008

Language:

english

File:

PDF, 270 KB

english, 2008

79

Synthesis and in Vitro Antiprotozoal Activities of Water-Soluble, Inexpensive 3,7-Bis(dialkylamino)phenoxazin-5-ium Derivatives

Ge, Jian-Feng, Arai, Chika, Kaiser, Marcel, Wittlin, Sergio, Brun, Reto, Ihara, Masataka

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 111 KB

english, 2008

80

Antiprotozoal Activities of Heterocyclic-Substituted Xanthones from the Marine-Derived Fungus Chaetomium sp.

Pontius, Alexander, Krick, Anja, Kehraus, Stefan, Brun, Reto, König, Gabriele M.

Journal:

Journal of Natural Products

Year:

2008

Language:

english

File:

PDF, 216 KB

english, 2008

81

Evaluation of the in vitro trypanocidal activity of methylated flavonoid constituents of Vitex simplicifolia leaves

Nwodo, Ngozi, Okoye, Festus, Lai, Daowan, Debbab, Abdesammed, Kaiser, Marcel, Brun, Reto, Proksch, Peter

Journal:

BMC Complementary and Alternative Medicine

Year:

2015

Language:

english

File:

PDF, 396 KB

english, 2015

82

Advancing Drug Innovation for Neglected Diseases—Criteria for Lead Progression

Nwaka, Solomon, Ramirez, Bernadette, Brun, Reto, Maes, Louis, Douglas, Frank, Ridley, Robert, Geary, Timothy G.

Journal:

PLoS Neglected Tropical Diseases

Year:

2009

Language:

english

File:

PDF, 350 KB

english, 2009

83

Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata

Kimani, Njogu M., Matasyoh, Josphat C., Kaiser, Marcel, Brun, Reto, Schmidt, Thomas J.

Journal:

Journal of Natural Products

Year:

2017

Language:

english

File:

PDF, 464 KB

english, 2017

84

The European Medicines Agency’s scientific opinion on oral fexinidazole for human African trypanosomiasis

Pelfrene, Eric, Harvey Allchurch, Martin, Ntamabyaliro, Nsengi, Nambasa, Victoria, Ventura, Fátima V., Nagercoil, Nithyanandan, Cavaleri, Marco, Brun, Reto

Journal:

PLoS Neglected Tropical Diseases

Year:

2019

Language:

english

File:

PDF, 341 KB

english, 2019

85

An Unusually Broad Series of Seven Cyclombandakamines, Bridged Dimeric Naphthylisoquinoline Alkaloids from the Congolese Liana Ancistrocladus ealaensis

Tshitenge, Dieudonné Tshitenge, Bruhn, Torsten, Feineis, Doris, Mudogo, Virima, Kaiser, Marcel, Brun, Reto, Bringmann, Gerhard

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 3.57 MB

english, 2019

86

ChemInform Abstract: Acetogenic Isoquinoline Alkaloids. Part 137. Jozimine B, a Constitutionally Unsymmetric, Antiplasmodial “Dimer” of the Naphthylisoquinoline Alkaloid Ancistrocladine.

Gerhard Bringmann, Wael Saeb, Juergen Kraus, Reto Brun, Guido Francois

Journal:

Year:

2000

File:

PDF, 30 KB

2000

87

Synthesis and Evaluation of Novel 7-Trifluoromethyl-4-(4-substituted anilino)quinolines as Antiparasitic and Antineoplastic Agents.

Ashraf H. Abadi, Reto Brun

Journal:

Year:

2003

File:

PDF, 132 KB

2003

88

Synthesis, Inhibition Potency, Binding Mode, and Antiprotozoal Activities of Fluorescent Inhibitors of Trypanothione Reductase Based on Mepacrine-Conjugated Diaryl Sulfide Scaffolds

Christian Eberle, Johannes A. Burkhard, Bernhard Stump, Marcel Kaiser, Reto Brun, R. Luise Krauth-Siegel, François Diederich

Journal:

Year:

2009

Language:

english

File:

PDF, 555 KB

english, 2009

89

Inside Cover: Synthesis, Inhibition Potency, Binding Mode, and Antiprotozoal Activities of Fluorescent Inhibitors of Trypanothione Reductase Based on Mepacrine-Conjugated Diaryl Sulfide Scaffolds (ChemMedChem 12/2009)

Christian Eberle, Johannes A. Burkhard, Bernhard Stump, Marcel Kaiser, Reto Brun, R. Luise Krauth-Siegel, François Diederich

Journal:

Year:

2009

File:

PDF, 467 KB

2009

90

A Novel β-Amino Acid in Cytotoxic Peptides from the Cyanobacterium Tychonema sp.

Christian Mehner, Daniela Müller, Anja Krick, Stefan Kehraus, Reik Löser, Michael Gütschow, Armin Maier, Heinz-Herbert Fiebig, Reto Brun, Gabriele M. König

Journal:

European Journal of Organic Chemistry

Year:

2008

Language:

english

File:

PDF, 198 KB

english, 2008

91

Antiplasmodial and antitrypanosomal activities of aminobicyclo[2.2.2]octyl ω-aminoalkanoates

Christian Schlapper, Werner Seebacher, Johanna Faist, Marcel Kaiser, Reto Brun, Robert Saf, Robert Weis

Journal:

European Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 281 KB

english, 2009

92

Studies on compounds promoting the in vitro transformation ofTrypanosoma bruceifrom bloodstream to procyclic forms

Marjory Hunt, Reto Brun, Peter Köhler

Journal:

Parasitology Research

Year:

1994

Language:

english

File:

PDF, 843 KB

english, 1994

93

Acyl derivatives of 5-amino-2-azabicyclo[3.2.2]nonanes

Robert Weis, Marcel Kaiser, Reto Brun, Robert Saf, Werner Seebacher

Journal:

Monatshefte für Chemie - Chemical Monthly

Year:

2008

Language:

english

File:

PDF, 185 KB

english, 2008

94

Diarylcyclohexanones: synthons for new bicyclic compounds

Sarfraz Ahmad, Robert Weis, Johanna Faist, Volker Wolkinger, Robert Saf, Ferdinand Belaj, Reto Brun, Marcel Kaiser, Werner Seebacher

Journal:

Monatshefte für Chemie - Chemical Monthly

Year:

2012

Language:

english

File:

PDF, 392 KB

english, 2012

95

Foreword

Journal:

Year:

1993

Language:

english

File:

PDF, 42 KB

english, 1993

96

Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test

Mhairi L Stewart, Sanjeev Krishna, Richard JS Burchmore, Reto Brun, Harry P de Koning, David W Boykin, Richard R Tidwell, J Ed Hall, Michael P Barrett

Journal:

Year:

2005

Language:

english

File:

PDF, 167 KB

english, 2005

97

Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents

Carvalho, Samir A., Feitosa, Larisse O., Soares, Márcio, Costa, Thadeu E.M.M., Henriques, Maria G., Salomão, Kelly, de Castro, Solange L., Kaiser, Marcel, Brun, Reto, Wardell, James L., Wardell, Solan

Journal:

European Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 507 KB

english, 2012

98

Mbandakamines A and B, Unsymmetrically Coupled Dimeric Naphthylisoquinoline Alkaloids, from a Congolese Ancistrocladus Species

Bringmann, Gerhard, Lombe, Blaise Kimbadi, Steinert, Claudia, Ioset, Karine Ndjoko, Brun, Reto, Turini, Florian, Heubl, Günther, Mudogo, Virima

Journal:

Organic Letters

Year:

2013

Language:

english

File:

PDF, 459 KB

english, 2013

99

Synthesis and Antiprotozoal Activity of Cationic 1,4-Diphenyl-1 H -1,2,3-triazoles

Bakunov, Stanislav A., Bakunova, Svetlana M., Wenzler, Tanja, Ghebru, Maedot, Werbovetz, Karl A., Brun, Reto, Tidwell, Richard R.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.10 MB

english, 2010

100

In vitro Screening of Traditional South African Malaria Remedies against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani , and Plasmodium falciparum

Mokoka, Tsholofelo, Zimmermann, Stefanie, Julianti, Tasqiah, Hata, Yoshie, Moodley, Nivan, Cal, Monica, Adams, Michael, Kaiser, Marcel, Brun, Reto, Koorbanally, Neil, Hamburger, Matthias

Journal:

Year:

2011

Language:

english

File:

PDF, 109 KB

english, 2011

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