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1

The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems

Stefan Tümpel, K. Lenhard Rudolph

Journal:

Annals of the New York Academy of Sciences

Year:

2012

Language:

english

File:

PDF, 600 KB

english, 2012

2

The Role of Telomeres in Stem Cells and Cancer

Günes, Cagatay, Rudolph, K. Lenhard

Journal:

Year:

2013

Language:

english

File:

PDF, 290 KB

english, 2013

3

Cellular and epigenetic drivers of stem cell ageing

Ermolaeva, Maria, Neri, Francesco, Ori, Alessandro, Rudolph, K. Lenhard

Journal:

Nature Reviews Molecular Cell Biology

Year:

2018

Language:

english

File:

PDF, 1.85 MB

english, 2018

4

A Dual Role of p21 in Stem Cell Aging

ZHENYU JU, AAHELI ROY CHOUDHURY, K. LENHARD RUDOLPH

Journal:

Annals of the New York Academy of Sciences

Year:

2007

Language:

english

File:

PDF, 89 KB

english, 2007

5

Cell intrinsic and extrinsic mechanisms of stem cell aging depend on telomere status

Zhangfa Song, Zhenyu Ju, K. Lenhard Rudolph

Journal:

Experimental Gerontology

Year:

2009

Language:

english

File:

PDF, 227 KB

english, 2009

6

Clonal Analysis Unveils Self-Renewing Lineage-Restricted Progenitors Generated Directly from Hematopoietic Stem Cells

Yamamoto, Ryo, Morita, Yohei, Ooehara, Jun, Hamanaka, Sanae, Onodera, Masafumi, Rudolph, Karl Lenhard, Ema, Hideo, Nakauchi, Hiromitsu

Journal:

Year:

2013

Language:

english

File:

PDF, 4.02 MB

english, 2013

7

Aging Stem Cells: Transcriptome Meets Epigenome Meets Methylome

Tümpel, Stefan, Rudolph, K. Lenhard

Journal:

Year:

2014

Language:

english

File:

PDF, 216 KB

english, 2014

8

Inhibition of wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mammalian target of rapamycin

Zhang, Lingling, Liu, Leiming, He, Zhiyong, Li, Guangbing, Liu, Junping, Song, Zhangfa, Jin, Hongchuan, Rudolph, Karl Lenhard, Yang, Huayu, Mao, Yilei, Zhang, Lianfeng, Zhang, Hongbing, Xiao, Zhicheng

Journal:

Year:

2015

Language:

english

File:

PDF, 2.21 MB

english, 2015

9

The addition of interferon or high dose cyclophosphamide to standard chemotherapy in the treatment of patients with multiple myeloma : Phase III Eastern Cooperative Oncology Group clinical trial EST 9486

Martin M. Oken, Traci Leong, Raymond E. Lenhard Jr., Philip R. Greipp, Neil E. Kay, Brian Van Ness, Rudolph M. Keimowitz, Robert A. Kyle

Journal:

Year:

1999

Language:

english

File:

PDF, 133 KB

english, 1999

10

Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma

Ruben R. Plentz, Martin Caselitz, Joerg S. Bleck, Michael Gebel, Peer Flemming, Stefan Kubicka, Michael P. Manns, K. Lenhard Rudolph

Journal:

Year:

2004

Language:

english

File:

PDF, 291 KB

english, 2004

11

Telomeres and telomerase: A dual role in hepatocarcinogenesis

Ande Satyanarayana, Michael P. Manns, K. Lenhard Rudolph

Journal:

Year:

2004

Language:

english

File:

PDF, 201 KB

english, 2004

12

Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma

Meta W. Djojosubroto, Allison C. Chin, Ning Go, Sonja Schaetzlein, Michael P. Manns, Sergei Gryaznov, Calvin B. Harley, K. Lenhard Rudolph

Journal:

Year:

2005

Language:

english

File:

PDF, 634 KB

english, 2005

13

Telomere shortening correlates with increasing aneuploidy of chromosome 8 in human hepatocellular carcinoma

Ruben R. Plentz, Brigitte Schlegelberger, Peer Flemming, Michael Gebel, Hans Kreipe, Michael P. Manns, K. Lenhard Rudolph, Ludwig Wilkens

Journal:

Year:

2005

Language:

english

File:

PDF, 139 KB

english, 2005

14

Improve organ health by chewing up old proteins?

Luis Miguel Guachalla, K. Lenhard Rudolph

Journal:

Year:

2009

Language:

english

File:

PDF, 149 KB

english, 2009

15

Differential regulation of extracellular matrix synthesis during liver regeneration after partial hepatectomy in rats

K. Lenhard Rudolph, Christian Trautwein, Stefan Kubicka, Tim Rakemann, Matthias J. Bahr, Nick Sedlaczek, Detlef Schuppan, Michael P. Manns

Journal:

Year:

1999

Language:

english

File:

PDF, 652 KB

english, 1999

16

Hepatocellular carcinoma in Germany: a retrospective epidemiological study from a low-endemic area

Stefan Kubicka, Karl Lenhard Rudolph, Martina Hanke, Maja Katrin Tietze, Hans Ludger Tillmann, Christian Trautwein, Michael Manns

Journal:

Liver International

Year:

2000

Language:

english

File:

PDF, 143 KB

english, 2000

17

Clinical features, etiology, and survival of hepatocellular carcinoma among different countries

MASAO OMATA, YOSHIYUKI DAN, BRUNO DANIELE, RUBEN PLENTZ, KARL LENHARD RUDOLPH, MICHAEL MANNS, TEERHA PIRATVISUTH, DING S CHEN, RYOSUKE TATEISHI, ANUCHIT CHUTAPUTTI

Journal:

Journal of Gastroenterology and Hepatology

Year:

2002

Language:

english

File:

PDF, 266 KB

english, 2002

18

Role of telomere dysfunction in aging and its detection by biomarkers

Guido von Figura, Daniel Hartmann, Zhangfa Song, Karl Lenhard Rudolph

Journal:

Journal of Molecular Medicine

Year:

2009

Language:

english

File:

PDF, 172 KB

english, 2009

19

Impact of the simultaneous administration of the (+)- and (−)-forms of formyl-tetrahydrofolic acid on plasma and intracellular pharmacokinetics of (−)-tetrahydrofolic acid

Eberhard Schleyer, Karl Lenhard Rudolph, Jan Braess, Michael Unterhalt, Gerhard Ehninger, Wolfgang Hiddemann, Wolfgang Kern

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2000

Language:

english

File:

PDF, 109 KB

english, 2000

20

PROSPECTIVE ANALYSIS OF GERMAN PATIENTS WITH HEPATOCELLULAR CARCINOMA UNDERGOING TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION WITH OR WITHOUT PROPHYLACTIC ANTIBIOTIC THERAPY

Ruben R Plentz, Tim O Lankisch, Murat Bastürk, Corinna CM Müller, Timm Kirchhoff, Michael Gebel, Jörg S Bleck, Stefan Kubicka, Michael P Manns, Peter N Meier, K Lenhard Rudolph

Journal:

Journal of Gastroenterology and Hepatology

Year:

2005

Language:

english

File:

PDF, 425 KB

english, 2005

21

Lifestyle impacts on the aging-associated expression of biomarkers of DNA damage and telomere dysfunction in human blood

Zhangfa Song, Guido Von Figura, Yan Liu, Johann M. Kraus, Chad Torrice, Patric Dillon, Masami Rudolph-Watabe, Zhenyu Ju, Hans A. Kestler, Hanna Sanoff, Karl Lenhard Rudolph

Journal:

Year:

2010

Language:

english

File:

PDF, 760 KB

english, 2010

22

10.1038/79232

DePinho, Ronald A., Wong, Kwok-Kin, Chang, Sandy, Weiler, Sarah R., Ganesan, Shridar, Chaudhuri, Jayanta, Zhu, Chengming, Artandi, Steven E., Rudolph, Karl Lenhard, Gottlieb, Geoffrey J., Chin, Lynda,

Journal:

Nature Genetics

Year:

2000

Language:

english

File:

PDF, 722 KB

english, 2000

23

10.1038/88871

Rudolph, Karl Lenhard, Millard, Melissa, Bosenberg, Marcus W., DePinho, Ronald A.

Journal:

Nature Genetics

Year:

2001

Language:

english

File:

PDF, 3.42 MB

english, 2001

24

CHK2-independent induction of telomere dysfunction checkpoints in stem and progenitor cells

Nalapareddy, Kodandaramireddy, Choudhury, Aaheli Roy, Gompf, Anne, Ju, Zhenyu, Ravipati, Satyavani, Leucht, Thomas, Lechel, André, Rudolph, K Lenhard

Journal:

Year:

2010

Language:

english

File:

PDF, 1.16 MB

english, 2010

25

Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment

Ju, Zhenyu, Jiang, Hong, Jaworski, Maike, Rathinam, Chozhavendan, Gompf, Anne, Klein, Christoph, Trumpp, Andreas, Rudolph, K Lenhard

Journal:

Nature Medicine

Year:

2007

Language:

english

File:

PDF, 453 KB

english, 2007

26

Contrasting effects of telomere shortening on organ homeostasis, tumor suppression, and survival during chronic liver damage

Wiemann, Stefanie U, Satyanarayana, Ande, Buer, Jan, Kamino, Kenji, Manns, Michael P, Rudolph, Karl Lenhard

Journal:

Year:

2004

Language:

english

File:

PDF, 222 KB

english, 2004

27

p53 Mutation Pattern and Expression of c-erbB2 and c-met in Gastric Cancer: Relation to Histological Subtypes, Helicobacter pylori Infection, and Prognosis

Stefan Kubicka, Christiane Claas, Sven Staab, Florian Kühnel, Lars Zender, Christian Trautwein, Siegfried Wagner, Karl Lenhard Rudolph, Michael Manns

Journal:

Digestive Diseases and Sciences

Year:

2002

Language:

english

File:

PDF, 98 KB

english, 2002

28

Telomere length, telomerase activity and osteogenic differentiation are maintained in adipose-derived stromal cells from senile osteoporotic SAMP6 mice

Ali Mirsaidi, Karin N. Kleinhans, Markus Rimann, André N. Tiaden, Martin Stauber, K. Lenhard Rudolph, Peter J. Richards

Journal:

Journal of Tissue Engineering and Regenerative Medicine

Year:

2012

Language:

english

File:

PDF, 483 KB

english, 2012

29

Determining the influence of telomere dysfunction and DNA damage on stem and progenitor cell aging – what markers can we use?

Kodandaramireddy Nalapareddy, Hong Jiang, Luis Miguel Guachalla Gutierrez, K. Lenhard Rudolph

Journal:

Experimental Gerontology

Year:

2008

Language:

english

File:

PDF, 201 KB

english, 2008

30

Establishment of immortalized multipotent hematopoietic progenitor cell lines by retroviral-mediated gene transfer of β-catenin

Christian Templin, Daniel Kotlarz, Chozhavendan Rathinam, Cornelia Rudolph, Sonja Schätzlein, Kodanda Ramireddy, K. Lenhard Rudolph, Brigitte Schlegelberger, Christoph Klein, Helmut Drexler

Journal:

Experimental Hematology

Year:

2008

Language:

english

File:

PDF, 961 KB

english, 2008

31

Telomeres shorten while Tert expression increases during ageing of the short-lived fish Nothobranchius furzeri

Nils Hartmann, Kathrin Reichwald, André Lechel, Michael Graf, Jeanette Kirschner, Alexander Dorn, Eva Terzibasi, Juliane Wellner, Matthias Platzer, Karl Lenhard Rudolph, Alessandro Cellerino, Christop

Journal:

Mechanisms of Ageing and Development

Year:

2009

Language:

english

File:

PDF, 354 KB

english, 2009

32

Telomere dysfunctional environment induces loss of quiescence and inherent impairments of hematopoietic stem cell function

Zhangfa Song, Junling Zhang, Zhenyu Ju, K. Lenhard Rudolph

Journal:

Year:

2012

Language:

english

File:

PDF, 295 KB

english, 2012

33

DNA damage checkpoints in stem cells, ageing and cancer

Sperka, Tobias, Wang, Jianwei, Rudolph, K. Lenhard

Journal:

Nature Reviews Molecular Cell Biology

Year:

2012

Language:

english

File:

PDF, 472 KB

english, 2012

34

Telomere dysfunction and stem cell ageing

Zhenyu Ju, Lenhard Rudolph

Journal:

Year:

2008

Language:

english

File:

PDF, 258 KB

english, 2008

35

Corrigendum to “Telomere dysfunction and stem cell ageing” [Biochimie 90 (1) (2008) 24–32]

Zhenyu Ju, K. Lenhard Rudolph

Journal:

Year:

2008

Language:

english

File:

PDF, 64 KB

english, 2008

36

Immunoaging induced by hematopoietic stem cell aging

Jianwei Wang, Hartmut Geiger, K Lenhard Rudolph

Journal:

Current Opinion in Immunology

Year:

2011

Language:

english

File:

PDF, 230 KB

english, 2011

37

Telomeres and telomerase in cancer stem cells

Zhenyu Ju, Karl Lenhard Rudolph

Journal:

European Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 206 KB

english, 2006

38

Aging in the lympho-hematopoietic stem cell compartment

Hartmut Geiger, K. Lenhard Rudolph

Journal:

Trends in Immunology

Year:

2009

Language:

english

File:

PDF, 219 KB

english, 2009

39

Telomeres and telomerase: new targets for the treatment of liver cirrhosis and hepatocellular carcinoma

André Lechel, Michael P. Manns, K.Lenhard Rudolph

Journal:

Journal of Hepatology

Year:

2004

Language:

english

File:

PDF, 314 KB

english, 2004

40

The GAPs between hepatocellular carcinoma and RAS

Luis Miguel Guachalla, K. Lenhard Rudolph

Journal:

Journal of Hepatology

Year:

2011

Language:

english

File:

PDF, 323 KB

english, 2011

41

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

Karl Lenhard Rudolph, Sandy Chang, Han-Woong Lee, Maria Blasco, Geoffrey J Gottlieb, Carol Greider, Ronald A DePinho

Journal:

Year:

1999

Language:

english

File:

PDF, 641 KB

english, 1999

42

Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors

Schwitalla, Sarah, Ziegler, Paul K., Horst, David, Becker, Valentin, Kerle, Irina, Begus-Nahrmann, Yvonne, Lechel, André, Rudolph, K. Lenhard, Langer, Rupert, Slotta-Huspenina, Julia, Bader, Franz G.,

Journal:

Year:

2013

Language:

english

File:

PDF, 2.68 MB

english, 2013

43

Final results of the phase III trial of the German working party of regional chemotherapy (ART) comparing chemoocclusion vs. chemoperfusion for the treatment of advanced hepatocellular carcinoma

K.Lenhard Rudolph, Timm Kirchhoff, Ajay Chavan, Micahel Galanski, Uwe Gallkowski, Gunter Layer, Michael P. Manns, Stefan Kubicka

Journal:

Journal of Hepatology

Year:

2002

Language:

english

File:

PDF, 338 KB

english, 2002

44

Telomere shortening inhibits progression of hepatoma in telomerase deficient mice

K.Lenhard Rudolph, Evi Paraskevi, Ronald A. DePinho

Journal:

Journal of Hepatology

Year:

2002

Language:

english

File:

PDF, 170 KB

english, 2002

45

Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis

Satyanarayana Ande, Stefanie Wiemann, Martina Tsahuridu, Hans Tillmann, Michael P. Manns, K.Lenhard Rudolph

Journal:

Journal of Hepatology

Year:

2002

Language:

english

File:

PDF, 176 KB

english, 2002

46

Profiling of gene expression changes of cirrhosis induced by telomere shortening in telomerase deficient mice

Stefanie Wiemann, Jan Buhr, Birthe Zipfel, Michael Manns, Lenhard Rudolph

Journal:

Journal of Hepatology

Year:

2002

Language:

english

File:

PDF, 221 KB

english, 2002

47

Critical short telomeres of epithelial cells characterize the adenoma-carcinoma-transition of human colorectal cancer

Ruben R. Plentz, Stefanie U. Wiemann, Peer Flemming, Hans Kreipe, Peter N. Meier, Stefan Kubicka, Michael P. Manns, K. Lenhard Rudolph

Journal:

Gastroenterology

Year:

2003

Language:

english

File:

PDF, 177 KB

english, 2003

48

Telomerase Deletion Limits Progression of p53-Mutant Hepatocellular Carcinoma With Short Telomeres in Chronic Liver Disease

André Lechel, Henne Holstege, Yvonne Begus, Andrea Schienke, Kenji Kamino, Ulrich Lehmann, Stefan Kubicka, Peter Schirmacher, Jos Jonkers, K. Lenhard Rudolph

Journal:

Gastroenterology

Year:

2007

Language:

english

File:

PDF, 2.49 MB

english, 2007

49

Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis

Hashem B. El–Serag, K. Lenhard Rudolph

Journal:

Gastroenterology

Year:

2007

Language:

english

File:

PDF, 1.81 MB

english, 2007

50

,Gastroenterology Teaching Project (GTP) Liver Cancer Unit [CD slide presentation] (2007) Web site for subscribing: ..

K. Lenhard Rudolph

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 70 KB

english, 2008