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1

Addressing the Opioid Crisis: The Importance of Choosing Translational Endpoints in Analgesic Drug Discovery

Negus, S. Stevens

Journal:

Trends in Pharmacological Sciences

Year:

2018

Language:

english

File:

PDF, 1.26 MB

english, 2018

2

ChemInform Abstract: Mixed ϰ Agonists and μ Agonists/Antagonists as Potential Pharmacotherapeutics for Cocaine Abuse: Synthesis and Opioid Receptor Binding Affinity of N-Substituted Derivatives of Morphinan.

John L. Neumeyer, Xiao-Hui Gu, L. Alexander van Vliet, Nicholas J. DeNunzio, Daniela E. Rusovici, Dana J. Cohen, S. Stevens Negus, Nancy K. Mello, Jean M. Bidlack

Journal:

Year:

2002

File:

PDF, 41 KB

2002

3

Mixed κ agonists and μ agonists/Antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan

John L Neumeyer, Xiao-Hui Gu, L.Alexander van Vliet, Nicholas J DeNunzio, Daniela E Rusovici, Dana J Cohen, S.Stevens Negus, Nancy K Mello, Jean M Bidlack

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 136 KB

english, 2001

4

Interactions between the reinforcing effects of cocaine and heroin in a drug-vs-food choice procedure in rhesus monkeys: a dose-addition analysis

S. Stevens Negus

Journal:

Psychopharmacology

Year:

2005

Language:

english

File:

PDF, 171 KB

english, 2005

5

Agonist Medications for the Treatment of Cocaine Use Disorder

Negus, S Stevens, Henningfield, Jack

Journal:

Neuropsychopharmacology

Year:

2015

Language:

english

File:

PDF, 459 KB

english, 2015

6

Lack of paclitaxel effects on intracranial self-stimulation in male and female rats

Legakis, Luke P., Bigbee, John W., Negus, S. Stevens

Journal:

Behavioural Pharmacology

Year:

2018

Language:

english

File:

PDF, 334 KB

english, 2018

7

Abuse Potential of Biased Mu Opioid Receptor Agonists

Negus, S. Stevens, Freeman, Kevin B.

Journal:

Trends in Pharmacological Sciences

Year:

2018

Language:

english

File:

PDF, 579 KB

english, 2018

8

Core Outcome Measures in Preclinical Assessment of Candidate Analgesics

Negus, S. Stevens, Nader, Michael A.

Journal:

Pharmacological Reviews

Year:

2019

File:

PDF, 1.82 MB

2019

9

Core Outcome Measures in Preclinical Assessment of Candidate Analgesics

Negus, S. Stevens, Nader, Michael A.

Journal:

Pharmacological Reviews

Year:

2019

Language:

english

File:

PDF, 1.82 MB

english, 2019

10

Kappa antagonist properties of buprenorphine in non-tolerant and morphine-tolerant rats

S. Stevens Negus, Mitchell J. Picker, Linda A. Dykstra

Journal:

Psychopharmacology

Year:

1989

Language:

english

File:

PDF, 339 KB

english, 1989

11

Differential cross-tolerance to mu and kappa opioid agonists in morphine-tolerant rats responding under a schedule of food presentation

Mitchell J. Picker, S. Stevens Negus, Kelly R. Powell

Journal:

Psychopharmacology

Year:

1991

Language:

english

File:

PDF, 1.06 MB

english, 1991

12

Differential effects of systemically administered nor-binaltorphimine (nor-BNI) on κ-opioid agonists in the mouse writhing assay

Jillian H. Broadbear, S. Stevens Negus, Eduardo R. Butelman, Brian R. de Costa, James H. Woods

Journal:

Psychopharmacology

Year:

1994

Language:

english

File:

PDF, 1.22 MB

english, 1994

13

Interactions between mu and kappa opioid agonists in the rat drug discrimination procedure

S. Stevens Negus, Mitchell J. Picker, Linda A. Dykstra

Journal:

Psychopharmacology

Year:

1990

Language:

english

File:

PDF, 1.37 MB

english, 1990

14

Kappa opioid antagonist effects of the novel kappa antagonist 5′-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys

Stevens S. Negus, Nancy K. Mello, David C. Linsenmayer, R. Jones, Philip S. Portoghese

Journal:

Psychopharmacology

Year:

2002

Language:

english

File:

PDF, 167 KB

english, 2002

15

Effects of chronicd-amphetamine treatment on cocaine- and food-maintained responding under a progressive-ratio schedule in rhesus monkeys

S. Stevens Negus, Nancy K. Mello

Journal:

Psychopharmacology

Year:

2003

Language:

english

File:

PDF, 253 KB

english, 2003

16

The utility of “tolerance” as a concept in the study of drug self-administration

S.Stevens Negus, NancyK. Mello, S. Barak Caine

Journal:

Psychopharmacology

Year:

2004

Language:

english

File:

PDF, 110 KB

english, 2004

17

Effects of the kappa opioid agonist U50,488 and the kappa opioid antagonist nor-binaltorphimine on choice between cocaine and food in rhesus monkeys

S. Stevens Negus

Journal:

Psychopharmacology

Year:

2004

Language:

english

File:

PDF, 191 KB

english, 2004

18

Effects of punishment on choice between cocaine and food in rhesus monkeys

S. Stevens Negus

Journal:

Psychopharmacology

Year:

2005

Language:

english

File:

PDF, 158 KB

english, 2005

19

Effects of kappa opioids in an assay of pain-depressed intracranial self-stimulation in rats

S. Stevens Negus, Ember M. Morrissey, Marisa Rosenberg, K. Cheng, Kenner C. Rice

Journal:

Psychopharmacology

Year:

2010

Language:

english

File:

PDF, 270 KB

english, 2010

20

Effects of the delta-opioid agonist SNC80 on the abuse liability of methadone in rhesus monkeys: a behavioral economic analysis

Matthew L. Banks, Peter G. Roma, John E. Folk, Kenner C. Rice, S. Stevens Negus

Journal:

Psychopharmacology

Year:

2011

Language:

english

File:

PDF, 241 KB

english, 2011

21

Effects of GABA agonists and GABA-A receptor modulators on cocaine discrimination in rhesus monkeys

S. Stevens Negus, Nancy K. Mello, Peter A. Fivel

Journal:

Psychopharmacology

Year:

2000

Language:

english

File:

PDF, 121 KB

english, 2000

22

Antinociceptive effects of monoamine reuptake inhibitors administered alone or in combination with mu opioid agonists in rhesus monkeys

Michael B. Gatch, S. Stevens Negus, Nancy K. Mello

Journal:

Psychopharmacology

Year:

1998

Language:

english

File:

PDF, 337 KB

english, 1998

23

Method for training operant responding and evaluating cocaine self-administration behavior in mutant mice

S. B. Caine, S. Stevens Negus, Nancy K. Mello

Journal:

Psychopharmacology

Year:

1999

Language:

english

File:

PDF, 51 KB

english, 1999

24

Effects of gonadal steroid hormone treatments on opioid antinociception in ovariectomized rhesus monkeys

Stevens S. Negus, Nancy K. Mello

Journal:

Psychopharmacology

Year:

2002

Language:

english

File:

PDF, 111 KB

english, 2002

25

In Vivo Characterization of (−)(−)MCL-144 and (+)(−)MCL-193: Isomeric, Bivalent Ligands with Mu/Kappa Agonist Properties

Jennifer L. Mathews, Brian S. Fulton, S. Stevens Negus, John L. Neumeyer, Jean M. Bidlack

Journal:

Neurochemical Research

Year:

2008

Language:

english

File:

PDF, 407 KB

english, 2008

26

Bleeding events are associated with an increase in markers of inflammation in acute coronary syndromes: an ACUITY trial substudy

Charles L. Campbell, Steven R. Steinhubl, William C. Hooper, Joseph Jozic, Susan S. Smyth, Debra Bernstein, Christine De Staercke, George Syros, Brian H. Negus, Thomas Stuckey, Gregg W. Stone, Roxana

Journal:

Journal of Thrombosis and Thrombolysis

Year:

2011

Language:

english

File:

PDF, 196 KB

english, 2011

27

BW373U86: A Non-Peptidic, Systemically-Active δ Opioid Agonist

S. Stevens Negus, Mitchell J. Picker

Journal:

CNS Drug Reviews

Year:

1996

Language:

english

File:

PDF, 1.45 MB

english, 1996

28

Interactions between Kappa Opioid Agonists and Cocaine: Preclinical Studies

NANCY K. MELLO, S. STEVENS NEGUS

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 1.21 MB

english, 2000

29

Intravenous self-administration studies with l-deprenyl (selegiline) in monkeys*

Winger, Gail D, Yasar, Sevil, Negus, S Steven, Goldberg, Steven R

Journal:

Clinical Pharmacology & Therapeutics

Year:

1994

Language:

english

File:

PDF, 642 KB

english, 1994

30

Clinically Employed Opioid Analgesics Produce Antinociception via μ-δ Opioid Receptor Heteromers in Rhesus Monkeys

Yekkirala, Ajay S., Banks, Matthew L., Lunzer, Mary M., Negus, Stevens S., Rice, Kenner C., Portoghese, Philip S.

Journal:

ACS Chemical Neuroscience

Year:

2012

Language:

english

File:

PDF, 1.26 MB

english, 2012

31

Butorphanol's efficacy at mu and kappa opioid receptors: Interences based on the schedule-controlled behavior of nontolerant and morphine-tolerant rats and on the responding of rats under a drug discrimination procedure

Mitchell J. Picker, S. Stevens Negus, Rebecca M. Craft

Journal:

Pharmacology Biochemistry and Behavior

Year:

1990

Language:

english

File:

PDF, 638 KB

english, 1990

32

Preclinical evaluation of pharmacotherapies for treatment of cocaine and opioid abuse using drug self-administration procedures

Nancy K. Mello, S. Stevens Negus

Journal:

Neuropsychopharmacology

Year:

1996

Language:

english

File:

PDF, 5.29 MB

english, 1996

33

Some implications of receptor theory for in vivo assessment of agonists, antagonists and inverse agonists

S. Stevens Negus

Journal:

Biochemical Pharmacology

Year:

2006

Language:

english

File:

PDF, 390 KB

english, 2006

34

κ-Opioid receptors are differentially labeled by arylacetamides and benzomorphans

Daniela E. Rusovici, S.Stevens Negus, Nancy K. Mello, Jean M. Bidlack

Journal:

European Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 266 KB

english, 2004

35

Effects of the mixed-action κ/μ opioid agonist 8-carboxamidocyclazocine on cocaine- and food-maintained responding in rhesus monkeys

Glenn W. Stevenson, Mark P. Wentland, Jean M. Bidlack, Nancy K. Mello, S. Stevens Negus

Journal:

European Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 193 KB

english, 2004

36

Effects of the selective delta opioid agonist SNC80 on cocaine- and food-maintained responding in rhesus monkeys

Gail Pereira Do Carmo, Nancy K. Mello, Kenner C. Rice, John E. Folk, S. Stevens Negus

Journal:

European Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 258 KB

english, 2006

37

Effects of kappa opioid agonists alone and in combination with cocaine on heart rate and blood pressure in conscious squirrel monkeys

Charles W. Schindler, Zofi Graczyk, Joanne P. Gilman, S. Stevens Negus, Jack Bergman, Nancy K. Mello, Steven R. Goldberg

Journal:

European Journal of Pharmacology

Year:

2007

Language:

english

File:

PDF, 317 KB

english, 2007

38

Role of delta opioid efficacy as a determinant of mu/delta opioid interactions in rhesus monkeys

S. Stevens Negus, Ashley E. Bear, John E. Folk, Kenner C. Rice

Journal:

European Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 333 KB

english, 2009

39

The selective non-peptidic delta opioid agonist SNC80 does not facilitate intracranial self-stimulation in rats

Gail Pereira Do Carmo, John E. Folk, Kenner C. Rice, Elena Chartoff, William A. Carlezon Jr., S. Stevens Negus

Journal:

European Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 747 KB

english, 2009

40

Effects of gender and menstrual cycle phase on food-maintained responding under a progressive-ratio schedule in cynomolgus monkeys

Megan E. Roth, S. Stevens Negus, Inge M. Knudson, Melanie P. Burgess, Nancy K. Mello

Journal:

Pharmacology Biochemistry and Behavior

Year:

2005

Language:

english

File:

PDF, 438 KB

english, 2005

41

Electroencephalographic and convulsant effects of the delta opioid agonist SNC80 in rhesus monkeys

Ingela Danielsson, Maciej Gasior, Glenn W. Stevenson, John E. Folk, Kenner C. Rice, S. Stevens Negus

Journal:

Pharmacology Biochemistry and Behavior

Year:

2006

Language:

english

File:

PDF, 891 KB

english, 2006

42

Effects of the CRF1 antagonist antalarmin on cocaine self-administration and discrimination in rhesus monkeys

Nancy K. Mello, S. Stevens Negus, Kenner C. Rice, Jack H. Mendelson

Journal:

Pharmacology Biochemistry and Behavior

Year:

2006

Language:

english

File:

PDF, 536 KB

english, 2006

43

Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys

Heather L. Kimmel, S. Stevens Negus, Kristin M. Wilcox, Sarah B. Ewing, Jeffrey Stehouwer, Mark M. Goodman, John R. Votaw, Nancy K. Mello, F. Ivy Carroll, Leonard L. Howell

Journal:

Pharmacology Biochemistry and Behavior

Year:

2008

Language:

english

File:

PDF, 350 KB

english, 2008

44

Behavioral and neurochemical effects of amphetamine analogs that release monoamines in the squirrel monkey

Heather L. Kimmel, Daniel F. Manvich, Bruce E. Blough, S. Stevens Negus, Leonard L. Howell

Journal:

Pharmacology Biochemistry and Behavior

Year:

2009

Language:

english

File:

PDF, 300 KB

english, 2009

45

Selective enhancement of fentanyl-induced antinociception by the delta agonist SNC162 but not by ketamine in rhesus monkeys: Further evidence supportive of delta agonists as candidate adjuncts to mu opioid analgesics

Matthew L. Banks, John E. Folk, Kenner C. Rice, S. Stevens Negus

Journal:

Pharmacology Biochemistry and Behavior

Year:

2010

Language:

english

File:

PDF, 603 KB

english, 2010

46

Kappa opioid agonists as targets for pharmacotherapies in cocaine abuse

John L. Neumeyer, Nancy K. Mello, S. Stevens Negus, Jean M. Bidlack

Journal:

Pharmaceutica Acta Helvetiae

Year:

2000

Language:

english

File:

PDF, 237 KB

english, 2000

47

Effects of Heroin/Cocaine Combinations in Rats Trained to Discriminate Heroin or Cocaine from Saline

Xavier Lamas, S.Stevens Negus, Michael B. Gatch, Nancy K. Mello

Journal:

Pharmacology Biochemistry and Behavior

Year:

1998

Language:

english

File:

PDF, 168 KB

english, 1998

48

Antinociceptive Effects of Cocaine in Rhesus Monkeys

Michael B. Gatch, S.Stevens Negus, Nancy K. Mello

Journal:

Pharmacology Biochemistry and Behavior

Year:

1999

Language:

english

File:

PDF, 138 KB

english, 1999

49

Lack of evidence for opioid tolerance or dependence in rhesus monkeys following high-dose anabolic–androgenic steroid administration

S.Stevens Negus, Harrison G. Pope, Jr., Gen Kanayama, James D. Wines, Jr., Bradford D. Fischer

Journal:

Psychoneuroendocrinology

Year:

2001

Language:

english

File:

PDF, 51 KB

english, 2001

50

The effects of heroin on prolactin levels in male rhesus monkeys: use of cumulative-dosing procedures

Carrie A. Bowen, S. Stevens Negus, Maureen Kelly, Nancy K. Mello

Journal:

Psychoneuroendocrinology

Year:

2002

Language:

english

File:

PDF, 198 KB

english, 2002