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101

Synthesis, metabolism, and biological activity of 2-[3-(tetrazolyl)propyl]-1α,25-dihydroxy-19-norvitamin D3

Takano, Masashi, Yasuda, Kaori, Higuchi, Erika, Tohyama, Eri, Takeuchi, Akiko, Sakaki, Toshiyuki, Kittaka, Atsushi

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2015

Language:

english

File:

PDF, 693 KB

english, 2015

102

Synthesis and evaluation of geometric analogs of 1α,25-dihydroxyvitamin D2 as potential therapeutics

Bolla, Narasimha Rao, Corcoran, Aoife, Yasuda, Kaori, Chodyński, Michał, Krajewski, Krzysztof, Cmoch, Piotr, Marcinkowska, Ewa, Brown, Geoffrey, Sakaki, Toshiyuki, Kutner, Andrzej

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2015

Language:

english

File:

PDF, 226 KB

english, 2015

103

No Enzyme Activity of 25-Hydroxyvitamin D 3 1α-Hydroxylase Gene Product in Pseudovitamin D Deficiency Rickets, Including That with Mild Clinical Manifestation

Kitanaka, Sachiko, Murayama, Akiko, Sakaki, Toshiyuki, Inouye, Kuniyo, Seino, Yoshiki, Fukumoto, Seiji, Shima, Masaaki, Yukizane, Shigenori, Takayanagi, Masaki, Niimi, Hiroo, Takeyama, Ken-ichi, Kato,

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

1999

Language:

english

File:

PDF, 228 KB

english, 1999

104

Development of novel bioluminescent sensor to detect and discriminate between vitamin D receptor agonists and antagonists in living cells

Mano, Hiroki, Nishikawa, Miyu, Yasuda, Kaori, Ikushiro, Shinichi, Saito, Nozomi, Takano, Masashi, Kittaka, Atsushi, Sakaki, Toshiyuki

Journal:

Bioconjugate Chemistry

Year:

2015

Language:

english

File:

PDF, 1.45 MB

english, 2015

105

Identification and in silico prediction of metabolites of the model compound, tebufenozide by human CYP3A4 and CYP2C19

Shirotani, Naoki, Togawa, Moe, Ikushiro, Shinichi, Sakaki, Toshiyuki, Harada, Toshiyuki, Miyagawa, Hisashi, Matsui, Masayoshi, Nagahori, Hirohisa, Mikata, Kazuki, Nishioka, Kazuhiko, Hirai, Nobuhiro,

Journal:

Bioorganic & Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 963 KB

english, 2015

106

Potent 19-norvitamin D analogs for prostate and liver cancer therapy

Kittaka, Atsushi, Yoshida, Akihiro, Chiang, Kun-Chun, Takano, Masashi, Sawada, Daisuke, Sakaki, Toshiyuki, Chen, Tai C

Journal:

Future Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.38 MB

english, 2012

107

Herbicide-Resistant Tobacco Plants Expressing the Fused Enzyme between Rat Cytochrome P4501A1 (CYP1A1) and Yeast NADPH-Cytochrome P450 Oxidoreductase

Noriaki Shiota, Akitu Nagasawa, Toshiyuki Sakaki, Yoshiyasu Yabusaki and Hideo Ohkawa

Journal:

PLANT PHYSIOLOGY

Year:

1994

Language:

english

File:

PDF, 1.04 MB

english, 1994

108

Influence of sesamin on CYP2C-mediated diclofenac metabolism: in vitro and in vivo analysis

Yasuda, Kaori, Ueno, Sera, Ueda, Erika, Nishikawa, Miyu, Takeda, Kie, Kamakura, Masaki, Ikushiro, Shinichi, Sakaki, Toshiyuki

Journal:

Pharmacology Research & Perspectives

Year:

2015

Language:

english

File:

PDF, 482 KB

english, 2015

109

Sequential hydroxylation of vitamin D2 by a genetically engineered CYP105A1

Hayashi, Keiko, Yasuda, Kaori, Yogo, Yuya, Takita, Teisuke, Yasukawa, Kiyoshi, Ohta, Miho, Kamakura, Masaki, Ikushiro, Shinichi, Sakaki, Toshiyuki

Journal:

Biochemical and Biophysical Research Communications

Year:

2016

Language:

english

File:

PDF, 909 KB

english, 2016

110

Biosynthesis of Drug Glucuronide Metabolites in Budding Yeast Saccharomyces cerevisiae

Ikushiro, Shinichi, Nishikawa, Miyu, Masuyama, Yuuka, Shouji, Tadashi, Fujii, Miharu, Hamada, Masahiro, Nakajima, Noriyuki, Finel, Moshe, Yasuda, Kaori, Kamakura, Masaki, Sakaki, Toshiyuki

Journal:

Molecular Pharmaceutics

Year:

2016

Language:

english

File:

PDF, 1.46 MB

english, 2016

111

LIPAc personnel protection system for realizing radiation licensing conditions on injector commissioning with deuteron beam

Takahashi, Hiroki, Narita, Takahiro, Kasugai, Atsushi, Kojima, Toshiyuki, Marqueta, Alvaro, Nishiyama, Koichi, Sakaki, Hironao, Gobin, Raphael

Journal:

Fusion Engineering and Design

Year:

2015

Language:

english

File:

PDF, 2.10 MB

english, 2015

112

Enzymatic synthesis of novel oligosaccharides from N -acetylsucrosamine and melibiose using Aspergillus niger α-galactosidase, and properties of the products

Sakaki, Yohei, Tashiro, Mitsuru, Katou, Moe, Sakuma, Chiseko, Hirano, Takako, Hakamata, Wataru, Nishio, Toshiyuki

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2016

Language:

english

File:

PDF, 919 KB

english, 2016

113

Structural determinants of the position of 2,3′,4,4′,5-pentachlorobiphenyl (CB118) hydroxylation by mammalian cytochrome P450 monooxygenases

Mise, Shintaro, Haga, Yuki, Itoh, Toshimasa, Kato, Akira, Fukuda, Itsuko, Goto, Erika, Yamamoto, Keiko, Yabu, Miku, Matsumura, Chisato, Nakano, Takeshi, Sakaki, Toshiyuki, Inui, Hideyuki

Journal:

Toxicological Sciences

Year:

2016

Language:

english

File:

PDF, 792 KB

english, 2016

114

SPIE Proceedings [SPIE Photomask and NGL Mask Technology XV - Yokohama, Japan (Wednesday 16 April 2008)] Photomask and Next-Generation Lithography Mask Technology XV - UV-NIL mask making and imprint evaluation

Fujii, Akiko, Horiuchi, Toshiyuki, Sakai, Yuko, Mizuochi, Jun, Hiraka, Takaaki, Yusa, Satoshi, Kuriyama, Koki, Sakaki, Masashi, Sutou, Takanori, Sasaki, Shiho, Morikawa, Yasutaka, Mohri, Hiroshi, Haya

Year:

2008

Language:

english

File:

PDF, 9.47 MB

english, 2008

115

Evidence for Post-translational Generation of Multiple Forms of Aspergillus awamori var. kawachi Glucoamylase

Hayashida, Shinsaku, Nakahara, Koichi, Kuroda, Kazutaka, Kamachi, Teruyuki, Ohta, Kazuyoshi, Iwanaga, Sadaaki, Miyata, Toshiyuki, Sakaki, Yoshiyuki

Journal:

Agricultural and Biological Chemistry

Year:

1988

Language:

english

File:

PDF, 534 KB

english, 1988

116

Progesterone metabolism in recombinant yeast simultaneously expressing bovine cytochromes P450cl7 (CYP17A1) and P450c21 (CYP21B1) and yeast NADPH-P450 oxidoreductase

Sakaki, Toshiyuki, Akiyoshi-Shibata, Megumi, Yabusaki, Yoshiyasu, Manabe, Kayo, Murakami, Hiroko, Ohkawa, Hideo

Journal:

Pharmacogenetics

Year:

1991

File:

PDF, 617 KB

1991

117

Human hepatic metabolism of the anti-osteoporosis drug eldecalcitol involves sterol C4-methyl oxidase

Yasuda, Kaori, Iwanaga, Yuasa, Ogawa, Kazuaki, Mano, Hiroki, Ueno, Sera, Kimoto, Shutaro, Ohta, Miho, Kamakura, Masaki, Ikushiro, Shinichi, Sakaki, Toshiyuki

Journal:

Pharmacology Research & Perspectives

Year:

2015

Language:

english

File:

PDF, 1.55 MB

english, 2015

118

Synthesis of 25-Hydroxy-19-norvitamin D3 Analogs and Their Antiproliferative Activities on Prostate Cells

Kittaka, Atsushi, A. Arai, Midori, Tsutsumi, Ryuji, Hara, Hideki, C. Chen, Tai, Sakaki, Toshiyuki, Urushino, Naoko, Inouye, Kuniyo

Journal:

Year:

2005

Language:

english

File:

PDF, 680 KB

english, 2005

119

Novel screening system for high-affinity ligand of heredity vitamin D-resistant rickets-associated vitamin D receptor mutant R274L using bioluminescent sensor

Mano, Hiroki, Nishikawa, Miyu, Yasuda, Kaori, Ikushiro, Shinichi, Saito, Nozomi, Sawada, Daisuke, Honzawa, Shinobu, Takano, Masashi, Kittaka, Atsushi, Sakaki, Toshiyuki

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2016

Language:

english

File:

PDF, 758 KB

english, 2016

120

Synthesis and Biological Activities of 1^|^#945;,4^|^#945;,25- and 1^|^#945;,4^|^#946;,25-Trihydroxyvitamin D3 and Their Metabolism by Human CYP24A1 and UDP-Glucuronosyltransferase

Sawada, Daisuke, Tsukuda, Yuya, Yasuda, Kaori, Sakaki, Toshiyuki, Saito, Hiroshi, Takagi, Ken-ichiro, Takenouchi, Kazuya, Chen, Tai C., Reddy, G. Satyanarayana, Kittaka, Atsushi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2012

Language:

english

File:

PDF, 609 KB

english, 2012

121

Synthesis and Biological Activity of 1α,2α,25-Trihydroxyvitamin D3: Active Metabolite of 2α-(3-Hydroxypropoxy)-1α,25-dihydroxyvitamin D3 by Human CYP3A4

Takano, Masashi, Ohya, Saori, Yasuda, Kaori, Nishikawa, Miyu, Takeuchi, Akiko, Sawada, Daisuke, Sakaki, Toshiyuki, Kittaka, Atsushi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2014

Language:

english

File:

PDF, 487 KB

english, 2014

122

Assessment of warfarin therapy under full dose using indium-111 platelet scintigraphy in patients with intracardiac thrombi.

YAMADA, MAKOTO, ONISHI, KENJI, FUKUNAMI, MASATAKE, HIRANAKA, TOSHIYUKI, OHMORI, MASAHARU, SAKAKI, SHIGEHIKO, NISHIMURA, MOTONOBU, SAKAMOTO, TOMOSABURO, HASHIMURA, KAZUHIKO, IKEDA, TOSHITARO, UMEMOTO,

Journal:

Japanese Circulation Journal

Year:

1988

File:

PDF, 1.11 MB

1988

123

Application of the Mixed-Potential Theory to the Interpretation of the Potential Response of a PVC Membrane Ion-Selective Electrode for Desipramine

OSAKAI, Toshiyuki, IMOTO, Maya, SATO, Yoshitsugu, SAKAKI, Toru

Journal:

Analytical Sciences

Year:

2012

Language:

english

File:

PDF, 1.11 MB

english, 2012

124

Influence of Royal Jelly on Mouse Hepatic Gene Expression and Safety Assessment with a DNA Microarray

KAMAKURA, Masaki, MAEBUCHI, Motohiro, OZASA, Sayaka, KOMORI, Masashi, OGAWA, Tadashi, SAKAKI, Toshiyuki, MORIYAMA, Tatsuya

Journal:

Journal of Nutritional Science and Vitaminology

Year:

2005

Language:

english

File:

PDF, 1.46 MB

english, 2005

125

Practical Application of Cytochrome P450

Sakaki, Toshiyuki

Journal:

Biological & Pharmaceutical Bulletin

Year:

2012

Language:

english

File:

PDF, 507 KB

english, 2012

126

Synthesis of the CYP24A1 major metabolite of 2α-[2-(tetrazol-2-yl)ethyl]-1α,25-dihydroxyvitamin D3

Takano, Masashi, Yasuda, Kaori, Tohyama, Eri, Higuchi, Erika, Sakaki, Toshiyuki, Kittaka, Atsushi

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2016

Language:

english

File:

PDF, 544 KB

english, 2016

127

Nongenomic effects of 1α,25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice

Hirota, Yoshihisa, Nakagawa, Kimie, Mimatsu, Shino, Sawada, Natsumi, Sakaki, Toshiyuki, Kubodera, Noboru, Kamao, Maya, Tsugawa, Naoko, Suhara, Yoshitomo, Okano, Toshio

Journal:

Biochemical and Biophysical Research Communications

Year:

2017

Language:

english

File:

PDF, 2.43 MB

english, 2017

128

The roles of cytochrome P450 enzymes in prostate cancer development and treatment

Chen, Tai C., Sakaki, Toshiyuki, Yamamoto, Keiko, Kittaka, Atsushi

Journal:

Anticancer research

Year:

2012

Language:

english

File:

PDF, 237 KB

english, 2012

129

Comparison of Serotonin Glucuronidation Activity of UDP-glucuronosyltransferase 1a6a (Ugt1a6a) and Ugt1a6b: Evidence for the Preferential Expression of Ugt1a6a in the Mouse Brain

Uchihashi, Shinsuke, Nishikawa, Miyu, Sakaki, Toshiyuki, Ikushiro, Shin-ichi

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2013

Language:

english

File:

PDF, 471 KB

english, 2013

130

Enzymatic synthesis and the structure elucidation of novel trisaccharides comprised of D-galactose, N- acetyl-D-glucosamine, and D-fructose

Tashiro, Mitsuru, Fujimoto, Takashi, Furihata, Kazuo, Sakaki, Yohei, Hirano, Takako, Hakamata, Wataru, Nishio, Toshiyuki

Journal:

Journal of Carbohydrate Chemistry

Year:

2016

Language:

english

File:

PDF, 880 KB

english, 2016

131

Production of an active form of vitamin D 2 by genetically engineered CYP105A1

Yasuda, Kaori, Yogo, Yuya, Sugimoto, Hiroshi, Mano, Hiroki, Takita, Teisuke, Ohta, Miho, Kamakura, Masaki, Ikushiro, Shinichi, Yasukawa, Kiyoshi, Shiro, Yoshitsugu, Sakaki, Toshiyuki

Journal:

Biochemical and Biophysical Research Communications

Year:

2017

Language:

english

File:

PDF, 891 KB

english, 2017

132

In vivo absorption and metabolism of leptosperin and methyl syringate, abundantly present in manuka honey

Ishisaka, Akari, Ikushiro, Shinichi, Takeuchi, Mie, Araki, Yukako, Juri, Maki, Yoshiki, Yui, Kawai, Yoshichika, Niwa, Toshio, Kitamoto, Noritoshi, Sakaki, Toshiyuki, Ishikawa, Hirohito, Kato, Yoji

Journal:

Molecular Nutrition & Food Research

Year:

2017

Language:

english

File:

PDF, 1.02 MB

english, 2017

133

Protein engineering of CYP105s for their industrial uses

Yasuda, Kaori, Sugimoto, Hiroshi, Hayashi, Keiko, Takita, Teisuke, Yasukawa, Kiyoshi, Ohta, Miho, Kamakura, Masaki, Ikushiro, Shinichi, Shiro, Yoshitsugu, Sakaki, Toshiyuki

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2017

Language:

english

File:

PDF, 813 KB

english, 2017

134

Overexpression and Purification of the Recombinant Ca2+-Binding Protein, Apoaequorin1

Inouye, Satoshi, Aoyama, Shigeyuki, Miyata, Toshiyuki, Tsuji, Frederick I., Sakaki, Yoshiyuki

Journal:

Journal of Biochemistry

Year:

1989

Language:

english

File:

PDF, 1.84 MB

english, 1989

135

Monospecific Antipeptide Antibodies Against Human Hepatic UDP-Glucuronosyltransferase 1A Subfamily (UGT1A) Isoforms

Ikushiro, Shin-ichi, Emi, Yoshikazu, Kato, Yoshihisa, Yamada, Shizuo, Sakaki, Toshiyuki

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2006

Language:

english

File:

PDF, 136 KB

english, 2006

136

Molecular Insights into the Role of a Distal F240A Mutation that Alters CYP1A1 Activity towards Persistent Organic Pollutants

Navrátilová, Veronika, Paloncýová, Markéta, Berka, Karel, Mise, Shintaro, Haga, Yuki, Matsumura, Chisato, Sakaki, Toshiyuki, Inui, Hideyuki, Otyepka, Michal

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2017

Language:

english

File:

PDF, 1.51 MB

english, 2017

137

S -Equol Activates cAMP Signaling at the Plasma Membrane of INS-1 Pancreatic β-Cells and Protects against Streptozotocin-Induced Hyperglycemia by Increasing β-Cell Function in Male Mice

Horiuchi, Hiroko, Usami, Atsuko, Shirai, Rie, Harada, Naoki, Ikushiro, Shinichi, Sakaki, Toshiyuki, Nakano, Yoshihisa, Inui, Hiroshi, Yamaji, Ryoichi

Journal:

Journal of Nutrition

Year:

2017

Language:

english

File:

PDF, 1.44 MB

english, 2017

138

Development of a highly sensitive in vitro system to detect and discriminate between vitamin D receptor agonists and antagonists based on split-luciferase technique

Mano, Hiroki, Ikushiro, Shinichi, Saito, Nozomi, Kittaka, Atsushi, Sakaki, Toshiyuki

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2017

Language:

english

File:

PDF, 356 KB

english, 2017

139

Whole-cell-dependent biosynthesis of sulfo-conjugate using human sulfotransferase expressing budding yeast

Nishikawa, Miyu, Masuyama, Yuuka, Nunome, Motomichi, Yasuda, Kaori, Sakaki, Toshiyuki, Ikushiro, Shinichi

Journal:

Applied Microbiology and Biotechnology

Year:

2017

Language:

english

File:

PDF, 1.35 MB

english, 2017

140

Metabolism of 2α-[2-(tetrazol-2-yl)ethyl]-1α,25-dihydroxyvitamin D 3 by CYP24A1 and biological activity of its 24 R -hydroxylated metabolite

Yasuda, Kaori, Tohyama, Eri, Takano, Masashi, Kittaka, Atsushi, Ohta, Miho, Ikushiro, Shinichi, Sakaki, Toshiyuki

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2018

Language:

english

File:

PDF, 643 KB

english, 2018

141

Metabolism of Sesamin and Drug-Sesamin Interaction; セサミンの代謝及び医薬品との相互作用;

Sakaki, Toshiyuki, Yasuda, Kaori, Nishikawa, Miyu, Ikushiro, Shinichi

Journal:

YAKUGAKU ZASSHI

Year:

2018

Language:

english

File:

PDF, 442 KB

english, 2018

142

Evidence for post-translational generation of multiple forms of Aspergillus awamori var. kawachi glucoamylase.

HAYASHIDA, Shinsaku, NAKAHARA, Koichi, KURODA, Kazutaka, KAMACHI, Teruyuki, OHTA, Kazuyoshi, IWANAGA, Sadaaki, MIYATA, Toshiyuki, SAKAKI, Yoshiyuki

Journal:

Agricultural and Biological Chemistry

Year:

1988

Language:

english

File:

PDF, 173 KB

english, 1988

143

3P099 Crystal structure of cytochrome P450SU-1 (CYP105A1) reveals the mechanism of two-step activation of vitamin D_3(Hemeproteins,Poster Presentations)

Sugimoto, Hiroshi, Shinkyo, Raku, Hayashi, Keiko, Yamada, Masato, Nakabayashi, Sachie, Ikeda, Shinnosuke, Kamakura, Masaki, Ikushiro, Shin-ichi, Shiro, Yoshitsugu, Sakaki, Toshiyuki

Journal:

Seibutsu Butsuri

Year:

2007

File:

PDF, 250 KB

2007

144

Co-precipitation molecules hemopexin and transferrin may be key molecules for fibrillogenesis in TTR V30M amyloidogenesis

Ohta, Mika, Sugano, Aki, Hatano, Naoya, Sato, Hirotaka, Shimada, Hirofumi, Niwa, Hitoshi, Sakaeda, Toshiyuki, Tei, Hajime, Sakaki, Yoshiyuki, Yamamura, Ken-ichi, Takaoka, Yutaka

Journal:

Transgenic Research

Year:

2018

Language:

english

File:

PDF, 1.57 MB

english, 2018

145

Microbial production of novel sulphated alkaloids for drug discovery

Matsumura, Eitaro, Nakagawa, Akira, Tomabechi, Yusuke, Ikushiro, Shinichi, Sakaki, Toshiyuki, Katayama, Takane, Yamamoto, Kenji, Kumagai, Hidehiko, Sato, Fumihiko, Minami, Hiromichi

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 2.33 MB

english, 2018

146

Avian Cytochrome P450 (CYP) 1-3 Family Genes: Isoforms, Evolutionary Relationships, and mRNA Expression in Chicken Liver

Watanabe, Kensuke P., Kawai, Yusuke K., Ikenaka, Yoshinori, Kawata, Minami, Ikushiro, Shin-Ichi, Sakaki, Toshiyuki, Ishizuka, Mayumi, Rotter, Varda

Journal:

Year:

2013

Language:

english

File:

PDF, 1.84 MB

english, 2013

147

Frontiers in Bioscience 10, 119-134, January 1, 2005

Sakaki, Toshiyuki

Journal:

Frontiers in Bioscience

Year:

2005

Language:

english

File:

PDF, 886 KB

english, 2005

148

Biological Evaluation of Double Point Modified Analogues of 1,25-Dihydroxyvitamin D2 as Potential Anti-Leukemic Agents

Corcoran, Aoife, Nadkarni, Sharmin, Yasuda, Kaori, Sakaki, Toshiyuki, Brown, Geoffrey, Kutner, Andrzej, Marcinkowska, Ewa

Journal:

International Journal of Molecular Sciences

Year:

2016

Language:

english

File:

PDF, 2.27 MB

english, 2016

149

Novel split luciferase-based biosensors for evaluation of vitamin D receptor ligands and their application to estimate CYP27B1 activity in living cells

Mano, Hiroki, Ikushiro, Shinichi, Sakaki, Toshiyuki

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2018

Language:

english

File:

PDF, 380 KB

english, 2018

150

VERIFICATION OF DIRECT MARKETING METHODS UTILIZING BRAIN IMAGING

OCHIAI, Toshiyuki, SUGANUMA, Mitsuru, NAKAMURA, Yūichi, SAKAKI, Akiko, NAKAGAWA, Masafumi

Journal:

Year:

2017

Language:

english

File:

PDF, 6.17 MB

english, 2017