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1

Synthesis and antibacterial activity of FR21818, a new, potent 1β-methylcarbapenem

Hidenori Azami, David Barrett, Akira Tanaka, Hiroshi Sasaki, Keiji Matsuda, Toshiyuki Chiba, Yoshimi Matsumoto, Satoru Matsumoto, Chizu Morinaga, Kaori Ishiguro, Shuichi Tawara, Kazuo Sakane, Hisashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 216 KB

english, 1995

2

ChemInform Abstract: Discovery of FR166124, a Novel Water-Soluble Pyrazolo[1,5-a]pyridine Adenosine A1 Receptor Antagonist.

Satoru Kuroda, Atsushi Akahane, Hiromichi Itani, Shintaro Nishimura, Kieran Durkin, Takayoshi Kinoshita, Yoshiyuki Tenda, Kazuo Sakane

Journal:

Year:

1999

File:

PDF, 32 KB

1999

3

ChemInform Abstract: Synthesis and Biological Properties of a Novel Cephalosporin FR86521 Having Potent Activity Against Methicillin-Resistant Staphylococcus aureus (MRSA).

Kohei Kishi, Hidenori Ohki, Shinya Okuda, Kohji Kawabata, Kazuo Sakane, Yoshimi Matsumoto, Satoru Matsumoto, Shuichi Tawara

Journal:

Year:

2000

File:

PDF, 28 KB

2000

4

ChemInform Abstract: Anti-Helicobacter pylori Agents. Part 4. 2-(Substituted guanidino)-4-phenylthiazoles and Some Structurally Rigid Derivatives.

Yousuke Katsura, Tetsuo Tomishi, Yoshikazu Inoue, Kazuo Sakane, Yoshimi Matsumoto, Chizu Morinaga, Hirohumi Ishikawa, Hisashi Takasugi

Journal:

Year:

2000

File:

PDF, 30 KB

2000

5

ChemInform Abstract: A Novel Pyridazinone Derivative as a Nonprostanoid PGI2 Agonist.

Kazunori Tsubaki, Kiyoshi Taniguchi, Seiichiro Tabuchi, Osamu Okitsu, Kouji Hattori, Jiro Seki, Kazuo Sakane, Hirokazu Tanaka

Journal:

Year:

2001

File:

PDF, 32 KB

2001

6

ChemInform Abstract: Design, Synthesis and Biological Evaluation of a Novel Series of Potent, Orally Active Adenosine A1 Receptor Antagonists with High Blood—Brain Barrier Permeability.

Satoru Kuroda, Fujiko Takamura, Yoshiyuki Tenda, Hiromichi Itani, Yasuyo Tomishima, Atsushi Akahane, Kazuo Sakane

Journal:

Year:

2002

File:

PDF, 35 KB

2002

7

ChemInform Abstract: anti-Helicobacter pylori Agents. Part 5. 2-(Substituted guanidino)-4-arylthiazoles and Aryloxazole Analogues.

Yousuke Katsura, Shigetaka Nishino, Yoshikazu Inoue, Kazuo Sakane, Yoshimi Matsumoto, Chizu Morinaga, Hirohumi Ishikawa, Hisashi Takasugi

Journal:

Year:

2002

File:

PDF, 35 KB

2002

8

ChemInform Abstract: Synthesis and Antibacterial Evaluation of Novel 2-[N-Imidoylpyrrolidinyl] Carbapenems.

Kouji Hattori, Akira Yamada, Satoru Kuroda, Toshiyuki Chiba, Masayoshi Murata, Kazuo Sakane

Journal:

Year:

2002

File:

PDF, 28 KB

2002

9

Structure-Based De Novo Design of Non-nucleoside Adenosine Deaminase Inhibitors.

Tadashi Terasaka, Isao Nakanishi, Katsuya Nakamura, Yoshiteru Eikyu, Takayoshi Kinoshita, Nobuya Nishio, Akihiro Sato, Masako Kuno, Nobuo Seki, Kazuo Sakane

Journal:

Year:

2003

File:

PDF, 59 KB

2003

10

Discovery of New Diphenyloxazole Derivatives Containing a Pyrrolidine Ring: Orally Active Prostacyclin Mimetics. Part 2.

Kouji Hattori, Osamu Okitsu, Seiichiro Tabuchi, Kiyoshi Taniguchi, Mie Nishio, Satoshi Koyama, Jiro Seki, Kazuo Sakane

Journal:

Year:

2005

File:

PDF, 26 KB

2005

11

Discovery of Diphenylcarbamate Derivatives as Highly Potent and Selective IP Receptor Agonists: Orally Active Prostacyclin Mimetics. Part 3.

Kouji Hattori, Akira Tanaka, Osamu Okitsu, Seiichiro Tabuchi, Kiyoshi Taniguchi, Mie Nishio, Satoshi Koyama, Masahide Higaki, Jiro Seki, Kazuo Sakane

Journal:

Year:

2005

File:

PDF, 29 KB

2005

12

Revisions of the absolute configurations of C-8 methyl groups in dehydroiridodiol, neonepetalactone, and matatabiether from Actinidia polygama miq

Tsutomu Sakai, Kimiko Nakajima, Kazuo Yoshihara, Takeo Sakan, Sachihiko Isoe

Journal:

Year:

1980

Language:

english

File:

PDF, 397 KB

english, 1980

13

A novel synthesis of the pyrazolo[1,5-a]quinoline ring system. New N1-C2 bridged DNA gyrase inhibitors via a novel tandem 1,4-conjugate addition-Michael [3+2] annulation process

David Barrett, Hiroshi Sasaki, Takayoshi Kinoshita, Akihiko Fujikawa, Kazuo Sakane

Journal:

Year:

1996

Language:

english

File:

PDF, 1020 KB

english, 1996

14

New reagents for controlled release of nitric oxide. Structure-stability relationships

Masayuki Kato, Shigetaka Nishino, Mitsuko Ohno, Shinichi Fukuyama, Yasuhiro Kita, Yoshimi Hirasawa, Isao Nakanishi, Hisashi Takasugi, Kazuo Sakane

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 275 KB

english, 1996

15

Discovery of new diphenyloxazole derivatives containing a pyrrolidine ring: Orally active prostacyclin mimetics. Part 2

Kouji Hattori, Osamu Okitsu, Seiichiro Tabuchi, Kiyoshi Taniguchi, Mie Nishio, Satoshi Koyama, Jiro Seki, Kazuo Sakane

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 264 KB

english, 2005

16

Structure and total synthesis of chryscandin, a new antifungal antibiotic

Michio Yamashita, Yoshio Kawai, Itsuo Uchida, Tadaaki Komori, Masanobu Kohsaka, Hiroshi Imanaka, Kazuo Sakane, Hiroyuki Setoi, Tsutomu Teraji

Journal:

Tetrahedron Letters

Year:

1984

Language:

english

File:

PDF, 209 KB

english, 1984

17

Total synthesis of d1-hirsutic acid

Hisanobu Hashimoto, Kazuo Tsuzuki, Fujio Sakan, Haruhisa Shirahama, Takeshi Matsumoto

Journal:

Tetrahedron Letters

Year:

1974

Language:

english

File:

PDF, 170 KB

english, 1974

18

Cycloaddition reaction of tropylium ion and cycloheptatriene

Shô Itô, Akira Mori, Ikuo Saito, Kunio Sakan, Hiromi Ishiyama, Kazuo Sasaki

Journal:

Tetrahedron Letters

Year:

1973

Language:

english

File:

PDF, 211 KB

english, 1973

19

A novel pyridazinone derivative as a nonprostanoid PGI2 agonist

Kazunori Tsubaki, Kiyoshi Taniguchi, Seiichiro Tabuchi, Osamu Okitsu, Kouji Hattori, Jiro Seki, Kazuo Sakane, Hirokazu Tanaka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 224 KB

english, 2000

20

Synthesis and antibacterial evaluation of novel 2-[N-Imidoylpyrrolidinyl] carbapenems

Kouji Hattori, Akira Yamada, Satoru Kuroda, Toshiyuki Chiba, Masayoshi Murata, Kazuo Sakane

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 120 KB

english, 2002

21

Synthesis and biological evaluation of novel 2-vinyl carbapenems. Remarkable DHP-1 stability of 1′-substituted analogs

Akira Yamada, Kouji Hattori, Satoru Kuroda, Toshiyuki Chiba, Toshiaki Kamimura, Kazuo Sakane

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 213 KB

english, 1996

22

Studies on β-lactam antibiotics. Synthesis and antibacterial activity of novel 1β-methylcarbapenems related to FR21818: 5-membered ring analogs

Hidenori Azami, David Barrett, Akira Tanaka, Hiroshi Sasaki, Keiji Matsuda, Minoru Sakurai, Yoshimi Matsumoto, Shuichi Tawara, Toshiyuki Chiba, Kazuo Sakane

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 476 KB

english, 1997

23

Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles

Yousuke Katsura, Shigetaka Nishino, Tetsuo Tomishi, Kazuo Sakane, Yoshimi Matsumoto, Hirohumi Ishikawa, Hisashi Takasugi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 269 KB

english, 1998

24

Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-α]pyridine adenosine A1 receptor antagonist

Satoru Kuroda, Atsushi Akahane, Hiromichi Itani, Shintaro Nishimura, Kieran Durkin, Takayoshi Kinoshita, Yoshiyuki Tenda, Kazuo Sakane

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 360 KB

english, 1999

25

Orally active cephalosporins. Part 2: Synthesis, structure–activity relationships and oral absorption of cephalosporins having a C-3 pyridyl side chain

Hirofumi Yamamoto, Takeshi Terasawa, Ayako Nakamura, Kohji Kawabata, Kazuo Sakane, Satoru Matsumoto, Yoshimi Matsumoto, Shuichi Tawara

Journal:

Bioorganic & Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 262 KB

english, 2000

26

Studies on 3′-quaternary ammonium cephalosporins—IV. Synthesis and antibacterial activity of 3′-(2-alkyl-3-aminopyrazolium)cephalosporins related to FK037

Hidenori Ohki, Kohji Kawabata, Yoshiko Inamoto, Shinya Okuda, Toshiaki Kamimura, Kazuo Sakane

Journal:

Bioorganic & Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 849 KB

english, 1997

27

The expression of parathyroid hormone-related protein (PTHrP) in normal parathyroid: histochemistry and in situ hybridization

Riko Kitazawa, Sohei Kitazawa, Masaaki Fukase, Takuo Fujita, Akira Kobayashi, Kazuo Chihara, Sakan Maeda

Journal:

Histochemistry and Cell Biology

Year:

1992

Language:

english

File:

PDF, 3.51 MB

english, 1992

28

Clinicopathological relevance of parathyroid hormone-related protein in various types of cancer tissues

Riko Kitazawa, Sohei Kitazawa, Hidenobu Fukunishi, Norio Kohno, Akinobu Gotoh, Yuka Yamamura-Idei, Masaaki Fukase, Kazuo Chihara, Takuo Fujita, Sakan Maeda

Journal:

Journal of Bone and Mineral Metabolism

Year:

1994

Language:

english

File:

PDF, 345 KB

english, 1994

29

Asymmetric synthesis of FR165914: A novel β3-adrenergic agonist with a benzocycloheptene structure

Kouji Hattori, Masanobu Nagano, Takeshi Kato, Isao Nakanishi, Keisuke Imai, Takayoshi Kinoshita, Kazuo Sakane

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 174 KB

english, 1995

30

Corrigendum to “Structure-Based de novo design of non-nucleoside adenosine deaminase inhibitors” [Bioorg. Med. Chem. Lett. 13 (2003) 1115]☆

Tadashi Terasaka, Isao Nakanishi, Katsuya Nakamura, Yoshiteru Eikyu, Takayoshi Kinoshita, Nobuya Nishio, Akihiro Sato, Masako Kuno, Nobuo Seki, Kazuo Sakane

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

File:

PDF, 68 KB

2003

31

Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: Orally active prostacyclin mimetics. Part 3

Kouji Hattori, Akira Tanaka, Osamu Okitsu, Seiichiro Tabuchi, Kiyoshi Taniguchi, Mie Nishio, Satoshi Koyama, Masahide Higaki, Jiro Seki, Kazuo Sakane

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 200 KB

english, 2005

32

Metabolism investigation leading to novel drug design: Orally active prostacyclin mimetics. Part 4

Kouji Hattori, Fujiko Takamura, Akira Tanaka, Hisashi Takasugi, Kiyoshi Taniguchi, Mie Nishio, Satoshi Koyama, Jiro Seki, Kazuo Sakane

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 168 KB

english, 2005

33

Synthesis of the water-soluble adenosine A1 receptor antagonist FR166124 through a novel sequential Horner-Emmons / isomerization reaction

Satoru Kuroda, Atsushi Akahane, Hiromichi Itani, Shintaro Nishimura, Kieran Durkin, Takayoshi Kinoshita, Isao Nakanishi, Kazuo Sakane

Journal:

Year:

1999

Language:

english

File:

PDF, 633 KB

english, 1999

34

Structure-Based de novo design of non-nucleoside adenosine deaminase inhibitors

Tadashi Terasaka, Isao Nakanishi, Katsuya Nakamura, Yoshiteru Eikyu, Takayoshi Kinoshita, Nobuya Nishio, Akihiro Sato, Masako Kuno, Nobuo Seki, Kazuo Sakane

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 335 KB

english, 2003

35

Studies on 3′-quaternary ammonium cephalosporins—III. Synthesis and antibacterial activity of 3′-(3-aminopyrazolium)cephalosporins

Hidenori Ohki, Kohji Kawabata, Yoshiko Inamoto, Shinya Okuda, Toshiaki Kamimura, Kazuo Sakane

Journal:

Bioorganic & Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 870 KB

english, 1997

36

Novel adenosine A1 receptor antagonists. Synthesis and structure–activity relationships of a novel series of 3-(2-cyclohexenyl-3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo[1,5-a]pyridines

Satoru Kuroda, Atsushi Akahane, Hiromichi Itani, Shintaro Nishimura, Kieran Durkin, Yoshiyuki Tenda, Kazuo Sakane

Journal:

Bioorganic & Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 251 KB

english, 2000

37

Orally active cephalosporins: synthesis, structure–activity relationships and oral absorption of 3-[(E) and (Z)-2-Substituted vinyl]-cephalosporins

Hirofumi Yamamoto, Takeshi Terasawa, Ayako Ohki, Fumiyuki Shirai, Kohji Kawabata, Kazuo Sakane, Satoru Matsumoto, Yoshimi Matsumoto, Shuichi Tawara

Journal:

Bioorganic & Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 242 KB

english, 2000

38

Association of decreased calcium-sensing receptor expression with proliferation of parathyroid cells in secondary hyperparathyroidism

Yano, Shozo, Sugimoto, Toshitsugu, Tsukamoto, Tatsuo, Chihara, Kazuo, Kobayashi, Akira, Kitazawa, Sohei, Maeda, Sakan, Kitazawa, Riko

Journal:

Kidney International

Year:

2000

Language:

english

File:

PDF, 389 KB

english, 2000

39

Molecular cloning and analysis of the 5′-flanking region of the human bone morphogenetic protein-6 (BMP-6)

Hiroshi Tamada, Riko Kitazawa, Kazuo Gohji, Sadao Kamidono, Sakan Maeda, Sohei Kitazawa

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1998

Language:

english

File:

PDF, 288 KB

english, 1998

40

Kinetic resolution of an indan derivative using Bacillus sp. SUI-12: Synthesis of a key intermediate of the melatonin receptor agonist TAK-375

Naoki Tarui, Yoichi Nagano, Takeshi Sakane, Kiyoharu Matsumoto, Mitsuru Kawada, Osamu Uchikawa, Shigenori Ohkawa, Kazuo Nakahama

Journal:

Journal of Bioscience and Bioengineering

Year:

2002

Language:

english

File:

PDF, 423 KB

english, 2002

41

Preservation of pathological tissue specimens by freeze-drying for immunohistochemical staining and various molecular biological analyses

Shinji Matsuo, Taketoshi Sugiyama, Takazo Okuyama, Kiyotsugu Yoshikawa, Kazuo Honda, Rei Takahashi, Sakan Maeda

Journal:

Pathology International

Year:

1999

Language:

english

File:

PDF, 399 KB

english, 1999

42

Expression of parathyroid hormone-related protein (PTHrP) in multiple myeloma

Riko Kitazawa, Sohei Kitazawa, Kazuyoshi Kajimoto, Hideaki Sowa, Toshitsugu Sugimoto, Tosimitsu Matsui, Kazuo Chihara, Sakan Maeda

Journal:

Pathology International

Year:

2002

Language:

english

File:

PDF, 150 KB

english, 2002

43

Histological and cytogenetic characterization of bone marrow in relation to prognosis and diagnosis of myelodysplastic syndromes

Toshiko Sakuma, Yoshitake Hayashi, Naoki Kanomata, Tohru Murayama, Toshimitsu Matsui, Kazuyoshi Kajimoto, Keisuke Hanioka, Kazuo Chihara, Sakan Maeda

Journal:

Pathology International

Year:

2006

Language:

english

File:

PDF, 212 KB

english, 2006

44

Anti- Helicobacter p ylori Agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and Some Structurally Rigid Derivatives

Katsura, Yousuke, Tomishi, Tetsuo, Inoue, Yoshikazu, Sakane, Kazuo, Matsumoto, Yoshimi, Morinaga, Chizu, Ishikawa, Hirohumi, Takasugi, Hisashi

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 81 KB

english, 2000

45

Anti- Helicobacter p ylori Agents. 5. 2-(Substituted guanidino)-4-arylthiazoles and Aryloxazole Analogues

Katsura, Yousuke, Nishino, Shigetaka, Inoue, Yoshikazu, Sakane, Kazuo, Matsumoto, Yoshimi, Morinaga, Chizu, Ishikawa, Hirohumi, Takasugi, Hisashi

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 125 KB

english, 2002

46

Anti- Helicobacter pylori Agents. 3. 2-[(Arylalkyl)guanidino]-4-furylthiazoles

Katsura, Yousuke, Nishino, Shigetaka, Ohno, Mitsuko, Sakane, Kazuo, Matsumoto, Yoshimi, Morinaga, Chizu, Ishikawa, Hirohumi, Takasugi, Hisashi

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 176 KB

english, 1999

47

Anti- Helicobacter pylori Agents. 1. 2-(Alkylguanidino)-4-furylthiazoles and Related Compounds

Katsura, Yousuke, Tomishi, Tetsuo, Inoue, Yoshikazu, Sakane, Kazuo, Matsumoto, Yoshimi, Ishikawa, Hirohumi, Takasugi, Hisashi

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 154 KB

english, 1997

48

A Concise, Practical Synthesis of the Pyrido[3,2,1-i,j]Cinnoline Ring System of Potent DNA Gyrase Inhibitors

Barrett, David, Sasaki, Hiroshi, Tsutsumi, Hideo, Murata, Masayoshi, Terasawa, Takeshi, Sakane, Kazuo

Journal:

Journal of Organic Chemistry

Year:

1995

Language:

english

File:

PDF, 394 KB

english, 1995

49

Discovery of Diphenyloxazole and Nδ-Z-Ornithine Derivatives as Highly Potent and Selective Human Prostaglandin EP 4 Receptor Antagonists

Hattori, Kouji, Tanaka, Akira, Fujii, Naoaki, Takasugi, Hisashi, Tenda, Yoshiyuki, Tomita, Masayuki, Nakazato, Shoko, Nakano, Keiko, Kato, Yasuko, Kono, Yutaka, Murai, Hidetsugu, Sakane, Kazuo

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 251 KB

english, 2005

50

A novel [3 + 2] annulation: synthesis and X-ray crystallographic structure of a novel tetrahydropyrazolo[1,5-a] quinoline, an intermediate towards new tricyclic quinolone antibacterials

Barrett, David, Sasaki, Hiroshi, Kinoshita, Takayoshi, Sakane, Kazuo

Journal:

Chemical Communications

Year:

1996

Language:

english

File:

PDF, 257 KB

english, 1996

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