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51

Posttransplant Lymphoproliferative Diseases

Gross, Thomas G., Savoldo, Barbara, Punnett, Angela

Journal:

Pediatric Clinics of North America

Year:

2010

Language:

english

File:

PDF, 586 KB

english, 2010

52

A ″Non-Fratricidal″ αβ-T Cell Receptor That Targets Survivin Expressed By Hematological Malignancies

Arber, Caroline, Feng, Xiang, Abhyankar, Harshal, Heslop, Helen E., Brenner, Malcolm K., Barth, Patrick, Dotti, Gianpietro, Savoldo, Barbara

Journal:

Biology of Blood and Marrow Transplantation

Year:

2014

Language:

english

File:

PDF, 52 KB

english, 2014

53

Improving immune reconstitution after cord blood transplantation using ex vivo expanded virus-specific T cells: a phase I clinical study

Hanley, P.J., Martinez, C., Cruz, R., Lam, S., Savoldo, B., Dotti, G., Brenner, M., Rooney, C., Heslop, H., Krance, R., Shpall, E.J., Bollard, C.M.

Journal:

Year:

2013

Language:

english

File:

PDF, 47 KB

english, 2013

54

Infusion of CD19-directed/multivirus specific-cytotoxic T lymphocytes after allogeneic hematopoietic stem cell transplantation for B cell malignancies

Cruz, C.R., Micklethwaite, K.P., Savoldo, B., Lam, S., Ku, S., Krance, R.A., Diouf, O., Leen, A.M., Kamble, R.T., Kennedy-Nasser, A., Barrett, J., Shpall, E., Heslop, H.E., Rooney, C.M., Brenner, M.K.

Journal:

Year:

2013

Language:

english

File:

PDF, 51 KB

english, 2013

55

Naïve T-cell-derived CTL recognize atypical epitopes of CMVpp65 with higher avidity than CMV-seropositive donor-derived CTL - a basis for treatment of post-transplant viral infection by adoptive transfer of T-Cells from virus-naïve donors

Hanley, P.J., Cruz, R.Y., Melenhorst, J., Scheinberg, P., Blaney, J., Savoldo, B., Dotti, G., Heslop, H., Rooney, C., Shpall, E.J., Barrett, J.A., Rodgers, J., Bollard, C.M.

Journal:

Year:

2013

Language:

english

File:

PDF, 41 KB

english, 2013

56

Ultra low-dose IL-2 mediated expansion of regulatory T cells as GvHD prophylaxis for recipients of allogeneic hematopoietic stem cells

Ku, S., Kennedy-Nasser, A.A., Hazrat, Y., Melenhorst, J., Barrett, A., Ito, S., Durett, A.G., Foster, A., Savoldo, B., Yvon, E., Heslop, H.E., Carrum, G., Kamble, R.T., Brenner, M.K., Krance, R.A., Bo

Journal:

Year:

2013

Language:

english

File:

PDF, 72 KB

english, 2013

57

Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15

Xu, Y., Zhang, M., Ramos, C. A., Durett, A., Liu, E., Dakhova, O., Liu, H., Creighton, C. J., Gee, A. P., Heslop, H. E., Rooney, C. M., Savoldo, B., Dotti, G.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.54 MB

english, 2014

58

Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor-Modified T Cells in Solid Tumors

Nishio, N., Diaconu, I., Liu, H., Cerullo, V., Caruana, I., Hoyos, V., Bouchier-Hayes, L., Savoldo, B., Dotti, G.

Journal:

Cancer Research

Year:

2014

Language:

english

File:

PDF, 1.26 MB

english, 2014

59

Interleukin-7 Mediates Selective Expansion of Tumor-redirected Cytotoxic T Lymphocytes (CTLs) without Enhancement of Regulatory T-cell Inhibition

Perna, S. K., Pagliara, D., Mahendravada, A., Liu, H., Brenner, M. K., Savoldo, B., Dotti, G.

Journal:

Clinical Cancer Research

Year:

2014

Language:

english

File:

PDF, 965 KB

english, 2014

60

High throughput quantitative reverse transcription PCR assays revealing over-expression of cancer testis antigen genes in multiple myeloma stem cell-like side population cells

Wen, Jianguo, Li, Hangwen, Tao, Wenjing, Savoldo, Barbara, Foglesong, Jessica A., King, Lauren C., Zu, Youli, Chang, Chung-Che

Journal:

British Journal of Haematology

Year:

2014

Language:

english

File:

PDF, 723 KB

english, 2014

61

The Use of Cytotoxic T Cells for the Prevention and Treatment of Epstein-Barr Virus Induced Lymphoma in Transplant Recipients

Savoldo, Barbara, Heslop, Helen E., Rooney, Cliona M.

Journal:

Leukemia and Lymphoma

Year:

2000

Language:

english

File:

PDF, 866 KB

english, 2000

62

Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation

Micklethwaite, K. P., Savoldo, B., Hanley, P. J., Leen, A. M., Demmler-Harrison, G. J., Cooper, L. J. N., Liu, H., Gee, A. P., Shpall, E. J., Rooney, C. M., Heslop, H. E., Brenner, M. K., Bollard, C.

Journal:

Year:

2010

Language:

english

File:

PDF, 1.72 MB

english, 2010

63

Design and development of therapies using chimeric antigen receptor-expressing T cells

Dotti, Gianpietro, Gottschalk, Stephen, Savoldo, Barbara, Brenner, Malcolm K.

Journal:

Immunological Reviews

Year:

2014

Language:

english

File:

PDF, 378 KB

english, 2014

64

What influence has B-cell depletion on viral infections?

Kaka, Anjum S., Rooney, Cliona M., Savoldo, Barbara

Journal:

Leukemia and Lymphoma

Year:

2007

Language:

english

File:

PDF, 60 KB

english, 2007

65

Fifteen Years of Gene Therapy Based on Chimeric Antigen Receptors: “Are We Nearly There Yet?”

Dotti, Gianpietro, Savoldo, Barbara, Brenner, Malcolm

Journal:

Human Gene Therapy

Year:

2009

Language:

english

File:

PDF, 11.51 MB

english, 2009

66

Cytotoxic T Lymphocytes Simultaneously Targeting Multiple Tumor-associated Antigens to Treat EBV Negative Lymphoma

Gerdemann, Ulrike, Katari, Usha, Christin, Anne S, Cruz, Conrad R, Tripic, Tamara, Rousseau, Alexandra, Gottschalk, Stephen M, Savoldo, Barbara, Vera, Juan F, Heslop, Helen E, Brenner, Malcolm K, Boll

Journal:

Molecular Therapy

Year:

2011

Language:

english

File:

PDF, 484 KB

english, 2011

67

766. Immunotherapy for Her2-Positive Medulloblastoma: Regression of Experimental Tumors by Transfer of Her2-Redirected T Cells In Vivo

Ahmed, Nabil M., Ratnayake, Maheshika K., Savoldo, Barbara, Perlaky, Laszlo, Dotti, Gianpietro, Wels, Winfried, Bhattacharjee, Meenakshi B., Shine, H. David, Rooney, Cliona M., Heslop, Helen E., Gotts

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 90 KB

english, 2006

68

798. Epstein Barr Virus-Specific Cytotoxic T Lymphocytes (EBV-CTL) Expressing an Anti-CD30 Chimeric T-Cell Receptor (cTcR) for the Treatment of Hodgkin's Disease (HD)

SAVOLDO, B, ROONEY, C, HESLOP, H, ABKEN, H, HOMBACH, A, ZHANG, L, PULE, M, DOTTI, G, BRENNER, M

Journal:

Molecular Therapy

Year:

2005

Language:

english

File:

PDF, 80 KB

english, 2005

69

801. Fas Knockdown Mediated by siRNA in EBV-Specific Cytotoxic T-Lymphocytes (CTL) Reduces Their Sensitivity to Fas/FasL-Induced Apoptosis

DOTTI, G, SAVOLDO, B, PULE, M, STRAATHOF, K, BIAGI, E, YVON, E, VIGOUROUX, S, ROONEY, C, BRENNER, M

Journal:

Molecular Therapy

Year:

2005

Language:

english

File:

PDF, 88 KB

english, 2005

70

768. Redirected T Cells to Selectively Target Mature B Cell Derived Malignancies

Vera, Juan, Savoldo, Barbara, Vigouroux, Stephane, Biagi, Ettore, Pule, Martin, Rossig, Claudia, Brenner, Malcolm, Dotti, Gianpietro

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 84 KB

english, 2006

71

The immunogenicity of virus-derived 2A sequences in immunocompetent individuals

Arber, C, Abhyankar, H, Heslop, H E, Brenner, M K, Liu, H, Dotti, G, Savoldo, B

Journal:

Year:

2013

Language:

english

File:

PDF, 599 KB

english, 2013

72

K562-Derived Whole-Cell Vaccine Enhances Antitumor Responses of CAR-Redirected Virus-Specific Cytotoxic T Lymphocytes In Vivo

Caruana, I., Weber, G., Ballard, B. C., Wood, M. S., Savoldo, B., Dotti, G.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 1.51 MB

english, 2015

73

Human Papillomavirus Type 16 E6/E7-specific Cytotoxic T Lymphocytes for Adoptive Immunotherapy of HPV-associated Malignancies

Ramos, Carlos A., Narala, Neeharika, Vyas, Gayatri M., Leen, Ann M., Gerdemann, Ulrike, Sturgis, Erich M., Anderson, Matthew L., Savoldo, Barbara, Heslop, Helen E., Brenner, Malcolm K., Rooney, Cliona

Journal:

Journla of Immunotherapy

Year:

2013

Language:

english

File:

PDF, 597 KB

english, 2013

74

CD19-CAR Trials

Ramos, Carlos A., Savoldo, Barbara, Dotti, Gianpietro

Journal:

The Cancer Journal

Year:

2014

Language:

english

File:

PDF, 148 KB

english, 2014

75

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

Caruana, Ignazio, Savoldo, Barbara, Hoyos, Valentina, Weber, Gerrit, Liu, Hao, Kim, Eugene S, Ittmann, Michael M, Marchetti, Dario, Dotti, Gianpietro

Journal:

Nature Medicine

Year:

2015

Language:

english

File:

PDF, 1.57 MB

english, 2015

76

Immunotherapy of Metastatic Melanoma Using Genetically Engineered GD2-Specific T cells

Yvon, E., Del Vecchio, M., Savoldo, B., Hoyos, V., Dutour, A., Anichini, A., Dotti, G., Brenner, M. K.

Journal:

Clinical Cancer Research

Year:

2009

Language:

english

File:

PDF, 617 KB

english, 2009

77

Regression of Experimental Medulloblastoma following Transfer of HER2-Specific T Cells

Ahmed, N., Ratnayake, M., Savoldo, B., Perlaky, L., Dotti, G., Wels, W. S., Bhattacharjee, M. B., Gilbertson, R. J., Shine, H. D., Weiss, H. L., Rooney, C. M., Heslop, H. E., Gottschalk, S.

Journal:

Cancer Research

Year:

2007

Language:

english

File:

PDF, 842 KB

english, 2007

78

Safety of multiple doses of car T cells

Fousek, Kristen, Rouce, Rayne, Ahmed, Nabil, Gottschalk, Stephen, Savoldo, Barbara, Dotti, Gianpietro, Ramos, Carlos, Louis, Chrystal U., Rooney, Cliona, Brenner, Malcom, Heslop, Helen

Journal:

Year:

2015

Language:

english

File:

PDF, 280 KB

english, 2015

79

Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation

Zhou, X., Dotti, G., Krance, R. A., Martinez, C. A., Naik, S., Kamble, R. T., Durett, A. G., Dakhova, O., Savoldo, B., Di Stasi, A., Spencer, D. M., Lin, Y.-F., Liu, H., Grilley, B. J., Gee, A. P., Ro

Journal:

Year:

2015

Language:

english

File:

PDF, 321 KB

english, 2015

80

Cytotoxic T lymphocytes for the treatment of viral infections and posttransplant lymphoproliferative disorders in transplant recipients

Pagliara, Daria, Savoldo, Barbara

Journal:

Current Opinion in Infectious Diseases

Year:

2012

Language:

english

File:

PDF, 361 KB

english, 2012

81

Adoptive T-Cell Therapy for EBV-Associated Post-Transplant Lymphoproliferative Disease

Bollard, Catherine M., Savoldo, Barbara, Rooney, Cliona M., Heslop, Helen E.

Journal:

Acta Haematologica

Year:

2003

Language:

english

File:

PDF, 95 KB

english, 2003

82

Activation of Wnt Signaling Arrests Effector Differentiation in Human Peripheral and Cord Blood-Derived T Lymphocytes

Muralidharan, S., Hanley, P. J., Liu, E., Chakraborty, R., Bollard, C., Shpall, E., Rooney, C., Savoldo, B., Rodgers, J., Dotti, G.

Journal:

The Journal of Immunology

Year:

2011

Language:

english

File:

PDF, 3.75 MB

english, 2011

83

Generation of EBV-Specific CD4+ Cytotoxic T Cells from Virus Naive Individuals

Savoldo, B., Cubbage, M. L., Durett, A. G., Goss, J., Huls, M. H., Liu, Z., Teresita, L., Gee, A. P., Ling, P. D., Brenner, M. K., Heslop, H. E., Rooney, C. M.

Journal:

The Journal of Immunology

Year:

2002

Language:

english

File:

PDF, 665 KB

english, 2002

84

CARs on Track in the Clinic

Kohn, Donald B, Dotti, Gianpietro, Brentjens, Renier, Savoldo, Barbara, Jensen, Michael, Cooper, Laurence JN, June, Carl H, Rosenberg, Steven, Sadelain, Michel, Heslop, Helen E

Journal:

Molecular Therapy

Year:

2011

Language:

english

File:

PDF, 262 KB

english, 2011

85

Genetic Manipulation of Tumor-specific Cytotoxic T Lymphocytes to Restore Responsiveness to IL-7

Vera, Juan F, Hoyos, Valentina, Savoldo, Barbara, Quintarelli, Concetta, Giordano Attianese, Greta MP, Leen, Ann M, Liu, Hao, Foster, Aaron E, Heslop, Helen E, Rooney, Cliona M, Brenner, Malcolm K, Do

Journal:

Molecular Therapy

Year:

2009

Language:

english

File:

PDF, 6.10 MB

english, 2009

86

T Cells Expressing Constitutively Active Akt Resist Multiple Tumor-associated Inhibitory Mechanisms

Sun, Jiali, Dotti, Gianpietro, Huye, Leslie E, Foster, Aaron E, Savoldo, Barbara, Gramatges, Maria M, Spencer, David M, Rooney, Cliona M

Journal:

Molecular Therapy

Year:

2010

Language:

english

File:

PDF, 615 KB

english, 2010

87

Cancer battlefield: six characters in search of an author

Huye, Leslie, Savoldo, Barbara

Journal:

Year:

2012

Language:

english

File:

PDF, 612 KB

english, 2012

88

Combining mTor Inhibitors With Rapamycin-resistant T Cells: A Two-pronged Approach to Tumor Elimination

Huye, Leslie E, Nakazawa, Yozo, Patel, Mayuri P, Yvon, Eric, Sun, Jiali, Savoldo, Barbara, Wilson, Matthew H, Dotti, Gianpietro, Rooney, Cliona M

Journal:

Molecular Therapy

Year:

2011

Language:

english

File:

PDF, 915 KB

english, 2011

89

Chimeric antigen receptor-redirected T cells return to the bench

Geldres, Claudia, Savoldo, Barbara, Dotti, Gianpietro

Journal:

Seminars in Immunology

Year:

2016

Language:

english

File:

PDF, 1.21 MB

english, 2016

90

Genetic modification of human T lymphocytes for the treatment of hematologic malignancies

Hoyos, V., Savoldo, B., Dotti, G.

Journal:

Year:

2012

Language:

english

File:

PDF, 1.40 MB

english, 2012

91

Chimeric Antigen Receptor Gene-Modified Virus-Specific T-Cell Expanded in Patients with Reactivated Epstein-Barr Virus Post Allogeneic Stem Cell Transplant

Lapteva, N., Gilbert, M., Hiregange, M., Diaconu, I., Dakhova, O, Rouce, R., Rollins, L., Liu, H., Savoldo, B., Durett, A., Krance, R.A., Heslop, H., Gee, A., Ramos, C., Rooney, C.

Journal:

Year:

2016

Language:

english

File:

PDF, 473 KB

english, 2016

92

Robust and cost effective expansion of human regulatory T cells highly functional in a xenograft model of graft-versus-host disease

Chakraborty, R., Mahendravada, A., Perna, S. K., Rooney, C. M., Heslop, H. E., Vera, J. F., Savoldo, B., Dotti, G.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.68 MB

english, 2013

93

Changes in Chemokine Receptor Expression of Regulatory T Cells After Ex Vivo Culture

Chakraborty, Rikhia, Rooney, Cliona, Dotti, Gianpietro, Savoldo, Barbara

Journal:

Journal of Immunotherapy

Year:

2012

Language:

english

File:

PDF, 526 KB

english, 2012

94

Plasma Markers of B-Cell Activation and Clonality in Pediatric Liver and Hematopoietic Stem Cell Transplant Recipients

Engels, Eric A., Savoldo, Barbara, Pfeiffer, Ruth M., Costello, Rene, Zingone, Adriana, Heslop, Helen E., Landgren, Ola

Journal:

Transplantation Journal

Year:

2013

Language:

english

File:

PDF, 329 KB

english, 2013

95

T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model

Di Stasi, A., De Angelis, B., Rooney, C. M., Zhang, L., Mahendravada, A., Foster, A. E., Heslop, H. E., Brenner, M. K., Dotti, G., Savoldo, B.

Journal:

Year:

2009

Language:

english

File:

PDF, 876 KB

english, 2009

96

Long-term outcome after haploidentical stem cell transplant and infusion of T cells expressing the inducible caspase 9 safety transgene

Zhou, X., Di Stasi, A., Tey, S.-K., Krance, R. A., Martinez, C., Leung, K. S., Durett, A. G., Wu, M.-F., Liu, H., Leen, A. M., Savoldo, B., Lin, Y.-F., Grilley, B. J., Gee, A. P., Spencer, D. M., Roon

Journal:

Year:

2014

Language:

english

File:

PDF, 1.29 MB

english, 2014

97

Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30 artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease

Savoldo, B., Rooney, C. M., Di Stasi, A., Abken, H., Hombach, A., Foster, A. E., Zhang, L., Heslop, H. E., Brenner, M. K., Dotti, G.

Journal:

Year:

2007

Language:

english

File:

PDF, 554 KB

english, 2007

98

507. Chondroitin Sulfate Proteoglycan 4 (CSPG4)-Redirected T Cells Eliminate Glioblastoma-Derived Neurospheres

Pellegatta, Serena, Savoldo, Barbara, Su, Chuang, Ferrone, Soldano, Finocchiaro, Gaetano, Dotti, Gianpietro

Journal:

Molecular Therapy

Year:

2016

Language:

english

File:

PDF, 298 KB

english, 2016

99

748. A Clinical Trial Using Third Generation CD19 Targeting CAR T Cells for Relapsed Lymphoma and Leukemia

Enblad, Gunilla, Karlsson, Hannah, Wenthe, Jessica, Wikstrom, Kristina I., Essand, Magnus, Savoldo, Barbara, Dotti, Gianpietro, Hoglund, Martin, Hallbook, Helene, Brenner, Malcolm K., Hagberg, Hans, L

Journal:

Molecular Therapy

Year:

2016

Language:

english

File:

PDF, 348 KB

english, 2016

100

721. Safety of Multiple Doses of CAR T Cells

Fousek, Kristen, Rouce, Rayne, Ahmed, Nabil, Gottschalk, Stephen, Savoldo, Barbara, Dotti, Gianpietro, Ramos, Carlos, Louis, Chrystal, Rooney, Cliona, Brenner, Malcolm, Heslop, Helen

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 272 KB

english, 2015