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51

CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis

Takatsugu Ishimoto, Hiroko Oshima, Masanobu Oshima, Kazuharu Kai, Ryota Torii, Takashi Masuko, Hideo Baba, Hideyuki Saya, Osamu Nagano

Journal:

Year:

2010

Language:

english

File:

PDF, 919 KB

english, 2010

52

Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition

Yoshimi Arima, Toru Hirota, Christian Bronner, Marc Mousli, Toshiyoshi Fujiwara, Shin-ichiro Niwa, Hiroyuki Ishikawa, Hideyuki Saya

Journal:

Year:

2004

Language:

english

File:

PDF, 360 KB

english, 2004

53

Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1

Takashi Sasayama, Tomotoshi Marumoto, Naoko Kunitoku, Dongwei Zhang, Norihiko Tamaki, Eiji Kohmura, Hideyuki Saya, Toru Hirota

Journal:

Year:

2005

Language:

english

File:

PDF, 337 KB

english, 2005

54

Molecular mechanisms regulating dissociation of cell–cell junction of epithelial cells by oxidative stress

Junko Inumaru, Osamu Nagano, Eri Takahashi, Takatsugu Ishimoto, Satoshi Nakamura, Yoshimi Suzuki, Shin-ichiro Niwa, Kazuo Umezawa, Hidenobu Tanihara, Hideyuki Saya

Journal:

Year:

2009

Language:

english

File:

PDF, 6.36 MB

english, 2009

55

Identification of CD44 as a cell surface marker for Müller glia precursor cells

Toru Shinoe, Hiroshi Kuribayashi, Hideyuki Saya, Motoharu Seiki, Hiroyuki Aburatani, Sumiko Watanabe

Journal:

Journal of Neurochemistry

Year:

2010

Language:

english

File:

PDF, 1.20 MB

english, 2010

56

Decreased expression of neurofibromin contributes to epithelial–mesenchymal transition in neurofibromatosis type 1

Yoshimi Arima, Hidemi Hayashi, Kanako Kamata, Takaaki M. Goto, Mikako Sasaki, Akira Kuramochi, Hideyuki Saya

Journal:

Experimental Dermatology

Year:

2010

Language:

english

File:

PDF, 925 KB

english, 2010

57

Activated macrophages promote Wnt signalling through tumour necrosis factor-α in gastric tumour cells

Oguma, Keisuke, Oshima, Hiroko, Aoki, Masahiro, Uchio, Ryusei, Naka, Kazuhito, Nakamura, Satoshi, Hirao, Atsushi, Saya, Hideyuki, Taketo, Makoto Mark, Oshima, Masanobu

Journal:

The EMBO Journal

Year:

2008

Language:

english

File:

PDF, 896 KB

english, 2008

58

Chfr is required for tumor suppression and Aurora A regulation

Yu, Xiaochun, Minter-Dykhouse, Katherine, Malureanu, Liviu, Zhao, Wei-Meng, Zhang, Dongwei, Merkle, Carolin J, Ward, Irene M, Saya, Hideyuki, Fang, Guowei, van Deursen, Jan

Journal:

Nature Genetics

Year:

2005

Language:

english

File:

PDF, 412 KB

english, 2005

59

Aurora-A — A guardian of poles

Marumoto, Tomotoshi, Zhang, Dongwei, Saya, Hideyuki

Journal:

Nature Reviews Cancer

Year:

2005

Language:

english

File:

PDF, 227 KB

english, 2005

60

Impairment of cell adhesion by expression of the mutant neurofibromatosis type 2 (NF2) genes which lack exons in the ERM-homology domain

Koga, Hisashi, Araki, Norie, Takeshima, Hideo, Nishi, Toru, Hirota, Toru, Kimura, Yoriyoshi, Nakao, Mitsuyoshi, Saya, Hideyuki

Journal:

Year:

1998

Language:

english

File:

PDF, 1.07 MB

english, 1998

61

CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration

Okamoto, Isamu, Kawano, Yoshiaki, Tsuiki, Hiromasa, Sasaki, Ji-ichiro, Nakao, Mitsuyoshi, Matsumoto, Mitsuhiro, Suga, Moritaka, Ando, Masayuki, Nakajima, Motowo, Saya, Hideyuki

Journal:

Year:

1999

Language:

english

File:

PDF, 706 KB

english, 1999

62

A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes

Koga, Hisashi, Matsui, Shin-ichi, Hirota, Toru, Takebayashi, Shin-ichiro, Okumura, Katsuzumi, Saya, Hideyuki

Journal:

Year:

1999

Language:

english

File:

PDF, 1.88 MB

english, 1999

63

The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association

Nagata, Yoichi, Anan, Tadashi, Yoshida, Tetsuo, Mizukami, Tamio, Taya, Yoichi, Fujiwara, Toshiyoshi, Kato, Hirohisa, Saya, Hideyuki, Nakao, Mitsuyoshi

Journal:

Year:

1999

Language:

english

File:

PDF, 573 KB

english, 1999

64

Mechanism of hyperploid cell formation induced by microtubule inhibiting drug in glioma cell lines

Tsuiki, Hiromasa, Nitta, Masayuki, Tada, Mitsuhiro, Inagaki, Masaki, Ushio, Yukitaka, Saya, Hideyuki

Journal:

Year:

2001

Language:

english

File:

PDF, 357 KB

english, 2001

65

Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44

Murakami, Daizo, Okamoto, Isamu, Nagano, Osamu, Kawano, Yoshiaki, Tomita, Taisuke, Iwatsubo, Takeshi, De Strooper, Bart, Yumoto, Eiji, Saya, Hideyuki

Journal:

Year:

2003

Language:

english

File:

PDF, 290 KB

english, 2003

66

Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents

Nitta, Masayuki, Kobayashi, Osamu, Honda, Shinobu, Hirota, Toru, Kuninaka, Shinji, Marumoto, Tomotoshi, Ushio, Yukitaka, Saya, Hideyuki

Journal:

Year:

2004

Language:

english

File:

PDF, 674 KB

english, 2004

67

Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer

Yoshimi Arima, Naoki Hayashi, Hidemi Hayashi, Mikako Sasaki, Kazuharu Kai, Eiji Sugihara, Eriko Abe, Atsushi Yoshida, Shuji Mikami, Seigo Nakamura, Hideyuki Saya

Journal:

International Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 1.49 MB

english, 2012

68

Structural alterations of the p53 gene in human leukemias

Hiroshi Miwa, Kenkichi Kita, Hideyuki Saya, Akira Otsuji, Masahiro Masuya, Kazuhiro Nishii, Norihisa Morita, Nobuyuki Takakura, Koushi Ohishi, Kaori Nasu, Kazunori Nakase, Shigeru Shirakawa

Journal:

Leukemia Research

Year:

1992

Language:

english

File:

PDF, 1.56 MB

english, 1992

69

The ERK-RSK1 activation by growth factors at G2 phase delays cell cycle progression and reduces mitotic aberrations

Hyun-Ja Nam, Sujeong Kim, Min-Woo Lee, Bok-Soon Lee, Toshihiro Hara, Hideyuki Saya, Hyeseong Cho, Jae-Ho Lee

Journal:

Cellular Signalling

Year:

2008

Language:

english

File:

PDF, 2.00 MB

english, 2008

70

The UHRF family: Oncogenes that are drugable targets for cancer therapy in the near future?

Christian Bronner, Mayada Achour, Yoshimi Arima, Thierry Chataigneau, Hideyuki Saya, Valérie B. Schini-Kerth

Journal:

Pharmacology & Therapeutics

Year:

2007

Language:

english

File:

PDF, 559 KB

english, 2007

71

Identification of a Novel, Tissue-Specific Calpainhtra-3;a Human Homologue of theCaenorhabditis elegansSex Determination Gene

Norifumi Mugita, Yoriyoshi Kimura, Michio Ogawa, Hideyuki Saya, Mitsuyoshi Nakao

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 224 KB

english, 1997

72

Bacterial expression of an active tyrosine kinase from a protein A/truncated c-src fusion protein

Hideyuki Saya, Polly S.Y. Lee, Toru Nishi, Ichiro Izawa, Motowo Nakajima, Gary E. Gallick, Victor A. Levin

Journal:

Year:

1993

Language:

english

File:

PDF, 779 KB

english, 1993

73

Establishment of a Choriocarcinoma Model from Immortalized Normal Extravillous Trophoblast Cells Transduced with HRASV12

Yusuke Kobayashi, Takatsune Shimizu, Hideaki Naoe, Arisa Ueki, Joe Ishizawa, Tatsuyuki Chiyoda, Nobuyuki Onishi, Eiji Sugihara, Osamu Nagano, Kouji Banno, Shinji Kuninaka, Daisuke Aoki, Hideyuki Saya

Journal:

The American Journal of Pathology

Year:

2011

Language:

english

File:

PDF, 3.59 MB

english, 2011

74

Oncogenicity of L-type amino-acid transporter 1 (LAT1) revealed by targeted gene disruption in chicken DT40 cells: LAT1 is a promising molecular target for human cancer therapy

Mayumi Ohkawa, Yoshiya Ohno, Kazue Masuko, Akiko Takeuchi, Kentaro Suda, Akihiro Kubo, Rieko Kawahara, Shogo Okazaki, Toshiyuki Tanaka, Hideyuki Saya, Masayuki Seki, Takemi Enomoto, Hideki Yagi, Yoshi

Journal:

Biochemical and Biophysical Research Communications

Year:

2011

Language:

english

File:

PDF, 840 KB

english, 2011

75

EGFR and ErbB2 are functionally coupled to CD44 and regulate shedding, internalization and motogenic effect of CD44

Zsuzsanna Pályi-Krekk, Márk Barok, Tamás Kovács, Hideyuki Saya, Osamu Nagano, János Szöllősi, Peter Nagy

Journal:

Year:

2008

Language:

english

File:

PDF, 1012 KB

english, 2008

76

Serum response factor is modulated by the SUMO-1 conjugation system

Kazuhito Matsuzaki, Takeshi Minami, Masahide Tojo, Yoshiomi Honda, Yasuhiro Uchimura, Hisato Saitoh, Hideyo Yasuda, Shinji Nagahiro, Hideyuki Saya, Mitsuyoshi Nakao

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 199 KB

english, 2003

77

Receptor protein tyrosine kinase DDR is up-regulated by p53 protein

Shirou Sakuma, Hideyuki Saya, Mitsuhiro Tada, Mitsuyoshi Nakao, Toshiyoshi Fujiwara, Jack A. Roth, Yutaka Sawamura, Yumiko Shinohe, Hiroshi Abe

Journal:

Year:

1996

Language:

english

File:

PDF, 577 KB

english, 1996

78

Tight-binding inhibitory sequences against pp60c−src identified using a random 15-amino-acid peptide library

Toru Nishi, Raymond J.A. Budde, John S. McMurray, Nihal U. Obeyesekere, Naueen Safdar, Victor A. Levin, Hideyuki Saya

Journal:

Year:

1996

Language:

english

File:

PDF, 425 KB

english, 1996

79

Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55

Hideo Nakamura, Tamotsu Sudo, Hiromasa Tsuiki, Hideaki Miyake, Tetsuro Morisaki, Ji-ichiro Sasaki, Norio Masuko, Masato Kochi, Yukitaka Ushio, Hideyuki Saya

Journal:

Year:

1998

Language:

english

File:

PDF, 398 KB

english, 1998

80

A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis

Yasuyuki Nishiyama, Toru Hirota, Tetsuro Morisaki, Toshihiro Hara, Tomotoshi Marumoto, Shin-ichi Iida, Keishi Makino, Hideyuki Yamamoto, Takehisa Hiraoka, Nobuo Kitamura, Hideyuki Saya

Journal:

Year:

1999

Language:

english

File:

PDF, 765 KB

english, 1999

81

Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells

Toru Hirota, Naoko Kunitoku, Takashi Sasayama, Tomotoshi Marumoto, Dongwei Zhang, Masayuki Nitta, Katsuyoshi Hatakeyama, Hideyuki Saya

Journal:

Year:

2003

Language:

english

File:

PDF, 843 KB

english, 2003

82

Alternative splicing of the erythropoietin receptor gene correlates with erythroid differentiation in rat hematopoietic and leukemic cells

Masayuki Fujita, Rei Takahashi, Kazuhiro Kitada, Rei Watanabe, Sohei Kitazawa, Faramarz Ashoori, Ping Liang, Hideyuki Saya, Tadao Serikawa, Sakan Maeda

Journal:

Year:

1997

Language:

english

File:

PDF, 1016 KB

english, 1997

83

Expression of random peptide fused to invasin on bacterial cell surface for selection of cell-targeting peptides

Hiroto Nakajima, Naoki Shimbara, Yoko Shimonishi, Tatsuyuki Mimori, Shin-ichiro Niwa, Hideyuki Saya

Journal:

Year:

2000

Language:

english

File:

PDF, 2.10 MB

english, 2000

84

Rapid identification of Leishmania species from formalin-fixed biopsy samples by polymorphism-specific polymerase chain reaction

Tatsuyuki Mimori, Ji-ichiro Sasaki, Motomi Nakata, Eduardo A Gomez, Hiroshi Uezato, Shigeo Nonaka, Yoshihisa Hashiguchi, Masato Furuya, Hideyuki Saya

Journal:

Year:

1998

Language:

english

File:

PDF, 366 KB

english, 1998

85

Study of autoantibodies against advanced glycation endproducts of the Maillard reaction

Norie Araki, Rie Shibayama, Yumiko Ejima, Ryoji Nagai, Tomohiro Araki, Hideyuki Saya, Seikoh Horiuchi

Journal:

International Congress Series

Year:

2001

Language:

english

File:

PDF, 151 KB

english, 2001

86

Reactive Oxygen Species-Induced Autophagic Degradation of Helicobacter pylori CagA Is Specifically Suppressed in Cancer Stem-like Cells

Hitoshi Tsugawa, Hidekazu Suzuki, Hideyuki Saya, Masanori Hatakeyama, Toshiya Hirayama, Kenro Hirata, Osamu Nagano, Juntaro Matsuzaki, Toshifumi Hibi

Journal:

Cell Host & Microbe

Year:

2012

Language:

english

File:

PDF, 1.99 MB

english, 2012

87

CENP-A Phosphorylation by Aurora-A in Prophase Is Required for Enrichment of Aurora-B at Inner Centromeres and for Kinetochore Function

Naoko Kunitoku, Takashi Sasayama, Tomotoshi Marumoto, Dongwei Zhang, Shinobu Honda, Osamu Kobayashi, Katsuyoshi Hatakeyama, Yukitaka Ushio, Hideyuki Saya, Toru Hirota

Journal:

Developmental Cell

Year:

2003

Language:

english

File:

PDF, 697 KB

english, 2003

88

Complexity of cancer stem cells

Sugihara, Eiji, Saya, Hideyuki

Journal:

International Journal of Cancer

Year:

2013

Language:

english

File:

PDF, 805 KB

english, 2013

89

Tumor necrosis factor-α (TNF-α) stimulates the epithelial–mesenchymal transition regulator Snail in cholangiocarcinoma

Anchalee Techasen, Nisana Namwat, Watcharin Loilome, Pornpan Bungkanjana, Narong Khuntikeo, Anucha Puapairoj, Patcharee Jearanaikoon, Hideyuki Saya, Puangrat Yongvanit

Journal:

Medical Oncology

Year:

2012

Language:

english

File:

PDF, 784 KB

english, 2012

90

Angiographic classification of aneurysms of the horizontal segment of the anterior cerebral artery

Toshimitsu Wakabayashi, Norihiko Tamaki, Hideyuki Yamashita, Hideyuki Saya, Tohru Suyama, Satoshi Matsumoto

Journal:

Surgical Neurology

Year:

1985

Language:

english

File:

PDF, 552 KB

english, 1985

91

Functional analysis ofHOXD9in human gliomas and glioma cancer stem cells

Masanao Tabuse, Shigeki Ohta, Yohei Ohashi, Raita Fukaya, Aya Misawa, Kazunari Yoshida, Takeshi Kawase, Hideyuki Saya, Cécile Thirant, Hérve Chneiweiss, Yumi Matsuzaki, Hideyuki Okano, Yutaka Kawakami

Journal:

Molecular Cancer

Year:

2011

Language:

english

File:

PDF, 4.83 MB

english, 2011

92

Characteristics of glioma stem cells

Sampetrean, Oltea, Saya, Hideyuki

Journal:

Brain Tumor Pathology

Year:

2013

Language:

english

File:

PDF, 322 KB

english, 2013

93

Arf and p53 act as guardians of a quiescent cellular state by protecting against immortalization of cells with stable genomes

Osawa, Tomoyuki, Atsumi, Yuko, Sugihara, Eiji, Saya, Hideyuki, Kanno, Masamoto, Tashiro, Fumio, Masutani, Mitsuko, Yoshioka, Ken-ichi

Journal:

Biochemical and Biophysical Research Communications

Year:

2013

Language:

english

File:

PDF, 1.20 MB

english, 2013

94

Identification of novel small compounds that restore E-cadherin expression and inhibit tumor cell motility and invasiveness

Hirano, Tamaki, Satow, Reiko, Kato, Asami, Tamura, Mana, Murayama, Yumi, Saya, Hideyuki, Kojima, Hirotatsu, Nagano, Tetsuo, Okabe, Takayoshi, Fukami, Kiyoko

Journal:

Biochemical Pharmacology

Year:

2013

Language:

english

File:

PDF, 1000 KB

english, 2013

95

Three-dimensional culture of sebaceous gland cells revealing the role of prostaglandin E2-induced activation of canonical Wnt signaling

Yoshida, Go J., Saya, Hideyuki

Journal:

Biochemical and Biophysical Research Communications

Year:

2013

Language:

english

File:

PDF, 1.89 MB

english, 2013

96

TSPAN2 Is Involved in Cell Invasion and Motility during Lung Cancer Progression

Otsubo, Chihiro, Otomo, Ryo, Miyazaki, Makoto, Matsushima-Hibiya, Yuko, Kohno, Takashi, Iwakawa, Reika, Takeshita, Fumitaka, Okayama, Hirokazu, Ichikawa, Hitoshi, Saya, Hideyuki, Kiyono, Tohru, Ochiya

Journal:

Year:

2014

Language:

english

File:

PDF, 2.75 MB

english, 2014

97

Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation

Yoshida, Go J., Saya, Hideyuki

Journal:

Biochemical and Biophysical Research Communications

Year:

2014

Language:

english

File:

PDF, 1.88 MB

english, 2014

98

Invasion Precedes Tumor Mass Formation in a Malignant Brain Tumor Model of Genetically Modified Neural Stem Cells

Sampetrean, Oltea, Saga, Isako, Nakanishi, Masaya, Sugihara, Eiji, Fukaya, Raita, Onishi, Nobuyuki, Osuka, Satoru, Akahata, Masaki, Kai, Kazuharu, Sugimoto, Hachiro, Hirao, Atsushi, Saya, Hideyuki

Journal:

Year:

2011

Language:

english

File:

PDF, 2.18 MB

english, 2011

99

EpCAM expression in the prostate cancer makes the difference in the response to growth factors

Yoshida, Go J., Saya, Hideyuki

Journal:

Biochemical and Biophysical Research Communications

Year:

2014

Language:

english

File:

PDF, 1.96 MB

english, 2014

100

Sa1900 CD44v9 Results in Resistance to Trastuzumab via Induction of ROS Resistance

Mori, Hideki, Suzuki, Hidekazu, Matsuzaki, Juntaro, Tsugawa, Hitoshi, Okada, Sawako, Fukuhara, Seiichiro, Masaoka, Tatsuhiro, Kanai, Takanori, Saya, Hideyuki

Journal:

Gastroenterology

Year:

2014

Language:

english

File:

PDF, 117 KB

english, 2014