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51

β-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins

Carlo Sala Frigerio, Julia V. Fadeeva, Aedín M. Minogue, Martin Citron, Fred Van Leuven, Matthias Staufenbiel, Paolo Paganetti, Dennis J. Selkoe, Dominic M. Walsh

Journal:

Year:

2010

Language:

english

File:

PDF, 616 KB

english, 2010

52

Toward a Comprehensive Theory for Alzheimer's Disease. Hypothesis: Alzheimer's Disease Is Caused by the Cerebral Accumulation and Cytotoxicity of Amyloid β-Protein

DENNIS J. SELKOE

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 604 KB

english, 2000

53

Rapid Notch1 Nuclear Translocation after Ligand Binding Depends on Presenilin-associated γ-Secretase Activity

OKSANA BEREZOVSKA, CHRISTINE JACK, PAMELA McLEAN, JON C. ASTER, CAROL HICKS, WEIMING XIA, MICHAEL S. WOLFE, GERRY WEINMASTER, DENNIS J. SELKOE, BRADLEY T. HYMAN

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 523 KB

english, 2000

54

Toward the Characterization and Identification of γ-Secretases Using Transition-state Analogue Inhibitors

CHAD L. MOORE, THEKLA S. DIEHL, DENNIS J. SELKOE, MICHAEL S. WOLFE

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 2.91 MB

english, 2000

55

Developing Preventive Therapies for Chronic Diseases: Lessons Learned from Alzheimer's Disease

Dennis J. Selkoe

Journal:

Nutrition Reviews

Year:

2007

Language:

english

File:

PDF, 149 KB

english, 2007

56

Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins

Ihara, Yasuo, Abraham, Carmela, Selkoe, Dennis J.

Journal:

Year:

1983

File:

PDF, 844 KB

1983

57

Amyloid β-protein deposition in tissues other than brain in Alzheimer's disease

Joachim, Catharine L., Mori, Hiroshi, Selkoe, Dennis J.

Journal:

Year:

1989

File:

PDF, 622 KB

1989

58

10.1038/34800

Haass, Christian, Selkoe, Dennis J.

Journal:

Year:

1998

Language:

english

File:

PDF, 264 KB

english, 1998

59

10.1038/35017062

Wolfe, Michael S., Esler, William P., Kimberly, W. Taylor, Ostaszewski, Beth L., Diehl, Thekla S., Moore, Chad L., Tsai, Jui-Yi, Rahmati, Talat, Xia, Weiming, Selkoe, Dennis J.

Journal:

Nature Cell Biology

Year:

2000

Language:

english

File:

PDF, 414 KB

english, 2000

60

In the beginning ...

Selkoe, Dennis J.

Journal:

Year:

1991

File:

PDF, 286 KB

1991

61

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Citron, Martin, Oltersdorf, Tilman, Haass, Christian, McConlogue, Lisa, Hung, Albert Y., Seubert, Peter, Vigo-Pelfrey, Carmen, Lieberburg, Ivan, Selkoe, Dennis J.

Journal:

Year:

1992

File:

PDF, 414 KB

1992

62

Amyloid precursor on the Go

Hanley, Michael R., Selkoe, Dennis J.

Journal:

Year:

1993

File:

PDF, 328 KB

1993

63

Missense on the membrane

Selkoe, Dennis J.

Journal:

Year:

1995

File:

PDF, 255 KB

1995

64

Translating cell biology into therapeutic advances in Alzheimer's disease

Selkoe, Dennis J.

Journal:

Year:

1999

Language:

english

File:

PDF, 316 KB

english, 1999

65

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Walsh, Dominic M., Klyubin, Igor, Fadeeva, Julia V., Cullen, William K., Anwyl, Roger, Wolfe, Michael S., Rowan, Michael J., Selkoe, Dennis J.

Journal:

Year:

2002

Language:

english

File:

PDF, 547 KB

english, 2002

66

Imaging Alzheimer's amyloid

Selkoe, Dennis J.

Journal:

Nature Biotechnology

Year:

2000

Language:

english

File:

PDF, 328 KB

english, 2000

67

10.1038/81937

Fezoui, Youcef, Teplow, David B., Hartley, Dean M., Walsh, Dominic M., Selkoe, Dennis J., Osterhout, John J.

Journal:

Natural Structural Biology

Year:

2000

Language:

english

File:

PDF, 946 KB

english, 2000

68

Inflammation and therapeutic vaccination in CNS diseases

Weiner, Howard L., Selkoe, Dennis J.

Journal:

Year:

2002

Language:

english

File:

PDF, 236 KB

english, 2002

69

erratum: Folding proteins in fatal ways

Selkoe, Dennis J.

Journal:

Year:

2004

Language:

english

File:

PDF, 66 KB

english, 2004

70

Structural biology: Enzyme target to latch on to

Leissring, Malcolm A., Selkoe, Dennis J.

Journal:

Year:

2006

Language:

english

File:

PDF, 300 KB

english, 2006

71

Amyloid-lowering isocoumarins are not direct inhibitors of γ-secretase

Esler, William P., Das, Chittaranjan, Campbell, William A., Kimberly, W. Taylor, Kornilova, Anna Y., Diehl, Thekla S., Ye, Wenjuan, Ostaszewski, Beth L., Xia, Weiming, Selkoe, Dennis J.

Journal:

Nature Cell Biology

Year:

2002

Language:

english

File:

PDF, 465 KB

english, 2002

72

Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases

Selkoe, Dennis J.

Journal:

Nature Cell Biology

Year:

2004

Language:

english

File:

PDF, 341 KB

english, 2004

73

The ups and downs of Aβ

Selkoe, Dennis J

Journal:

Nature Medicine

Year:

2006

Language:

english

File:

PDF, 455 KB

english, 2006

74

Alzheimer's amyloid of another flavour

Selkoe, Dennis J.

Journal:

Nature Medicine

Year:

1995

File:

PDF, 440 KB

1995

75

Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo

Klyubin, Igor, Walsh, Dominic M, Lemere, Cynthia A, Cullen, William K, Shankar, Ganesh M, Betts, Vicki, Spooner, Edward T, Jiang, Liying, Anwyl, Roger, Selkoe, Dennis J

Journal:

Nature Medicine

Year:

2005

Language:

english

File:

PDF, 486 KB

english, 2005

76

The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway

Haass, Christian, Lemere, Cynthia A., Capell, Anja, Citron, Martin, Seubert, Peter, Schenk, Dale, Lannfelt, Lars, Selkoe, Dennis J.

Journal:

Nature Medicine

Year:

1995

File:

PDF, 865 KB

1995

77

Dopamine covalently modifies and functionally inactivates parkin

LaVoie, Matthew J, Ostaszewski, Beth L, Weihofen, Andreas, Schlossmacher, Michael G, Selkoe, Dennis J

Journal:

Nature Medicine

Year:

2005

Language:

english

File:

PDF, 324 KB

english, 2005

78

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

Haass, Christian, Selkoe, Dennis J.

Journal:

Nature Reviews Molecular Cell Biology

Year:

2007

Language:

english

File:

PDF, 677 KB

english, 2007

79

Aging Brain, Aging Mind

Selkoe, Dennis J.

Journal:

Scientific American

Year:

1992

Language:

english

File:

PDF, 1.14 MB

english, 1992

80

Amyloid Protein and Alzheimer's Disease

Selkoe, Dennis J.

Journal:

Scientific American

Year:

1991

Language:

english

File:

PDF, 911 KB

english, 1991

81

Effects of secreted oligomers of amyloid β-protein on hippocampal synaptic plasticity: a potent role for trimers

Matthew Townsend, Ganesh M. Shankar, Tapan Mehta, Dominic M. Walsh, Dennis J. Selkoe

Journal:

The Journal of Physiology

Year:

2006

Language:

english

File:

PDF, 487 KB

english, 2006

82

[Research and Perspectives in Alzheimer's Disease] Synaptic Plasticity and the Mechanism of Alzheimer's Disease Volume 6 || Soluble Oligomers of the Amyloid β-Protein: Impair Synaptic Plasticity and Behavior

Selkoe, Dennis J., Triller, Antoine, Christen, Yves

Year:

2008

Language:

english

File:

PDF, 310 KB

english, 2008

83

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

Bartels, Tim, Choi, Joanna G., Selkoe, Dennis J.

Journal:

Year:

2011

Language:

english

File:

PDF, 413 KB

english, 2011

84

γ-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons

Aedín M. Minogue, Adam K. Stubbs, Carlo Sala Frigerio, Barry Boland, Julia V. Fadeeva, Jordan Tang, Dennis J. Selkoe, Dominic M. Walsh

Journal:

Year:

2009

Language:

english

File:

PDF, 1.02 MB

english, 2009

85

Small non-fibrillar assemblies of amyloid β-protein bearing the Arctic mutation induce rapid neuritic degeneration

Brian M. Whalen, Dennis J. Selkoe, Dean M. Hartley

Journal:

Neurobiology of Disease

Year:

2005

Language:

english

File:

PDF, 1.75 MB

english, 2005

86

Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid β-protein metabolism in mouse models of Alzheimer disease

Matthew L. Hemming, Dennis J. Selkoe, Wesley Farris

Journal:

Neurobiology of Disease

Year:

2007

Language:

english

File:

PDF, 884 KB

english, 2007

87

LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-β peptide in a blood–brain barrier in vitro model

Babak Nazer, Soyon Hong, Dennis J. Selkoe

Journal:

Neurobiology of Disease

Year:

2008

Language:

english

File:

PDF, 795 KB

english, 2008

88

Aggregation and catabolism of disease-associated intra-Aβ mutations: reduced proteolysis of AβA21G by neprilysin

Vicki Betts, Malcolm A. Leissring, Georgia Dolios, Rong Wang, Dennis J. Selkoe, Dominic M. Walsh

Journal:

Neurobiology of Disease

Year:

2008

Language:

english

File:

PDF, 756 KB

english, 2008

89

Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Aβ assembly forms throughout life

Ganesh M. Shankar, Malcolm A. Leissring, Anthony Adame, Xiaoyan Sun, Edward Spooner, Eliezer Masliah, Dennis J. Selkoe, Cynthia A. Lemere, Dominic M. Walsh

Journal:

Neurobiology of Disease

Year:

2009

Language:

english

File:

PDF, 1.20 MB

english, 2009

90

Plasma C-peptide levels and rates of cognitive decline in older, community-dwelling women without diabetes

Olivia I. Okereke, Michael N. Pollak, Frank B. Hu, Susan E. Hankinson, Dennis J. Selkoe, Francine Grodstein

Journal:

Psychoneuroendocrinology

Year:

2008

Language:

english

File:

PDF, 244 KB

english, 2008

91

Toward Structural Elucidation of the γ-Secretase Complex

Huilin Li, Michael S. Wolfe, Dennis J. Selkoe

Journal:

Year:

2009

Language:

english

File:

PDF, 628 KB

english, 2009

92

The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease

Dennis J Selkoe

Journal:

Trends in Cell Biology

Year:

1998

Language:

english

File:

PDF, 418 KB

english, 1998

93

Presenilins, β-amyloid precursor protein and the molecular basis of Alzheimer's disease

Dennis J. Selkoe

Journal:

Clinical Neuroscience Research

Year:

2001

Language:

english

File:

PDF, 276 KB

english, 2001

94

α-Synuclein Neuropathology is Controlled by Nuclear Hormone Receptors and Enhanced by Docosahexaenoic Acid in A Mouse Model for Parkinson's Disease

Eugenia Yakunin, Virginie Loeb, Haya Kisos, Yoav Biala, Shlomo Yehuda, Yoel Yaari, Dennis J. Selkoe, Ronit Sharon

Journal:

Brain Pathology

Year:

2012

Language:

english

File:

PDF, 1.08 MB

english, 2012

95

Co-expression of β-amyloid precursor protein (βAPP) and apolipoprotein E in cell culture: analysis of βAPP processing

Anja Leona Biere, Beth Ostaszewski, Hongwei Zhao, Susan Gillespie, Steven G. Younkin, Dennis J. Selkoe

Journal:

Neurobiology of Disease

Year:

1995

Language:

english

File:

PDF, 576 KB

english, 1995

96

Permeability and Residual Plasma Volume of Human, Dutch Variant, and Rat Amyloid β-Protein 1-40 at the Blood–Brain Barrier

Joseph F. Poduslo, Geoffry L. Curran, Jill J. Haggard, Anja Leona Biere, Dennis J. Selkoe

Journal:

Neurobiology of Disease

Year:

1997

Language:

english

File:

PDF, 232 KB

english, 1997

97

Additive Effects of PS1 and APP Mutations on Secretion of the 42-Residue Amyloid β-Protein

Martin Citron, Christopher B. Eckman, Thekla S. Diehl, Chris Corcoran, Beth L. Ostaszewski, Weiming Xia, Georges Levesque, Peter St. George Hyslop, Steven G. Younkin, Dennis J. Selkoe

Journal:

Neurobiology of Disease

Year:

1998

Language:

english

File:

PDF, 315 KB

english, 1998

98

Cytosolic Phospholipase A2(cPLA2) Immunoreactivity Is Elevated in Alzheimer's Disease Brain

Diane T. Stephenson, Cynthia A. Lemere, Dennis J. Selkoe, James A. Clemens

Journal:

Neurobiology of Disease

Year:

1996

Language:

english

File:

PDF, 405 KB

english, 1996

99

Receptor-Mediated Transport of Human Amyloid β-Protein 1–40 and 1–42 at the Blood–Brain Barrier

Joseph F. Poduslo, Geoffry L. Curran, Bharati Sanyal, Dennis J. Selkoe

Journal:

Neurobiology of Disease

Year:

1999

Language:

english

File:

PDF, 146 KB

english, 1999

100

FAD Mutations in Presenilin-1 or Amyloid Precursor Protein Decrease the Efficacy of a γ-Secretase Inhibitor: Evidence for Direct Involvement of PS1 in the γ-Secretase Cleavage Complex

Weiming Xia, Beth L. Ostaszewski, W.Taylor Kimberly, Talat Rahmati, Chad L. Moore, Michael S. Wolfe, Dennis J. Selkoe

Journal:

Neurobiology of Disease

Year:

2000

Language:

english

File:

PDF, 170 KB

english, 2000