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51

Target epitopes of HTLV-1 recognized by class I MHC-restricted cytotoxic T lymphocytes in patients with myelopathy and spastic paraparesis and infected patients with autoimmune disorders

Tomohiro Kozako, Masaki Akimoto, Shingo Toji, Yohann White, Susumu Suzuki, Takehiro Arima, Yukio Suruga, Kakushi Matsushita, Hiroshi Shimeno, Shinji Soeda, Ryuji Kubota, Shuji Izumo, Kimiharu Uozumi,

Journal:

Journal of Medical Virology

Year:

2011

Language:

english

File:

PDF, 407 KB

english, 2011

52

Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo

Takashi Ochiai, Hiroshi Shimeno, Ken-ichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara, Hiroyuki Tanaka, Yukihiro Shoyama, Akihisa Toda, Reiko Eyanagi, Shinji Soeda

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2007

Language:

english

File:

PDF, 878 KB

english, 2007

53

Crocin prevents the death of PC-12 cells through sphingomyelinase-ceramide signaling by increasing glutathione synthesis

Takashi Ochiai, Shinji Soeda, Shigekazu Ohno, Hiroyuki Tanaka, Yukihiro Shoyama, Hiroshi Shimeno

Journal:

Neurochemistry International

Year:

2004

Language:

english

File:

PDF, 420 KB

english, 2004

54

Inhibitory Effect of Oversulfated Fucoidan on Tube Formation by Human Vascular Endothelial Cells.

SOEDA, Shinji, SHIBATA, Yoshiaki, SHIMENO, Hiroshi

Journal:

Biological & Pharmaceutical Bulletin

Year:

1997

File:

PDF, 1.13 MB

1997

55

Two Molecular Species of Oxytocinase (L-Cystine Aminopeptidase) in Human Placenta: Purification and Characterization.

ITOH, Chie, WATANABE, Maho, NAGAMATSU, Atsuo, SOEDA, Shinji, KAWARABAYASHI, Tatsuhiko, SHIMENO, Hiroshi

Journal:

Biological & Pharmaceutical Bulletin

Year:

1997

File:

PDF, 1013 KB

1997

56

Comparative effects of DL, D and L-3-pyridylalanine on serotonin concentration and tryptophan-serotonin metabolizing enzymes.

SHIMENO, HIROSHI, FUKUMOTO, YOKO, FUJI, MASAKATSU, NAGAMATSU, ATSUO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1984

File:

PDF, 621 KB

1984

57

ChemInform Abstract: Stereoselective Reduction of Cyclopropylalkanones Possessing a Difluoromethylenephosphonate Group at the Ring: Application to Stereoselective Synthesis of Novel Cyclopropane Nucleotide Analogues.

Tsutomu Yokomatsu, Takehiro Yamagishi, Kenji Suemune, Hiroshi Abe, Taro Kihara, Shinji Soeda, Hiroshi Shimeno, Shiroshi Shibuya

Journal:

Year:

2000

File:

PDF, 32 KB

2000

58

ChemInform Abstract: Synthesis and Evaluation of a Difluoromethylene Analogue of Sphingomyelin as an Inhibitor of Sphingomyelinase.

Tsutomu Yokomatsu, Hiroaki Takechi, Takeshi Akiyama, Shiroishi Shibuya, Takaaki Kominato, Shinji Soeda, Hiroshi Shimeno

Journal:

Year:

2001

File:

PDF, 33 KB

2001

59

Synthesis and biological evaluation of 9-(5′,5′-difluoro-5′-phosphonopentyl)guanine derivatives for PNP-inhibitors

Sadao Hikishima, Machiko Isobe, Satoru Koyanagi, Shinji Soeda, Hiroshi Shimeno, Shiroshi Shibuya, Tsutomu Yokomatsu

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 235 KB

english, 2006

60

Synthesis and evaluation of a difluoromethylene analogue of sphingomyelin as an inhibitor of sphingomyelinase

Tsutomu Yokomatsu, Hiroaki Takechi, Takeshi Akiyama, Shiroishi Shibuya, Takaaki Kominato, Shinji Soeda, Hiroshi Shimeno

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 243 KB

english, 2001

61

Synthesis of non-competitive inhibitors of Sphingomyelinases with significant activity

Tsutomu Yokomatsu, Tetsuo Murano, Takeshi Akiyama, Junichi Koizumi, Shiroshi Shibuya, Yoshiaki Tsuji, Shinji Soeda, Hiroshi Shimeno

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 225 KB

english, 2003

62

Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of α-tocopherol

Takashi Ochiai, Shigekazu Ohno, Shinji Soeda, Hiroyuki Tanaka, Yukihiro Shoyama, Hiroshi Shimeno

Journal:

Neuroscience Letters

Year:

2004

Language:

english

File:

PDF, 171 KB

english, 2004

63

Glucocorticoid Regulation of 24-Hour Oscillation in Interferon Receptor Gene Expression in Mouse Liver

Koyanagi, Satoru, Suyama, Hinako, Kuramoto, Yukako, Matsunaga, Noaya, Takane, Hiroshi, Soeda, Shinji, Shimeno, Hiroshi, Higuchi, Shun, Ohdo, Shigehiro

Journal:

Year:

2006

Language:

english

File:

PDF, 273 KB

english, 2006

64

Metabolism of Drugs. LXX. Further Study on Antipyrine Metabolism

YOSHIMURA, HIDETOSHI, SHIMENO, HIROSHI, TSUKAMOTO, HISAO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1971

File:

PDF, 675 KB

1971

65

Fibrinolytic and anticoagulant activities of highly sulfated fucoidan

Shinji Soeda, Shinya Sakaguchi, Hiroshi Shimeno, Atsuo Nagamatsu

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 541 KB

english, 1992

66

Handcrafted two-channel colonoscope for grasping-forceps-assisted resection of giant pedunculated polyps

Mitsunobu Matsushita, Hiroshi Takakuwa, Yuji Matsubayashi, Masahiro Kido, Naoto Shimeno, Kazuichi Okazaki

Journal:

Gastrointestinal Endoscopy

Year:

2005

Language:

english

File:

PDF, 214 KB

english, 2005

67

Synthesis of ceramides and cerebrosides in rat brain: comparison with synthesis of lignoceroyl-coenzyme A

Mori, Masa-aki, Shimeno, Hiroshi, Kishimoto, Yasuo

Journal:

Neurochemistry International

Year:

1985

Language:

english

File:

PDF, 402 KB

english, 1985

68

Possible Implication of a Aldehyde Metabolite in Aminopyrine Allergy

Shimeno, Hiroshi, Yoshimura, Hidetoshi

Journal:

Year:

1972

Language:

english

File:

PDF, 608 KB

english, 1972

69

Inhibition of sphingomyelinase activity helps to prevent neuron death caused by ischemic stress

Shinji Soeda, Yoshiaki Tsuji, Takashi Ochiai, Ken-ichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara, Tsutomu Yokomatsu, Tetsuo Murano, Shiroshi Shibuya, Hiroshi Shimeno

Journal:

Neurochemistry International

Year:

2004

Language:

english

File:

PDF, 355 KB

english, 2004

70

Effects of Pyridylalanine Analogs, Glycyrrhizin and Cortisone on Brain Biogenic Amine Contents, Tryptophan Pyrrolase and Tyrosine Aminotransferase in Rats

SHIMENO, HIROSHI, KUROIWA, TEIKO, NAGAMATSU, ATSUO

Journal:

YAKUGAKU ZASSHI

Year:

1980

File:

PDF, 815 KB

1980

71

Inhibition of proline endopeptidase activity by acyl-coenzyme A esters

Naomi Yamakawa, Hiroshi Shimeno, Shinji Soeda, Atsuo Nagamatsu

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1990

Language:

english

File:

PDF, 434 KB

english, 1990

72

Sphingosine inhibits attachment of murine Lewis lung carcinoma cells to laminin and type IV collagen

Jin-ichi Inokuchi, Yukihiro Kumamoto, Masayuki Jimbo, Hiroshi Shimeno, Atsuo Nagamatsu

Journal:

Year:

1991

Language:

english

File:

PDF, 632 KB

english, 1991

73

The stimulatory effects of caffeine with oseltamivir (Tamiflu®) on light–dark behavior and open-field behavior in mice

Hidemori Uchiyama, Akihisa Toda, Masumi Imoto, Satoko Nishimura, Hiroaki Kuroki, Shinji Soeda, Hiroshi Shimeno, Shigenori Watanabe, Reiko Eyanagi

Journal:

Neuroscience Letters

Year:

2010

Language:

english

File:

PDF, 287 KB

english, 2010

74

Effect of combined administration of tryptophan with putative tryptophan pyrrolase inhibitors, DL-3-pyridylalanine, allopurinol or nicotinamide, on brain serotonin concentration.

SHIMENO, HIROSHI, FUKUMOTO, YOKO, FUJI, MASAKATSU, NAGAMATSU, ATSUO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1984

File:

PDF, 1020 KB

1984

75

Release of plasminogen activator inhibitor-1 from human astrocytes is regulated by intracellular ceramide

Masahiko Kimura, Shinji Soeda, Masatoshi Oda, Takashi Ochiai, Taro Kihara, Nobufumi Ono, Hiroshi Shimeno

Journal:

Journal of Neuroscience Research

Year:

2000

Language:

english

File:

PDF, 202 KB

english, 2000

76

Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice

Satoru Hayashida, Akie Arimoto, Yukako Kuramoto, Tomohiro Kozako, Shin-ichiro Honda, Hiroshi Shimeno, Shinji Soeda

Journal:

Molecular and Cellular Biochemistry

Year:

2010

Language:

english

File:

PDF, 659 KB

english, 2010

77

High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells

Tomohiro Kozako, Akiyoshi Aikawa, Teruhisa Shoji, Takahiro Fujimoto, Makoto Yoshimitsu, Senji Shirasawa, Hiroaki Tanaka, Shin-ichiro Honda, Hiroshi Shimeno, Naomichi Arima, Shinji Soeda

Journal:

International Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 1.81 MB

english, 2012

78

Tissue plasminogen activator catalyzed Lys-Plasminogen activation on heparin-inserted phospholipid liposomes

Soeda, Shinji, Sakaguchi, Shinya, Shimeno, Hiroshi, Nagamatsu, Atsuo

Journal:

Year:

1990

Language:

english

File:

PDF, 886 KB

english, 1990

79

Anti-inflammatory activities of pyridylalanine analogues and their influences on the anti-inflammatory action of cortisone.

SHIMENO, HIROSHI, SOEDA, SHINJI, NAGAMATSU, ATSUO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1977

File:

PDF, 610 KB

1977

80

Further characterization of the heat-stable factor in the α-hydroxylation and oxidation of lignoceric acid in brain: Effect of acidic amino acids and hexose-phosphates on brain fatty acid metabolism

Hiroshi Shimeno, Nobuyuki Okamura, Anupam Wali, Yasuo Kishimoto

Journal:

Archives of Biochemistry and Biophysics

Year:

1983

Language:

english

File:

PDF, 998 KB

english, 1983

81

Tumor necrosis factor-α-induced release of plasminogen activator inhibitor-1 from human umbilical vein endothelial cells: involvement of intracellular ceramide signaling event

Shinji Soeda, Takeshi Tsunoda, Yousuke Kurokawa, Hiroshi Shimeno

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1998

Language:

english

File:

PDF, 228 KB

english, 1998

82

Deficient release of plasminogen activator inhibitor-1 from astrocytes triggers apoptosis in neuronal cells

Shinji Soeda, Masatoshi Oda, Takashi Ochiai, Hiroshi Shimeno

Journal:

Molecular Brain Research

Year:

2001

Language:

english

File:

PDF, 944 KB

english, 2001

83

Vascular endothelial cell monolayer formed on membrane filter potentiates the defense against tumor cell invasion by treatment with brefeldin A

Shinji Soeda, Okinobu Honda, Hiroshi Shimeno

Journal:

Year:

1996

Language:

english

File:

PDF, 629 KB

english, 1996

84

PROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-α MEDIATES HIGH-FAT, DIET-ENHANCED DAILY OSCILLATION OF PLASMINOGEN ACTIVATOR INHIBITOR-1 ACTIVITY IN MICE

Hayashida, Satoru, Kuramoto, Yukako, Koyanagi, Satoru, Oishi, Katsutaka, Fujiki, Junya, Matsunaga, Naoya, Ikeda, Eriko, Ohdo, Shigehiro, Shimeno, Hiroshi, Soeda, Shinji

Journal:

Chronobiology International

Year:

2010

Language:

english

File:

PDF, 599 KB

english, 2010

85

Two molecular species of proline endopeptidase in human plasma: Isolation and characterization.

SOEDA, SHINJI, OHYAMA, MASANORI, YAMAKAWA, NAOMI, SHIMENO, HIROSHI, NAGAMATSU, ATSUO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1984

File:

PDF, 915 KB

1984

86

Synthesis of 1,1-difluoro-5-(1H-9-purinyl)-2-pentenylphosphonic acids and the related methano analogues. Remarkable effect of the nucleobases and the cyclopropane rings on inhibitory activity toward purine nucleoside phosphorylase

Tsutomu Yokomatsu, Hiroshi Abe, Mutsumi Sato, Kenji Suemune, Taro Kihara, Shinji Soeda, Hiroshi Shimeno, Shiroshi Shibuya

Journal:

Bioorganic & Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 1.09 MB

english, 1998

87

Synthesis and evaluation of multisubstrate analogue inhibitors of purine nucleoside phosphorylases

Tsutomu Yokomatsu, Yoshinobu Hayakawa, Taro Kihara, Satoru Koyanagi, Shinji Soeda, Hiroshi Shimeno, Shiroshi Shibuya

Journal:

Bioorganic & Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 231 KB

english, 2000

88

Expression of ganglioside GM3 and H-2 antigens in clones with different metastatic and growth potentials isolated from Lewis lung carcinoma (3LL) cell line

Jin-ichi Inokuchi, Masayuki Jimbo, Yukihiro Kumamoto, Hiroshi Shimeno, Atsuo Nagamatsu

Journal:

Clinical and Experimental Metastasis

Year:

1993

Language:

english

File:

PDF, 865 KB

english, 1993

89

Circadian regulation of mouse topoisomerase I gene expression by glucocorticoid hormones

Yukako Kuramoto, Koujirou Hata, Satoru Koyanagi, Shigehiro Ohdo, Hiroshi Shimeno, Shinji Soeda

Journal:

Biochemical Pharmacology

Year:

2006

Language:

english

File:

PDF, 372 KB

english, 2006

90

Aminated fucoidan promotes the invasion of 3 LL cells through reconstituted basement membrane: its possible mechanism of action

Soeda, Shinji, Ishida, Satoshi, Honda, Okinobu, Shimeno, Hiroshi, Nagamatsu, Atsuo

Journal:

Year:

1994

Language:

english

File:

PDF, 636 KB

english, 1994

91

Stereoselective Reduction of Cyclopropylalkaones Possessing a Difluoromethylenephosphonate Group at the Ring: Application to Stereoselective Synthesis of Novel Cyclopropane Nucleotide Analogues

Tsutomu Yokomatsu, Takehiro Yamagishi, Kenji Suemune, Hiroshi Abe, Taro Kihara, Shinji Soeda, Hiroshi Shimeno, Shiroshi Shibuya

Journal:

Year:

2000

Language:

english

File:

PDF, 219 KB

english, 2000

92

Diastereoselective Synthesis of γ-Amino-δ-hydroxy-α,α-difluorophosphonates: A Vehicle for Structure−activity Relationship Studies on SMA-7, a Potent Sphingomyelinase Inhibitor

Yamagishi, Takehiro, Muronoi, Shin, Hikishima, Sadao, Shimeno, Hiroshi, Soeda, Shinji, Yokomatsu, Tsutomu

Journal:

Journal of Organic Chemistry

Year:

2009

Language:

english

File:

PDF, 901 KB

english, 2009

93

Regulation of prolyl oligopeptidase activity in regenerating rat liver

Yamakawa, Naomi, Shimeno, Hiroshi, Soeda, Shinji, Nagamatsu, Atsuo

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

1994

Language:

english

File:

PDF, 533 KB

english, 1994

94

Chronic Treatment with Prednisolone Represses the Circadian Oscillation of Clock Gene Expression in Mouse Peripheral Tissues

Koyanagi, Satoru, Okazawa, Sumako, Kuramoto, Yukako, Ushijima, Kentarou, Shimeno, Hiroshi, Soeda, Shinji, Okamura, Hitoshi, Ohdo, Shigehiro

Journal:

Molecular Endocrinology

Year:

2006

Language:

english

File:

PDF, 623 KB

english, 2006

95

Synthesis of Non-Competitive Inhibitors of Sphingomyelinases with Significant Activity.

Tsutomu Yokomatsu, Tetsuo Murano, Takeshi Akiyama, Junichi Koizumi, Shiroshi Shibuya, Yoshiaki Tsuji, Shinji Soeda, Hiroshi Shimeno

Journal:

Year:

2003

File:

PDF, 238 KB

2003

96

α-Hydroxylation and oxidation of lignoceric acid in brain: The role of heat-stable and heat-labile factors

Hiroshi Shimeno, Anupam Wali, Yasuo Kishimoto

Journal:

Neurochemical Research

Year:

1984

Language:

english

File:

PDF, 646 KB

english, 1984

97

Inhibition of lipopolysaccharide-induced release of interleukin-8 from intestinal epithelial cells by SMA, a novel inhibitor of sphingomyelinase and its therapeutic effect on dextran sulphate sodium-induced colitis in mice

Akira Sakata, Kazuya Yasuda, Takashi Ochiai, Hiroshi Shimeno, Sadao Hikishima, Tsutomu Yokomatsu, Shiroshi Shibuya, Shinji Soeda

Journal:

Cellular Immunology

Year:

2007

Language:

english

File:

PDF, 315 KB

english, 2007

98

Metabolism of drugs—LIX: A new metabolite of antipyrine

Yoshimura Hidetoshi, Shimeno Hiroshi, Tsukamoto Hisao

Journal:

Biochemical Pharmacology

Year:

1968

Language:

english

File:

PDF, 422 KB

english, 1968

99

Crocin suppresses tumor necrosis factor-α-induced cell death of neuronally differentiated PC-12 cells

Shinji Soeda, Takashi Ochiai, Loungratana Paopong, Hiroyuki Tanaka, Yukihiro Shoyama, Hiroshi Shimeno

Journal:

Year:

2001

Language:

english

File:

PDF, 230 KB

english, 2001

100

Modulation of Circadian Rhythm of DNA Synthesis in Tumor Cells by Inhibiting Platelet-Derived Growth Factor Signaling

Nakagawa, Hiroo, Koyanagi, Satoru, Kuramoto, Yukako, Yoshizumi, Akiko, Matsunaga, Naoya, Shimeno, Hiroshi, Soeda, Shinji, Ohdo, Shigehiro

Journal:

Journal of Pharmacological Sciences

Year:

2008

Language:

english

File:

PDF, 389 KB

english, 2008

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