STEPHEN NEIDLE: search on Z-Library

The world's largest scientific articles store. 70,000,000+ articles for free.

Don't use scam websites

51

TRAP–LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules

Julie Reed, Mekala Gunaratnam, Monica Beltran, Anthony P Reszka, Ramon Vilar, Stephen Neidle

Journal:

Analytical Biochemistry

Year:

2008

Language:

english

File:

PDF, 790 KB

english, 2008

52

Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives

Giuseppe Zagotto, Claudia Sissi, Stefano Moro, Diego Dal Ben, Gary N. Parkinson, Keith R. Fox, Stephen Neidle, Manlio Palumbo

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 437 KB

english, 2008

53

Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors

Christoph M Schultes, Bérangère Guyen, Javier Cuesta, Stephen Neidle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 322 KB

english, 2004

54

Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding

R. John Harrison, Anthony P. Reszka, Shozeb M. Haider, Barbara Romagnoli, James Morrell, Martin A. Read, Sharon M. Gowan, Christopher M. Incles, Lloyd R. Kelland, Stephen Neidle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 293 KB

english, 2004

55

Truncated azinomycin analogues intercalate into DNA

Maxwell A. Casely-Hayford, Klaus Pors, Laurence H. Patterson, Clive Gerner, Stephen Neidle, Mark Searcey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 301 KB

english, 2005

56

Natural and synthetic G-quadruplex interactive berberine derivatives

Marco Franceschin, Luigi Rossetti, Anna D’Ambrosio, Stefano Schirripa, Armandodoriano Bianco, Giancarlo Ortaggi, Maria Savino, Christoph Schultes, Stephen Neidle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 317 KB

english, 2006

57

Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents

Cristina Martins, Mekala Gunaratnam, John Stuart, Vaidahi Makwana, Olga Greciano, Anthony P. Reszka, Lloyd R. Kelland, Stephen Neidle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 1.04 MB

english, 2007

58

Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands

Francisco Cuenca, Olga Greciano, Mekala Gunaratnam, Shozeb Haider, Deeksha Munnur, Rupesh Nanjunda, W. David Wilson, Stephen Neidle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 590 KB

english, 2008

59

Selective G-quadruplex ligands: The significant role of side chain charge density in a series of perylene derivatives

Emanuela Micheli, Caterina Maria Lombardo, Danilo D’Ambrosio, Marco Franceschin, Stephen Neidle, Maria Savino

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 564 KB

english, 2009

60

Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells

Sonja M. Hampel, Assitan Sidibe, Mekala Gunaratnam, Jean-François Riou, Stephen Neidle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 730 KB

english, 2010

61

C-11 diamino cryptolepine derivatives NSC748392, NSC748393, and NSC748394: Anticancer profile and G-quadruplex stabilization

João Lavrado, Anthony P. Reszka, Rui Moreira, Stephen Neidle, Alexandra Paulo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 206 KB

english, 2010

62

On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis

Shozeb Haider, Caleb G. Joseph, Stephen Neidle, Carol A. Fierke, Matthew J. Fuchter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 453 KB

english, 2011

63

Structure-specific recognition of quadruplex DNA by organic cations: Influence of shape, substituents and charge

Elizabeth W. White, Farial Tanious, Mohamed A. Ismail, Anthony P. Reszka, Stephen Neidle, David W. Boykin, W. David Wilson

Journal:

Biophysical Chemistry

Year:

2007

Language:

english

File:

PDF, 1.84 MB

english, 2007

64

G-quadruplex nucleic acids as therapeutic targets

Shankar Balasubramanian, Stephen Neidle

Journal:

Current Opinion in Chemical Biology

Year:

2009

Language:

english

File:

PDF, 423 KB

english, 2009

65

Derivatives of 2′,3′-dithiouridine and [1-β-D-(2,3-dithioxylofuranosyl)]uracil

Richard Johnson, Bhalchandra V. Joshi, Stephen Neidle, Colin B. Reese, Chris F. Snook

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 207 KB

english, 1992

66

Reaction between glycal benzyl ethers and thallium(III) nitrate. Synthesis of showdomycin analogues.

Andrew Kaye, Stephen Neidle, Colin B. Reese

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 225 KB

english, 1988

67

Synthesis of a novel dimeric bis-benzimidazole with site-selective DNA-binding properties

Xiao-Wen Sun, Stephen Neidle, John Mann

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 66 KB

english, 2002

68

A novel inhibitor of human telomerase derived from 10H-indolo[3,2-b]quinoline

Vittorio Caprio, Berengere Guyen, Yaw Opoku-Boahen, John Mann, Sharon M Gowan, Lloyd M Kelland, Martin A Read, Stephen Neidle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 186 KB

english, 2000

69

DNA minor groove interactions and the biological activity of 2,5-bis-[4-(N-alkylamidino)phenyl] furans

Ian J Simpson, Michael Lee, Arvind Kumar, David W Boykin, Stephen Neidle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 349 KB

english, 2000

70

Mercaptoacyl matrix metalloproteinase inhibitors: The effect of substitution at the mercaptoacyl moiety

Andrew D Baxter, Ranjev Bhogal, John B Bird, George M Buckley, David S Gregory, Paul C Hedger, David T Manallack, Tracy Massil, Kevin J Minton, John G Montana, Stephen Neidle, David A Owen, Robert J W

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 265 KB

english, 1997

71

DNA sequence specificity of triplex-binding ligands

Melanie D. Keppler, Peter L. James, Stephen Neidle, Tom Brown, Keith R. Fox

Journal:

Year:

2003

Language:

english

File:

PDF, 691 KB

english, 2003

72

Targeting the DNA minor groove with fused ring dicationic compounds: Comparison of in silico screening and a high-resolution crystal structure

Nancy H. Campbell, David A. Evans, Michael P.H. Lee, Gary N. Parkinson, Stephen Neidle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 243 KB

english, 2006

73

The structure of the antitumor complex cis-(diammino) (1,1-cyclobutanedicarboxylato)-Pt(II): X ray and nmr studies

Stephen Neidle, Ismail M. Ismail, Peter J. Sadler

Journal:

Journal of Inorganic Biochemistry

Year:

1980

Language:

english

File:

PDF, 475 KB

english, 1980

74

New renin inhibitors containing novel analogues of statine

D. MICHAEL JONES, JAVIER SUEIRAS-DIAZ, MICHAEL SZELKE, BRENDA J. LECKIE, SHEILA R BEATTIE, JAMES MORTON, STEPHEN NEIDLE, REIKO KURODA

Journal:

Chemical Biology & Drug Design

Year:

1997

Language:

english

File:

PDF, 1.05 MB

english, 1997

75

Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer

Journal:

Year:

2010

Language:

english

File:

PDF, 284 KB

english, 2010

76

Approaches to effective anti-cancer drugs

Neidle, Stephen

Journal:

Year:

1977

File:

PDF, 228 KB

1977

77

Twists and turns of DNA

Neidle, Stephen

Journal:

Year:

1978

File:

PDF, 122 KB

1978

78

Carcinogen binding to DNA

Neidle, Stephen

Journal:

Year:

1978

File:

PDF, 328 KB

1978

79

Transfer RNAs

Neidle, Stephen

Journal:

Year:

1979

File:

PDF, 124 KB

1979

80

Nucleic acid statics and dynamics

Neidle, Stephen

Journal:

Year:

1979

File:

PDF, 393 KB

1979

81

Carcinogens and DNA

Neidle, Stephen

Journal:

Year:

1980

File:

PDF, 145 KB

1980

82

New twists to DNA and DNA–carcinogen interactions

Neidle, Stephen

Journal:

Year:

1981

File:

PDF, 250 KB

1981

83

The structure of a pseudo intercalated complex between actinomycin and the DNA binding sequence d(GpC)

Takusagawa, Fusao, Dabrow, Michael, Neidle, Stephen, Berman, Helen M.

Journal:

Year:

1982

File:

PDF, 653 KB

1982

84

Nucleic acid structure: New twists to left-handed DNA

Neidle, Stephen

Journal:

Year:

1983

File:

PDF, 137 KB

1983

85

Crystal structure of parallel quadruplexes from human telomeric DNA

Parkinson, Gary N., Lee, Michael P. H., Neidle, Stephen

Journal:

Year:

2002

Language:

english

File:

PDF, 486 KB

english, 2002

86

Chemical approaches to the discovery and development of cancer therapies

Neidle, Stephen, Thurston, David E.

Journal:

Nature Reviews Cancer

Year:

2005

Language:

english

File:

PDF, 256 KB

english, 2005

87

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

Balasubramanian, Shankar, Hurley, Laurence H., Neidle, Stephen

Journal:

Nature Reviews Drug Discovery

Year:

2011

Language:

english

File:

PDF, 1.26 MB

english, 2011

88

TELOMERE MAINTENANCE AS A TARGET FOR ANTICANCER DRUG DISCOVERY

Neidle, Stephen, Parkinson, Gary

Journal:

Nature Reviews Drug Discovery

Year:

2002

Language:

english

File:

PDF, 1.01 MB

english, 2002

89

The structure of chain-linked DNA as a possible model for the transcription bubble

Nunn, Christine M., Neidle, Stephen

Journal:

Natural Structural Biology

Year:

1995

File:

PDF, 273 KB

1995

90

2,7-Disubstituted Amidofluorenone Derivatives as Inhibitors of Human Telomerase

Perry, Philip J., Read, Martin A., Davies, Rhian T., Gowan, Sharon M., Reszka, Anthony P., Wood, Alexis A., Kelland, Lloyd R., Neidle, Stephen

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 115 KB

english, 1999

91

Synthesis of distamycin A polyamides targeting G-quadruplex DNA

Moore, Michael J. B., Cuenca, Francisco, Searcey, Mark, Neidle, Stephen

Journal:

Organic & Biomolecular Chemistry

Year:

2006

Language:

english

File:

PDF, 212 KB

english, 2006

92

Molecular Dynamics Studies of the STAT3 Homodimer:DNA Complex: Relationships between STAT3 Mutations and Protein–DNA Recognition

Husby, Jarmila, Todd, Alan K., Haider, Shozeb M., Zinzalla, Giovanna, Thurston, David E., Neidle, Stephen

Journal:

Journal of Chemical Information and Modeling

Year:

2012

Language:

english

File:

PDF, 941 KB

english, 2012

93

Structural Basis for Telomeric G-Quadruplex Targeting by Naphthalene Diimide Ligands

Collie, Gavin W., Promontorio, Rossella, Hampel, Sonja M., Micco, Marialuisa, Neidle, Stephen, Parkinson, Gary N.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 3.14 MB

english, 2012

94

DNA minor-groove recognition by small molecules (up to 2000)

Neidle, Stephen

Journal:

Natural Product Reports

Year:

2001

Language:

english

File:

PDF, 1.88 MB

english, 2001

95

A G-Rich Sequence within the c-kit Oncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics

Varnai, Peter, Bugaut, Anthony, Reszka, Anthony P., Neidle, Stephen, Hsu, Shang-Te Danny, Balasubramanian, Shankar

Journal:

Journal of the American Chemical Society

Year:

2009

Language:

english

File:

PDF, 513 KB

english, 2009

96

Symmetric Bis-benzimidazoles Are Potent Anti-Staphylococcal Agents with Dual Inhibitory Mechanisms against DNA Gyrase

Dale, Aaron G., Hinds, Jason, Mann, John, Taylor, Peter W., Neidle, Stephen

Journal:

Year:

2012

Language:

english

File:

PDF, 487 KB

english, 2012

97

Human Telomerase Inhibition by Regioisomeric Disubstituted Amidoanthracene-9,10-diones

Perry, Philip J., Reszka, Anthony P., Wood, Alexis A., Read, Martin A., Gowan, Sharon M., Dosanjh, Harvinder S., Trent, John O., Jenkins, Terence C., Kelland, Lloyd R., Neidle, Stephen

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 216 KB

english, 1998

98

Synthesis of Small Molecules Targeting Multiple DNA Structures using Click Chemistry

Dr. Lesley A. Howell, Dr. Richard A. Bowater, Dr. Maria A. O'Connell, Anthony P. Reszka, Prof. Stephen Neidle, Prof. Mark Searcey

Journal:

Year:

2012

Language:

english

File:

PDF, 690 KB

english, 2012

99

Bioactive Compounds from Carissa spinarum

Ruchira Wangteeraprasert, Vimolmas Lipipun, Mekala Gunaratnam, Stephen Neidle, Simon Gibbons, Kittisak Likhitwitayawuid

Journal:

Phytotherapy Research

Year:

2012

Language:

english

File:

PDF, 121 KB

english, 2012

100

Mechanism of acridine-based telomerase inhibition and telomere shortening

Mekala Gunaratnam, Olga Greciano, Cristina Martins, Anthony P. Reszka, Christoph M. Schultes, Hamid Morjani, Jean-Francois Riou, Stephen Neidle

Journal:

Biochemical Pharmacology

Year:

2007

Language:

english

File:

PDF, 1.40 MB

english, 2007