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51

Dose–response of alkylation-induced colorectal carcinogenesis in MGMT-proficient and -deficient mice

Fahrer, Jörg, Frisch, Janina, Nagel, Georg, Reißig, Sonja, Waisman, Ari, Samson, Leona D., Kaina, Bernd

Journal:

Toxicology Letters

Year:

2013

Language:

english

File:

PDF, 71 KB

english, 2013

52

Suppression of Human DNA Alkylation-Repair Defects by Escherichia coli DNA-Repair Genes

Leona Samson, Bruce Derfler and Evelyn A. Waldstein

Journal:

Proceedings of the National Academy of Sciences

Year:

1986

Language:

english

File:

PDF, 721 KB

english, 1986

53

A Second DNA Methyltransferase Repair Enzyme in Escherichia coli

G. William Rebeck, Susan Coons, Patrick Carroll and Leona Samson

Journal:

Proceedings of the National Academy of Sciences

Year:

1988

Language:

english

File:

PDF, 918 KB

english, 1988

54

Cloning a Eukaryotic DNA Glycosylase Repair Gene by the Suppression of a DNA Repair Defect in Escherichia coli

Jin Chen, Bruce Derfler, Azmat Maskati and Leona Samson

Journal:

Proceedings of the National Academy of Sciences

Year:

1989

Language:

english

File:

PDF, 1.08 MB

english, 1989

55

Increasing DNA Repair Methyltransferase Levels Via Bone Marrow Stem Cell Transduction Rescues Mice from the Toxic Effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a Chemotherapeutic Alkylating Agent

Rodney Maze, James P. Carney, Mark R. Kelley, Brian J. Glassner, David A. Williams and Leona Samson

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 403 KB

english, 1996

56

Base Excision Repair Deficient Mice Lacking the Aag Alkyladenine DNA Glycosylase

Bevin P. Engelward, Geert Weeda, Michael D. Wyatt, Jose L. M. Broekhof, Jan De Wit, Ingrid Donker, James M. Allan, Barry Gold, Jan H. J. Hoeijmakers and Leona D. Samson

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.33 MB

english, 1997

57

Generation of a Strong Mutator Phenotype in Yeast by Imbalanced Base Excision Repair

Brian J. Glassner, Lene Juel Rasmussen, Mark T. Najarian, Lauren M. Posnick and Leona D. Samson

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.10 MB

english, 1998

58

Global Response of Saccharomyces cerevisiae to an Alkylating Agent

Scott A. Jelinsky and Leona D. Samson

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.86 MB

english, 1999

59

Role of DNA Mismatch Repair and p53 in Signaling Induction of Apoptosis by Alkylating Agents

Mark J. Hickman and Leona D. Samson

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.62 MB

english, 1999

60

Integrated Molecular Analysis Indicates Undetectable Change in DNA Damage in Mice after Continuous Irradiation at ~ 400-fold Natural Background Radiation

Werner Olipitz, Dominika Wiktor-Brown, Joe Shuga, Bo Pang, Jose McFaline, Pallavi Lonkar, Aline Thomas, James T. Mutamba, Joel S. Greenberger, Leona D. Samson, Peter C. Dedon, Jacquelyn C. Yanch and B

Journal:

Environmental Health Perspectives

Year:

2012

Language:

english

File:

PDF, 1.88 MB

english, 2012

61

O⁶-Methylguanine-DNA Methyltransferase Leu84Phe and Ile143Val Polymorphisms and Risk of Colorectal Cancer in the Nurses' Health Study and Physicians' Health Study (United States)

Gregory J. Tranah, James Bugni, Edward Giovannucci, Jing Ma, Charles Fuchs, Lisa Hines, Leona Samson and David J. Hunter

Journal:

Cancer Causes & Control

Year:

2006

Language:

english

File:

PDF, 2.14 MB

english, 2006

62

Repair of endogenous DNA base lesions modulate lifespan in mice

Meira, Lisiane B., Calvo, Jennifer A., Shah, Dharini, Klapacz, Joanna, Moroski-Erkul, Catherine A., Bronson, Roderick T., Samson, Leona D.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.02 MB

english, 2014

63

Recognition and Processing of a New Repertoire of DNA Substrates by Human 3-Methyladenine DNA Glycosylase (AAG) †

Lee, Chun-Yue I., Delaney, James C., Kartalou, Maria, Lingaraju, Gondichatnahalli M., Maor-Shoshani, Ayelet, Essigmann, John M., Samson, Leona D.

Journal:

Year:

2009

Language:

english

File:

PDF, 5.09 MB

english, 2009

64

Cisplatin Adducts Inhibit 1, N 6 -Ethenoadenine Repair by Interacting with the Human 3-Methyladenine DNA Glycosylase

Kartalou, Maria, Samson, Leona D., Essigmann, John M.

Journal:

Year:

2000

Language:

english

File:

PDF, 155 KB

english, 2000

65

Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine

Pegg, Anthony E., Boosalis, Michael, Samson, Leona, Moschel, Robert C., Byers, Timothy L., Swenn, Kristin, Dolan, M. Eileen

Journal:

Year:

1993

Language:

english

File:

PDF, 1.08 MB

english, 1993

66

Searching for DNA Lesions: Structural Evidence for Lower- and Higher-Affinity DNA Binding Conformations of Human Alkyladenine DNA Glycosylase

Setser, Jeremy W., Lingaraju, Gondichatnahalli M., Davis, C. Ainsley, Samson, Leona D., Drennan, Catherine L.

Journal:

Year:

2012

Language:

english

File:

PDF, 3.20 MB

english, 2012

67

DNA Repair Functions in Heterologous Cells

Memisoglu, Asli, Samson, Leona

Journal:

Critical Reviews in Biochemistry and Molecular Biology

Year:

1996

Language:

english

File:

PDF, 3.33 MB

english, 1996

68

Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney

Ebrahimkhani, Mohammad R., Daneshmand, Ali, Mazumder, Aprotim, Allocca, Mariacarmela, Calvo, Jennifer A., Abolhassani, Nona, Jhun, Iny, Muthupalani, Sureshkumar, Ayata, Cenk, Samson, Leona D.

Journal:

Proceedings of the National Academy of Sciences

Year:

2014

Language:

english

File:

PDF, 1.65 MB

english, 2014

69

The Saccharomyces cerevisiae MGT1 DNA repair methyltransferease gene: its promoter and entire coding sequence, regulation and in vivo biological functions

Xiao, Wei, Samson, Leona

Journal:

Nucleic Acids Research

Year:

1992

Language:

english

File:

PDF, 803 KB

english, 1992

70

Induction of S.cerevisiae MAG 3-methyladenine DNA glycosylase transcript levels in response to DNA damage

Chen, Jin, Samson, Leona

Journal:

Nucleic Acids Research

Year:

1991

Language:

english

File:

PDF, 5.11 MB

english, 1991

71

Integrated Molecular Analysis Indicates Undetectable Change in DNA Damage in Mice after Continuous Irradiation at ~ 400-fold Natural Background Radiation

Olipitz, Werner, Wiktor-Brown, Dominika, Shuga, Joe, Pang, Bo, McFaline, Jose, Lonkar, Pallavi, Thomas, Aline, Mutamba, James T, Greenberger, Joel S, Samson, Leona D, Dedon, Peter C, Yanch, Jacquelyn

Journal:

Environmental Health Perspectives

Year:

2012

Language:

english

File:

PDF, 627 KB

english, 2012

72

Cloning and characterization of a mouse 3-methyladenine/7-methl-guanine/-methylguanine DNA glycosylase cDNA whose gene maps to chromosme 11

P.Engelward, Bevin, S.Boosalis, Michael, J.Chen, Beiru, Deng, Zuoming, J.Siciliano, Michael, D.Samson, Leona

Journal:

Year:

1993

Language:

english

File:

PDF, 5.89 MB

english, 1993

73

The Escherichia coli MutS DNA mismatch binding protein specifically binds O 6 -methylguanine DNA lesions

Rasmussen, Lene Juel, Samson, Leona

Journal:

Year:

1996

Language:

english

File:

PDF, 1.63 MB

english, 1996

74

DNA alkylation repair and the induction of cell death and sister chromatid exchange in human cells

Samson, Leona, Linn, Stuart

Journal:

Year:

1987

Language:

english

File:

PDF, 405 KB

english, 1987

75

In vivo Evidence for Endogeneous DNA Alkylation Damage as a Source of Spontaneous Mutation in Eukaryotic Cells

Wei Xiao and Leona Samson

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 1.08 MB

english, 1993

76

Protection Against Chloroethylnitrosourea Cytotoxicity by Eukaryotic 3- Methyladenine DNA Glycosylase

Zdenka Matijasevic, Michael Boosalis, William Mackay, Leona Samson and David B. Ludlum

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 910 KB

english, 1993

77

The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants

Fu, Dragony, Samson, Leona D., Hübscher, Ullrich, van Loon, Barbara

Journal:

Year:

2015

Language:

english

File:

PDF, 1.28 MB

english, 2015

78

On the 50th Anniversary of Solving the Structure of DNA

Leona D. Samson

Journal:

Environmental Health Perspectives

Year:

2003

Language:

english

File:

PDF, 1.37 MB

english, 2003

79

Cloning and Characterization of a 3-Methyladenine DNA Glycosylase cDNA from Human Cells whose Gene Maps to Chromosome 16

Leona Samson, Bruce Derfler, Michael Boosalis and Katherine Call

Journal:

Proceedings of the National Academy of Sciences

Year:

1991

Language:

english

File:

PDF, 1.07 MB

english, 1991

80

Does the cycad genotoxin MAM implicated in Guam ALS-PDC induce disease-relevant changes in mouse brain that includes olfaction?

Kisby, Glen, Palmer, Valerie, Lasarev, Mike, Fry, Rebecca, Iordanov, Mihail, Magun, Eli, Samson, Leona, Spencer, Peter

Journal:

Communicative & Integrative Biology

Year:

2011

Language:

english

File:

PDF, 520 KB

english, 2011

81

Replication Protein A Binds to Regulatory Elements in Yeast DNA Repair and DNA Metabolism Genes

Keshav K. Singh and Leona Samson

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 1.32 MB

english, 1995

82

Session 5: Signaling Networks in Tumorigenesis; Responses to DNA Damaging Agents; Is the EGF Receptor a Therapeutic Target in Human Cancer?;

CAVENEE, WEBSTER, Samson, Leona, ARTEAGA, CARLOS

Journal:

Toxicologic Pathology

Year:

2004

Language:

english

File:

PDF, 37 KB

english, 2004

83

Polymorphisms in O6-methylguanine DNA methyltransferase and breast cancer risk

Han, Jiali, Tranah, Gregory J., Hankinson, Susan E., Samson, Leona D., Hunter, David J.

Journal:

Pharmacogenetics and Genomics

Year:

2006

Language:

english

File:

PDF, 87 KB

english, 2006

84

Base Excision Repair of N 6- Deoxyadenosine Adducts of 1,3-Butadiene

Wickramaratne, Susith, Banda, Douglas M., Ji, Shaofei, Manlove, Amelia H., Malayappan, Bhaskar, Nuñez, Nicole N., Samson, Leona, Campbell, Colin, David, Sheila S., Tretyakova, Natalia

Journal:

Year:

2016

Language:

english

File:

PDF, 3.34 MB

english, 2016

85

A novel role for transcription-coupled nucleotide excision repair for the in vivo repair of 3, N 4 -ethenocytosine

Chaim, Isaac A., Gardner, Alycia, Wu, Jie, Iyama, Teruaki, Wilson, David M., Samson, Leona D.

Journal:

Nucleic Acids Research

Year:

2017

Language:

english

File:

PDF, 1.63 MB

english, 2017

86

The proline rich domain of p53 is dispensable for MGMT-dependent DNA repair and cell survival following alkylation damage

Baran, Katherine, Yang, Mao, Dillon, Christopher P, Samson, Leona L, Green, Douglas R

Journal:

Cell Death & Differentiation

Year:

2017

Language:

english

File:

PDF, 2.96 MB

english, 2017

87

ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage

Jordan, Jennifer J, Chhim, Sophea, Margulies, Carrie M, Allocca, Mariacarmela, Bronson, Roderick T, Klungland, Arne, Samson, Leona D, Fu, Dragony

Journal:

Cell Death and Disease

Year:

2017

Language:

english

File:

PDF, 2.12 MB

english, 2017

88

In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities

Chaim, Isaac A., Nagel, Zachary D., Jordan, Jennifer J., Mazzucato, Patrizia, Ngo, Le P., Samson, Leona D.

Journal:

Proceedings of the National Academy of Sciences

Year:

2017

Language:

english

File:

PDF, 1.35 MB

english, 2017

89

Nitric Oxide Induced S-Nitrosation Causes Base Excision Repair Imbalance

Parrish, Marcus C., Chaim, Isaac A., Nagel, Zachary D., Tannenbaum, Steven R., Samson, Leona D., Engelward, Bevin P.

Journal:

Year:

2018

Language:

english

File:

PDF, 1.13 MB

english, 2018

90

Transcriptional Networks in S. cerevisiae Linked to an Accumulation of Base Excision Repair Intermediates

Rusyn, Ivan, Fry, Rebecca C., Begley, Thomas J., Klapacz, Joanna, Svensson, J. Peter, Ambrose, Mark, Samson, Leona D., Fairhead, Cecile

Journal:

Year:

2007

Language:

english

File:

PDF, 502 KB

english, 2007

91

Identification of Novel Human Damage Response Proteins Targeted through Yeast Orthology

Svensson, J. Peter, Fry, Rebecca C., Wang, Emma, Somoza, Luis A., Samson, Leona D., Vertessy, Beata G.

Journal:

Year:

2012

Language:

english

File:

PDF, 2.77 MB

english, 2012

92

Genomic Phenotyping by Barcode Sequencing Broadly Distinguishes between Alkylating Agents, Oxidizing Agents, and Non-Genotoxic Agents, and Reveals a Role for Aromatic Amino Acids in Cellular Recovery after Quinone Exposure

Svensson, J. Peter, Quirós Pesudo, Laia, McRee, Siobhan K., Adeleye, Yeyejide, Carmichael, Paul, Samson, Leona D., Marinus, Martin G.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.55 MB

english, 2013

93

A target to suppress inflammation

Samson, Leona D.

Journal:

Year:

2018

Language:

english

File:

PDF, 650 KB

english, 2018

94

Hypermutation of Immunoglobulin Genes in Memory B Cells of DNA Repair–deficient Mice

Jacobs, Heinz, Fukita, Yosho, van der Horst, Gijsbertus T.J., de Boer, Jan, Weeda, Geert, Essers, Jeroen, de Wind, Niels, Engelward, Bevin P., Samson, Leona, Verbeek, Sjef, de Murcia, Josiane Ménissie

Journal:

Journal of Experimental Medicine

Year:

1998

Language:

english

File:

PDF, 170 KB

english, 1998

95

Microcolony Size Distribution Assay Enables High-Throughput Cell Survival Quantitation

Ngo, Le P., Chan, Tze Khee, Ge, Jing, Samson, Leona D., Engelward, Bevin P.

Journal:

Year:

2019

Language:

english

File:

PDF, 2.85 MB

english, 2019

96

Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration

Allocca, Mariacarmela, Corrigan, Joshua J., Mazumder, Aprotim, Fake, Kimberly R., Samson, Leona D.

Journal:

Science Signaling

Year:

2019

Language:

english

File:

PDF, 2.13 MB

english, 2019

97

H. John F. Cairns (1922–2018)

D. Samson, Leona

Journal:

Nature Structural and Molecular Biology

Year:

2019

File:

PDF, 648 KB

2019

98

Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells

Nagel, Zachary D., Beharry, Andrew A., Mazzucato, Patrizia, Kitange, Gaspar J., Sarkaria, Jann N., Kool, Eric T., Samson, Leona D., Price, Brendan D

Journal:

Year:

2019

Language:

english

File:

PDF, 1.13 MB

english, 2019

99

Inflammation-induced DNA damage, mutations and cancer

Kay, Jennifer, Thadhani, Elina, Samson, Leona, Engelward, Bevin

Journal:

Year:

2019

Language:

english

File:

PDF, 1.29 MB

english, 2019

100

Sensitive CometChip assay for screening potentially carcinogenic DNA adducts by trapping DNA repair intermediates

Ngo, Le P, Owiti, Norah A, Swartz, Carol, Winters, John, Su, Yang, Ge, Jing, Xiong, Aoli, Han, Jongyoon, Recio, Leslie, Samson, Leona D, Engelward, Bevin P

Journal:

Nucleic Acids Research

Year:

2019

File:

PDF, 1.35 MB

2019