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51

Immunoglobujin A in Graves’ orbital tissue: Deoxyribonucleic acid amplification by polymerase chain reaction

Sandra M. McLachlan Ph. D.,M. F. Prummel…

Journal:

Journal of Endocrinological Investigation

Year:

1994

Language:

english

File:

PDF, 1.11 MB

english, 1994

52

Prescience of a Surgeon in 1980

McLachlan, Sandra M.

Journal:

Year:

2013

Language:

english

File:

PDF, 44 KB

english, 2013

53

Thyrotropin Receptor Autoantibodies Recognizing Two Different Epitopes on the TSH Receptor: Lack of Relationship to Patient Age, Sex, and Ophthalmopathy

JAUME, JUAN CARLOS, PRUMMEL, MARK F., WIERSINGA, WILMAR M., MCLACHLAN, SANDRA M., RAPOPORT, BASIL

Journal:

Year:

1993

Language:

english

File:

PDF, 697 KB

english, 1993

54

Variable Suppression of Serum Thyroxine in Female Mice of Different Inbred Strains by Triiodothyronine Administered in Drinking Water

Hamidi, Sepehr, Aliesky, Holly, Chen, Chun-Rong, Rapoport, Basil, McLachlan, Sandra M.

Journal:

Year:

2010

Language:

english

File:

PDF, 508 KB

english, 2010

55

Comparison of Recombinant Human Thyrotropin Receptors Versus Porcine Thyrotropin Receptors in the Thyrotropin Binding Inhibition Assay for Thyrotropin Receptor Autoantibodies

KAKINUMA, AYUMU, MORIMOTO, ISAO, KURODA, TAMAKI, FUJIHIRA, TAKASHI, ETO, SUMIYA, McLACHLAN, SANDRA M., RAPOPORT, BASIL

Journal:

Year:

1999

Language:

english

File:

PDF, 870 KB

english, 1999

56

An Attempt to Induce “Graves' Disease of the Gonads” by Immunizing Mice with the Luteinizing Hormone Receptor Provides Insight into Breaking Tolerance to Self-Antigens

Chen, Chun-Rong, Aliesky, Holly A., Rapoport, Basil, McLachlan, Sandra M.

Journal:

Year:

2011

Language:

english

File:

PDF, 399 KB

english, 2011

57

Does the Autoantibody Immunodominant Region on Thyroid Peroxidase Include Amino Acid Residues 742–771?

Xiong, Zhenggang, Farilla, Loredana, Guo, Jin, McLachlan, Sandra, Rapoport, Basil

Journal:

Year:

2001

Language:

english

File:

PDF, 193 KB

english, 2001

58

Insight into Thyroid-Stimulating Autoantibody Interaction with the Thyrotropin Receptor N-Terminus Based on Mutagenesis and Re-Evaluation of Ambiguity in This Region of the Receptor Crystal Structure

Hamidi, Sepehr, Chen, Chun-Rong, McLachlan, Sandra M., Rapoport, Basil

Journal:

Year:

2011

Language:

english

File:

PDF, 550 KB

english, 2011

59

Review and Hypothesis: Does Graves' Disease Develop in Non-Human Great Apes?

McLachlan, Sandra M., Alpi, Kristine, Rapoport, Basil

Journal:

Year:

2011

Language:

english

File:

PDF, 315 KB

english, 2011

60

Reassessment of the Location of the Thyrotropin Receptor 50 Amino Acid "Insertion" Provides Evidence in Favor of a Second Downstream Cleavage Site

Tanaka, Kunihiko, Chazenbalk, Gregorio D., Rapoport, Basil, McLachlan, Sandra M.

Journal:

Year:

2001

Language:

english

File:

PDF, 168 KB

english, 2001

61

Human Monoclonal Autoantibodies to B-Cell Epitopes Outside the Thyroid Peroxidase Autoantibody Immunodominant Region

Pichurin, Pavel, Guo, Jin, Yan, Xinmin, Rapoport, Basil, McLachlan, Sandra M.

Journal:

Year:

2001

Language:

english

File:

PDF, 502 KB

english, 2001

62

Thyrotropin Receptor-DNA Vaccination of Transgenic Mice Expressing HLA-DR3 or HLA-DQ6b

Pichurin, Pavel, Chen, Chun-Rong, Pichurina, Oxana, David, Chella, Rapoport, Basil, McLachlan, Sandra M.

Journal:

Year:

2003

Language:

english

File:

PDF, 401 KB

english, 2003

63

Evidence That the Thyrotropin Receptor Protease is Membrane-Associated and is Not Within Lipid Rafts

Latrofa, Francesco, Chazenbalk, Gregorio D., McLachlan, Sandra M., Rapoport, Basil

Journal:

Year:

2004

Language:

english

File:

PDF, 99 KB

english, 2004

64

A Major Role for Non-Major Histocompatibility Complex Genes But not for Microorganisms in a Novel Murine Model of Graves' Hyperthyroidism

Nagayama, Yuji, McLachlan, Sandra M., Rapoport, Basil, Niwa, Masami

Journal:

Year:

2003

Language:

english

File:

PDF, 187 KB

english, 2003

65

Keeping Our Eyes Open

Rapoport, Basil, McLachlan, Sandra M.

Journal:

Year:

2001

Language:

english

File:

PDF, 61 KB

english, 2001

66

HLA-DR3 Transgenic Mice Immunized with Adenovirus Encoding the Thyrotropin Receptor: T Cell Epitopes and Functional Analysis of the CD40 Graves' Polymorphism

Pichurin, Pavel, Pham, Nancy, David, Chella S., Rapoport, Basil, McLachlan, Sandra M.

Journal:

Year:

2006

Language:

english

File:

PDF, 355 KB

english, 2006

67

Genetic Linkages for Thyroxine Released in Response to Thyrotropin Stimulation in Three Sets of Recombinant Inbred Mice Provide Evidence for Shared and Novel Genes Controlling Thyroid Function

Hamidi, Sepehr, Aliesky, Holly A., Williams, Robert W., Rapoport, Basil, McLachlan, Sandra M.

Journal:

Year:

2013

Language:

english

File:

PDF, 604 KB

english, 2013

68

The Greater Glycan Content of Recombinant Human Thyroid Peroxidase of Mammalian Than of Insect Cell Origin Facilitates Purification to Homogeneity of Enzymatically Protein Remaining Soluble at High Concentration 1

Guo, Jin, McLachlan, Sandra M., Hutchison, Scott, Rapoport, Basil

Journal:

Year:

1998

Language:

english

File:

PDF, 266 KB

english, 1998

69

Peptide Scanning for Thyrotropin Receptor T-Cell Epitopes in Mice Vaccinated with Naked DNA

Pichurin, Pavel, Schwarz-Lauer, Lise, Braley-Mullen, Helen, Paras, Charmaine, Pichurina, Oxana, Morris, John C., Rapoport, Basil, McLachlan, Sandra M.

Journal:

Year:

2002

Language:

english

File:

PDF, 440 KB

english, 2002

70

Evidence for a Potential Common T-Cell Epitope Between Human Thyroid Peroxidase and Human Thyroglobulin with Implications for the Pathogenesis of Autoimmune Thyroid Disease

Mclachlan, Sandra Melissa, Rapoport, Basil

Journal:

Year:

1989

Language:

english

File:

PDF, 421 KB

english, 1989

71

Gene Expression Profiles Differ Markedly in Mouse Strains That Are (or Are Not) Susceptible to Hyperthyroidism Induced Using Thyrotropin Receptor-Expressing Adenovirus

Chen, Chun-Rong, Abbud, Rula, Wang, Charles, Tan, Yongxi, Rapoport, Basil, McLachlan, Sandra M.

Journal:

Year:

2005

Language:

english

File:

PDF, 142 KB

english, 2005

72

Evidence that the Complement Control Protein-Epidermal Growth Factor-Like Domain of Thyroid Peroxidase Lies on the Fringe of the Immunodominant Region Recognized by Autoantibodies

Pichurin, Pavel N., Guo, Jin, Estienne, Valerie, Carayon, Pierre, Ruf, Jean, Rapoport, Basil, McLachlan, Sandra M.

Journal:

Year:

2002

Language:

english

File:

PDF, 323 KB

english, 2002

73

Blockade of Costimulation Between T Cells and Antigen-Presenting Cells: An Approach to Suppress Murine Graves' Disease Induced Using Thyrotropin Receptor-Expressing Adenovirus

Chen, Chun-Rong, Aliesky, Holly A., Guo, Jin, Rapoport, Basil, McLachlan, Sandra M.

Journal:

Year:

2006

Language:

english

File:

PDF, 1.31 MB

english, 2006

74

Graves' Disease: The T H 1/T H 2 Paradigm versus the "Hygiene" Hypothesis and Defective Immune Regulation

McLachlan, Sandra M., Rapoport, Basil

Journal:

Year:

2003

Language:

english

File:

PDF, 63 KB

english, 2003

75

Role of Self-Tolerance and Chronic Stimulation in the Long-Term Persistence of Adenovirus-Induced Thyrotropin Receptor Antibodies in Wild-Type and Transgenic Mice

McLachlan, Sandra M., Aliesky, Holly A., Chen, Chun-Rong, Rapoport, Basil

Journal:

Year:

2012

Language:

english

File:

PDF, 302 KB

english, 2012

76

Endocrine Ophthalmopathy: A Re-Evaluation of the Association with Thyroid Autoantibodies

McLachlan, Sandra M., Bahn, Rebecca, Rapoport, Basil

Journal:

Year:

1992

Language:

english

File:

PDF, 545 KB

english, 1992

77

Elephantiasic Pretibial Myxedema: Insight into and a Hypothesis Regarding the Pathogenesis of the Extrathyroidal Manifestations of Graves' Disease

Rapoport, Basil, Alsabeh, Randa, Aftergood, David, McLachlan, Sandra M.

Journal:

Year:

2000

Language:

english

File:

PDF, 1.98 MB

english, 2000

78

Carbimazole and the Autoimmune Response in Graves' Disease

McGregor, Alan M., Petersen, Meryl M., McLachlan, Sandra M., Rooke, Patricia, Smith, Bernard Rees, Hall, Reginald

Journal:

Boston Medical and Surgical Journal

Year:

1980

Language:

english

File:

PDF, 842 KB

english, 1980

79

Whither TSH Receptor Blocking Antibodies in the Treatment of Graves' Disease?

Rapoport, Basil, McLachlan, Sandra M.

Journal:

Year:

2008

Language:

english

File:

PDF, 49 KB

english, 2008

80

Thyroid Antigens, Not Central Tolerance, Control Responses to Immunization in BALB/c Versus C57BL/6 Mice

Misharin, Alexander V., Rapoport, Basil, McLachlan, Sandra M.

Journal:

Year:

2009

Language:

english

File:

PDF, 10.90 MB

english, 2009

81

The Thyrotropin Receptor in Graves' Disease

Rapoport, Basil, McLachlan, Sandra M.

Journal:

Year:

2007

Language:

english

File:

PDF, 19.25 MB

english, 2007

82

Crystal Structure of a TSH Receptor Monoclonal Antibody: Insight Into Graves' Disease Pathogenesis

Chen, Chun-Rong, Hubbard, Paul A., Salazar, Larry M., McLachlan, Sandra M., Murali, Ramachandran, Rapoport, Basil

Journal:

Molecular Endocrinology

Year:

2015

Language:

english

File:

PDF, 1.49 MB

english, 2015

83

Vitamin D Deficiency Modulates Graves’ Hyperthyroidism Induced in BALB/c Mice by Thyrotropin Receptor Immunization

Misharin, Alexander, Hewison, Martin, Chen, Chun-Rong, Lagishetty, Venu, Aliesky, Holly A., Mizutori, Yumiko, Rapoport, Basil, McLachlan, Sandra M.

Journal:

Year:

2009

Language:

english

File:

PDF, 230 KB

english, 2009

84

Lack of Female Bias in a Mouse Model of Autoimmune Hyperthyroidisim (Graves' Disease)

Jaume, Juan Carlos, Rapoport, Basil, McLachlan, Sandra M.

Journal:

Year:

1999

Language:

english

File:

PDF, 276 KB

english, 1999

85

The Thyrotropin Receptor Hinge Region as a Surrogate Ligand: Identification of Loci Contributing to the Coupling of Thyrotropin Binding and Receptor Activation

Chen, Chun-Rong, Salazar, Larry M., McLachlan, Sandra M., Rapoport, Basil

Journal:

Year:

2012

Language:

english

File:

PDF, 1.23 MB

english, 2012

86

Grazing livestock are exposed to terrestrial cyanobacteria

McGorum, Bruce C, Pirie, R, Glendinning, Laura, McLachlan, Gerry, Metcalf, James S, Banack, Sandra A, Cox, Paul A, Codd, Geoffrey A

Journal:

Veterinary Research

Year:

2015

Language:

english

File:

PDF, 916 KB

english, 2015

87

Recombinant Thyroid Peroxidase-Specific Fab Converted to Immunoglobulin G (IgG) Molecules: Evidence for Thyroid Cell Damage by IgG1, but Not IgG4, Autoantibodies 1

Guo, Jin, Jaume, Juan Carlos, Rapoport, Basil, McLachlan, Sandra M.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

1997

Language:

english

File:

PDF, 438 KB

english, 1997

88

The Thyrotropin (TSH)-Releasing Hormone Receptor: Interaction with TSH and Autoantibodies 1

Rapoport, Basil, Chazenbalk, Gregorio D., Jaume, Juan Carlos, McLachlan, Sandra M.

Journal:

Endocrine Reviews

Year:

1998

Language:

english

File:

PDF, 1.15 MB

english, 1998

89

Cellular Thyroid Peroxidase (TPO), Unlike Purified TPO and Adjuvant, Induces Antibodies in Mice That Resemble Autoantibodies in Human Autoimmune Thyroid Disease 1

Jaume, Juan Carlos, Guo, Jin, Wang, Yan, Rapoport, Basil, McLachlan, Sandra M.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

1999

Language:

english

File:

PDF, 203 KB

english, 1999

90

A Monoclonal Antibody with Thyrotropin (TSH) Receptor Inverse Agonist and TSH Antagonist Activities Binds to the Receptor Hinge Region as Well as to the Leucine-Rich Domain

Chen, Chun-Rong, McLachlan, Sandra M., Rapoport, Basil

Journal:

Year:

2009

Language:

english

File:

PDF, 422 KB

english, 2009

91

Autoantibodies to the Thyrotropin Receptor

SMITH, BERNARD REES, McLACHLAN, SANDRA MELISSA, FURMANIAK, JADWIGA

Journal:

Endocrine Reviews

Year:

1988

Language:

english

File:

PDF, 2.25 MB

english, 1988

92

Evidence for Genetic Transmission of Thyroid Peroxidase Autoantibody Epitopic “Fingerprints” 1

Jaume, Juan Carlos, Guo, Jin, Pauls, David L., Zakarija, Margita, McKenzie, J. Maxwell, Egeland, Janice A., Burek, C. Lynne, Rose, Noel R., Hoffman, William H., Rapoport, Basil, McLachlan, Sandra M.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

1999

Language:

english

File:

PDF, 204 KB

english, 1999

93

Graves’ Hyperthyroidism and the Hygiene Hypothesis in a Mouse Model

Nagayama, Yuji, McLachlan, Sandra M., Rapoport, Basil, Oishi, Kazunori

Journal:

Year:

2004

Language:

english

File:

PDF, 204 KB

english, 2004

94

Evidence that TSH Receptor A-Subunit Multimers, Not Monomers, Drive Antibody Affinity Maturation in Graves' Disease

Rapoport, Basil, Aliesky, Holly A., Chen, Chun-Rong, McLachlan, Sandra M.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2015

Language:

english

File:

PDF, 776 KB

english, 2015

95

Autosomal Dominant Inheritance of Autoantibodies to Thyroid Peroxidase and Thyroglobulin—Studies in Families Not Selected for Autoimmune Thyroid Disease*

PHILLIPS, DAVID, PRENTICE, LOUISE, UPADHYAYA, MEENA, LUNT, PETER, CHAMBERLAIN, SUSAN, ROBERTS, DEREK F., McLACHLAN, SANDRA, SMITH, BERNARD REES

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

1991

Language:

english

File:

PDF, 314 KB

english, 1991

96

Autosomal Dominant Transmission of Autoantibodies to Thyroglobulin and Thyroid Peroxidase*

PHILLIPS, DAVID, McLACHLAN, SANDRA, STEPHENSON, ANTHEA, ROBERTS, DEREK, MOFFITT, SANDRA, McDONALD, DOROTHY, AD'HIAH, ALI, STRATTON, ANN, YOUNG, ERIC, CLARK, FREDERICK, BEEVER, KAREN, BRADBURY, KAREN,

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

1990

Language:

english

File:

PDF, 633 KB

english, 1990

97

Thyroglobulin-Thyroperoxidase Autoantibodies Are Polyreactive, Not Bispecific: Analysis Using Human Monoclonal Autoantibodies

Latrofa, Francesco, Pichurin, Pavel, Guo, Jin, Rapoport, Basil, McLachlan, Sandra M.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2003

Language:

english

File:

PDF, 162 KB

english, 2003

98

Evidence That the Thyrotropin Receptor Ectodomain Contains Not One, But Two, Cleavage Sites 1

Chazenbalk, Gregorio D., Tanaka, Kunihiko, Nagayama, Yuji, Kakinuma, Ayumu, Jaume, Juan Carlos, McLachlan, Sandra M., Rapoport, Basil

Journal:

Year:

1997

Language:

english

File:

PDF, 3.80 MB

english, 1997

99

Deleting the Redundant TSH Receptor C-Peptide Region Permits Generation of the Conformationally Intact Extracellular Domain by Insect Cells

Chen, Chun-Rong, Salazar, Larry M., McLachlan, Sandra M., Rapoport, Basil

Journal:

Year:

2015

Language:

english

File:

PDF, 748 KB

english, 2015

100

Immunoglobulin Heavy Chain Variable Region and Major Histocompatibility Region Genes Are Linked to Induced Graves' Disease in Females From Two Very Large Families of Recombinant Inbred Mice

McLachlan, Sandra M., Aliesky, Holly, Banuelos, Bianca, Magana, Jessica, Williams, Robert W., Rapoport, Basil

Journal:

Year:

2014

Language:

english

File:

PDF, 989 KB

english, 2014