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51

Clinical manifestation of hemophilia A in the absence of mutations in the F8 gene that encodes FVIII: role of microRNAs

Jankowska, Katarzyna I., McGill, Joseph, Pezeshkpoor, Behnaz, Oldenburg, Johannes, Atreya, Chintamani D., Sauna, Zuben E.

Journal:

Transfusion (Wiley)

Year:

2019

File:

PDF, 6.89 MB

2019

52

Catalytic Cycle of ATP Hydrolysis by P-Glycoprotein: Evidence for Formation of the E·S Reaction Intermediate with ATP-γ-S, a Nonhydrolyzable Analogue of ATP †

Sauna, Zuben E., Kim, In-Wha, Nandigama, Krishnamachary, Kopp, Stephan, Chiba, Peter, Ambudkar, Suresh V.

Journal:

Year:

2007

Language:

english

File:

PDF, 515 KB

english, 2007

53

Type C Botulism Due to Toxic Feed Affecting 52,000 Farmed Foxes and Minks in Finland

Lindstrom, M., Nevas, M., Kurki, J., Sauna-aho, R., Latvala-Kiesila, A., Polonen, I., Korkeala, H.

Journal:

Journal of Clinical Microbiology

Year:

2004

Language:

english

File:

PDF, 233 KB

english, 2004

54

Further Evidence That MicroRNAs Can Play a Role in Hemophilia A Disease Manifestation: F8 Gene Downregulation by miR-19b-3p and miR-186-5p

Jankowska, Katarzyna I., McGill, Joseph, Pezeshkpoor, Behnaz, Oldenburg, Johannes, Sauna, Zuben E., Atreya, Chintamani D.

Journal:

Frontiers in Cell and Developmental Biology

Year:

2020

File:

PDF, 2.05 MB

2020

55

A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity

Kimchi-Sarfaty, C., Oh, J. M., Kim, I.-W., Sauna, Z. E., Calcagno, A. M., Ambudkar, S. V., Gottesman, M. M.

Journal:

Year:

2007

Language:

english

File:

PDF, 509 KB

english, 2007

56

Cyclosporin A Impairs the Secretion and Activity of ADAMTS13 (A Disintegrin and Metalloprotease with Thrombospondin Type 1 Repeat)

Hershko, Klilah, Simhadri, Vijaya L., Blaisdell, Adam, Hunt, Ryan C., Newell, Jordan, Tseng, Sandra C., Hershko, Alon Y., Choi, Jae Won, Sauna, Zuben E., Wu, Andrew, Bram, Richard J., Komar, Anton A.,

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 2.61 MB

english, 2012

57

Wooden blocks and straw as environmental enrichments for juvenile blue foxes (Alopex lagopus)

H. Korhonen, L. Jauhiainen, P. Niemelä, R. Sauna-aho

Journal:

Acta ethologica

Year:

2002

Language:

english

File:

PDF, 116 KB

english, 2002

58

About a switch: how P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work

Sauna, Z. E., Ambudkar, S. V.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 283 KB

english, 2007

59

Detection of intracellular ADAMTS13, a secreted zinc-metalloprotease, via flow cytometry

S. Geetha, Courtni E. Allen, Ryan C. Hunt, Elizabeth Plum, Susan Garfield, Scott L. Friedman, Kenji Soejima, Zuben E. Sauna, Chava Kimchi-Sarfaty

Journal:

Cytometry Part A

Year:

2009

Language:

english

File:

PDF, 1.09 MB

english, 2009

60

The Mechanism of Action of Multidrug-Resistance-Linked P-Glycoprotein

Zuben E. Sauna, Melissa M. Smith, Marianna Müller, Kathleen M. Kerr, Suresh V. Ambudkar

Journal:

Journal of Bioenergetics and Biomembranes

Year:

2001

Language:

english

File:

PDF, 372 KB

english, 2001

61

Volume regulation of spermatozoa by quinine-sensitive channels

Satish B. Kulkarni, Zuben E. Sauna, V. Somlata, V. Sitaramam

Journal:

Molecular Reproduction and Development

Year:

1997

Language:

english

File:

PDF, 255 KB

english, 1997

62

Plasma derivatives: New products and new approaches

Zuben E. Sauna, Gouri Shankar Pandey, Nisha Jain, Ifthekar Mahmood, Chava Kimchi-Sarfaty, Basil Golding

Journal:

Year:

2012

Language:

english

File:

PDF, 342 KB

english, 2012

63

The Molecular Basis of the Action of Disulfiram as a Modulator of the Multidrug Resistance-Linked ATP Binding Cassette Transporters MDR1 (ABCB1) and MRP1 (ABCC1)

Journal:

Molecular Pharmacology

Year:

2004

Language:

english

File:

PDF, 392 KB

english, 2004

64

Functionally Similar Vanadate-induced 8-Azidoadenosine 5'-[ -32P]Diphosphate-trapped Transition State Intermediates of Human P-glycoprotein Are Generated in the Absence and Presence of ATP Hydrolysis

Sauna, Z. E., Smith, M. M., Muller, M., Ambudkar, S. V.

Journal:

Journal of Biological Chemistry

Year:

2001

Language:

english

File:

PDF, 731 KB

english, 2001

65

Exploiting Reaction Intermediates of the ATPase Reaction to Elucidate the Mechanism of Transport by P-glycoprotein (ABCB1)

Journal:

Journal of Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 865 KB

english, 2006

66

Hepatitis a among men who have sex with men in Barcelona, 1989-2010: insufficient control and need for new approaches

Cecilia Tortajada, Patricia G de Olalla, Elia Diez, Rosa M Pinto, Albert Bosch, Unai Perez, Milagros Sanz, Joan A Caylà, Saunas Working Group

Journal:

BMC Infectious Diseases

Year:

2012

Language:

english

File:

PDF, 132 KB

english, 2012

67

A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1)

Suresh V. Ambudkar, Zuben E. Sauna, Michael M. Gottesman, Gergely Szakacs

Journal:

Trends in Pharmacological Sciences

Year:

2005

Language:

english

File:

PDF, 1.36 MB

english, 2005

68

Pharmacogenetics and the Immunogenicity of Protein Therapeutics

Pandey, Gouri S., Sauna, Zuben E.

Journal:

Journal of Interferon & Cytokine Research

Year:

2014

Language:

english

File:

PDF, 224 KB

english, 2014

69

The sounds of silence: synonymous mutations affect function

Sauna, Zuben E, Kimchi-Sarfaty, Chava, Ambudkar, Suresh V, Gottesman, Michael M

Journal:

Pharmacogenomics

Year:

2007

Language:

english

File:

PDF, 510 KB

english, 2007

70

Immunogenicity assessment during the development of protein therapeutics

Rosenberg, Amy S., Sauna, Zuben E.

Journal:

Journal of Pharmacy and Pharmacology

Year:

2017

Language:

english

File:

PDF, 333 KB

english, 2017

71

Complete Inhibition of the Pdr5p Multidrug Efflux Pump ATPase Activity by Its Transport Substrate Clotrimazole Suggests that GTP as Well as ATP May Be Used as an Energy Source †

Golin, John, Kon, Zachary N., Wu, Chung-Pu, Martello, Justin, Hanson, Leanne, Supernavage, Sherry, Ambudkar, Suresh V., Sauna, Zuben E.

Journal:

Year:

2007

Language:

english

File:

PDF, 292 KB

english, 2007

72

SAE Technical Paper Series [SAE International 2001 Internal Combustion Engines - (SEP. 23, 2001)] SAE Technical Paper Series - Estimation of fuel consumption and pollutant emissions of road vehicles by computer simulation and their validation by field measurements

Koskinen, Olavi H., Sauna-aho, Jussi

Year:

2001

Language:

english

File:

PDF, 700 KB

english, 2001

73

Characterization of the Catalytic Cycle of ATP Hydrolysis by Human P-glycoprotein. THE TWO ATP HYDROLYSIS EVENTS IN A SINGLE CATALYTIC CYCLE ARE KINETICALLY SIMILAR BUT AFFECT DIFFERENT FUNCTIONAL OUTCOMES

Sauna, Z. E., Ambudkar, S. V.

Journal:

Journal of Biological Chemistry

Year:

2001

Language:

english

File:

PDF, 785 KB

english, 2001

74

Genetic determinants of immunogenicity to factor IX during the treatment of haemophilia B

Saini, S., Hamasaki-Katagiri, N., Pandey, G. S., Yanover, C., Guelcher, C., Simhadri, V. L., Dandekar, S., Guerrera, M. F., Kimchi-Sarfaty, C., Sauna, Z. E.

Journal:

Year:

2015

Language:

english

File:

PDF, 408 KB

english, 2015

75

Mutations Define Cross-talk between the N-terminal Nucleotide-binding Domain and Transmembrane Helix-2 of the Yeast Multidrug Transporter Pdr5: POSSIBLE CONSERVATION OF A SIGNALING INTERFACE FOR COUPLING ATP HYDROLYSIS TO DRUG TRANSPORT

Sauna, Z. E., Bohn, S. S., Rutledge, R., Dougherty, M. P., Cronin, S., May, L., Xia, D., Ambudkar, S. V., Golin, J.

Journal:

Journal of Biological Chemistry

Year:

2008

Language:

english

File:

PDF, 1.19 MB

english, 2008

76

Correlation between Steady-state ATP Hydrolysis and Vanadate-induced ADP Trapping in Human P-glycoprotein: EVIDENCE FOR ADP RELEASE AS THE RATE-LIMITING STEP IN THE CATALYTIC CYCLE AND ITS MODULATION BY SUBSTRATES

Kerr, K. M., Sauna, Z. E., Ambudkar, S. V.

Journal:

Journal of Biological Chemistry

Year:

2001

Language:

english

File:

PDF, 623 KB

english, 2001

77

Large scale analysis of the mutational landscape in HT-SELEX improves aptamer discovery

Hoinka, Jan, Berezhnoy, Alexey, Dao, Phuong, Sauna, Zuben E., Gilboa, Eli, Przytycka, Teresa M.

Journal:

Nucleic Acids Research

Year:

2015

Language:

english

File:

PDF, 2.02 MB

english, 2015

78

Small ncRNA Expression-Profiling of Blood from Hemophilia A Patients Identifies miR-1246 as a Potential Regulator of Factor 8 Gene

Sarachana, Tewarit, Dahiya, Neetu, Simhadri, Vijaya L., Pandey, Gouri Shankar, Saini, Surbhi, Guelcher, Christine, Guerrera, Michael F., Kimchi-Sarfaty, Chava, Sauna, Zuben E., Atreya, Chintamani D.,

Journal:

Year:

2015

Language:

english

File:

PDF, 739 KB

english, 2015

79

Combined Effect of Fly-Ash and Ferrochrome Ash as Partial Replacement of Cement on Mechanical Properties of Concrete

Mohanty, Tribikram, Majhi, Sauna, Saha, Purnachandra, Das, Bitanjaya, Wang, Y.

Journal:

E3S Web of Conferences

Year:

2019

File:

PDF, 465 KB

2019

80

The Signaling Interface of the Yeast Multidrug Transporter Pdr5 Adopts a Cis Conformation, and There Are Functional Overlap and Equivalence of the Deviant and Canonical Q-Loop Residues

Ananthaswamy, Neeti, Rutledge, Robert, Sauna, Zuben E., Ambudkar, Suresh V., Dine, Elliot, Nelson, Emily, Xia, Di, Golin, John

Journal:

Year:

2010

Language:

english

File:

PDF, 4.75 MB

english, 2010

81

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

Sauna, Z. E., Ambudkar, S. V.

Journal:

Proceedings of the National Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 182 KB

english, 2000

82

Congenital Portosystemic Shunt: Our Experience

Timpanaro, Tiziana, Passanisi, Stefano, Sauna, Alessandra, Trombatore, Claudia, Pennisi, Monica, Petrillo, Giuseppe, Smilari, Pierluigi, Greco, Filippo

Journal:

Case Reports in Pediatrics

Year:

2015

Language:

english

File:

PDF, 1.51 MB

english, 2015

83

UltraâConserved Elements and morphology reciprocally illuminate conflicting phylogenetic hypotheses in Chalcididae (Hymenoptera, Chalcidoidea)

Cruaud, Astrid, Delvare, GÃ©rard, Nidelet, Sabine, SaunÃ©, Laure, Ratnasingham, Sujeevan, Chartois, Marguerite, Blaimer, Bonnie B., Gates, Michael, Brady, SeÃ¡n G., Faure, Sariana, Noort, Simon, Rossi

Journal:

Year:

2020

File:

PDF, 4.18 MB

2020

84

Ageing and cognition in men with fragile X syndrome

Sauna-aho, Oili, Bjelogrlic-Laakso, Nina, Rautava, PÃ¤ivi, Arvio, Maria

Journal:

Journal of Applied Research in Intellectual Disabilities

Year:

2020

File:

PDF, 405 KB

2020

85

The power of the pump: Mechanisms of action of P-glycoprotein (ABCB1)

Suresh V. Ambudkar, In-Wha Kim, Zuben E. Sauna

Journal:

European Journal of Pharmaceutical Sciences

Year:

2006

Language:

english

File:

PDF, 372 KB

english, 2006

86

Evidence for the Vectorial Nature of Drug (Substrate)-stimulated ATP Hydrolysis by Human P-glycoprotein

Sauna, Z. E., Smith, M. M., Muller, M., Ambudkar, S. V.

Journal:

Journal of Biological Chemistry

Year:

2001

Language:

english

File:

PDF, 612 KB

english, 2001

87

Relationship Between Lineprotein Profile and Urinary Albumin Excretion in Type II Diabetic Patients With Stable Metabolic Control

Reverter, J. L., Pizarro, E., Senti, M., Pedro-Botet, J., Rubies-Prat, J., Romero, R., Lucas, A., Sanmarti, A., Saunas, I.

Journal:

Year:

1994

Language:

english

File:

PDF, 718 KB

english, 1994

88

Previously Unreported COL7A1 Mutation in a Somali Patient with Dystrophic Epidermolysis Bullosa

Venti, Valeria, Scalia, Bruna, Sauna, Alessandra, Nasca, Maria Rita, Smilari, Pierluigi, Praticò, Andrea D., Fiumara, Agata, Pappalardo, Xena G., Pavone, Piero

Journal:

Molecular Syndromology

Year:

2019

File:

PDF, 926 KB

2019

89

SampPick: Selection of a Cohort of Subjects Matching a Population HLA Distribution

McGill, Joseph R., Yogurtcu, Osman N., Verthelyi, Daniela, Yang, Hong, Sauna, Zuben E.

Journal:

Frontiers in Immunology

Year:

2019

File:

PDF, 3.22 MB

2019

90

Aptamers as a Sensitive Tool to Detect Subtle Modifications in Therapeutic Proteins

Zichel, Ran, Chearwae, Wanida, Pandey, Gouri Shankar, Golding, Basil, Sauna, Zuben E., Rossi, John J.

Journal:

Year:

2012

Language:

english

File:

PDF, 918 KB

english, 2012

91

RuvBL2 Is Involved in Histone Deacetylase Inhibitor PCI-24781-Induced Cell Death in SK-N-DZ Neuroblastoma Cells

Zhan, Qinglei, Tsai, Sauna, Lu, Yonghai, Wang, Chunmei, Kwan, Yiuwa, Ngai, Saiming, Bishopric, Nanette H.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.94 MB

english, 2013

92

Observations regarding the immunogenicity of BDD-rFVIII derived from a mechanistic personalized medicine perspective

Z. E. SAUNA, A. AMERI, B. KIM, C. YANOVER, K. R. VIEL, R. RAJALINGAM, S. A. COLE, T. E. HOWARD

Journal:

Journal of Thrombosis and Haemostasis

Year:

2012

Language:

english

File:

PDF, 455 KB

english, 2012

93

Silent Polymorphisms Speak: How They Affect Pharmacogenomics and the Treatment of Cancer

Sauna, Z. E., Kimchi-Sarfaty, C., Ambudkar, S. V., Gottesman, M. M.

Journal:

Cancer Research

Year:

2007

Language:

english

File:

PDF, 352 KB

english, 2007

94

Polymorphisms in the F8 Gene and MHC-II Variants as Risk Factors for the Development of Inhibitory Anti-Factor VIII Antibodies during the Treatment of Hemophilia A: A Computational Assessment

Pandey, Gouri Shankar, Yanover, Chen, Howard, Tom E., Sauna, Zuben E., Nielsen, Morten

Journal:

PLoS Computational Biology

Year:

2013

Language:

english

File:

PDF, 1.27 MB

english, 2013

95

[Topics in Medicinal Chemistry] Protein Therapeutics Volume 21 || Immunogenicity Lessons Learned from the Clinical Development of Vatreptacog Alfa, A Recombinant Activated Factor VII Analog, in Hemophilia with Inhibitors

Sauna, Zuben E., Kimchi-Sarfaty, Chava

Year:

2017

Language:

english

File:

PDF, 900 KB

english, 2017

96

Solvent interconnectedness permits measurement of proximal as well as distant phase transitions in polymer mixtures by fluorescence

C.N. Madhavarao, Z.E. Sauna, V. Sitaramam

Journal:

Biophysical Chemistry

Year:

2001

Language:

english

File:

PDF, 144 KB

english, 2001

97

Retrieving geomagnetic secular variations from lava flows: evidence from Mounts Arso, Etna and Vesuvius (southern Italy)

Alberto Incoronato, Antimo Angelino, Romolo Romano, Agostino Ferrante, Renata Sauna, Gianpio Vanacore, Claudio Vecchione

Journal:

Geophysical Journal International

Year:

2002

Language:

english

File:

PDF, 110 KB

english, 2002

98

Biochemical Basis of Polyvalency as a Strategy for Enhancing the Efficacy of P-Glycoprotein (ABCB1) Modulators: Stipiamide Homodimers Separated with Defined-Length Spacers Reverse Drug Efflux with Greater Efficacy

Sauna, Zuben E., Andrus, Merritt B., Turner, Timothy M., Ambudkar, Suresh V.

Journal:

Year:

2004

Language:

english

File:

PDF, 358 KB

english, 2004

99

Recent advances in (therapeutic protein) drug development

Lagassé, H.A. Daniel, Alexaki, Aikaterini, Simhadri, Vijaya L., Katagiri, Nobuko H., Jankowski, Wojciech, Sauna, Zuben E., Kimchi-Sarfaty, Chava

Journal:

Year:

2017

Language:

english

File:

PDF, 1.54 MB

english, 2017

100

A Foundational Study for Normal F8-Containing Mouse Models for the miRNA Regulation of Hemophilia A: Identification and Analysis of Mouse miRNAs that Downregulate the Murine F8 Gene

Jankowska, Katarzyna I., Chattopadhyay, Maitreyi, Sauna, Zuben E., Atreya, Chintamani D.

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 1.89 MB

2020

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