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51

Geldanamycins exquisitely inhibit HGF/SF-mediated tumor cell invasion

Hay, Rick, Gustafson, Margaret, Shen, Yuehai, Wenkert, David, Woude, George F Vande, Xie, Qian, Gao, Chong-Feng, Shinomiya, Nariyoshi, Sausville, Edward

Journal:

Year:

2005

Language:

english

File:

PDF, 507 KB

english, 2005

52

Preclinical Modeling of Combination Treatments: Fantasy or Requirement?

SHANNON DECKER, EDWARD A. SAUSVILLE

Journal:

Annals of the New York Academy of Sciences

Year:

2005

Language:

english

File:

PDF, 84 KB

english, 2005

53

UCN-01 Enhances the In Vitro Toxicity of Clinical Agents in Human Tumor Cell Lines

Anne Monks, Erik D. Harris, Anne Vaigro-Wolff, Curtis D. Hose, John W. Connelly, Edward A. Sausville

Journal:

Investigational New Drugs

Year:

2000

Language:

english

File:

PDF, 202 KB

english, 2000

54

The Challenge of Pathway and Environment-mediated Drug Resistance

Edward A. Sausville

Journal:

Cancer and Metastasis Reviews

Year:

2001

Language:

english

File:

PDF, 62 KB

english, 2001

55

Antitumor Benzothiazoles. 8.1 Synthesis, Metabolic Formation, and Biological Properties of the C- and N-Oxidation Products of Antitumor 2-(4-Aminophenyl)benzothiazoles∇

Kashiyama, Eiji, Hutchinson, Ian, Chua, Mei-Sze, Stinson, Sherman F., Phillips, Lawrence R., Kaur, Gurmeet, Sausville, Edward A., Bradshaw, Tracey D., Westwell, Andrew D., Stevens, Malcolm F. G.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 195 KB

english, 1999

56

Clinical pharmacology of UCN-01: Initial observations and comparison to preclinical models

Sausville, Edward A., Lush, Richard D., Headlee, Donna, Smith, Adaline C., Figg, William D., Arbuck, Susan G., Senderowicz, Adrian M., Fuse, Eiichi, Tanii, Hiromi, Kuwabara, Takashi

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1998

Language:

english

File:

PDF, 1.90 MB

english, 1998

57

The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor

Akrit Sodhi, Risa Chaisuparat, Jiadi Hu, Amanda K. Ramsdell, Brendan D. Manning, Edward A. Sausville, Earl T. Sawai, Alfredo Molinolo, J. Silvio Gutkind, Silvia Montaner

Journal:

Year:

2006

Language:

english

File:

PDF, 940 KB

english, 2006

58

Cytotoxicity and apoptosis of benzoquinones: redox cycling, cytochrome c release, and BAD protein expression

Gabriela Tudor, Peter Gutierrez, Angelica Aguilera-Gutierrez, Edward A Sausville

Journal:

Biochemical Pharmacology

Year:

2003

Language:

english

File:

PDF, 475 KB

english, 2003

59

Different early effects of tyrphostin AG957 and geldanamycins on mitogen-activated protein kinase and p120cbl phosphorylation in anti CD-3-stimulated T-lymphoblasts

Michael D. Losiewicz, Gurmeet Kaur, Edward A. Sausville

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 563 KB

english, 1999

60

Cyclin-Dependent Kinases: Initial Approaches to Exploit a Novel Therapeutic Target

Edward A. Sausville, Daniel Zaharevitz, Robert Gussio, Laurent Meijer, Maryse Louarn-Leost, Conrad Kunick, Robert Schultz, Tyler Lahusen, Donna Headlee, Sherman Stinson, Susan G. Arbuck, Adrian Sender

Journal:

Pharmacology & Therapeutics

Year:

1999

Language:

english

File:

PDF, 392 KB

english, 1999

61

Scientific summation and future goals

Journal:

Journal of Controlled Release

Year:

2001

Language:

english

File:

PDF, 179 KB

english, 2001

62

UCN-01 induces cytotoxicity toward human CLL cells through a p53-independent mechanism

John C Byrd, Charlotte Shinn, Carl R Willis, Ian W Flinn, Theresa Lehman, Edward Sausville, David Lucas, Michael R Grever

Journal:

Experimental Hematology

Year:

2001

Language:

english

File:

PDF, 100 KB

english, 2001

63

Salmonella Infection of a Penile Prosthesis

Justin Sausville, Gopal Gupta, Graeme Forrest, Toby Chai

Journal:

The Journal of Sexual Medicine

Year:

2009

Language:

english

File:

PDF, 109 KB

english, 2009

64

Penile Prosthesis Implantation Compares Favorably in Malpractice Outcomes to Other Common Urological Procedures: Findings from a Malpractice Insurance Database

Juddson Chason, Justin Sausville, Andrew C. Kramer

Journal:

The Journal of Sexual Medicine

Year:

2009

Language:

english

File:

PDF, 146 KB

english, 2009

65

Selective Effects of Mastoparan Analogs: Separation of G-Protein-Directed and Membrane-Perturbing Activities

M. Danilenko, P. Worland, B. Carlson, E.A. Sausville, Y. Sharoni

Journal:

Biochemical and Biophysical Research Communications

Year:

1993

File:

PDF, 390 KB

1993

66

Potent Inhibition of Cdc2 Kinase Activity by the Flavonoid L86-8275

M.D. Losiewicz, B.A. Carlson, G. Kaur, E.A. Sausville, P.J. Worland

Journal:

Biochemical and Biophysical Research Communications

Year:

1994

File:

PDF, 374 KB

1994

67

Selective Accumulation of the Endoplasmic Reticulum–Golgi Intermediate Compartment Induced by the Antitumor Drug KRN5500

Masaru Kamishohara, Susan Kenney, Renee Domergue, David T. Vistica, Edward A. Sausville

Journal:

Experimental Cell Research

Year:

2000

Language:

english

File:

PDF, 598 KB

english, 2000

68

Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells: Correlation with decreased H1 kinase activity

Peter J. Worland, Gurmeet Kaur, Maryalice Stetler-Stevenson, Sandra Sebers, Oliver Sartor, Edward A. Sausville

Journal:

Biochemical Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.02 MB

english, 1993

69

Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity

James C Burnett, James J Schmidt, Robert G Stafford, Rekha G Panchal, Tam L Nguyen, Ann R Hermone, Jonathan L Vennerstrom, Connor F McGrath, Douglas J Lane, Edward A Sausville, Daniel W Zaharevitz, Ri

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 383 KB

english, 2003

70

The hollow fibre model in cancer drug screening: the NCI experience

S. Decker, M. Hollingshead, C.A. Bonomi, J.P. Carter, E.A. Sausville

Journal:

European Journal of Cancer

Year:

2004

Language:

english

File:

PDF, 169 KB

english, 2004

71

A potential role for imaging technology in anticancer efficacy evaluations

M.G. Hollingshead, C.A. Bonomi, S.D. Borgel, J.P. Carter, R. Shoemaker, G. Melillo, E.A. Sausville

Journal:

European Journal of Cancer

Year:

2004

Language:

english

File:

PDF, 420 KB

english, 2004

72

Preclinical models in cancer drug discovery and development

E.A Sausville, David R Newell

Journal:

European Journal of Cancer

Year:

2004

Language:

english

File:

PDF, 65 KB

english, 2004

73

Transcription profiling of gene expression in drug discovery and development: the NCI experience

Edward A. Sausville, Susan L. Holbeck

Journal:

European Journal of Cancer

Year:

2004

Language:

english

File:

PDF, 461 KB

english, 2004

74

Pediatric renal cell carcinoma

Justin E. Sausville, David J. Hernandez, Pedram Argani, John P. Gearhart

Journal:

Journal of Pediatric Urology

Year:

2009

Language:

english

File:

PDF, 167 KB

english, 2009

75

Bortezomib with concurrent radiation therapy in head and neck squamous cell carcinoma

Angela A. Chang, Barbara A. Conley, Peter F. Lebowitz, Kevin A. Camphausen, David R. Gius, Zhong Chen, Edward A. Sausville, Carter Van Waes

Journal:

Otolaryngology - Head and Neck Surgery

Year:

2004

Language:

english

File:

PDF, 36 KB

english, 2004

76

Annexin a2 expression in head and neck squamous cell carcinomas

Juan Pablo Rodrigo, Juana Garcia-Pedrero, Pilar Fernandez, Carlos Suarez-Nieto, Agustin Herrero, Carlos Suarez-Nieto, Edward A. Sausville, Carter Van Waes

Journal:

Otolaryngology - Head and Neck Surgery

Year:

2004

Language:

english

File:

PDF, 36 KB

english, 2004

77

Expression of the hypoxia inducible factor-1alpha in head and neck squamous cell carcinoma

Ruben Cabanillas, Marta Canel, Juan Pablo Rodrigo, Maria Dolores Chiara, Carlos Suarez-Nieto, Edward A. Sausville, Carter Van Waes

Journal:

Otolaryngology - Head and Neck Surgery

Year:

2004

Language:

english

File:

PDF, 36 KB

english, 2004

78

Extending inferior limits in organ preservation surgery: A clinico-pathologic correlation

Anthony Michael Sparano, Rebecca Chernock, Michael Feldman, Ollivier Laccourreye, Daniel F. Brasnu, Gregory S. Weinstein, Edward A. Sausville, Carter Van Waes

Journal:

Otolaryngology - Head and Neck Surgery

Year:

2004

Language:

english

File:

PDF, 35 KB

english, 2004

79

Combined Nephron-sparing Techniques for the Management of Bilateral Synchronous Renal Masses

Jay Heintz, Jared Berkowitz, Justin Sausville, Michael Phelan

Journal:

Year:

2011

Language:

english

File:

PDF, 964 KB

english, 2011

80

A novel bombesin receptor antagonist inhibits autocrine signals in a small cell lung carcinoma cell line

Jane B. Trepel, James D. Moyer, Frank Cuttitta, Harold Frucht, David H. Coy, Ronald B. Natale, James L. Mulshine, Robert T. Jensen, Edward A. Sausville

Journal:

Biochemical and Biophysical Research Communications

Year:

1988

Language:

english

File:

PDF, 423 KB

english, 1988

81

Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells

Kimberly L.K. Duncan, Mark D. Duncan, Michael C. Alley, Edward A. Sausville

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 976 KB

english, 1996

82

Identification of cytosolic aldehyde dehydrogenase 1 from non-small cell lung carcinomas as a flavopiridol-binding protein

Joachim B. Schnier, Gurmet Kaur, Astrid Kaiser, Sherman F. Stinson, Edward A. Sausville, John Gardner, Kayoko Nishi, E.Morton Bradbury, Adrian M. Senderowicz

Journal:

Year:

1999

Language:

english

File:

PDF, 318 KB

english, 1999

83

Metabolism of the anticancer drug flavopiridol, a new inhibitor of cyclin dependent kinases, in rat liver

Walter Jäger, Bettina Zembsch, Peter Wolschann, Ernst Pittenauer, Adrian M. senderowicz, Edward A. Sausville, Hans H. Sedlacek, Jürg Graf, Therese Thalhammer

Journal:

Year:

1998

Language:

english

File:

PDF, 825 KB

english, 1998

84

Imatinib for chronic myelogenous leukaemia: a 9 or 24 carat gold standard?

Edward A Sausville

Journal:

Year:

2003

Language:

english

File:

PDF, 54 KB

english, 2003

85

Complexities in the development of cyclin-dependent kinase inhibitor drugs

Edward A. Sausville

Journal:

Trends in Molecular Medicine

Year:

2002

Language:

english

File:

PDF, 63 KB

english, 2002

86

Mining the National Cancer Institute's Tumor-Screening Database: Identification of Compounds with Similar Cellular Activities

Rabow, Alfred A., Shoemaker, Robert H., Sausville, Edward A., Covell, David G.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 1.16 MB

english, 2002

87

Principles of Clinical Pharmacology || Drug Discovery

Sausville, Edward A.

Year:

2012

Language:

english

File:

PDF, 210 KB

english, 2012

88

Changes in the exposure of tryptophyl and tyrosyl residues in thrombin due to diisopropylphosphorofluoridate and benzamidine inhibitions

German B. Villanueva, C. William Batt, Edward Sausville, Victor Tortorelli, Kenneth Cubelli, William Brunner

Journal:

Biochemical and Biophysical Research Communications

Year:

1975

Language:

english

File:

PDF, 404 KB

english, 1975

89

A role for ferrous ion and oxygen in the degradation of DNA by bleomycin

Edward A. Sausville, Jack Peisach, Susan B. Horwitz

Journal:

Biochemical and Biophysical Research Communications

Year:

1976

Language:

english

File:

PDF, 476 KB

english, 1976

90

Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: Differential accumulation and metabolism

Maria I Rivera, Sherman F Stinson, David T Vistica, Jean L Jorden, Susan Kenney, Edward A Sausville

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 280 KB

english, 1999

91

46 Biological testing of the tyrphostin tyrosine kinase inhibitor Adaphostin (NSC 680410) as a vascular endothelial growth factor secretion inhibitor in human and murine tumor cells and tumor-activated bone marrow stromal cells

E. Egilegor, L. Mendoza, N. Gallot, M. Valcárcel, M. Solaun, M. Hollingshead, E. Sausville, F. Vidal-Vanaclocha

Journal:

European Journal of Cancer Supplements

Year:

2004

Language:

english

File:

PDF, 147 KB

english, 2004

92

190 Adaphostin (NSC680410) down regulates VEGF expression in human umbilical vein endothelial cells under hypoxia

G. Kaur, M. Hollingshead, K. Fisher-Nielsen, J. Zalek, K. Bonomi, S. Borgel, J. Thaillainathan, B. Uranchimeg, G. Melillo, E. Sausville

Journal:

European Journal of Cancer Supplements

Year:

2004

Language:

english

File:

PDF, 147 KB

english, 2004

93

139 POSTER Phase I dose escalation safety/tolerance study of PPl-2458 in subjects with Non-Hodgkin's lymphoma or solid tumors

K. Stiede, J. Eder, S. Anthony, P. Conkling, L. Fayad, D. Petrylak, E. Sausville, C. Verschraegen, G. Bhat

Journal:

European Journal of Cancer Supplements

Year:

2006

Language:

english

File:

PDF, 60 KB

english, 2006

94

6 keto prostaglandin F1α plasma levels in aminonucleoside nephrosis in the rat

Eduardo H. Garin, Pamela J. Sausville, George A. Richard

Journal:

Year:

1982

Language:

english

File:

PDF, 282 KB

english, 1982

95

Neuromedin-B receptor transfected BALB/3T3 cells: signal transduction and effects of ectopic receptor expression on cell growth

David Dobrzanski, Yoav Sharoni, Etsuko Wada, James Battey, Edward Sausville

Journal:

Regulatory Peptides

Year:

1993

Language:

english

File:

PDF, 791 KB

english, 1993

96

Serum inhibitor of phytohemagglutinin-inducedlymphocyte proliferation in Bartter syndrome

Eduardo H. Garin, Pamela J. Sausville, George A. Richard

Journal:

The Journal of Pediatrics

Year:

1983

Language:

english

File:

PDF, 297 KB

english, 1983

97

Plasma prostaglandin E2 concentration in nephrotic syndrome

Eduardo H. Garin, Pamela J. Sausville, George A. Richard

Journal:

The Journal of Pediatrics

Year:

1983

Language:

english

File:

PDF, 338 KB

english, 1983

98

Histologic assessment of lymph nodes in mycosis fungoides/sézary syndrome (cutaneous T-cell lymphoma): Clinical correlations and prognostic import of a new classification system

E.A. Sausville, G.F. Worsham, M.J. Matthews, R.W. Makuch, A.B. Fischmann, G.P. Schechter, A.F. Gazdar, P.A. Bunn Jr

Journal:

Human Pathology

Year:

1985

Language:

english

File:

PDF, 6.09 MB

english, 1985

99

8 INVITED Pitfalls for cancer drug discovery with “genetic” animal models

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 56 KB

english, 2008

100

1207 Results of study PX-171–007 a phase 1b/2 study of carfilzomib, a selective proteasome inhibitor, in patients with selected advanced metastatic solid tumors

M. Gordon, J. Infante, K.P. Papadopoulos, P. Lee, E. Sausville, D. Mendelson, A.F. Wong, M. Vallone, P.J. Rosen, H. Burris

Journal:

European Journal of Cancer Supplements

Year:

2009

Language:

english

File:

PDF, 68 KB

english, 2009