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1

Pharmacologic Targeting of Hypoxia-Inducible Factors

Semenza, Gregg L.

Journal:

Annual Review of Pharmacology

Year:

2019

Language:

english

File:

PDF, 1.64 MB

english, 2019

2

Pathways for Oxygen Regulation and Homeostasis

Kaelin, William G., Ratcliffe, Peter J., Semenza, Gregg L.

Journal:

JAMA The Journal of the American Medical Association

Year:

2016

Language:

english

File:

PDF, 151 KB

english, 2016

3

Vasculogenesis, angiogenesis, and arteriogenesis: Mechanisms of blood vessel formation and remodeling

Gregg L. Semenza

Journal:

Journal of Cellular Biochemistry

Year:

2007

Language:

english

File:

PDF, 136 KB

english, 2007

4

Targeting HIF-1 for cancer therapy

Semenza, Gregg L.

Journal:

Nature Reviews Cancer

Year:

2003

Language:

english

File:

PDF, 465 KB

english, 2003

5

Enhanced Bone Regeneration Associated With Decreased Apoptosis in Mice With Partial HIF-1α Deficiency

David E Komatsu, Marta Bosch-Marce, Gregg L Semenza, Michael Hadjiargyrou

Journal:

Journal of Bone and Mineral Research

Year:

2007

Language:

english

File:

PDF, 2.25 MB

english, 2007

6

Regulation of Osteogenesis-Angiogenesis Coupling by HIFs and VEGF

Ernestina Schipani, Christa Maes, Geert Carmeliet, Gregg L Semenza

Journal:

Journal of Bone and Mineral Research

Year:

2009

Language:

english

File:

PDF, 764 KB

english, 2009

7

Regulation of cancer cell metabolism by hypoxia-inducible factor 1

Gregg L. Semenza

Journal:

Seminars in Cancer Biology

Year:

2009

Language:

english

File:

PDF, 481 KB

english, 2009

8

Oxygen Sensing, Homeostasis, and Disease

Semenza, Gregg L.

Journal:

Boston Medical and Surgical Journal

Year:

2011

Language:

english

File:

PDF, 1.39 MB

english, 2011

9

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

Semenza, Gregg L.

Journal:

Annual Review of Pathology Mechanisms of Disease

Year:

2014

Language:

english

File:

PDF, 1.35 MB

english, 2014

10

Tumor metabolism: cancer cells give and take lactate

Semenza, Gregg L.

Journal:

Journal of Clinical Investigation

Year:

2008

Language:

english

File:

PDF, 721 KB

english, 2008

11

Hypoxia-Inducible Factor 1 is a Basic-Helix-Loop-Helix-PAS Heterodimer Regulated by Cellular O2Tension

Guang L. Wang, Bing-Hua Jiang, Elizabeth A. Rue and Gregg L. Semenza

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 1.13 MB

english, 1995

12

Age-dependent impairment of HIF-1α expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells

Lixin Liu, Guy P. Marti, Xiaofei Wei, Xianjie Zhang, Huafeng Zhang, Ye V. Liu, Manuel Nastai, Gregg L. Semenza, John W. Harmon

Journal:

Journal of Cellular Physiology

Year:

2008

Language:

english

File:

PDF, 279 KB

english, 2008

13

Regulation of angiogenesis by hypoxia-inducible factor 1

Kiichi Hirota, Gregg L. Semenza

Journal:

Critical Reviews in Oncology/Hematology

Year:

2006

Language:

english

File:

PDF, 193 KB

english, 2006

14

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

Xu, Qing, Briggs, Jon, Park, Sungman, Niu, Guilian, Kortylewski, Marcin, Zhang, Shumin, Gritsko, Tanya, Turkson, James, Kay, Heidi, Semenza, Gregg L

Journal:

Year:

2005

Language:

english

File:

PDF, 254 KB

english, 2005

15

Transcriptional Regulation by Hypoxia-Inducible Factor 1 Molecular Mechanisms of Oxygen Homeostasis

Gregg L Semenza

Journal:

Trends in Cardiovascular Medicine

Year:

1996

Language:

english

File:

PDF, 1.99 MB

english, 1996

16

Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning

Gregg L. Semenza

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2011

Language:

english

File:

PDF, 733 KB

english, 2011

17

Delayed wound healing in aged mice is associated with diminished mobilization of circulating angiogenic cells

Xianjie Zhang, Kakali Sarkar, Efstathia Andrikopoulou, Dongmei Xing, Lixin Liu, Maura Reinblatt, Raul Sebastian Laines, Guy P. Marti, Gregg L. Semenza, John W. Harmon

Journal:

Journal of the American College of Surgeons

Year:

2010

Language:

english

File:

PDF, 93 KB

english, 2010

18

Oncogenic alterations of metabolism

Chi V Dang, Gregg L Semenza

Journal:

Trends in Biochemical Sciences

Year:

1999

Language:

english

File:

PDF, 119 KB

english, 1999

19

Hypoxia-Inducible Factor 1 and Cardiovascular Disease

Semenza, Gregg L.

Journal:

Annual Review of Physiology

Year:

2014

Language:

english

File:

PDF, 671 KB

english, 2014

20

Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer

Xiang, Lisha, Gilkes, Daniele M., Chaturvedi, Pallavi, Luo, Weibo, Hu, Hongxia, Takano, Naoharu, Liang, Houjie, Semenza, Gregg L.

Journal:

Journal of Molecular Medicine

Year:

2014

Language:

english

File:

PDF, 1.37 MB

english, 2014

21

Role of hypoxia-inducible factors in breast cancer metastasis

Gilkes, Daniele M, Semenza, Gregg L

Journal:

Future Oncology

Year:

2013

Language:

english

File:

PDF, 1.08 MB

english, 2013

22

Serendipity, Generosity, and Inspiration

Semenza, Gregg L.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.59 MB

english, 2016

23

Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors

Samanta, Debangshu, Semenza, Gregg L.

Journal:

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Year:

2018

Language:

english

File:

PDF, 781 KB

english, 2018

24

Editorial overview: Hypoxia

Sadek, Hesham A, Semenza, Gregg L

Journal:

Current Opinion in Physiology

Year:

2019

Language:

english

File:

PDF, 258 KB

english, 2019

25

Endothelial HIF-2Î± as a Key Endogenous Mediator Preventing Emphysema

Pasupneti, Shravani, Tian, Wen, Tu, Allen B, Dahms, Petra, Granucci, Eric, Gandjeva, Aneta, Xiang, Menglan, Butcher, Eugene, Semenza, Gregg L., Tuder, Rubin, Jiang, Xinguo, Nicolls, Mark R

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

2020

File:

PDF, 5.52 MB

2020

26

Segregation of a familial balanced (12;10) insertion resulting in dup(10)(q21.2q22.1) and del(10)(q21.2q22.1) in first cousins

Doheny, Kimberly F., Rasmussen, Sonja A., Rutberg, Julie, Semenza, Gregg L., Stamberg, Judith, Schwartz, Marcia, Batista, Denise A. S., Stetten, Gail, Thomas, George H.

Journal:

American Journal of Medical Genetics

Year:

1997

Language:

english

File:

PDF, 576 KB

english, 1997

27

Expression of hypoxia-inducible factor 1α in brain tumors : Association with angiogenesis, invasion, and progression

David Zagzag, Hua Zhong, Joanne M. Scalzitti, Erik Laughner, Jonathan W. Simons, Gregg L. Semenza

Journal:

Year:

2000

Language:

english

File:

PDF, 916 KB

english, 2000

28

Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain

Marcelle Bergeron, Jeffrey M. Gidday, Aimee Y. Yu, Gregg L. Semenza, Donna M. Ferriero, Frank R. Sharp

Journal:

Annals of Neurology

Year:

2000

Language:

english

File:

PDF, 3.93 MB

english, 2000

29

Molecular cytogenetic characterization of a subtle interstitial del(3)(p25.3p26.2) in a patient with deletion 3p syndrome

Colyn B. Cargile, Denise L.-M. Goh, Barbara K. Goodman, Xiao-Ning Chen, Julie R. Korenberg, Gregg L. Semenza, George H. Thomas

Journal:

American Journal of Medical Genetics Part A

Year:

2002

Language:

english

File:

PDF, 138 KB

english, 2002

30

Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma

Reinhard Bos, Petra van der Groep, Astrid E. Greijer, Avi Shvarts, Sybren Meijer, Herbert M. Pinedo, Gregg L. Semenza, Paul J. van Diest, Elsken van der Wall

Journal:

Year:

2003

Language:

english

File:

PDF, 189 KB

english, 2003

31

Altered hypoxia-inducible factor-1 alpha expression levels correlate with coronary vessel anomalies

Jamie Wikenheiser, Julie A. Wolfram, Madhusudhana Gargesha, Ke Yang, Ganga Karunamuni, David L. Wilson, Gregg L. Semenza, Faton Agani, Steven A. Fisher, Nicole Ward, Michiko Watanabe

Journal:

Developmental Dynamics

Year:

2009

Language:

english

File:

PDF, 754 KB

english, 2009

32

Transcriptional regulation of gene expression: Mechanisms and pathophysiology

Gregg L. Semenza

Journal:

Year:

1994

Language:

english

File:

PDF, 1.98 MB

english, 1994

33

Hypoxia-inducible factor 1 and cancer pathogenesis

Gregg L. Semenza

Journal:

Year:

2008

Language:

english

File:

PDF, 235 KB

english, 2008

34

Induction of HIF-1α expression by intermittent hypoxia: Involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR

Guoxiang Yuan, Jayasri Nanduri, Shakil Khan, Gregg L. Semenza, Nanduri R. Prabhakar

Journal:

Journal of Cellular Physiology

Year:

2008

Language:

english

File:

PDF, 466 KB

english, 2008

35

Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia

Guoxiang Yuan, Shakil A. Khan, Weibo Luo, Jayasri Nanduri, Gregg L. Semenza, Nanduri R. Prabhakar

Journal:

Journal of Cellular Physiology

Year:

2011

Language:

english

File:

PDF, 795 KB

english, 2011

36

The use of in situ hybridization to study erythropoietin gene expression in murine kidney and liver

Ph.D. Stephen T. Koury, Maurice C. Bondurant, Gregg L. Semenza, Mark J. Koury

Journal:

Microscopy Research and Technique

Year:

1993

Language:

english

File:

PDF, 1.47 MB

english, 1993

37

HIF-1α, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors

Hilde L.K Janssen, Karin M.G Haustermans, Debbie Sprong, Gerard Blommestijn, Ingrid Hofland, Frank J Hoebers, Elke Blijweert, James A Raleigh, Gregg L Semenza, Mahesh A Varia, Alfons J Balm, Marie-Lou

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2002

Language:

english

File:

PDF, 410 KB

english, 2002

38

Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain

Marcelle Bergeron, Aimee Y. Yu, Karen E. Solway, Gregg L. Semenza, Frank R. Sharp

Journal:

European Journal of Neuroscience

Year:

1999

Language:

english

File:

PDF, 1.66 MB

english, 1999

39

Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis

Rubin M. Tuder, Mati Chacon, Lori Alger, Jun Wang, Laimute Taraseviciene-Stewart, Yasunori Kasahara, Carlyne D. Cool, Anne E. Bishop, Mark Geraci, Gregg L. Semenza, Magdi Yacoub, Julia M. Polak, Norbe

Journal:

The Journal of Pathology

Year:

2001

Language:

english

File:

PDF, 399 KB

english, 2001

40

Oxygen homeostasis

Gregg L. Semenza

Journal:

Wiley Interdisciplinary Reviews: Systems Biology and Medicine

Year:

2010

Language:

english

File:

PDF, 337 KB

english, 2010

41

The expanding universe of hypoxia

Huafeng Zhang, Gregg L. Semenza

Journal:

Journal of Molecular Medicine

Year:

2008

Language:

english

File:

PDF, 184 KB

english, 2008

42

Fostering trust—J Mol Med’sscientific integrity policy

Detlev Ganten, Gregg L. Semenza, Christiane Nolte

Journal:

Journal of Molecular Medicine

Year:

2009

Language:

english

File:

PDF, 58 KB

english, 2009

43

Recent advances in vascular biology and their clinical relevance

Journal:

Journal of Molecular Medicine

Year:

2009

Language:

english

File:

PDF, 51 KB

english, 2009

44

Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1α and HIF-2α

Donghoon Yoon, David V. Okhotin, Bumjun Kim, Yulia Okhotina, Daniel J. Okhotin, Galina Y. Miasnikova, Adelina I. Sergueeva, Lydia A. Polyakova, Alexei Maslow, Yonggu Lee, Gregg L. Semenza, Josef T. Pr

Journal:

Journal of Molecular Medicine

Year:

2010

Language:

english

File:

PDF, 231 KB

english, 2010

45

A return to cancer metabolism

Gregg L. Semenza

Journal:

Journal of Molecular Medicine

Year:

2011

Language:

english

File:

PDF, 64 KB

english, 2011

46

Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds

Xianjie Zhang, Kakali Sarkar, Sergio Rey, Raul Sebastian, Efstathia Andrikopoulou, Guy P. Marti, Karen Fox-Talbot, Gregg L. Semenza, John W. Harmon

Journal:

Journal of Molecular Medicine

Year:

2011

Language:

english

File:

PDF, 716 KB

english, 2011

47

Gaseous messengers in oxygen sensing

Nanduri R. Prabhakar, Gregg L. Semenza

Journal:

Journal of Molecular Medicine

Year:

2012

Language:

english

File:

PDF, 240 KB

english, 2012

48

Gas biology: small molecular medicine

Gregg L. Semenza, Nanduri R. Prabhakar

Journal:

Journal of Molecular Medicine

Year:

2012

Language:

english

File:

PDF, 70 KB

english, 2012

49

Biographical sketch—Gregg L. Semenza

Gregg L. Semenza

Journal:

Cancer and Metastasis Reviews

Year:

2007

Language:

english

File:

PDF, 57 KB

english, 2007

50

Hypoxia and cancer

Gregg L. Semenza

Journal:

Cancer and Metastasis Reviews

Year:

2007

Language:

english

File:

PDF, 55 KB

english, 2007

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