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51

New highly specific botulinum type C1 endopeptidase immunoassays utilising SNAP25 or Syntaxin substrates

Russell G.A. Jones, Yvonne Liu, Dorothea Sesardic

Journal:

Journal of Immunological Methods

Year:

2009

Language:

english

File:

PDF, 614 KB

english, 2009

52

Development and use of a novel in vitro assay for testing of diphtheria toxoid in combination vaccines

Laura Coombes, Paul Stickings, Rob Tierney, Peter Rigsby, Dorothea Sesardic

Journal:

Journal of Immunological Methods

Year:

2009

Language:

english

File:

PDF, 319 KB

english, 2009

53

Ambiguities in the preclinical quality assessment of microparticulate vaccines

Pål Johansen, Bruno Gander, Hans P Merkle, Dorothea Sesardic

Journal:

Trends in Biotechnology

Year:

2000

Language:

english

File:

PDF, 193 KB

english, 2000

54

A monoclonal antibody raised to rat liver cytochrome P-448 (form c) which recognises an epitope common to many other forms of cytochrome P-450

Alan R. Boobis, Jamie McQuade, Dorothea Sesardic, Richard T. Robson, Chris Hayward, Edward A. Lock, Cliff R. Elcombe, Michael S. Rose, Donald S. Davies

Journal:

Biochemical Pharmacology

Year:

1985

Language:

english

File:

PDF, 942 KB

english, 1985

55

Immunocytochemical localization of cytochrome P-450 in hepatic and extra-hepatic tissues of the rat with a monoclonal antibody against cytochrome P-450 c

John R. Foster, Clifford R. Elcombe, Alan R. Boobis, Donald S. Davies, Dorothea Sesardic, Jamie McQuade, Richard T. Robson, Christopher Hayward, Edward A. Lock

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 3.38 MB

english, 1986

56

Antibodies to a synthetic peptide that react specifically with a common surface region on two hydrocarbon-inducible isoenzymes of cytochrome P-450 in the rat

Robert J. Edwards, Alison M. Singleton, Dorothea Sesardic, Alan R. Boobis, Donald S. Davies

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 828 KB

english, 1988

57

The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man

Shinichi Kobayashi, Stephen Murray, David Watson, Dorothea Sesardic, Donald S. Davies, Alan R. Boobis

Journal:

Biochemical Pharmacology

Year:

1989

Language:

english

File:

PDF, 611 KB

english, 1989

58

Immunohistochemical localization of cytochrome P450b/e in hepatic and extrahepatic tissues of the rat

Kim J. Rich, Dorothea Sesardic, John R. Foster, Donald S. Davies, Alan R. Boobis

Journal:

Biochemical Pharmacology

Year:

1989

Language:

english

File:

PDF, 2.45 MB

english, 1989

59

High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat

Dorothea Sesardic, Robert J. Edwards, Donald S. Davies, Paul E. Thomas, Wayne Levin, Alan R. Boobis

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 1.20 MB

english, 1990

60

The inducibility and catalytic activity of cytochromes P450c (P450IA1) and P450d (P450IA2) in rat tissues

Dorothea Sesardic, Kathleen J. Cole, Robert J. Edwards, Donald S. Davies, Paul E. Thomas, Wayne Levin, Alan R. Boobis

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 1.02 MB

english, 1990

61

Identification of the epitope of a monoclonal antibody which binds to several cytochromes P450 in the CYP1A subfamily

Robert J. Edwards, Dorothea Sesardic, Bernard P. Murray, Alison M. Singleton, Donald S. Davies, Alan R. Boobis

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 1.05 MB

english, 1992

62

Therapeutic botulinum type a toxin: Factors affecting potency

Kay Mclellan, Rose E. Gaines Das, Theresa A.N. Ekong, Dorothea Sesardic

Journal:

Year:

1996

Language:

english

File:

PDF, 875 KB

english, 1996

63

David J. Bartholomew, ,Measuring Intelligence: Facts and Fallacies (2004) Cambridge University Press,Cambridge, UK 0 521 83619 0 hbk, 0 521 54478 5 pbk. Pp. xiv+172.

Journal:

Year:

2005

Language:

english

File:

PDF, 63 KB

english, 2005

64

Botulinum type A toxin neutralisation by specific IgG and its fragments: A comparison of mouse systemic toxicity and local flaccid paralysis assays

R.G.A. Jones, T.-A. Alsop, R. Hull, R. Tierney, P. Rigsby, J. Holley, D. Sesardic

Journal:

Year:

2006

Language:

english

File:

PDF, 163 KB

english, 2006

65

Development of a novel non-formaldehyde botulinum toxoid inducing high levels of neutralising antibody

Jones Russell, Liu Yvonne, Sesardic Dorothea

Journal:

Year:

2008

Language:

english

File:

PDF, 38 KB

english, 2008

66

Measurement of botulinum types A, B and E neurotoxicity using the phrenic nerve–hemidiaphragm: Improved precision with in-bred mice

C. Rasetti-Escargueil, R.G.A. Jones, Y. Liu, D. Sesardic

Journal:

Year:

2009

Language:

english

File:

PDF, 402 KB

english, 2009

67

In vivo uptake of an experimental microencapsulated diphtheria vaccine following sub-cutaneous immunisation

Marisa Peyre, Roland Fleck, David Hockley, Bruno Gander, Dorothea Sesardic

Journal:

Year:

2004

Language:

english

File:

PDF, 249 KB

english, 2004

68

European union regulatory developments for new vaccine adjuvants and delivery systems

Dorothea Sesardic, Roland Dobbelaer

Journal:

Year:

2004

Language:

english

File:

PDF, 59 KB

english, 2004

69

Regulatory considerations on new adjuvants and delivery systems

Journal:

Year:

2006

Language:

english

File:

PDF, 57 KB

english, 2006

70

Immune interaction between components of acellular pertussis-diphtheria-tetanus (DTaP) vaccine and Haemophilus influenzae b (Hib) conjugate vaccine in a rat model

Fatme Mawas, Robert Dickinson, Alexandra Douglas-Bardsley, Dorothy K.L. Xing, Dorothea Sesardic, Michael J. Corbel

Journal:

Year:

2006

Language:

english

File:

PDF, 167 KB

english, 2006

71

Induction of protective and mucosal immunity against diphtheria by a immune stimulating complex (ISCOMS) based vaccine

Antonio Aguila, Anne M. Donachie, Marisa Peyre, Charles P. McSharry, Dorothea Sesardic, Allan McI. Mowat

Journal:

Year:

2006

Language:

english

File:

PDF, 336 KB

english, 2006

72

A review of the international issues surrounding the availability and demand for diphtheria antitoxin for therapeutic use

K.S. Wagner, P. Stickings, J.M. White, S. Neal, N.S. Crowcroft, D. Sesardic, A. Efstratiou

Journal:

Year:

2009

Language:

english

File:

PDF, 489 KB

english, 2009

73

A single-dose cytomegalovirus-based vaccine encoding tetanus toxin fragment C induces sustained levels of protective tetanus toxin antibodies in mice

Rob Tierney, Toru Nakai, Christopher J. Parkins, Patrizia Caposio, Neil F. Fairweather, Dorothea Sesardic, Michael A. Jarvis

Journal:

Year:

2012

Language:

english

File:

PDF, 403 KB

english, 2012

74

Comparison of in vitro and in vivo methods to study stability of PLGA microencapsulated tetanus toxoid vaccines

Anna B. Sasiak, Barbara Bolgiano, Dennis T. Crane, David J. Hockley, Michael J. Corbel, Dorothea Sesardic

Journal:

Year:

2000

Language:

english

File:

PDF, 440 KB

english, 2000

75

Immunogenicity and reactogenicity of acellular diphtheria/tetanus/pertussis vaccines given as a pre-school booster: effect of simultaneous administration of MMR

E. Miller, P. Waight, H. Laurichesse, N. Andrews, C. Thornton, D. Sesardic, M. Corbel

Journal:

Year:

2001

Language:

english

File:

PDF, 257 KB

english, 2001

76

Physicochemical and immunological studies on the stability of free and microsphere-encapsulated tetanus toxoid in vitro

Dorothy K.-L. Xing, Dennis T. Crane, Barbara Bolgiano, Michael J. Corbel, Christopher Jones, Dorothea Sesardic

Journal:

Year:

1996

Language:

english

File:

PDF, 1.18 MB

english, 1996

77

Immunogenicity of single-dose diphtheria vaccines based on PLA/PLGA microspheres in guinea pigs

Pål Johansen, Linda Moon, Harjit Tamber, Hans P Merkle, Bruno Gander, Dorothea Sesardic

Journal:

Year:

1999

Language:

english

File:

PDF, 150 KB

english, 1999

78

Dynamics of motor nerve terminal remodeling unveiled using SNARE-cleaving botulinum toxins: the extent and duration are dictated by the sites of SNAP-25 truncation

F.rédéric A Meunier, Godfrey Lisk, Dorothea Sesardic, J.Oliver Dolly

Journal:

Molecular and Cellular Neuroscience

Year:

2003

Language:

english

File:

PDF, 717 KB

english, 2003

79

A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking.

D Sesardic, AR Boobis, RJ Edwards, DS Davies

Journal:

British Journal of Clinical Pharmacology

Year:

1988

Language:

english

File:

PDF, 1.64 MB

english, 1988

80

Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.

D Sesardic, AR Boobis, BP Murray, S Murray, J Segura, R de la Torre, DS Davies

Journal:

British Journal of Clinical Pharmacology

Year:

1990

Language:

english

File:

PDF, 1.81 MB

english, 1990

81

Non-animal replacement methods for human vaccine potency testing: state of the science and future directions

McFarland, Richard, Verthelyi, Daniela, Casey, Warren, Arciniega, Juan, Isbrucker, Richard, Schmitt, Michael, Finn, Theresa, Descamps, Johan, Horiuchi, Yoshinobu, Sesardic, Dorothea, Stickings, Paul,

Journal:

Procedia in Vaccinology

Year:

2011

Language:

english

File:

PDF, 386 KB

english, 2011

82

Animal Refinement and Reduction: Alternative Approaches for Potency Testing of Diphtheria and Tetanus Vaccines

Stickings, Paul, Rigsby, Peter, Coombes, Laura, Hockley, Jason, Tierney, Rob, Sesardic, Dorothea

Journal:

Procedia in Vaccinology

Year:

2011

Language:

english

File:

PDF, 782 KB

english, 2011

83

Diphtheria immunity in UK blood donors

P.A. Maple, A. Efstratiou, R.C. George, N.J. Andrews, D. Sesardic

Journal:

Year:

1995

Language:

english

File:

PDF, 382 KB

english, 1995

84

Immunological detection of Clostridium botulinum toxin type A in therapeutic preparations

Theresa A.N. Ekong, Kay McLellan, Dorothea Sesardic

Journal:

Journal of Immunological Methods

Year:

1995

Language:

english

File:

PDF, 1.04 MB

english, 1995

85

Interaction of Haemophilus influenzae type b conjugate vaccines with diphtheria-tetanus-pertussis vaccine in control tests

Keith Redhead, Dorothea Sesardic, Susan E. Yost, Ann-Marie Attwell, Johanna Watkins, Charlotte S. Hoy, Joanne E. Plumb, Michael J. Corbel

Journal:

Year:

1994

Language:

english

File:

PDF, 773 KB

english, 1994

86

In vitro antigen ELISA for quality control of tetanus vaccines

Laura Coombes, Rob Tierney, Peter Rigsby, Dorothea Sesardic, Paul Stickings

Journal:

Year:

2012

Language:

english

File:

PDF, 275 KB

english, 2012

87

Bioassays for evaluation of medical products derived from bacterial toxins

Journal:

Current Opinion in Microbiology

Year:

2012

Language:

english

File:

PDF, 677 KB

english, 2012

88

Phrenic nerve-hemidiaphragm as a highly sensitive replacement assay for determination of functional botulinum toxin antibodies

C. Rasetti-Escargueil, Y. Liu, P. Rigsby, R.G.A. Jones, D. Sesardic

Journal:

Year:

2011

Language:

english

File:

PDF, 291 KB

english, 2011

89

Preliminary results of the AntiBotABE project: Identification of neutralizing scFvs antibodies against botulinum toxins A and B

Sesardic, D., Rasetti-Escargueil, C., Chahboun, S., Hust, M., Liu, Y., Pelat, T., Helmsing, S., Mérens, A., Jones, R.G.A., Thullier, P.

Journal:

Year:

2013

Language:

english

File:

PDF, 47 KB

english, 2013

90

Calibration and commutability assessment of the 1st International Standard for Diphtheria Antitoxin Human

Stickings, Paul, Rigsby, Peter, Coombes, Laura, von Hunolstein, Christina, Ralli, Luisa, Pinto, Antonella, Sesardic, Dorothea

Journal:

Year:

2013

Language:

english

File:

PDF, 1.02 MB

english, 2013

91

In vitro assays for detection of diphtheria toxin

Hoy, C.S., Sesardic, D.

Journal:

Toxicology in Vitro

Year:

1994

Language:

english

File:

PDF, 196 KB

english, 1994

92

Development of functional cell-based assays as replacement assays for botulinum toxins and antitoxins

Rasetti-Escargueil, C., Machado, C.B., Charlesworth, P., Kolker, L., Fleck, R.A., Sesardic, D.

Journal:

Year:

2013

Language:

english

File:

PDF, 40 KB

english, 2013

93

Reducing animal consumption for the production of botulinum neurotoxin drugs

Journal:

Year:

2013

Language:

english

File:

PDF, 52 KB

english, 2013

94

Comparative activation of aromatic amines to mutagenic metabolites by human and rat liver

Harries, G.C., Boobis, A.R., Sesardic, D., Edwards, R.J., Davies, D.S.

Journal:

Food and Chemical Toxicology

Year:

1986

Language:

english

File:

PDF, 80 KB

english, 1986

95

Testing for neutralising potential of serum antibodies to tetanus and diphtheria toxin

Sesardic, D., Corbel, M.J.

Journal:

Year:

1992

Language:

english

File:

PDF, 361 KB

english, 1992

96

Peter Danielson, ed.,Modeling Rationality, Morality and Evolution

Sesardic, Neven

Journal:

Year:

2003

Language:

english

File:

PDF, 344 KB

english, 2003

97

Recombinant SINAP-25 is an effective substrate for Clostridium botulinum type A toxin endopeptidase activity in vitro

Ekong, T. A. N, Feavers, I. M., Sesardic, D.

Journal:

Microbiology (Society for General Microbiology)

Year:

1997

Language:

english

File:

PDF, 1.75 MB

english, 1997

98

Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors

Boobis, A. R., Sesardic, D., Murray, B. P., Edwards, R. J., Singleton, A. M., Rich, K. J., Murray, S., De La Torre, R., Segura, J., Pelkonen, O., Pasanen, M., Kobayashi, S., Zhi-guang, T., Davies, D.

Journal:

Year:

1990

Language:

english

File:

PDF, 1.56 MB

english, 1990

99

Review Article: Altruism

Review by: Neven Sesardic

Journal:

The British Journal for the Philosophy of Science

Year:

1999

Language:

english

File:

PDF, 1.24 MB

english, 1999

100

Immunochemical Analysis of the Structure of Diphtheria Toxin Shows All Three Domains Undergo Structural Changes at Low pH

Journal:

Journal of Biological Chemistry

Year:

1995

Language:

english

File:

PDF, 633 KB

english, 1995

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