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1

Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling

Shoukat Dedhar, Benjamin Williams, Gregory Hannigan

Journal:

Trends in Cell Biology

Year:

1999

Language:

english

File:

PDF, 348 KB

english, 1999

2

A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors

McDonald, Paul C., Chia, Stephen, Bedard, Philippe L., Chu, Quincy, Lyle, Michael, Tang, Liren, Singh, Madhu, Zhang, Zaihui, Supuran, Claudiu T., Renouf, Daniel J., Dedhar, Shoukat

Journal:

American Journal of Clinical Oncology

Year:

2020

File:

PDF, 219 KB

2020

3

Integrins and tumor invasion

Journal:

Year:

1990

Language:

english

File:

PDF, 923 KB

english, 1990

4

Epithelial–mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis

Yuanmei Lou, Olena Preobrazhenska, Ulrich auf dem Keller, Margaret Sutcliffe, Lorena Barclay, Paul C. McDonald, Calvin Roskelley, Christopher M. Overall, Shoukat Dedhar

Journal:

Developmental Dynamics

Year:

2008

Language:

english

File:

PDF, 9.93 MB

english, 2008

5

Integrin-linked kinase regulates E-cadherin expression through PARP-1

Timothy R. McPhee, Paul C. McDonald, Arusha Oloumi, Shoukat Dedhar

Journal:

Developmental Dynamics

Year:

2008

Language:

english

File:

PDF, 958 KB

english, 2008

6

Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis

Vasiliki Gkretsi, Wendy M. Mars, William C. Bowen, Lindsay Barua, Yu Yang, Lida Guo, René St.-Arnaud, Shoukat Dedhar, Chuanyue Wu, George K. Michalopoulos

Journal:

Year:

2007

Language:

english

File:

PDF, 939 KB

english, 2007

7

Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly

Vasiliki Gkretsi, Udayan Apte, Wendy M. Mars, William C. Bowen, Jian-Hua Luo, Yu Yang, Yan P. Yu, Ann Orr, René St.-Arnaud, Shoukat Dedhar, Klaus H. Kaestner, Chuanyue Wu, George K. Michalopoulos

Journal:

Year:

2008

Language:

english

File:

PDF, 455 KB

english, 2008

8

The importance of integrin-linked kinase in the regulation of bladder cancer invasion

Yoshiyuki Matsui, Kiran Assi, Osamu Ogawa, Peter A. Raven, Shoukat Dedhar, Martin E. Gleave, Baljinder Salh, Alan I. So

Journal:

International Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 1.14 MB

english, 2012

9

The effect of GM-CSF and G-CSF on the growth of human osteosarcoma cells in vitro and in vivo

J. Dean Thacker, Shoukat Dedhar, Donna E. Hogge

Journal:

International Journal of Cancer

Year:

1994

Language:

english

File:

PDF, 1.09 MB

english, 1994

10

Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption

Tanya Dossa, Alice Arabian, Jolene J. Windle, Shoukat Dedhar, Steven L. Teitelbaum, F. Patrick Ross, G. David Roodman, René St-Arnaud

Journal:

Journal of Cellular Biochemistry

Year:

2010

Language:

english

File:

PDF, 914 KB

english, 2010

11

Regulation of expression of the cell adhesion receptors, integrins, by recombinant human interleukin-1β in human osteosarcoma cells: Inhibition of cell proliferation and stimulation of alkaline phosphatase activity

Journal:

Journal of Cellular Physiology

Year:

1989

Language:

english

File:

PDF, 1016 KB

english, 1989

12

Targeting integrin linked kinase and FMS-like tyrosine kinase-3 is cytotoxic to acute myeloid leukemia stem cells but spares normal progenitors

Andrew L. Muranyi, Shoukat Dedhar, Donna E. Hogge

Journal:

Leukemia Research

Year:

2010

Language:

english

File:

PDF, 270 KB

english, 2010

13

Specific and sensitive combined high-performance liquid chromatographic—flow fluorometric assay for intracellular 6-thioguanine nucleotide metabolites of 6-mercaptopurine and 6-thioguanine

David M. Tidd, Shoukat Dedhar

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1978

Language:

english

File:

PDF, 835 KB

english, 1978

14

Integrin-linked kinase functions as a downstream signal of platelet-derived growth factor to regulate actin polymerization and vascular smooth muscle cell migration

Mitra Esfandiarei, Abdoli Sahar Yazdi, Virginia Gray, Shoukat Dedhar, Cornelis van Breemen

Journal:

BMC Cell Biology

Year:

2010

Language:

english

File:

PDF, 1.56 MB

english, 2010

15

Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire

Kiran Assi, Scott Patterson, Shoukat Dedhar, David Owen, Megan Levings, Baljinder Salh

Journal:

Year:

2011

Language:

english

File:

PDF, 1.26 MB

english, 2011

16

Targeting hypoxic tumour cells to overcome metastasis

Kevin L Bennewith, Shoukat Dedhar

Journal:

Year:

2011

Language:

english

File:

PDF, 198 KB

english, 2011

17

Specific alterations in the expression of α3β1 and α6β4 integrins in highly invasive and metastatic variants of human prostate carcinoma cells selected byin vitroinvasion through reconstituted basement membrane

Shoukat Dedhar, Ronald Saulnier, Raymond Nagle, Christopher M. Overall

Journal:

Clinical and Experimental Metastasis

Year:

1993

Language:

english

File:

PDF, 2.25 MB

english, 1993

18

Integrin mediated signal transduction in oncogenesis: An overview

Journal:

Cancer and Metastasis Reviews

Year:

1995

Language:

english

File:

PDF, 756 KB

english, 1995

19

Protein kinase mediators of integrin signal transduction

G. E. Hannigan, Shoukat Dedhar

Journal:

Journal of Molecular Medicine

Year:

1997

Language:

english

File:

PDF, 112 KB

english, 1997

20

The mitotic functions of integrin-linked kinase

Andrew B. Fielding, Shoukat Dedhar

Journal:

Cancer and Metastasis Reviews

Year:

2009

Language:

english

File:

PDF, 438 KB

english, 2009

21

Integrin-linked kinase is an essential link between integrins and uptake of bacterial pathogens by epithelial cells

Beinan Wang, Ryan S. Yurecko, Shoukat Dedhar, P. Patrick Cleary

Journal:

Cellular Microbiology

Year:

2006

Language:

english

File:

PDF, 254 KB

english, 2006

22

Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion

Beinan Wang, Shaoying Li, Shoukat Dedhar, P. Patrick Cleary

Journal:

Cellular Microbiology

Year:

2007

Language:

english

File:

PDF, 422 KB

english, 2007

23

Inhibition of nuclear hormone receptor activity by calreticulin

Dedhar, Shoukat, Rennie, Paul S., Shago, Mary, Hagesteijn, Chung-Yee Leung, Yang, Huiling, Filmus, Jorge, Hawley, Robert G., Bruchovsky, Nicholas, Cheng, Helen, Matusik, Robert J.

Journal:

Year:

1994

File:

PDF, 667 KB

1994

24

Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase

Hannigan, Gregory E., Leung-Hagesteijn, Chungyee, Fitz-Gibbon, Linda, Coppolino, Marc G., Radeva, Galina, Filmus, Jorge, Bell, John C., Dedhar, Shoukat

Journal:

Year:

1996

File:

PDF, 1.65 MB

1996

25

Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion

Coppolino, Marc G., Woodside, Michael J., Demaurex, Nicolas, Grinstein, Sergio, St-Arnaud, René, Dedhar, Shoukat

Journal:

Year:

1997

File:

PDF, 1.05 MB

1997

26

Integrin-linked kinase regulates E-cadherin expression by means of the transcription factor Snail

Dedhar, Shoukat

Journal:

Nature Genetics

Year:

2001

Language:

english

File:

PDF, 31 KB

english, 2001

27

Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy

Chen, Hua, Huang, Xueyin N, Yan, Wen, Chen, Ka, Guo, Lida, Tummalapali, Lekha, Dedhar, Shoukat, St-Arnaud, René, Wu, Chuanyue, Sepulveda, Jorge L

Journal:

Laboratory Investigation

Year:

2005

Language:

english

File:

PDF, 659 KB

english, 2005

28

Integrin-linked kinase: a cancer therapeutic target unique among its ILK

Hannigan, Gregory, Troussard, Armelle A., Dedhar, Shoukat

Journal:

Nature Reviews Cancer

Year:

2005

Language:

english

File:

PDF, 290 KB

english, 2005

29

The integrin-linked kinase (ILK) suppresses anoikis

Attwell, Sarah, Roskelley, Calvin, Dedhar, Shoukat

Journal:

Year:

2000

Language:

english

File:

PDF, 171 KB

english, 2000

30

The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9)

Troussard, Armelle A, Costello, Penny, Yoganathan, T Nathan, Kumagai, Shigehiro, Roskelley, Calvin D, Dedhar, Shoukat

Journal:

Year:

2000

Language:

english

File:

PDF, 342 KB

english, 2000

31

Inhibition of integrin linked kinase (ILK) suppresses β-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC−/− human colon carcinoma cells

Tan, Clara, Costello, Penny, Sanghera, Jasbinder, Dominguez, David, Baulida, Josep, Garcia de Herreros, Antonio, Dedhar, Shoukat

Journal:

Year:

2001

Language:

english

File:

PDF, 318 KB

english, 2001

32

Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis

Marotta, Anthony, Tan, Clara, Gray, Virginia, Malik, Saleem, Gallinger, Stephen, Sanghera, Jasbinder, Dupuis, Beverely, Owen, David, Dedhar, Shoukat, Salh, Baljinder

Journal:

Year:

2001

Language:

english

File:

PDF, 525 KB

english, 2001

33

Mammary epithelial-specific expression of the integrin linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice

White, Donald E, Cardiff, Robert D, Dedhar, Shoukat, Muller, William J

Journal:

Year:

2001

Language:

english

File:

PDF, 465 KB

english, 2001

34

αv integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells

Cruet-Hennequart, Séverine, Maubant, Sylvie, Luis, José, Gauduchon, Pascal, Staedel, Cathy, Dedhar, Shoukat

Journal:

Year:

2003

Language:

english

File:

PDF, 452 KB

english, 2003

35

Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells

Barberà, Maria José, Puig, Isabel, Domínguez, David, Julien-Grille, Sylvia, Guaita-Esteruelas, Sandra, Peiró, Sandra, Baulida, Josep, Francí, Clara, Dedhar, Shoukat, Larue, Lionel

Journal:

Year:

2004

Language:

english

File:

PDF, 484 KB

english, 2004

36

Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth

Edwards, Lincoln A, Thiessen, B, Dragowska, Wieslawa H, Daynard, Tim, Bally, Marcel B, Dedhar, Shoukat

Journal:

Year:

2005

Language:

english

File:

PDF, 488 KB

english, 2005

37

ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling

Qian, Yong, Zhong, Xiaosong, Flynn, Daniel C, Zheng, Jenny Z, Qiao, Meng, Wu, Chuanyue, Dedhar, Shoukat, Shi, Xianglin, Jiang, Bing-Hua

Journal:

Year:

2005

Language:

english

File:

PDF, 474 KB

english, 2005

38

Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells

Sutherland, Brent W, Kucab, Jill, Wu, Joyce, Lee, Cathy, Cheang, Maggie C U, Yorida, Erika, Turbin, Dmitry, Dedhar, Shoukat, Nelson, Colleen, Pollak, Michael

Journal:

Year:

2005

Language:

english

File:

PDF, 438 KB

english, 2005

39

Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via α-PIX

Filipenko, Nolan R, Attwell, Sarah, Roskelley, Calvin, Dedhar, Shoukat

Journal:

Year:

2005

Language:

english

File:

PDF, 295 KB

english, 2005

40

Watch this intracellular space: Receptors for extracellular matrix edited by John A. McDonald and Robert P. Mecham, Academic Press, 1991. $69.95 (xiii + 330 pages) ISBN 0 12 483365 9

Journal:

Trends in Cell Biology

Year:

1993

Language:

english

File:

PDF, 330 KB

english, 1993

41

Novel functions for calreticulin: interaction with integrins and modulation of gene expression?

Journal:

Trends in Biochemical Sciences

Year:

1994

Language:

english

File:

PDF, 645 KB

english, 1994

42

Regulation of E-cadherin expression and β-catenin/Tcf transcriptional activity by the integrin-linked kinase

Arusha Oloumi, Timothy McPhee, Shoukat Dedhar

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2004

Language:

english

File:

PDF, 850 KB

english, 2004

43

Combined inhibition of integrin linked kinase and FMS-like tyrosine kinase 3 is cytotoxic to acute myeloid leukemia progenitor cells

Andrew L. Muranyi, Shoukat Dedhar, Donna E. Hogge

Journal:

Experimental Hematology

Year:

2009

Language:

english

File:

PDF, 547 KB

english, 2009

44

Integrin-linked kinase (ILK): a “hot” therapeutic target

T.Nathan Yoganathan, Penny Costello, Xiaoyi Chen, Mojgan Jabali, Jun Yan, Dan Leung, Zaihui Zhang, Arthur Yee, Shoukat Dedhar, Jasbinder Sanghera

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 340 KB

english, 2000

45

Cell–substrate interactions and signaling through ILK

Journal:

Current Opinion in Cell Biology

Year:

2000

Language:

english

File:

PDF, 95 KB

english, 2000

46

Regulation of tumor angiogenesis by integrin-linked kinase (ILK)

Clara Tan, Severine Cruet-Hennequart, Armelle Troussard, Ladan Fazli, Penny Costello, Kym Sutton, Jeff Wheeler, Martin Gleave, Jasbinder Sanghera, Shoukat Dedhar

Journal:

Year:

2004

Language:

english

File:

PDF, 541 KB

english, 2004

47

Reciprocal Interactions between Human Ovarian Surface Epithelial Cells and Adjacent Extracellular Matrix

Patricia A. Kruk, Veli-Jukka Uitto, James D. Firth, Shoukat Dedhar, Nelly Auersperg

Journal:

Experimental Cell Research

Year:

1994

File:

PDF, 1.16 MB

1994

48

Modulation of the Retinoic Acid and Retinoid X Receptor Signaling Pathways in P19 Embryonal Carcinoma Cells by Calreticulin

Mary Shago, Grace Flock, Chung-Yee Leung Hagesteijn, Michael Woodside, Sergio Grinstein, Vincent Giguère, Shoukat Dedhar

Journal:

Experimental Cell Research

Year:

1997

Language:

english

File:

PDF, 2.16 MB

english, 1997

49

Heart, Brain, and Body Wall Defects in Mice Lacking Calreticulin

Frank Rauch, Josée Prud'homme, Alice Arabian, Shoukat Dedhar, René St-Arnaud

Journal:

Experimental Cell Research

Year:

2000

Language:

english

File:

PDF, 308 KB

english, 2000

50

Mapping of the Gene Encoding the Integrin-Linked Kinase, ILK, to Human Chromosome 11p15.5–p15.4

Gregory E. Hannigan, Jane Bayani, Rosanna Weksberg, Barbara Beatty, Ajay Pandita, Shoukat Dedhar, Jeremy Squire

Journal:

Year:

1997

Language:

english

File:

PDF, 229 KB

english, 1997