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51

Adenosine Mimetics as Inhibitors of NAD+-Dependent Histone Deacetylases, from Kinase to Sirtuin Inhibition

Trapp, Johannes, Jochum, Anne, Meier, Rene, Saunders, Laura, Marshall, Brett, Kunick, Conrad, Verdin, Eric, Goekjian, Peter, Sippl, Wolfgang, Jung, Manfred

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 1015 KB

english, 2006

52

Binding free energy calculations and biological testing of novel thiobarbiturates as inhibitors of the human NAD+ dependent histone deacetylase Sirt2

Uciechowska, Urszula, Schemies, Jörg, Scharfe, Michael, Lawson, Michael, Wichapong, Kanin, Jung, Manfred, Sippl, Wolfgang

Journal:

Year:

2012

Language:

english

File:

PDF, 559 KB

english, 2012

53

Rhodanine carboxylic acids as novel inhibitors of histone acetyltransferases

Furdas, Silviya D., Shekfeh, Suhaib, Kannan, Srinivasaraghavan, Sippl, Wolfgang, Jung, Manfred

Journal:

Year:

2012

Language:

english

File:

PDF, 459 KB

english, 2012

54

Fold space unlimited

Manfred J Sippl

Journal:

Current Opinion in Structural Biology

Year:

2009

Language:

english

File:

PDF, 3.82 MB

english, 2009

55

Self-Consistent Assignment of Asparagine and Glutamine Amide Rotamers in Protein Crystal Structures

Christian X. Weichenberger, Manfred J. Sippl

Journal:

Year:

2006

Language:

english

File:

PDF, 202 KB

english, 2006

56

Real Space Refinement of Crystal Structures with Canonical Distributions of Electrons

Simon W. Ginzinger, Markus Gruber, Hans Brandstetter, Manfred J. Sippl

Journal:

Year:

2011

Language:

english

File:

PDF, 555 KB

english, 2011

57

Detection of Spatial Correlations in Protein Structures and Molecular Complexes

Manfred J. Sippl, Markus Wiederstein

Journal:

Year:

2012

Language:

english

File:

PDF, 2.59 MB

english, 2012

58

Threading thrills and threats

Manfred J Sippl, Hannes Flöckner

Journal:

Year:

1996

File:

PDF, 731 KB

1996

59

Who solved the protein folding problem?

Manfred J Sippl

Journal:

Year:

1999

Language:

english

File:

PDF, 31 KB

english, 1999

60

Optimum superimposition of protein structures: ambiguities and implications

Feng Zu-Kang, Manfred J Sippl

Journal:

Folding and Design

Year:

1996

Language:

english

File:

PDF, 510 KB

english, 1996

61

Neutral networks in protein space: a computational study based on knowledge-based potentials of mean force

Aderonke Babajide, Ivo L Hofacker, Manfred J Sippl, Peter F Stadler

Journal:

Folding and Design

Year:

1997

Language:

english

File:

PDF, 218 KB

english, 1997

62

Analysis of the cDNA for phospholipase A2 from honeybee venom glands : The deduced amino acid sequence reveals homology to the corresponding vertebrate enzymes

Karl KUCHLER, Michael GMACHL, Manfred J. SIPPL, Günther KREIL

Journal:

Year:

1989

Language:

english

File:

PDF, 687 KB

english, 1989

63

Helmholtz Free Energy of Peptide Hydrogen Bonds in Proteins

Manfred J. Sippl

Journal:

Journal of Molecular Biology

Year:

1996

Language:

english

File:

PDF, 191 KB

english, 1996

64

Characterization of novel proteins based on known protein structures

Walter A Koppensteiner, Peter Lackner, Markus Wiederstein, Manfred J Sippl

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 524 KB

english, 2000

65

Structure-based evaluation of sequence comparison and fold recognition alignment accuracy

Francisco S. Domingues, Peter Lackner, Antonina Andreeva, Manfred J. Sippl

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 376 KB

english, 2000

66

Structure-derived hydrophobic potential: Hydrophobic potential derived from X-ray structures of globular proteins is able to identify native folds

Georg Casari, Manfred J. Sippl

Journal:

Journal of Molecular Biology

Year:

1992

Language:

english

File:

PDF, 777 KB

english, 1992

67

Knowledge-based potentials for proteins

Manfred J Sippl

Journal:

Current Opinion in Structural Biology

Year:

1995

Language:

english

File:

PDF, 670 KB

english, 1995

68

Inhibitors to understand molecular mechanisms of NAD+-dependent deacetylases (sirtuins)

Michael Lawson, Urszula Uciechowska, Jörg Schemies, Tobias Rumpf, Manfred Jung, Wolfgang Sippl

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Year:

2010

Language:

english

File:

PDF, 1.48 MB

english, 2010

69

Cancer treatment of the future: Inhibitors of histone methyltransferases

Astrid Spannhoff, Wolfgang Sippl, Manfred Jung

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2009

Language:

english

File:

PDF, 745 KB

english, 2009

70

Protein Sequence Randomization: Efficient Estimation of Protein Stability Using Knowledge-based Potentials

Markus Wiederstein, Manfred J. Sippl

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 527 KB

english, 2005

71

The role of protein structure in genomics

Francisco S. Domingues, Walter A. Koppensteiner, Manfred J. Sippl

Journal:

Year:

2000

Language:

english

File:

PDF, 228 KB

english, 2000

72

Empirical potentials and functions for protein folding and binding

Sandor Vajda, Manfred Sippl, Jiri Novotny

Journal:

Current Opinion in Structural Biology

Year:

1997

Language:

english

File:

PDF, 763 KB

english, 1997

73

Theory and simulation old problems, new paradigms

Jiri Novotny, Manfred Sippl

Journal:

Current Opinion in Structural Biology

Year:

1997

Language:

english

File:

PDF, 164 KB

english, 1997

74

Novel 3-Arylideneindolin-2-ones as Inhibitors of NAD + -Dependent Histone Deacetylases (Sirtuins)

Huber, Kilian, Schemies, Jörg, Uciechowska, Urszula, Wagner, Julia M., Rumpf, Tobias, Lewrick, Felicitas, Süss, Regine, Sippl, Wolfgang, Jung, Manfred, Bracher, Franz

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.41 MB

english, 2010

75

Molecular basis of lipoprotein lipase deficiency in two Austrian families with type I hyperlipoproteinemia

Bernhard Paulweber, Heiko Wiebusch, Gero Miesenboeck, Harald Funke, Gerd Assmann, Bertram Hoelzl, Manfred J. Sippl, Walter Friedl, Josef R. Patsch, Friedrich Sandhofer

Journal:

Atherosclerosis

Year:

1991

Language:

english

File:

PDF, 1.05 MB

english, 1991

76

On the problem of comparing protein structures: Development and applications of a new method for the assessment of structural similarities of polypeptide conformations

Manfred J. Sippl

Journal:

Journal of Molecular Biology

Year:

1982

Language:

english

File:

PDF, 1.72 MB

english, 1982

77

The role of histone demethylases in cancer therapy

Hoffmann, Inga, Roatsch, Martin, Schmitt, Martin L., Carlino, Luca, Pippel, Martin, Sippl, Wolfgang, Jung, Manfred

Journal:

Molecular Oncology

Year:

2012

Language:

english

File:

PDF, 1.57 MB

english, 2012

78

Identification of native protein folds amongst a large number of incorrect models: The calculation of low energy conformations from potentials of mean force

Manfred Hendlich, Peter Lackner, Sabine Weitckus, Hannes Floeckner, Rosina Froschauer, Karl Gottsbacher, Georg Casari, Manfred J. Sippl

Journal:

Journal of Molecular Biology

Year:

1990

Language:

english

File:

PDF, 1.50 MB

english, 1990

79

Calculation of conformational ensembles from potentials of mena force: An approach to the knowledge-based prediction of local structures in globular proteins

Manfred J. Sippl

Journal:

Journal of Molecular Biology

Year:

1990

Language:

english

File:

PDF, 2.41 MB

english, 1990

80

Intermolecular potentials from crystal data. 6. Determination of empirical potentials for O-H...O = C hydrogen bonds from packing configurations

Sippl, Manfred J., Nemethy, George, Scheraga, Harold A.

Journal:

Journal of Physical Chemistry

Year:

1984

Language:

english

File:

PDF, 321 KB

english, 1984

81

Detecting Repetitions and Periodicities in Proteins by Tiling the Structural Space

Parra, R. Gonzalo, Espada, Rocío, Sánchez, Ignacio E., Sippl, Manfred J., Ferreiro, Diego U.

Journal:

Journal of Physical Chemistry B

Year:

2013

Language:

english

File:

PDF, 613 KB

english, 2013

82

Two-Step Synthesis of Novel, Bioactive Derivatives of the Ubiquitous Cofactor Nicotinamide Adenine Dinucleotide (NAD)

Pesnot, Thomas, Kempter, Julia, Schemies, Jörg, Pergolizzi, Giulia, Uciechowska, Urszula, Rumpf, Tobias, Sippl, Wolfgang, Jung, Manfred, Wagner, Gerd K.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.06 MB

english, 2011

83

Current trends in epigenetic drug discovery

Stolfa, Diana A, Einsle, Oliver, Sippl, Wolfgang, Jung, Manfred

Journal:

Future Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.01 MB

english, 2012

84

Target-Based Approach to Inhibitors of Histone Arginine Methyltransferases

Spannhoff, Astrid, Heinke, Ralf, Bauer, Ingo, Trojer, Patrick, Metzger, Eric, Gust, Ronald, Schüle, Roland, Brosch, Gerald, Sippl, Wolfgang, Jung, Manfred

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 337 KB

english, 2007

85

Inhibitors of the NAD + -Dependent Protein Desuccinylase and Demalonylase Sirt5

Maurer, Benjamin, Rumpf, Tobias, Scharfe, Michael, Stolfa, Diana A., Schmitt, Martin L., He, Wenjuan, Verdin, Eric, Sippl, Wolfgang, Jung, Manfred

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 752 KB

english, 2012

86

Solution of the Embedding Problem and Decomposition of Symmetric Matrices

Manfred J. Sippl and Harold A. Scheraga

Journal:

Proceedings of the National Academy of Sciences

Year:

1985

Language:

english

File:

PDF, 1.26 MB

english, 1985

87

Cayley--Menger Coordinates

Manfred J. Sippl and Harold A. Scheraga

Journal:

Proceedings of the National Academy of Sciences

Year:

1986

Language:

english

File:

PDF, 707 KB

english, 1986

88

Structure–Activity Studies on Splitomicin Derivatives as Sirtuin Inhibitors and Computational Prediction of Binding Mode

Neugebauer, Robert C., Uchiechowska, Urszula, Meier, Rene, Hruby, Henning, Valkov, Vassil, Verdin, Eric, Sippl, Wolfgang, Jung, Manfred

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 408 KB

english, 2008

89

Virtual Screening of PRK1 Inhibitors: Ensemble Docking, Rescoring Using Binding Free Energy Calculation and QSAR Model Development

Slynko, Inna, Scharfe, Michael, Rumpf, Tobias, Eib, Julia, Metzger, Eric, Schüle, Roland, Jung, Manfred, Sippl, Wolfgang

Journal:

Journal of Chemical Information and Modeling

Year:

2014

Language:

english

File:

PDF, 4.24 MB

english, 2014

90

Structure-Based Characterization of Multiprotein Complexes

Wiederstein, Markus, Gruber, Markus, Frank, Karl, Melo, Francisco, Sippl, Manfred J.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.33 MB

english, 2014

91

Mind the Methyl: Methyllysine Binding Proteins in Epigenetic Regulation

Wagner, Tobias, Robaa, Dina, Sippl, Wolfgang, Jung, Manfred

Journal:

Year:

2014

Language:

english

File:

PDF, 4.80 MB

english, 2014

92

Targeting epigenetic modifiers: Inhibitors of histone methyltransferases

Bissinger, Elisabeth-Maria, Heinke, Ralf, Sippl, Wolfgang, Jung, Manfred

Journal:

Year:

2010

Language:

english

File:

PDF, 444 KB

english, 2010

93

Isoforms of the Major Allergen of Birch Pollen Induce Different Immune Responses after Genetic Immunization

Hartl, Arnulf, Kiesslich, Jan, Weiss, Richard, Bernhaupt, Andrea, Mostb&ouml, ck, Sven, Scheiblhofer, Sandra, Fl&ouml, ckner, Hannes, Sippl, Manfred, Ebner, Christof, Ferreira, F&aacute, tima, Thalhamer,

Journal:

International Archives of Allergy and Immunology

Year:

1999

Language:

english

File:

PDF, 435 KB

english, 1999

94

HDAC8: a multifaceted target for therapeutic interventions

Chakrabarti, Alokta, Oehme, Ina, Witt, Olaf, Oliveira, Guilherme, Sippl, Wolfgang, Romier, Christophe, Pierce, Raymond J., Jung, Manfred

Journal:

Trends in Pharmacological Sciences

Year:

2015

Language:

english

File:

PDF, 1.53 MB

english, 2015

95

Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives

Marek, Martin, Oliveira, Guilherme, Pierce, Raymond J, Jung, Manfred, Sippl, Wolfgang, Romier, Christophe

Journal:

Future Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 8.83 MB

english, 2015

96

Schistosome sirtuins as drug targets

Lancelot, Julien, Cabezas-Cruz, Alejandro, Caby, Stéphanie, Marek, Martin, Schultz, Johan, Romier, Christophe, Sippl, Wolfgang, Jung, Manfred, Pierce, Raymond J

Journal:

Future Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 2.08 MB

english, 2015

97

Inhibitors of NAD+ Dependent Histone Deacetylases (Sirtuins)

Jung, Manfred, Neugebauer, Robert, Sippl, Wolfgang

Journal:

Current Pharmaceutical Design

Year:

2008

Language:

english

File:

PDF, 383 KB

english, 2008

98

Synthesis and biological investigation of oxazole hydroxamates as highly selective histone deacetylase 6 (HDAC6) inhibitors

Senger, Johanna, Melesina, Jelena, Marek, Martin, Romier, Christophe, Oehme, Ina, Witt, Olaf, Sippl, Wolfgang, Jung, Manfred

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 2.49 MB

english, 2015

99

Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure–Activity Relationship Study

Schiedel, Matthias, Rumpf, Tobias, Karaman, Berin, Lehotzky, Attila, Oláh, Judit, Gerhardt, Stefan, Ovádi, Judit, Sippl, Wolfgang, Einsle, Oliver, Jung, Manfred

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.24 MB

english, 2016

100

KATching-Up on Small Molecule Modulators of Lysine Acetyltransferases

Simon, Roman P., Robaa, Dina, Alhalabi, Zayan, Sippl, Wolfgang, Jung, Manfred

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 2.73 MB

english, 2016