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1

Phospholipase Cε Hydrolyzes Perinuclear Phosphatidylinositol 4-Phosphate to Regulate Cardiac Hypertrophy

Zhang, Lianghui, Malik, Sundeep, Pang, Jinjiang, Wang, Huan, Park, Keigan M., Yule, David I., Blaxall, Burns C., Smrcka, Alan V.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.27 MB

english, 2013

2

Targeting G protein-coupled receptor signalling by blocking G proteins

Campbell, Adrian P., Smrcka, Alan V.

Journal:

Nature Reviews Drug Discovery

Year:

2018

Language:

english

File:

PDF, 736 KB

english, 2018

3

Direct-reversible binding of small molecules to G protein βγ subunits

A.M.P.B. Seneviratne, Michael Burroughs, Ernest Giralt, Alan V. Smrcka

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2011

Language:

english

File:

PDF, 1.19 MB

english, 2011

4

Conformational flexibility and binding interactions of the G protein βγ heterodimer

Min-Sun Park, Alan V. Smrcka, Harry A. Stern

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2011

Language:

english

File:

PDF, 739 KB

english, 2011

5

Supraspinal Gβγ-dependent stimulation of PLCβ3 originating from G inhibitory protein-μ opioid receptor-coupling is necessary for morphine induced acute hyperalgesia

Enrica Bianchi, Monica Norcini, Alan Smrcka, Carla Ghelardini

Journal:

Journal of Neurochemistry

Year:

2009

Language:

english

File:

PDF, 485 KB

english, 2009

6

EPAC regulation of cardiac EC coupling

&gt, Alan V. Smrcka, Emily A. Oestreich, Burns C. Blaxall, Robert T. Dirksen

Journal:

The Journal of Physiology

Year:

2007

Language:

english

File:

PDF, 280 KB

english, 2007

7

Epac2-dependent mobilization of intracellular Ca2+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ɛ knockout mice

Igor Dzhura, Oleg G. Chepurny, Grant G. Kelley, Colin A. Leech, Michael W. Roe, Elvira Dzhura, Parisa Afshari, Sundeep Malik, Michael J. Rindler, Xin Xu, Youming Lu, Alan V. Smrcka, George G. Holz

Journal:

The Journal of Physiology

Year:

2010

Language:

english

File:

PDF, 679 KB

english, 2010

8

G Protein Signaling Volume 237 || Detection of G Protein-Coupled Receptors by Immunofluorescence Microscopy

Smrcka, Alan V.

Year:

2003

Language:

english

File:

PDF, 93 KB

english, 2003

9

Role of phospholipase Cε in physiological phosphoinositide signaling networks

Alan V. Smrcka, Joan Heller Brown, George G. Holz

Journal:

Cellular Signalling

Year:

2012

Language:

english

File:

PDF, 611 KB

english, 2012

10

Protease-activated receptor 1 (PAR1) coupling to Gq/11 but not to Gi/o or G12/13 is mediated by discrete amino acids within the receptor second intracellular loop

Kelly L. McCoy, Stefka Gyoneva, Christopher P. Vellano, Alan V. Smrcka, Stephen F. Traynelis, John R. Hepler

Journal:

Cellular Signalling

Year:

2012

Language:

english

File:

PDF, 1.08 MB

english, 2012

11

Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling

Joe B. Blumer, Alan V. Smrcka, Stephen M. Lanier

Journal:

Pharmacology & Therapeutics

Year:

2007

Language:

english

File:

PDF, 1.25 MB

english, 2007

12

G Protein Signaling Volume 237 || Purification of G Protein Subunits from Sf9 Insect Cells Using Hexahistidine-Tagged α and βγ Subunits

Smrcka, Alan V.

Year:

2003

Language:

english

File:

PDF, 243 KB

english, 2003

13

Evaluating Docking Methods for Prediction of Binding Affinities of Small Molecules to the G Protein βγ Subunits

Park, Min-Sun, Dessal, Axel L., Smrcka, Alan V., Stern, Harry A.

Journal:

Journal of Chemical Information and Modeling

Year:

2009

Language:

english

File:

PDF, 1.49 MB

english, 2009

14

Purification and characterization of large and small subunits of ribulose 1,5-bisphosphate carboxylase expressed separately in Escherichia coli

Alan V. Smrcka, Robert T. Ramage, Hans J. Bohnert, Richard G. Jensen

Journal:

Archives of Biochemistry and Biophysics

Year:

1991

Language:

english

File:

PDF, 1.77 MB

english, 1991

15

Modulation of the tight binding of carboxyarabinitol 1,5-bisphosphate to the large subunit of ribulose 1,5-bisphosphate carboxylase/oxygenase

Alan V. Smrcka, Hans J. Bohnert, Richard G. Jensen

Journal:

Archives of Biochemistry and Biophysics

Year:

1991

Language:

english

File:

PDF, 701 KB

english, 1991

16

Taking the heart failure battle inside the cell: Small molecule targeting of Gβγ subunits

Fadia A. Kamal, Alan V. Smrcka, Burns C. Blaxall

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2011

Language:

english

File:

PDF, 247 KB

english, 2011

17

Directional Sensing Requires Gβγ-Mediated PAK1 and PIXα-Dependent Activation of Cdc42

Zhong Li, Michael Hannigan, Zhicheng Mo, Bo Liu, Wei Lu, Yue Wu, Alan V. Smrcka, Guanqing Wu, Lin Li, Mingyao Liu, Chi-Kuang Huang, Dianqing Wu

Journal:

Year:

2003

Language:

english

File:

PDF, 547 KB

english, 2003

18

Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics

Smrcka, Alan V.

Journal:

Trends in Pharmacological Sciences

Year:

2013

Language:

english

File:

PDF, 557 KB

english, 2013

19

The Role of G Protein Methylation in the Function of a Geranylgeranylated βγ Isoform †

Parish, Craig A., Smrcka, Alan V., Rando, Robert R.

Journal:

Year:

1996

Language:

english

File:

PDF, 302 KB

english, 1996

20

Regulation of phospholipase C by G proteins

Sternweis, Paul C., Smrcka, Alan V.

Journal:

Trends in Biochemical Sciences

Year:

1992

Language:

english

File:

PDF, 713 KB

english, 1992

21

G Protein Signaling Volume 237 || Cellular Localization of GFP-Tagged α Subunits

Smrcka, Alan V.

Year:

2003

Language:

english

File:

PDF, 290 KB

english, 2003

22

G Protein Signaling Volume 237 || Analysis of G Protein-Mediated Activation of Phospholipase C in Cultured Cells

Smrcka, Alan V.

Year:

2003

Language:

english

File:

PDF, 84 KB

english, 2003

23

Simultaneous Adrenal and Cardiac G-Protein–Coupled Receptor-Gβγ Inhibition Halts Heart Failure Progression

Kamal, Fadia A., Mickelsen, Deanne M., Wegman, Katherine M., Travers, Joshua G., Moalem, Jacob, Hammes, Stephen R., Smrcka, Alan V., Blaxall, Burns C.

Journal:

Journal of the American College of Cardiology

Year:

2014

Language:

english

File:

PDF, 944 KB

english, 2014

24

Fluorescence detection of cationic amyloid fibrils in human semen

Easterhoff, David, DiMaio, John T.M., Liyanage, Wathsala, Lo, Chi-Wen, Bae, Woori, Doran, Todd M., Smrcka, Alan, Nilsson, Bradley L., Dewhurst, Stephen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 786 KB

english, 2013

25

Identification of a Phospholipase C β2Region that Interacts with Gβ γ

Yanan Kuang, Yaqing Wu, Alan Smrcka, Huiping Jiang and Dianqing Wu

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 860 KB

english, 1996

26

Genetic Alteration of Phospholipase C β 3 Expression Modulates Behavioral and Cellular Responses to μ Opioids

Wei Xie, Gary M. Samoriski, Jay P. McLaughlin, Valerie A. Romoser, Alan Smrcka, Patricia M. Hinkle, Jean M. Bidlack, Robert A. Gross, Huiping Jiang and Dianqing Wu

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.58 MB

english, 1999

27

Nucleoside Triphosphatases in Energy Transduction, Cellular Regulation and Information Transfer in Biological Systems || Hormone Signalling via G-Protein: Regulation of Phosphatidylinositol 4,5-bisphosphate Hydrolysis by Gq[and Discussion]

Paul C. Sternweis, Alan V. Smrcka, Stephen Gutowski, F. McCormick and K. C. Holmes

Journal:

Philosophical Transactions Biological Sciences

Year:

1992

Language:

english

File:

PDF, 1.20 MB

english, 1992

28

Structural and Molecular Characterization of a Preferred Protein Interaction Surface on G Protein βγ Subunits †

Davis, Tara L., Bonacci, Tabetha M., Sprang, Stephen R., Smrcka, Alan V.

Journal:

Year:

2005

Language:

english

File:

PDF, 880 KB

english, 2005

29

Identification of a Region at the N-Terminus of Phospholipase C-β3 That Interacts with G Protein βγ Subunits †

Barr, Alastair J., Ali, Hydar, Haribabu, Bodduluri, Snyderman, Ralph, Smrcka, Alan V.

Journal:

Year:

2000

Language:

english

File:

PDF, 121 KB

english, 2000

30

G Protein β 5 Subunit Interactions with α Subunits and Effectors †

Yoshikawa, Daniel M., Hatwar, Mamata, Smrcka, Alan V.

Journal:

Year:

2000

Language:

english

File:

PDF, 185 KB

english, 2000

31

Functional significance of .beta..gamma.-subunit carboxymethylation for the activation of phospholipase C and phosphoinositide 3-kinase

Parish, Craig A., Smrcka, Alan V., Rando, Robert R.

Journal:

Year:

1995

Language:

english

File:

PDF, 780 KB

english, 1995

32

G Protein Signaling Volume 237 || Expression and Purification of Soluble Adenylyl Cyclase from Escherichia coli

Smrcka, Alan V.

Year:

2003

Language:

english

File:

PDF, 147 KB

english, 2003

33

G Protein Signaling Volume 237 ||

Smrcka, Alan V.

Year:

2003

Language:

english

File:

PDF, 1.85 MB

english, 2003

34

Phospholipase C Epsilon (PLCε) Induced TRPC6 Activation: A Common but Redundant Mechanism in Primary Podocytes

Kalwa, Hermann, Storch, Ursula, Demleitner, Jana, Fiedler, Susanne, Mayer, Tim, Kannler, Martina, Fahlbusch, Meike, Barth, Holger, Smrcka, Alan, Hildebrandt, Friedhelm, Gudermann, Thomas, Dietrich, Al

Journal:

Journal of Cellular Physiology

Year:

2015

Language:

english

File:

PDF, 1.28 MB

english, 2015

35

A Chemical Biology Approach Demonstrates G Protein βγ Subunits Are Sufficient to Mediate Directional Neutrophil Chemotaxis

Surve, Chinmay R., Lehmann, David, Smrcka, Alan V.

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 1.10 MB

english, 2014

36

Phospholipase Cɛ links G protein-coupled receptor activation to inflammatory astrocytic responses

Dusaban, Stephanie S., Purcell, Nicole H., Rockenstein, Edward, Masliah, Eliezer, Cho, Min Kyung, Smrcka, Alan V., Brown, Joan Heller

Journal:

Proceedings of the National Academy of Sciences

Year:

2013

Language:

english

File:

PDF, 916 KB

english, 2013

37

NMR Analysis of G-protein βγ Subunit Complexes Reveals a Dynamic Gα-Gβγ Subunit Interface and Multiple Protein Recognition Modes

Alan V. Smrcka, Nessim Kichik, Teresa Tarragó, Michael Burroughs, Min-Sun Park, Nathan K. Itoga, Harry A. Stern, Barry M. Willardson, Ernest Giralt and Melvin I. Simon

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.49 MB

english, 2010

38

Regulation of Phosphatidylinositol-specific Phospholipase C at the Nuclear Envelope in Cardiac Myocytes

Smrcka, Alan V.

Journal:

Journal of Cardiovascular Pharmacology

Year:

2015

Language:

english

File:

PDF, 359 KB

english, 2015

39

Identification and Characterization of Unique Proline-rich Peptides Binding to the Mitochondrial Fission Protein hFis1

Serasinghe, Madhavika N., Seneviratne, A. M. P. B., Smrcka, Alan V., Yoon, Yisang

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 3.06 MB

english, 2010

40

G Protein Signaling Volume 237 || Purification of Recombinant G Protein α Subunits from Escherichia coli

Smrcka, Alan V.

Year:

2003

Language:

english

File:

PDF, 149 KB

english, 2003

41

A Docking Site for G Protein βγ Subunits on the Parathyroid Hormone 1 Receptor Supports Signaling through Multiple Pathways

Mahon, Matthew J., Bonacci, Tabetha M., Divieti, Paola, Smrcka, Alan V.

Journal:

Molecular Endocrinology

Year:

2006

Language:

english

File:

PDF, 485 KB

english, 2006

42

G Protein Signaling Volume 237 || Measurement of G Protein-Coupled Receptor-Stimulated Phospholipase D Activity in Intact Cells

Smrcka, Alan V.

Year:

2003

Language:

english

File:

PDF, 179 KB

english, 2003

43

G Protein Signaling Volume 237 || Assay of G Protein-Coupled Receptor Activation of G Proteins in Native Cell Membranes Using [35S]GTPγS Binding

Smrcka, Alan V.

Year:

2003

Language:

english

File:

PDF, 103 KB

english, 2003

44

G Protein Signaling Volume 237 || Green Fluorescent Protein-Tagged β-Arrestin Translocation as a Measure of G Protein-Coupled Receptor Activation

Smrcka, Alan V.

Year:

2003

Language:

english

File:

PDF, 92 KB

english, 2003

45

G Protein Signaling Volume 237 || Ribozymes as Tools for Suppression of G Protein γ Subunits

Smrcka, Alan V.

Year:

2003

Language:

english

File:

PDF, 130 KB

english, 2003

46

Purification and Characterization of Recombinant G16αFrom Sf9 Cells: Activation of Purified Phospholipase C Isozymes by G-Protein α Subunits

Tohru Kozasa, John R. Hepler, Alan V. Smrcka, Melvin I. Simon, Sue Goo Rhee, Paul C. Sternweis and Alfred G. Gilman

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 932 KB

english, 1993

47

Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans

Dzhura, Igor, Chepurny, Oleg G., Leech, Colin A., Roe, Michael W., Dzhura, Elvira, Xu, Xin, Lu, Youming, Schwede, Frank, Genieser, Hans-G., Smrcka, Alan V., Holz, George G.

Journal:

Year:

2011

Language:

english

File:

PDF, 2.10 MB

english, 2011

48

G Protein Signaling Volume 237 || Assay for G Protein-Dependent Activation of Phospholipase C β Using Purified Protein Components

Smrcka, Alan V.

Year:

2003

Language:

english

File:

PDF, 104 KB

english, 2003

49

Thrombin Promotes Sustained Signaling and Inflammatory Gene Expression through the CDC25 and Ras-associating Domains of Phospholipase Cϵ

Dusaban, Stephanie S., Kunkel, Maya T., Smrcka, Alan V., Brown, Joan Heller

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 1.51 MB

english, 2015

50

G Protein Signaling Volume 237 || Methods for Measuring RGS Protein Phosphorylation by G Protein-Regulated Kinases

Smrcka, Alan V.

Year:

2003

Language:

english

File:

PDF, 222 KB

english, 2003

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