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101

An optimised version of the secretome protein enrichment with click sugars (SPECS) method leads to enhanced coverage of the secretome

Serdaroglu, Alperen, Müller, Stephan A., Schepers, Ute, Bräse, Stefan, Weichert, Wilko, Lichtenthaler, Stefan F., Kuhn, Peer-Hendrik

Journal:

Year:

2017

Language:

english

File:

PDF, 379 KB

english, 2017

102

PHYSIOLOGICAL SUBSTRATES OF BACE1 AND ADAM10: SAFETY ISSUES OR BIOMARKERS?

Lichtenthaler, Stefan

Journal:

Alzheimer's & Dementia

Year:

2016

Language:

english

File:

PDF, 51 KB

english, 2016

103

Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6

Zhu, Kaichuan, Xiang, Xianyuan, Filser, Severin, Marinković, Petar, Dorostkar, Mario M., Crux, Sophie, Neumann, Ulf, Shimshek, Derya R., Rammes, Gerhard, Haass, Christian, Lichtenthaler, Stefan F., Gu

Journal:

Biological Psychiatry

Year:

2016

Language:

english

File:

PDF, 13.01 MB

english, 2016

104

PERK activation mitigates tau pathology in vitro and in vivo

Bruch, Julius, Xu, Hong, Rösler, Thomas W, De Andrade, Anderson, Kuhn, Peer‐Hendrik, Lichtenthaler, Stefan F, Arzberger, Thomas, Winklhofer, Konstanze F, Müller, Ulrich, Höglinger, Günter U

Journal:

EMBO Molecular Medicine

Year:

2017

Language:

english

File:

PDF, 1.88 MB

english, 2017

105

Naphthoquinone-Tryptophan Hybrid Inhibits Aggregation of the Tau-Derived Peptide PHF6 and Reduces Neurotoxicity

Frenkel-Pinter, Moran, Tal, Sharon, Scherzer-Attali, Roni, Abu-Hussien, Malak, Alyagor, Idan, Eisenbaum, Tal, Gazit, Ehud, Segal, Daniel, Lichtenthaler, Stefan

Journal:

Journal of Alzheimer's Disease

Year:

2016

Language:

english

File:

PDF, 681 KB

english, 2016

106

Soluble BACE-1 Activity and sAβPPβ Concentrations in Alzheimer’s Disease and Age-Matched Healthy Control Cerebrospinal Fluid from the Alzheimer’s Disease Neuroimaging Initiative-1 Baseline Cohort

Savage, Mary J., Holder, Daniel J., Wu, Guoxin, Kaplow, June, Siuciak, Judith A., Potter, William Z., Lichtenthaler, Stefan

Journal:

Journal of Alzheimer's Disease

Year:

2015

Language:

english

File:

PDF, 601 KB

english, 2015

107

Proteasen in der Alzheimer-Forschung – Freund oder Feind?

Johanna Tüshaus,Tobias Brummer,Stephan A. Müller,Stefan F. Lichtenthaler

Journal:

Year:

2017

Language:

german

File:

PDF, 656 KB

german, 2017

108

Between new genetic discoveries and large randomized trials—neurological research in the era of systems medicine

Misgeld, Thomas, Lichtenthaler, Stefan F, Dichgans, Martin

Journal:

Year:

2013

Language:

english

File:

PDF, 139 KB

english, 2013

109

Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease

Kretner, Benedikt, Trambauer, Johannes, Fukumori, Akio, Mielke, Janina, Kuhn, Peer‐Hendrik, Kremmer, Elisabeth, Giese, Armin, Lichtenthaler, Stefan F, Haass, Christian, Arzberger, Thomas, Steiner, Har

Journal:

EMBO Molecular Medicine

Year:

2016

Language:

english

File:

PDF, 1.27 MB

english, 2016

110

An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function

Schlepckow, Kai, Kleinberger, Gernot, Fukumori, Akio, Feederle, Regina, Lichtenthaler, Stefan F, Steiner, Harald, Haass, Christian

Journal:

EMBO Molecular Medicine

Year:

2017

Language:

english

File:

PDF, 1.17 MB

english, 2017

111

Non‐cell‐autonomous function of DR6 in Schwann cell proliferation

Colombo, Alessio, Hsia, Hung‐En, Wang, Mengzhe, Kuhn, Peer‐Hendrik, Brill, Monika S, Canevazzi, Paolo, Feederle, Regina, Taveggia, Carla, Misgeld, Thomas, Lichtenthaler, Stefan F

Journal:

The EMBO Journal

Year:

2018

Language:

english

File:

PDF, 2.82 MB

english, 2018

112

Click chemistry-mediated biotinylation reveals a function for the protease BACE1 in modulating the neuronal surface glycoproteome

Herber, Julia, Njavro, Jasenka, Feederle, Regina, Schepers, Ute, Müller, Ulrike, Bräse, Stefan, Müller, Stephan, Lichtenthaler, Stefan F

Journal:

Molecular & Cellular Proteomics

Year:

2018

Language:

english

File:

PDF, 23.56 MB

english, 2018

113

CADASIL brain vessels show a HTRA1 loss-of-function profile

Zellner, Andreas, Scharrer, Eva, Arzberger, Thomas, Oka, Chio, Domenga-Denier, Valérie, Joutel, Anne, Lichtenthaler, Stefan F., Müller, Stephan A., Dichgans, Martin, Haffner, Christof

Journal:

Acta Neuropathologica

Year:

2018

Language:

english

File:

PDF, 2.05 MB

english, 2018

114

Prion replication in the mammalian cytosol: Functional regions within a prion domain driving induction, propagation and inheritance

Duernberger, Yvonne, Liu, Shu, Riemschoss, Katrin, Paulsen, Lydia, Bester, Romina, Kuhn, Peer-Hendrik, Schölling, Manuel, Lichtenthaler, Stefan F., Vorberg, Ina

Journal:

Molecular and Cellular Biology

Year:

2018

Language:

english

File:

PDF, 10.11 MB

english, 2018

115

Proteolytic ectodomain shedding of membrane proteins in mammals—hardware, concepts, and recent developments

Lichtenthaler, Stefan F, Lemberg, Marius K, Fluhrer, Regina

Journal:

The EMBO Journal

Year:

2018

Language:

english

File:

PDF, 809 KB

english, 2018

116

Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation

Hartlage-Rübsamen, Maike, Bluhm, Alexandra, Piechotta, Anke, Linnert, Miriam, Rahfeld, Jens-Ulrich, Demuth, Hans-Ulrich, Lues, Inge, Kuhn, Peer-Hendrik, Lichtenthaler, Stefan, Roßner, Steffen, Höfling

Journal:

Year:

2018

Language:

english

File:

PDF, 46.25 MB

english, 2018

117

Proteomic Substrate Identification for Membrane Proteases in the Brain

Müller, Stephan A., Scilabra, Simone D., Lichtenthaler, Stefan F.

Journal:

Frontiers in Molecular Neuroscience

Year:

2016

Language:

english

File:

PDF, 2.61 MB

english, 2016

118

The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer’s Disease and Beyond

Dislich, Bastian, Lichtenthaler, Stefan F.

Journal:

Frontiers in Physiology

Year:

2012

Language:

english

File:

PDF, 827 KB

english, 2012

119

Shedding of BAFF/APRIL Receptors Controls B Cells

Meinl, Edgar, Thaler, Franziska S., Lichtenthaler, Stefan F.

Journal:

Trends in Immunology

Year:

2018

Language:

english

File:

PDF, 632 KB

english, 2018

120

The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation

Brummer, Tobias, Pigoni, Martina, Rossello, Armando, Wang, Huanhuan, Noy, Peter J., Tomlinson, Michael G., Blobel, Carl P., Lichtenthaler, Stefan F.

Journal:

The FASEB Journal

Year:

2018

Language:

english

File:

PDF, 1.38 MB

english, 2018

121

BACE1 Inhibitor MK-8931 Alters Formation but Not Stability of Dendritic Spines

Blume, Tanja, Filser, Severin, Jaworska, Anna, Blain, Jean-Francois, Koenig, Gerhard, Moschke, Katrin, Lichtenthaler, Stefan F., Herms, Jochen

Journal:

Frontiers in Aging Neuroscience

Year:

2018

Language:

english

File:

PDF, 1.27 MB

english, 2018

122

Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor

Scilabra, Simone D., Pigoni, Martina, Pravatá, Veronica, Schätzl, Tobias, Müller, Stephan A., Troeberg, Linda, Lichtenthaler, Stefan F.

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 3.52 MB

english, 2018

123

Defined astrocytic expression of human amyloid precursor protein in Tg2576 mouse brain

Heiland, Tina, Zeitschel, Ulrike, Puchades, Maja A., Kuhn, Peer-Hendrik, Lichtenthaler, Stefan F., Bjaalie, Jan G., Hartlage-Rübsamen, Maike, Roßner, Steffen, Höfling, Corinna

Journal:

Year:

2018

Language:

english

File:

PDF, 2.33 MB

english, 2018

124

In vivo Ca 2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria

Montagna, Elena, Crux, Sophie, Luckner, Manja, Herber, Julia, Colombo, Alessio V., Marinković, Petar, Tahirovic, Sabina, Lichtenthaler, Stefan F., Wanner, Gerhard, Müller, Ulrike C., Sgobio, Carmelo,

Journal:

Year:

2019

File:

PDF, 4.23 MB

2019

125

Bioinformatics Identification of Modules of Transcription Factor Binding Sites in Alzheimer's Disease-Related Genes by In Silico Promoter Analysis and Microarrays

Augustin, Regina, Lichtenthaler, Stefan F., Greeff, Michael, Hansen, Jens, Wurst, Wolfgang, Trümbach, Dietrich

Journal:

International Journal of Alzheimer's Disease

Year:

2011

Language:

english

File:

PDF, 5.94 MB

english, 2011

126

Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer’s Disease

Höfling, Corinna, Shehabi, Emira, Kuhn, Peer-Hendrik, Lichtenthaler, Stefan F., Hartlage-Rübsamen, Maike, Roßner, Steffen

Journal:

Frontiers in Neuroscience

Year:

2019

File:

PDF, 3.72 MB

2019

127

NrCAM is a marker for substrate‐selective activation of ADAM10 in Alzheimer's disease

Brummer, Tobias, Müller, Stephan A, Pan‐Montojo, Francisco, Yoshida, Fumiaki, Fellgiebel, Andreas, Tomita, Taisuke, Endres, Kristina, Lichtenthaler, Stefan F

Journal:

EMBO Molecular Medicine

Year:

2019

Language:

english

File:

PDF, 2.90 MB

english, 2019

128

Functions of ‘A disintegrin and metalloproteases (ADAMs)’ in the mammalian nervous system

Hsia, Hung-En, Tüshaus, Johanna, Brummer, Tobias, Zheng, Yuanpeng, Scilabra, Simone D., Lichtenthaler, Stefan F.

Journal:

Cellular and Molecular Life Sciences

Year:

2019

Language:

english

File:

PDF, 1.88 MB

english, 2019

129

Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression

Bartels, Martin, Weckbecker, Daniel, Kuhn, Peer-Hendrik, Ryazanov, Sergey, Leonov, Andrei, Griesinger, Christian, Lichtenthaler, Stefan F., Bötzel, Kai, Giese, Armin

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 7.28 MB

english, 2019

130

Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR

Fang, Wei-Shuo, Sun, De-yang, Yang, Shuang, Cheng, Chen, Moschke, Katrin, Li, Tianqi, Sun, Shanshan, Lichtenthaler, Stefan F., Huang, Jian, Wang, Yinghong

Journal:

Bioorganic Chemistry

Year:

2019

File:

PDF, 1.61 MB

2019

131

Lack of Sez6 Family Proteins Impairs Motor Functions, Short-Term Memory, and Cognitive Flexibility and Alters Dendritic Spine Properties

Nash, Amelia, Aumann, Timothy D, Pigoni, Martina, Lichtenthaler, Stefan F, Takeshima, Hiroshi, Munro, Kathryn M, Gunnersen, Jenny M

Journal:

Cerebral Cortex

Year:

2019

Language:

english

File:

PDF, 2.25 MB

english, 2019

132

Lack of Sez6 Family Proteins Impairs Motor Functions, Short-Term Memory, and Cognitive Flexibility and Alters Dendritic Spine Properties

Nash, Amelia, Aumann, Timothy D, Pigoni, Martina, Lichtenthaler, Stefan F, Takeshima, Hiroshi, Munro, Kathryn M, Gunnersen, Jenny M

Journal:

Cerebral Cortex

Year:

2019

File:

PDF, 2.25 MB

2019

133

ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1)

Weskamp, Gisela, TÃ¼shaus, Johanna, Li, Daniel, Feederle, Regina, Maretzky, Thorsten, Swendeman, Steven, Falck-Pedersen, Erik, McIlwain, David R., Mak, Tak W., Salmon, Jane E, Lichtenthaler, Stefan F,

Journal:

Journal of Biological Chemistry

Year:

2020

File:

PDF, 1.99 MB

2020

134

The substrate repertoire of Î³-secretase/presenilin

GÃ¼ner, GÃ¶khan, Lichtenthaler, Stefan F.

Journal:

Seminars in Cell & Developmental Biology

Year:

2020

File:

PDF, 926 KB

2020

135

Basic Fibroblast Growth Factor 2-Induced Proteome Changes Endorse Lewy Body Pathology in Hippocampal Neurons

Kumar, Rohit, Donakonda, Sainitin, MÃ¼ller, Stephan A., Lichtenthaler, Stefan F., BÃ¶tzel, Kai, HÃ¶glinger, GÃ¼nter U., Koeglsperger, Thomas

Journal:

Year:

2020

File:

PDF, 7.12 MB

2020

136

To cut or not to cut: New rules for proteolytic shedding of membrane proteins

Lichtenthaler, Stefan F., Meinl, Edgar

Journal:

Journal of Biological Chemistry

Year:

2020

File:

PDF, 318 KB

2020

137

Neuronal Differentiation of LUHMES Cells Induces Substantial Changes of the Proteome

TÃ¼shaus, Johanna, Kataka, Evans Sioma, Zaucha, Jan, Frishman, Dmitrij, MÃ¼ller, Stephan A., Lichtenthaler, Stefan F.

Journal:

Year:

2020

File:

PDF, 717 KB

2020

138

Role of iRhoms 1 and 2 in Endochondral Ossification

Fang, Renpeng, Haxaire, Coline, Otero, Miguel, Lessard, Samantha, Weskamp, Gisela, McIlwain, David R., Mak, Tak W., Lichtenthaler, Stefan F., Blobel, Carl P.

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 3.66 MB

2020

139

Loss of Furin in Î² cells Induces an mTORC1-ATF4 Anabolic Pathway that Leads to Î² cell Dysfunction

Brouwers, Bas, Coppola, Ilaria, Vints, Katlijn, Dislich, Bastian, Jouvet, Nathalie, Van Lommel, Leentje, Segers, Charlotte, Gounko, Natalia V., Thorrez, Lieven, Schuit, Frans, Lichtenthaler, Stefan F.

Journal:

Year:

2020

File:

PDF, 7.77 MB

2020