Stefan A. Laufer: search on Z-Library

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1

Lungenkrebs: EGFR-Inhibitoren mit hoher Wirksamkeit gegen die therapieresistente L858R/T790M/C797S-Mutante.

Günther, Marcel, Juchum, Michael, Kelter, Gerhard, Fiebig, Heiner, Laufer, Stefan

Journal:

Angewandte Chemie

Year:

2016

Language:

german

File:

PDF, 1.14 MB

german, 2016

2

Candidate drugs against SARS-CoV-2 and COVID-19

McKee, Dwight L., Sternberg, Ariane, Stange, Ulrike, Laufer, Stefan, Naujokat, Cord

Journal:

Pharmacological Research

Year:

2020

File:

PDF, 2.48 MB

2020

3

Neue NSAR: Was bietet die Zukunft?

Journal:

Pharmazie in unserer Zeit

Year:

2002

Language:

german

File:

PDF, 150 KB

german, 2002

4

Alkoxymagnesium Iodide Complexes

Peter Haiss, Annette Kuhn, Norbert Kuhn, Cäcilia Maichle-Mößmer, Stefan Laufer, Manfred Steimann, Klaus-Peter Zeller

Journal:

European Journal of Inorganic Chemistry

Year:

2011

Language:

english

File:

PDF, 412 KB

english, 2011

5

Bioinformatical evaluation of modified nucleosides as biomedical markers in diagnosis of breast cancer

Dino Bullinger, Holger Fröhlich, Fabian Klaus, Hans Neubauer, Antje Frickenschmidt, Carsten Henneges, Andreas Zell, Stefan Laufer, Christoph H. Gleiter, Hartmut Liebich, Bernd Kammerer

Journal:

Analytica Chimica Acta

Year:

2008

Language:

english

File:

PDF, 382 KB

english, 2008

6

Vioxx® und die anderen Coxibe

Dieter Steinbilber, Stefan Laufer

Journal:

Pharmazie in unserer Zeit

Year:

2004

Language:

german

File:

PDF, 106 KB

german, 2004

7

Medizinische Chemie und molekulare Hemmmechanismen der Tyrosinkinase-Inhibitoren. Schwerpunkt pharmazeutischer Forschung

Melanie Holm, Frank Lehmann, Stefan Laufer

Journal:

Pharmazie in unserer Zeit

Year:

2008

Language:

german

File:

PDF, 1.71 MB

german, 2008

8

Metabonomics in cancer diagnosis: mass spectrometry-based profiling of urinary nucleosides from breast cancer patients

Frickenschmidt, Antje, Fröhlich, Holger, Bullinger, Dino, Zell, Andreas, Laufer, Stefan, Gleiter, Christoph H., Liebich, Hartmut, Kammerer, Bernd

Journal:

Year:

2008

Language:

english

File:

PDF, 349 KB

english, 2008

9

Abietane diterpenes induce cytotoxic effects in human pancreatic cancer cell line MIA PaCa-2 through different modes of action

Marcio Fronza, Evelyn Lamy, Stefan Günther, Berta Heinzmann, Stefan Laufer, Irmgard Merfort

Journal:

Year:

2012

Language:

english

File:

PDF, 1.35 MB

english, 2012

10

Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.)

Stefan Schwaiger, Iris Zeller, Petra Pölzelbauer, Sandra Frotschnig, Günther Laufer, Barbara Messner, Valerio Pieri, Hermann Stuppner, David Bernhard

Journal:

Journal of Ethnopharmacology

Year:

2011

Language:

english

File:

PDF, 524 KB

english, 2011

11

Chiral Sulfoxides as Metabolites of 2-Thioimidazole-Based p38α Mitogen-Activated Protein Kinase Inhibitors: Enantioselective Synthesis and Biological Evaluation

Bühler, Stefanie, Goettert, Marcia, Schollmeyer, Dieter, Albrecht, Wolfgang, Laufer, Stefan A.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.20 MB

english, 2011

12

Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors

Barbosa, Maria Letícia de Castro, Lima, Lídia Moreira, Tesch, Roberta, Sant'Anna, Carlos Mauricio R., Totzke, Frank, Kubbutat, Michael H.G., Schächtele, Christoph, Laufer, Stefan A., Barreiro, Eliezer

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.34 MB

english, 2014

13

A fraction of stem bark extract of Entada africana suppresses lipopolysaccharide-induced inflammation in RAW 264.7 cells

Ayissi Owona, Brice, Njayou, Nico Frederic, Laufer, Stefan, Moundipa, Paul Fewou, Schluesener, Hermann J.

Journal:

Journal of Ethnopharmacology

Year:

2013

Language:

english

File:

PDF, 1.49 MB

english, 2013

14

Development of First Lead Structures for Phosphoinositide 3-Kinase-C2γ Inhibitors

Freitag, Anne, Prajwal, Prajwal, Shymanets, Aliaksei, Harteneck, Christian, Nürnberg, Bernd, Schächtele, Christoph, Kubbutat, Michael, Totzke, Frank, Laufer, Stefan A.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.49 MB

english, 2015

15

Antinociceptive, anti-inflammatory and gastroprotective effects of a hydroalcoholic extract from the leaves of Eugenia punicifolia (Kunth) DC. in rodents

Basting, Rosanna T., Nishijima, Catarine M., Lopes, Juliana A., Santos, Raquel C., Lucena Périco, Larissa, Laufer, Stefan, Bauer, Silke, Costa, Miriam F., Santos, Lourdes C., Rocha, Lúcia R.M., Vilega

Journal:

Journal of Ethnopharmacology

Year:

2014

Language:

english

File:

PDF, 842 KB

english, 2014

16

Novel Hinge-Binding Motifs for Janus Kinase 3 Inhibitors: A Comprehensive Structure-Activity Relationship Study on Tofacitinib Bioisosteres

Gehringer, Matthias, Forster, Michael, Pfaffenrot, Ellen, Bauer, Silke M., Laufer, Stefan A.

Journal:

Year:

2014

Language:

english

File:

PDF, 703 KB

english, 2014

17

Regiospecific and Highly Flexible Synthesis of 1,4,5-Trisubstituted 2-Sulfanylimidazoles from Structurally Diverse Ethanone Precursors

Laufer, Stefan, Hauser, Dominik, Liedtke, Andy

Journal:

Year:

2008

Language:

english

File:

PDF, 254 KB

english, 2008

18

Tri- and Tetrasubstituted Pyridinylimidazoles as Covalent Inhibitors of c-Jun N-Terminal Kinase 3

Muth, Felix, El-Gokha, Ahmed, Ansideri, Francesco, Eitel, Michael, Döring, Eva, Sievers-Engler, Adrian, Lange, Andreas, Boeckler, Frank M., Lämmerhofer, Michael, Koch, Pierre, Laufer, Stefan A.

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 733 KB

english, 2017

19

Four New Flavonol Glycosides from the Leaves of Brugmansia suaveolens

Geller, Fabiana, Murillo, Renato, Steinhauser, Lisa, Heinzmann, Berta, Albert, Klaus, Merfort, Irmgard, Laufer, Stefan

Journal:

Year:

2014

Language:

english

File:

PDF, 242 KB

english, 2014

20

Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site

Günther, Marcel, Lategahn, Jonas, Juchum, Michael, Doering, Eva, Keul, Marina, Engel, Julian, Tumbrink, Hannah Lea, Rauh, Daniel, Laufer, Stefan A.

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.63 MB

english, 2017

21

Recent Developments in JAK3 Inhibition: Isoform Selectivity by Covalent Targeting of Cys909

Forster, Michael, Gehringer, Matthias, Laufer, Stefan A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 1.90 MB

english, 2017

22

Targeted gene expression analyses and immunohistology suggest a pro-proliferative state in tricuspid aortic valve-, and senescence and viral infections in bicuspid aortic valve-associated thoracic aortic aneurysms

Blunder, Stefan, Messner, Barbara, Scharinger, Bernhard, Doppler, Christian, Zeller, Iris, Zierer, Andreas, Laufer, Günther, Bernhard, David

Journal:

Atherosclerosis

Year:

2018

Language:

english

File:

PDF, 1.19 MB

english, 2018

23

The Cysteinome of Protein Kinases as a Target in Drug Development

Chaikuad, Apirat, Koch, Pierre, Laufer, Stefan A., Knapp, Stefan

Journal:

Angewandte Chemie International Edition

Year:

2018

File:

PDF, 1.33 MB

2018

24

Why Antidiabetic Vanadium Complexes are Not in the Pipeline of “Big Pharma” Drug Research? A Critical Review

Scior, Thomas, Guevara-Garcia, Jose, Do, Quoc-Tuan, Bernard, Philippe, Laufer, Stefan

Journal:

Current Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.87 MB

english, 2016

25

Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology

Gehringer, Matthias, Laufer, Stefan A.

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 3.60 MB

english, 2018

26

An updated patent review of p38 MAP kinase inhibitors (2014-2019)

Haller, Vanessa, Nahidino, Philipp, Forster, Michael, Laufer, Stefan A

Journal:

Expert Opinion on Therapeutic Patents

Year:

2020

File:

PDF, 1.04 MB

2020

27

Combining aptamers and antibodies: lateral flow quantification for thrombin and interleukin-6 with smartphone readout

Mahmoud, Mostafa, Ruppert, Christoph, Rentschler, Simone, Laufer, Stefan, Deigner, Hans-Peter

Journal:

Sensors and Actuators B: Chemical

Year:

2020

File:

PDF, 2.04 MB

2020

28

One, Thione und N-Oxide: ein allgemeiner Zugang zu Imidazolderivaten

Stefan Laufer, Gerd Wagner, Dunja Kotschenreuther

Journal:

Angewandte Chemie

Year:

2002

Language:

german

File:

PDF, 106 KB

german, 2002

29

Ones, Thiones, and N-Oxides: An Exercise in Imidazole Chemistry

Stefan Laufer, Gerd Wagner, Dunja Kotschenreuther

Journal:

Angewandte Chemie International Edition

Year:

2002

Language:

english

File:

PDF, 102 KB

english, 2002

30

Synthesis and Cyclooxygenase Inhibitory Properties of Novel (+) 2-(6-Methoxy-2-naphthyl)propanoic Acid (Naproxene) Derivatives

Ashraf H. Abadi, Stefan Laufer, Jochen Lehmann

Journal:

Archiv der Pharmazie

Year:

2001

Language:

english

File:

PDF, 66 KB

english, 2001

31

NO-Donors (VII [1]): Synthesis and Cyclooxygenase Inhibitory Properties of N-and S-Nitrooxypivaloyl-cysteine Derivatives of Naproxen — A Novel Type of NO-NSAID

Rahmana E. Kartasasmita, Stefan Laufer, Jochen Lehmann

Journal:

Archiv der Pharmazie

Year:

2002

Language:

english

File:

PDF, 72 KB

english, 2002

32

In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: Suppression of collagenase 1 and interleukin-1β synthesis

Dragan V. Jovanovic, Julio C. Fernandes, Johanne Martel-Pelletier, François-Cyril Jolicoeur, Pascal Reboul, Stefan Laufer, Susanne Tries, Jean-Pierre Pelletier

Journal:

Arthritis & Rheumatism

Year:

2001

Language:

english

File:

PDF, 11.79 MB

english, 2001

33

Effiziente Synthese neuer 2-Cycloalk(en)yl-propansäure-Derivate – mittlere und große Ringe als Bioisostere von Alkylphenylresten?

Björn Greve, Dr. Peter Imming, Dr. Stefan Laufer

Journal:

Angewandte Chemie

Year:

1996

Language:

german

File:

PDF, 372 KB

german, 1996

34

Dynamics in the p38α MAP Kinase–SB203580 Complex Observed by Liquid-State NMR Spectroscopy

Valerie S. Honndorf, Nicolas Coudevylle, Stefan Laufer, Stefan Becker, Christian Griesinger

Journal:

Angewandte Chemie

Year:

2008

Language:

english

File:

PDF, 542 KB

english, 2008

35

Efficient Synthesis of New 2-Cycloalk(en)ylpropanoic Acid Derivatives—Medium and Large Rings as Bioisosteres of Alkylphenyl Moieties?

Dipl.-Chem. Björn Greve, Priv.-Doz. Dr. Peter Imming, Dr. Stefan Laufer

Journal:

Angewandte Chemie International Edition

Year:

1996

Language:

english

File:

PDF, 362 KB

english, 1996

36

Dynamics in the p38α MAP Kinase–SB203580 Complex Observed by Liquid-State NMR Spectroscopy

Valerie S. Honndorf, Nicolas Coudevylle, Stefan Laufer, Stefan Becker, Christian Griesinger

Journal:

Angewandte Chemie International Edition

Year:

2008

Language:

english

File:

PDF, 542 KB

english, 2008

37

Inferential NMR/X-ray-Based Structure Determination of a Dibenzo[a,d]cycloheptenone Inhibitor–p38α MAP Kinase Complex in Solution

Dr. Valerie S. Honndorf, Dr. Nicolas Coudevylle, Prof. Dr. Stefan Laufer, Dr. Stefan Becker, Prof. Dr. Christian Griesinger, Dr. Michael Habeck

Journal:

Angewandte Chemie International Edition

Year:

2012

Language:

english

File:

PDF, 953 KB

english, 2012

38

Enaminodiester und -monoester mit semicyclischer CC-Bindung der Pyrrolidin- und Imidazolidin-Reihe

Gerd Dannhardt, Stefan Laufer, Klaus Ziereis

Journal:

Archiv der Pharmazie

Year:

1988

Language:

german

File:

PDF, 188 KB

german, 1988

39

Hypertensiv wirksame 5-(β-Aminoethyl)aminoisoxazole: Synthese und Prüfung von Derivaten mit teilrigidisierter C-5-Seitenkette bzw. ω-ständigem Heterocyclus

Gerd Dannhardt, Peter Dominiak, Stefan Laufer

Journal:

Archiv der Pharmazie

Year:

1990

File:

PDF, 649 KB

1990

40

Hypertensiv wirksame 5-(ω-Aminoalkyl)aminoisoxazole: Synthese und Prüfung von Verbindungen mit einer Sulfamid- oder Carboxyl-Gruppe am Ende der Seitenkette

Gerd Dannhardt, Peter Dominiak, Stefan Laufer

Journal:

Archiv der Pharmazie

Year:

1990

Language:

german

File:

PDF, 194 KB

german, 1990

41

Hypertensiv wirksame 5-(β-Aminoethyl)aminoisoxazole: Synthese und Prüfung von Isoxazolopyrazinen und Isoxazolodiazepinen

Gerd Dannhardt, Peter Dominiak, Stefan Laufer

Journal:

Archiv der Pharmazie

Year:

1991

File:

PDF, 840 KB

1991

42

Regioisomeric 5(3)-Aminomethyl-3(5)-phenylisoxazoles: Synthesis, Spectroscopic Discrimination, and Muscarinic Activity

Gerd Dannhardt, Günter Lambrecht, Stefan Laufer, Ernst Mutschler, Johannes Schweiger

Journal:

Archiv der Pharmazie

Year:

1995

Language:

english

File:

PDF, 557 KB

english, 1995

43

Synthesis and Evaluation of a Novel Series of Pyrrolizine Derivatives as Dual Cyclooxygenase-1 and 5-Lipoxygenase Inhibitors

Stefan Laufer, Hans-Günter Striegel, Karola Neher, Pia Zechmeister, Cornelia Donat, Katrin Stolingwa, Sibylle Baur, Susanne Tries, Thomas Kammermeier, Gerd Dannhardt, Werner Kiefer

Journal:

Archiv der Pharmazie

Year:

1997

Language:

english

File:

PDF, 625 KB

english, 1997

44

Antitubercular Isoniazid and Drug Resistance of Mycobacterium tuberculosis — A Review

Thomas Scior, Iván Meneses Morales, Solón Javier Garcés Eisele, David Domeyer, Stefan Laufer

Journal:

Archiv der Pharmazie

Year:

2002

Language:

english

File:

PDF, 528 KB

english, 2002

45

Design, Synthesis and Structure–Activity Relationship of Functionalized Tetrahydro-β-carboline Derivatives as Novel PDE5 Inhibitors

Nermin S. Ahmed, Bernard D. Gary, Hethar N. Tinsley, Gary A. Piazza, Stefan Laufer, Ashraf H. Abadi

Journal:

Archiv der Pharmazie

Year:

2011

Language:

english

File:

PDF, 360 KB

english, 2011

46

Study of the role of leukotriene B4 in abnormal function of human subchondral osteoarthritis osteoblasts: Effects of cyclooxygenase and/or 5-lipoxygenase inhibition

Yosabeth Paredes, Frédéric Massicotte, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Stefan Laufer, Daniel Lajeunesse

Journal:

Arthritis & Rheumatism

Year:

2002

Language:

english

File:

PDF, 130 KB

english, 2002

47

Regulation of the expression of 5-lipoxygenase–activating protein/5-lipoxygenase and the synthesis of leukotriene B4 in osteoarthritic chondrocytes: Role of transforming growth factor β and eicosanoids

Johanne Martel-Pelletier, François Mineau, Hassan Fahmi, Stefan Laufer, Pascal Reboul, Christelle Boileau, Martin Lavigne, Jean-Pierre Pelletier

Journal:

Arthritis & Rheumatism

Year:

2004

Language:

english

File:

PDF, 122 KB

english, 2004

48

Biological Evaluation and Structural Determinants of p38α Mitogen-Activated-Protein Kinase and c-Jun-N-Terminal Kinase 3 Inhibition by Flavonoids

Márcia Goettert, Verena Schattel, Dr. Pierre Koch, Prof. Dr. Irmgard Merfort, Prof. Dr. Stefan Laufer

Journal:

Year:

2010

Language:

english

File:

PDF, 746 KB

english, 2010

49

ChemInform Abstract: Synthesis and Cyclooxygenase Inhibitory Properties of Novel (+) 2-(6-Methoxy-2-naphthyl)propanoic Acid (Naproxene) Derivatives.

Ashraf H. Abadi, Stefan Laufer, Jochen Lehmann

Journal:

Year:

2001

File:

PDF, 34 KB

2001

50

ChemInform Abstract: New NSAR

Journal:

Year:

2002

File:

PDF, 22 KB

2002