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1

Methotrexate Hepatotoxicity and the Impact of Nonalcoholic Fatty Liver Disease

Akshay, Shetty, WonKyung, Cho, William, Alazawi, Wing-Kin, Syn

Journal:

The American Journal of the Medical Sciences

Year:

2017

Language:

english

File:

PDF, 731 KB

english, 2017

2

Non-nutritive sweeteners and their association with the metabolic syndrome and non-alcoholic fatty liver disease: a review of the literature

Green, Caitlin H., Syn, Wing-Kin

Journal:

European Journal of Nutrition

Year:

2019

Language:

english

File:

PDF, 649 KB

english, 2019

3

Hyperammonemia and Systemic Inflammatory Response Syndrome Predicts Presence of Hepatic Encephalopathy in Dogs with Congenital Portosystemic Shunts

Tivers, Mickey S., Handel, Ian, Gow, Adam G., Lipscomb, Vicky J., Jalan, Rajiv, Mellanby, Richard J., Syn, Wing-Kin

Journal:

Year:

2014

Language:

english

File:

PDF, 251 KB

english, 2014

4

Fibrosis in Chronic Liver Disease: An Update on Diagnostic and Treatment Modalities

Manka, Paul, Zeller, Amos, Syn, Wing-Kin

Journal:

Year:

2019

File:

PDF, 1.55 MB

2019

5

Significance of Simple Steatosis: An Update on the Clinical and Molecular Evidence

Mazzolini, Guillermo, Sowa, Jan-Peter, Atorrasagasti, Catalina, KÃ¼cÃ¼koglu, Ãzlem, Syn, Wing-Kin, Canbay, Ali

Journal:

Year:

2020

File:

PDF, 610 KB

2020

6

Role for hedgehog pathway in regulating growth and function of invariant NKT cells

Wing-Kin Syn, Rafal P. Witek, Stuart M. Curbishley, Youngmi Jung, Steve S. Choi, Barbara Enrich, Alessia Omenetti, Kolade M. Agboola, Caitlin M. Fearing, Herbert Tilg, David H. Adams, Anna Mae Diehl

Journal:

European Journal of Immunology

Year:

2009

Language:

english

File:

PDF, 445 KB

english, 2009

7

Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production

Alessia Omenetti, Wing-Kin Syn, Youngmi Jung, Heather Francis, Alessandro Porrello, Rafal P. Witek, Steve S. Choi, Liu Yang, Marlyn J. Mayo, M. Eric Gershwin, Gianfranco Alpini, Anna Mae Diehl

Journal:

Year:

2009

Language:

english

File:

PDF, 620 KB

english, 2009

8

Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis

Rafal P. Witek, W. Carl Stone, F. Gamze Karaca, Wing-Kin Syn, Thiago A. Pereira, Kolade M. Agboola, Alessia Omenetti, Youngmi Jung, Vanessa Teaberry, Steve S. Choi, Cynthia D. Guy, John Pollard, Peter

Journal:

Year:

2009

Language:

english

File:

PDF, 2.57 MB

english, 2009

9

Supporting evidence for natural killer T cell accumulation in progressive nonalcoholic fatty liver disease?

Wing-Kin Syn, Ye Htun Oo

Journal:

Year:

2010

Language:

english

File:

PDF, 54 KB

english, 2010

10

Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice

Begoña Ochoa, Wing-Kin Syn, Igotz Delgado, Gamze F. Karaca, Youngmi Jung, Jiangbo Wang, Ana M. Zubiaga, Olatz Fresnedo, Alessia Omenetti, Marzena Zdanowicz, Steve S. Choi, Anna Mae Diehl

Journal:

Year:

2010

Language:

english

File:

PDF, 765 KB

english, 2010

11

Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease

Wing-Kin Syn, Ye Htun Oo, Thiago A. Pereira, Gamze F. Karaca, Youngmi Jung, Alessia Omenetti, Rafal P. Witek, Steve S. Choi, Cynthia D. Guy, Caitlin M. Fearing, Vanessa Teaberry, Fausto E.L. Pereira,

Journal:

Year:

2010

Language:

english

File:

PDF, 2.31 MB

english, 2010

12

Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells

Steve S. Choi, Rafal P. Witek, Liu Yang, Alessia Omenetti, Wing-Kin Syn, Cynthia A. Moylan, Youngmi Jung, Gamze F. Karaca, Vanessa S. Teaberry, Thiago A. Pereira, Jiangbo Wang, Xiu-Rong Ren, Anna Mae

Journal:

Year:

2010

Language:

english

File:

PDF, 1.58 MB

english, 2010

13

Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis

Wing-Kin Syn, Steve S. Choi, Evaggelia Liaskou, Gamze F. Karaca, Kolade M. Agboola, Ye Htun Oo, Zhiyong Mi, Thiago A. Pereira, Marzena Zdanowicz, Padmini Malladi, Yuping Chen, Cynthia Moylan, Youngmi

Journal:

Year:

2011

Language:

english

File:

PDF, 2.09 MB

english, 2011

14

Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis

Judith Ertle, Alexander Dechêne, Jan-Peter Sowa, Volker Penndorf, Kerstin Herzer, Gernot Kaiser, Jörg F. Schlaak, Guido Gerken, Wing-Kin Syn, Ali Canbay

Journal:

International Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 402 KB

english, 2011

15

Natural history of unexplained chronic hepatitis after liver transplantation

Wing-Kin Syn, Peter Nightingale, Bridget Gunson, Stefan G. Hubscher, James M. Neuberger

Journal:

Liver Transplantation

Year:

2007

Language:

english

File:

PDF, 107 KB

english, 2007

16

Nonalcoholic fatty liver disease in a district general hospital: clinical presentation and risk factors

Wing-Kin Syn, Peter Nightingale, Jeffrey M. Bateman

Journal:

Hepatology International

Year:

2008

Language:

english

File:

PDF, 165 KB

english, 2008

17

Pathogenesis of alcohol-induced liver disease: Classical concepts and recent advances

Devanshi Seth, Paul S Haber, Wing-Kin Syn, Anna Mae Diehl, Christopher P Day

Journal:

Journal of Gastroenterology and Hepatology

Year:

2011

Language:

english

File:

PDF, 352 KB

english, 2011

18

Metallic stents in large bowel obstruction: experience in a District General Hospital

Wing-Kin Syn, M. Patel, M. M. Ahmed

Journal:

Colorectal Disease

Year:

2005

Language:

english

File:

PDF, 89 KB

english, 2005

19

Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice

Wing-Kin Syn, Liu Yang, Dian Jung Chiang, Yue Qian, Youngmi Jung, Gamze Karaca, Steve S. Choi, Rafal P. Witek, Alessia Omenetti, Thiago A. Pereira, Anna Mae Diehl

Journal:

Liver International

Year:

2009

Language:

english

File:

PDF, 886 KB

english, 2009

20

Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma

Pereira, Thiago de Almeida, Witek, Rafal P, Syn, Wing-Kin, Choi, Steve S, Bradrick, Shelton, Karaca, Gamze F, Agboola, Kolade M, Jung, Youngmi, Omenetti, Alessia, Moylan, Cynthia A

Journal:

Laboratory Investigation

Year:

2010

Language:

english

File:

PDF, 1.43 MB

english, 2010

21

Role of stress-induced NKG2D ligands in liver diseases

Alisan Kahraman, Christian D. Fingas, Wing-Kin Syn, Guido Gerken, Ali Canbay

Journal:

Liver International

Year:

2012

Language:

english

File:

PDF, 929 KB

english, 2012

22

The role of Hedgehog signaling in fibrogenic liver repair

Steve S. Choi, Alessia Omenetti, Wing-Kin Syn, Anna Mae Diehl

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2011

Language:

english

File:

PDF, 542 KB

english, 2011

23

Late venous outflow obstruction after liver transplant: The ‘piggy-back’ syndrome

Joshua M. Brostoff, Chandra S. Bhati, Wing-Kin Syn

Journal:

European Journal of Internal Medicine

Year:

2008

Language:

english

File:

PDF, 148 KB

english, 2008

24

Persistent pyrexia post-liver transplantation: A unique case of pericardial tuberculosis

Ye Htun Oo, Wing-Kin Syn

Journal:

European Journal of Internal Medicine

Year:

2008

Language:

english

File:

PDF, 106 KB

english, 2008

25

The Synergistic Use of Argon Plasma Coagulation (APC) and Self-Expanding Metallic Stents (SEMS) for the Palliation of Malignant Dysphagia

Wing-Kin Syn, Iqbal Khan, Minesh Patel, Adrian Parnell, Michael P. Skander, Monzur M. Ahmed

Journal:

Gastrointestinal Endoscopy

Year:

2004

Language:

english

File:

PDF, 52 KB

english, 2004

26

Hedgehog-responsive progenitors: Predictors of liver outcomes?

Coombes, Jason, Syn, Wing-Kin

Journal:

Year:

2012

Language:

english

File:

PDF, 316 KB

english, 2012

27

Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics

Liaskou, Evaggelia, Zimmermann, Henning W., Li, Ka-Kit, Oo, Ye H., Suresh, Shankar, Stamataki, Zania, Qureshi, Omar, Lalor, Patricia F., Shaw, Jean, Syn, Wing-kin, Curbishley, Stuart M., Adams, David

Journal:

Year:

2013

Language:

english

File:

PDF, 1.79 MB

english, 2013

28

Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury

El-Ghaiesh, Sabah, Sanderson, Joseph P., Farrell, John, Lavergne, Sidonie N., Syn, Wing-Kin, Pirmohamed, Munir, Park, B. Kevin, Naisbitt, Dean J.

Journal:

Journal of Allergy and Clinical Immunology

Year:

2011

Language:

english

File:

PDF, 989 KB

english, 2011

29

Liver Cell–Derived Microparticles Activate Hedgehog Signaling and Alter Gene Expression in Hepatic Endothelial Cells

Rafal P. Witek, Liu Yang, Renshui Liu, Youngmi Jung, Alessia Omenetti, Wing–Kin Syn, Steve S. Choi, Yeiwon Cheong, Caitlin M. Fearing, Kolade M. Agboola, Wei Chen, Anna Mae Diehl

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 3.59 MB

english, 2009

30

Hedgehog-Mediated Epithelial-to-Mesenchymal Transition and Fibrogenic Repair in Nonalcoholic Fatty Liver Disease

Wing–Kin Syn, Youngmi Jung, Alessia Omenetti, Manal Abdelmalek, Cynthia D. Guy, Liu Yang, Jiangbo Wang, Rafal P. Witek, Caitlin M. Fearing, Thiago A. Pereira, Vanessa Teaberry, Steve S. Choi, J. Conde

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 4.32 MB

english, 2009

31

Esophageal melanoma

Wing-Kin Syn, Rajul Singh, Mohammed Monzur Ahmed

Journal:

Gastrointestinal Endoscopy

Year:

2003

Language:

english

File:

PDF, 2.81 MB

english, 2003

32

Macrophage-derived hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni

Pereira, Thiago A., Xie, Guanhua, Choi, Steve S., Syn, Wing-Kin, Voieta, Izabela, Lu, Jiuyi, Chan, Isaac S., Swiderska, Marzena, Amaral, Kirsten B., Antunes, Carlos M., Secor, William E., Witek, Rafal

Journal:

Year:

2013

Language:

english

File:

PDF, 1.20 MB

english, 2013

33

Steroid and Ursodesoxycholic Acid Combination Therapy in Severe Drug-Induced Liver Injury

Wree, Alexander, Dechêne, Alexander, Herzer, Kerstin, Hilgard, Phillip, Syn, Wing-Kin, Gerken, Guido, Canbay, Ali

Journal:

Year:

2011

Language:

english

File:

PDF, 299 KB

english, 2011

34

Extrahepatic complications of nonalcoholic fatty liver disease

Armstrong, Matthew J., Adams, Leon A., Canbay, Ali, Syn, Wing-Kin

Journal:

Year:

2014

Language:

english

File:

PDF, 1.58 MB

english, 2014

35

T1964 Gene Expression Profiles During Activation of Human Hepatic Stellate Cells Suggest an Epithelial-to-Mesenchymal Transition-Like Process

Moylan, Cynthia A., Choi, Steve S., Acharya, Chaitanya R., Syn, Wing-Kin, Omenetti, Alessia, Jung, Youngmi, Sudan, Debra L., Muir, Andrew J., Potti, Anil, Diehl, Anna Mae

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 48 KB

english, 2010

36

294 Nr4a1 Nuclear Orphan Receptor is a Novel Regulator of Hepatic Fibrosis

Choi, Steve S., Syn, Wing-Kin, Swiderska, Marzena, Smith, Michael P., Diehl, Anna Mae, Michelotti, Gregory A.

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 58 KB

english, 2012

37

Endoscopic management is the treatment of choice for bile leaks after liver resection

Dechêne, Alexander, Jochum, Christoph, Fingas, Christian, Paul, Andreas, Heider, Dominik, Syn, Wing-Kin, Gerken, Guido, Canbay, Ali, Zöpf, Thomas

Journal:

Gastrointestinal Endoscopy

Year:

2014

Language:

english

File:

PDF, 914 KB

english, 2014

38

Apoptosis and Cytokines in Non-Alcoholic Steatohepatitis

Syn, Wing-Kin, Choi, Steve S., Diehl, Anna Mae

Journal:

Clinics in Liver Disease

Year:

2009

Language:

english

File:

PDF, 269 KB

english, 2009

39

343 Myofibroblasts Promote the Growth of Biliary Tree During Cholestatic Liver Injury By Suppressing Tryptophan Hydroxylase 2 (TPH2) Expression and Serotonin Secretion in Neighboring Cholangiocytes

Omenetti, Alessia, Yang, Liu, Gainetdinov, Raul R., Choi, Steve S., Witek, Rafal P., Jung, Youngmi, Syn, Wing-Kin, Chen, Wei, Caron, Marc G., Diehl, Anna Mae

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 51 KB

english, 2009

40

89 Sustained Activation of RAC1 Enhances Hedgehog-Mediated Epithelial-Mesenchymal Transition in Mice with Chronic Liver Injury

Choi, Steve S., Witek, Rafal P., Omenetti, Alessia, Yang, Liu, Syn, Wing-Kin, Jung, Youngmi, Sicklick, Jason K., Diehl, Anna Mae

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 51 KB

english, 2009

41

Utility of Osteopontin in Lineage Tracing Experiments

Coombes, Jason, Syn, Wing–Kin

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 76 KB

english, 2013

42

1 Specific Inhibition of Ikkβ in Hepatocytes Induces Proliferation of Liver Progenitors in Injured Livers

Jung, Youngmi, Witek, Rafal P., Syn, Wing-Kin, Choi, Steve S., Omenetti, Alessia, Diehl, Anna Mae

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 50 KB

english, 2009

43

T1960 Leptin Activates Hedgehog Pathway Signaling and Promotes Myofibroblastic Transition and Accumulation in Rat Hepatic Stellate Cells

Choi, Steve S., Syn, Wing-Kin, Karaca, Gamze F., Omenetti, Alessia, Wang, Xiaoling, Jung, Youngmi, Teaberry, Vanessa S., Moylan, Cynthia A., Diehl, Anna Mae

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 51 KB

english, 2010

44

M1577 Culture Activation of Murine Hepatic Stellate Cells Involves Hedgehog Pathway Activation and Epithelial-to-Mesenchymal Transitions

Choi, Steve S., Omenetti, Alessia, Yang, Liu, Witek, Rafal P., Brown, Kevin D., Vazquez-Chantada, Mercedes, Huang, Jiawen, Jung, Youngmi, Syn, Wing-Kin, Sicklick, Jason K., Diehl, Anna Mae

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 72 KB

english, 2008

45

T1821 Liver-Derived Microparticles Carry Biologically-Active Hedgehog Morphogens in Blood and Bile

Witek, Rafal P., Liu, Renshui, Yang, Liu, Jung, Youngmi, Brown, Kevin, Omenetti, Alessia, Vazquez-Chantada, Mercedes, Syn, Wing-Kin, Choi, Steve S., Huang, Jiawen, Chen, Wei, Diehl, Anna Mae

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 68 KB

english, 2008

46

S1585 Myofibroblast-Derived Soluble Factors Upregulate Chemokine Gene Expression in Neighboring Cholangiocytes

Omenetti, Alessia, Porrello, Alessandro, Syn, Wing-Kin, Choi, Steve S., Jung, Youngmi, Yang, Liu, Brown, Kevin D., Witek, Rafal P., Vandongen, Hendrika, Diehl, Anna Mae

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 61 KB

english, 2008

47

Vitamin D counteracts fibrogenic TGF-β signalling in human hepatic stellate cells both receptor-dependently and independently

Beilfuss, Anja, Sowa, Jan-Peter, Sydor, Svenja, Beste, Mechthild, Bechmann, Lars P, Schlattjan, Martin, Syn, Wing-Kin, Wedemeyer, Inga, Mathé, Zoltan, Jochum, Christoph, Gerken, Guido, Gieseler, Rober

Journal:

Year:

2015

Language:

english

File:

PDF, 2.47 MB

english, 2015

48

Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways

El-Ghaiesh, Sabah, Sanderson, Joseph P., Farrell, John, Lavergne, Sidonie N., Syn, Wing-Kin, Pirmohamed, Munir, Park, B. Kevin, Naisbitt, Dean J.

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 1.08 MB

english, 2011

49

Differential osteopontin functions: The role of osteopontin isoforms

Coombes, Jason D., Syn, Wing-Kin

Journal:

Year:

2015

Language:

english

File:

PDF, 344 KB

english, 2015

50

Hepatitis E Virus Infection as a Possible Cause of Acute Liver Failure in Europe

Manka, Paul, Bechmann, Lars P., Coombes, Jason D., Thodou, Viktoria, Schlattjan, Martin, Kahraman, Alisan, Syn, Wing-Kin, Saner, Fuat, Gerken, Guido, Baba, Hideo, Verheyen, Jens, Timm, Jörg, Canbay, A

Journal:

Clinical Gastroenterology and Hepatology

Year:

2015

Language:

english

File:

PDF, 440 KB

english, 2015