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51

Tumour cell/dendritic cell fusions as a vaccination strategy for multiple myeloma

Noopur Raje, Teru Hideshima, Faith E. Davies, Dharminder Chauhan, Steven P. Treon, Gloria Young, Yu-Tzu Tai, David Avigan, Jianlin Gong, Robert L. Schlossman, Paul Richardson, Donald W. Kufe, Kenneth

Journal:

British Journal of Haematology

Year:

2004

Language:

english

File:

PDF, 505 KB

english, 2004

52

Novel therapeutic strategies targeting growth factor signalling cascades in multiple myeloma

Hiroshi Yasui, Teru Hideshima, Paul G. Richardson, Kenneth C. Anderson

Journal:

British Journal of Haematology

Year:

2006

Language:

english

File:

PDF, 524 KB

english, 2006

53

FQPD, a novel immunomodulatory drug, has significant in vitro activity in multiple myeloma

Shaji Kumar, Noopur Raje, Teru Hideshima, Kenji Ishitsuka, Klaus Podar, Steven Le Gouille, Dharminder Chauhan, Paul Richardson, Nikhil C. Munshi, Kenneth Anderson

Journal:

British Journal of Haematology

Year:

2006

Language:

english

File:

PDF, 4.28 MB

english, 2006

54

In vivo and in vitro cytotoxicity of R-etodolac with dexamethasone in glucocorticoid-resistant multiple myeloma cells

Paola Neri, Hiroshi Yasui, Teru Hideshima, Pierfrancesco Tassone, Noopur Raje, Catley P. Laurence, Kenji Ishitsuka, Simona Blotta, Tanyel Kiziltepe, Enrique M. Ocio, Mariateresa Fulciniti, Sarath Kane

Journal:

British Journal of Haematology

Year:

2006

Language:

english

File:

PDF, 255 KB

english, 2006

55

Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib

Reshma Shringarpure, Laurence Catley, Deepak Bhole, Renate Burger, Klaus Podar, Yu-Tzu Tai, Benedikt Kessler, Paul Galardy, Hidde Ploegh, Pierfrancesco Tassone, Teru Hideshima, Constantine Mitsiades,

Journal:

British Journal of Haematology

Year:

2006

Language:

english

File:

PDF, 447 KB

english, 2006

56

Didox, a ribonucleotide reductase inhibitor, induces apoptosis and inhibits DNA repair in multiple myeloma cells

N. Raje, S. Kumar, T. Hideshima, K. Ishitsuka, H. Yasui, S. Chhetri, S. Vallet, E. Vonescu, N. Shiraishi, T. Kiziltepe, H.L. Elford, N.C. Munshi, K.C. Anderson

Journal:

British Journal of Haematology

Year:

2006

Language:

english

File:

PDF, 1.02 MB

english, 2006

57

BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth

Hiroshi Yasui, Teru Hideshima, Hiroshi Ikeda, Janice Jin, Enrique M. Ocio, Tanyel Kiziltepe, Yutaka Okawa, Sonia Vallet, Klaus Podar, Kenji Ishitsuka, Paul G. Richardson, Chris Pargellis, Neil Moss, N

Journal:

British Journal of Haematology

Year:

2007

Language:

english

File:

PDF, 756 KB

english, 2007

58

Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma

Iris Breitkreutz, Marc S. Raab, Sonia Vallet, Teru Hideshima, Noopur Raje, Dharminder Chauhan, Nikhil C. Munshi, Paul G. Richardson, Kenneth C. Anderson

Journal:

British Journal of Haematology

Year:

2007

Language:

english

File:

PDF, 630 KB

english, 2007

59

Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells

Teru Hideshima, Laurence Catley, Noopur Raje, Dharminder Chauhan, Klaus Podar, Constantine Mitsiades, Yu-Tzu Tai, Sonia Vallet, Tanyel Kiziltepe, Enrique Ocio, Hiroshi Ikeda, Yutaka Okawa, Hiromasa Hi

Journal:

British Journal of Haematology

Year:

2007

Language:

english

File:

PDF, 713 KB

english, 2007

60

p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications

Kenji Ishitsuka, Teru Hideshima, Paola Neri, Sonia Vallet, Norihiko Shiraishi, Yutaka Okawa, Zhenxin Shen, Noopur Raje, Tanyel Kiziltepe, Enrique M. Ocio, Dharminder Chauhan, Pierfrancesco Tassone, Ni

Journal:

British Journal of Haematology

Year:

2008

Language:

english

File:

PDF, 327 KB

english, 2008

61

Retraction: Fatty acid synthase is a novel therapeutic target in multiple myeloma

Yutaka Okawa, Teru Hideshima, Hiroshi Ikeda, Noopur Raje, Sonia Vallet, Tanyel Kiziltepe, Hiroshi Yasui, Sotaro Enatsu, Samantha Pozzi, Iris Breitkreutz, Diana Cirstea, Loredana Santo, Paul Richardson

Journal:

British Journal of Haematology

Year:

2008

Language:

english

File:

PDF, 876 KB

english, 2008

62

In vitro anti-myeloma activity of the Aurora kinase inhibitor VE-465

Joseph M. Negri, Douglas W. McMillin, Jake Delmore, Nicholas Mitsiades, Patrick Hayden, Steffen Klippel, Teru Hideshima, Dharminder Chauhan, Nikhil C. Munshi, Carolyn A. Buser, John Pollard, Paul G. R

Journal:

British Journal of Haematology

Year:

2009

Language:

english

File:

PDF, 351 KB

english, 2009

63

Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo

Kihyun Kim, Sun-Young Kong, Mariateresa Fulciniti, Xianfeng Li, Weihua Song, Sabikun Nahar, Peter Burger, Mathew J. Rumizen, Klaus Podar, Dharminder Chauhan, Teru Hideshima, Nikhil C. Munshi, Paul Ric

Journal:

British Journal of Haematology

Year:

2010

Language:

english

File:

PDF, 561 KB

english, 2010

64

Managing multiple myeloma: the emerging role of novel therapies and adapting combination treatment for higher risk settings

Paul G. Richardson, Jacob Laubach, Constantine S. Mitsiades, Robert Schlossman, Teru Hideshima, Katherine Redman, Dharminder Chauhan, Irene M. Ghobrial, Nikhil Munshi, Kenneth C. Anderson

Journal:

British Journal of Haematology

Year:

2011

Language:

english

File:

PDF, 693 KB

english, 2011

65

Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma

Raab, M S, Vallet, S, Hideshima, T, Raje, N, Mitsiades, C, Chauhan, D, Okawa, Y, Munshi, N C, Richardson, P G, Breitkreutz, I

Journal:

Year:

2008

Language:

english

File:

PDF, 227 KB

english, 2008

66

Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma

Hideshima, T, Raje, N, Mitsiades, C, Chauhan, D, Okawa, Y, Munshi, N C, Richardson, P G, Breitkreutz, I, Raab, M S, Vallet, S

Journal:

Year:

2008

Language:

english

File:

PDF, 65 KB

english, 2008

67

Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma

Raje, N, Hideshima, T, Mukherjee, S, Raab, M, Vallet, S, Chhetri, S, Cirstea, D, Pozzi, S, Mitsiades, C, Rooney, M

Journal:

Year:

2009

Language:

english

File:

PDF, 354 KB

english, 2009

68

The use of novel agents in the treatment of relapsed and refractory multiple myeloma

Laubach, J P, Mahindra, A, Mitsiades, C S, Schlossman, R L, Munshi, N C, Ghobrial, I M, Carreau, N, Hideshima, T, Anderson, K C, Richardson, P G

Journal:

Year:

2009

Language:

english

File:

PDF, 194 KB

english, 2009

69

Ascorbic acid inhibits antitumor activity of bortezomib in vivo

Perrone, G, Hideshima, T, Ikeda, H, Okawa, Y, Calabrese, E, Gorgun, G, Santo, L, Cirstea, D, Raje, N, Chauhan, D

Journal:

Year:

2009

Language:

english

File:

PDF, 337 KB

english, 2009

70

HDAC inhibition by LBH589 affects the phenotype and function of human myeloid dendritic cells

Song, W, Tai, Y-T, Tian, Z, Hideshima, T, Chauhan, D, Nanjappa, P, Exley, M A, Anderson, K C, Munshi, N C

Journal:

Year:

2010

Language:

english

File:

PDF, 705 KB

english, 2010

71

A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function

Vallet, S, Pozzi, S, Patel, K, Vaghela, N, Fulciniti, M T, Veiby, P, Hideshima, T, Santo, L, Cirstea, D, Scadden, D T

Journal:

Year:

2011

Language:

english

File:

PDF, 529 KB

english, 2011

72

Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets

Richardson, Paul G., Anderson, Kenneth C., Hideshima, Teru, Mitsiades, Constantine, Tonon, Giovanni

Journal:

Nature Reviews Cancer

Year:

2007

Language:

english

File:

PDF, 741 KB

english, 2007

73

Molecular mechanisms of novel therapeutic approaches for multiple myeloma

Hideshima, Teru, Anderson, Kenneth C.

Journal:

Nature Reviews Cancer

Year:

2002

Language:

english

File:

PDF, 2.56 MB

english, 2002

74

AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3β activation and RNA polymerase II inhibition

Santo, L, Vallet, S, Hideshima, T, Cirstea, D, Ikeda, H, Pozzi, S, Patel, K, Okawa, Y, Gorgun, G, Perrone, G

Journal:

Year:

2010

Language:

english

File:

PDF, 938 KB

english, 2010

75

A novel proteasome inhibitor NPI-0052 as an anticancer therapy

Chauhan, D, Hideshima, T, Anderson, K C

Journal:

British Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 129 KB

english, 2006

76

Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications

Gupta, D, Treon, SP, Shima, Y, Hideshima, T, Podar, K, Tai, YT, Lin, B, Lentzsch, S, Davies, FE, Chauhan, D

Journal:

Year:

2001

Language:

english

File:

PDF, 263 KB

english, 2001

77

Immunomodulatory analogs of thalidomide inhibit growth of Hs Sultan cells and angiogenesis in vivo

Lentzsch, S, LeBlanc, R, Podar, K, Davies, F, Lin, B, Hideshima, T, Catley, L, Stirling, D I, Anderson, K C

Journal:

Year:

2003

Language:

english

File:

PDF, 104 KB

english, 2003

78

Antimyeloma activity of two novel N-substituted and tetraflourinated thalidomide analogs

Kumar, S, Raje, N, Hideshima, T, Ishitsuka, K, Roccaro, A, Shiraishi, N, Hamasaki, M, Yasui, H, Munshi, N C, Richardson, P

Journal:

Year:

2005

Language:

english

File:

PDF, 279 KB

english, 2005

79

Inhibition of p38α MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-XL, Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo

Navas, T A, Nguyen, A N, Hideshima, T, Reddy, M, Ma, J Y, Haghnazari, E, Henson, M, Stebbins, E G, Kerr, I, O'Young, G

Journal:

Year:

2006

Language:

english

File:

PDF, 679 KB

english, 2006

80

Novel etodolac analog SDX-308 (CEP-18082) induces cytotoxicity in multiple myeloma cells associated with inhibition of β-catenin/TCF pathway

Yasui, H, Hideshima, T, Ikeda, H, Ocio, E M, Kiziltepe, T, Vallet, S, Okawa, Y, Neri, P, Sukhdeo, K, Podar, K

Journal:

Year:

2007

Language:

english

File:

PDF, 259 KB

english, 2007

81

RAFTK/PYK2-dependent and -independent apoptosis in multiple myeloma cells

Chauhan, Dharminder, Hideshima, Teru, Pandey, Pramod, Treon, Steve, Teoh, Gerrard, Raje, Noopur, Rosen, Steven, Krett, Nancy, Husson, Hervé, Avraham, Shalom

Journal:

Year:

1999

Language:

english

File:

PDF, 330 KB

english, 1999

82

The role of tumor necrosis factor α in the pathophysiology of human multiple myeloma: therapeutic applications

Hideshima, Teru, Chauhan, Dharminder, Schlossman, Robert, Richardson, Paul, Anderson, Kenneth C

Journal:

Year:

2001

Language:

english

File:

PDF, 262 KB

english, 2001

83

Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma

Hideshima, Teru, Nakamura, Noriaki, Chauhan, Dharminder, Anderson, Kenneth C

Journal:

Year:

2001

Language:

english

File:

PDF, 308 KB

english, 2001

84

Identification of genes regulated by Dexamethasone in multiple myeloma cells using oligonucleotide arrays

Chauhan, Dharminder, Auclair, Daniel, Robinson, Elisabeth K, Hideshima, Teru, Li, Guilan, Podar, Klaus, Gupta, Deepak, Richardson, Paul, Schlossman, Robert L, Krett, Nancy

Journal:

Year:

2002

Language:

english

File:

PDF, 443 KB

english, 2002

85

Activation of NF-κB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications

Mitsiades, Constantine S, Mitsiades, Nicholas, Poulaki, Vassiliki, Schlossman, Robert, Akiyama, Masaharu, Chauhan, Dharminder, Hideshima, Teru, Treon, Steven P, Munshi, Nikhil C, Richardson, Paul G

Journal:

Year:

2002

Language:

english

File:

PDF, 313 KB

english, 2002

86

Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells

Chauhan, Dharminder, Li, Guilan, Sattler, Martin, Podar, Klaus, Mitsiades, Constantine, Mitsiades, Nicholas, Munshi, Nikhil, Hideshima, Teru, Anderson, Kenneth C

Journal:

Year:

2003

Language:

english

File:

PDF, 194 KB

english, 2003

87

Biologic sequelae of c-Jun NH2-terminal kinase (JNK) activation in multiple myeloma cell lines

Hideshima, Teru, Hayashi, Toshiaki, Chauhan, Dharminder, Akiyama, Masaharu, Richardson, Paul, Anderson, Kenneth

Journal:

Year:

2003

Language:

english

File:

PDF, 183 KB

english, 2003

88

Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma

Hideshima, Teru, Chauhan, Dharminder, Hayashi, Toshiaki, Akiyama, Masaharu, Mitsiades, Nicholas, Mitsiades, Constantine, Podar, Klaus, Munshi, Nikhil C, Richardson, Paul G, Anderson, Kenneth C

Journal:

Year:

2003

Language:

english

File:

PDF, 261 KB

english, 2003

89

Blockade of ubiquitin-conjugating enzyme CDC34 enhances anti-myeloma activity of Bortezomib/Proteasome inhibitor PS-341

Chauhan, Dharminder, Li, Guilan, Hideshima, Teru, Podar, Klaus, Shringarpure, Reshma, Mitsiades, Constantine, Munshi, Nikhil, Yew, P Renee, Anderson, Kenneth C

Journal:

Year:

2004

Language:

english

File:

PDF, 230 KB

english, 2004

90

p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells

Hideshima, Teru, Podar, Klaus, Chauhan, Dharminder, Ishitsuka, Kenji, Mitsiades, Constantine, Tai, Yu-Tzu, Hamasaki, Makoto, Raje, Noopur, Hideshima, Hiromasa, Schreiner, George

Journal:

Year:

2004

Language:

english

File:

PDF, 241 KB

english, 2004

91

Molecular characterization of PS-341 (bortezomib) resistance: implications for overcoming resistance using lysophosphatidic acid acyltransferase (LPAAT)-β inhibitors

Hideshima, Teru, Chauhan, Dharminder, Ishitsuka, Kenji, Yasui, Hiroshi, Raje, Noopur, Kumar, Shaji, Podar, Klaus, Mitsiades, Constantine, Hideshima, Hiromasa, Bonham, Lynn

Journal:

Year:

2005

Language:

english

File:

PDF, 233 KB

english, 2005

92

Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway

Ishitsuka, Kenji, Hideshima, Teru, Hamasaki, Makoto, Raje, Noopur, Kumar, Shaji, Podar, Klaus, Le Gouill, Steven, Shiraishi, Norihiko, Yasui, Hiroshi, Roccaro, Aldo M

Journal:

Year:

2005

Language:

english

File:

PDF, 372 KB

english, 2005

93

A novel Bcl-2/Bcl-XL/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma

Chauhan, D, Velankar, M, Brahmandam, M, Hideshima, T, Podar, K, Richardson, P, Schlossman, R, Ghobrial, I, Raje, N, Munshi, N

Journal:

Year:

2006

Language:

english

File:

PDF, 320 KB

english, 2006

94

A pivotal role for Mcl-1 in Bortezomib-induced apoptosis

Podar, K, Gouill, S L, Zhang, J, Opferman, J T, Zorn, E, Tai, Y-T, Hideshima, T, Amiot, M, Chauhan, D, Harousseau, J-L

Journal:

Year:

2007

Language:

english

File:

PDF, 442 KB

english, 2007

95

The Effects of Lithium and Oxygen Contents Inducing Capacity Loss of the LiMn2O4Obtained at High Synthetic Temperature

Yun Sung Lee, Yasufumi Hideshima, Yang Kook Sun, Masaki Yoshio

Journal:

Journal of Electroceramics

Year:

2002

Language:

english

File:

PDF, 146 KB

english, 2002

96

Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma

Gorgun, G., Calabrese, E., Soydan, E., Hideshima, T., Perrone, G., Bandi, M., Cirstea, D., Santo, L., Hu, Y., Tai, Y.-T., Nahar, S., Mimura, N., Fabre, C., Raje, N., Munshi, N., Richardson, P., Anders

Journal:

Year:

2010

Language:

english

File:

PDF, 797 KB

english, 2010

97

Pathological crystallization of human immunoglobulins

Wang, Y., Lomakin, A., Hideshima, T., Laubach, J. P., Ogun, O., Richardson, P. G., Munshi, N. C., Anderson, K. C., Benedek, G. B.

Journal:

Proceedings of the National Academy of Sciences

Year:

2012

Language:

english

File:

PDF, 688 KB

english, 2012

98

ChemInform Abstract: Synthesis and Crystal Inclusion Properties of 1,3,5-Tris(para- substituted aryl)benzenes and Double-Decker Phanes.

T. YAMATO, C. HIDESHIMA, Y. NAGANO, M. TASHIRO

Journal:

Year:

1996

File:

PDF, 32 KB

1996

99

Esophago-jejuno-duodenal anastomoses with an ultra-short duodenum

Koho Akimaru, Masayuki Kokuma, Amane Hideshima, Manabu Gotoh, Tetsuo Shibuya, Tasuku Shoji

Journal:

Year:

1993

Language:

english

File:

PDF, 428 KB

english, 1993

100

Postoperative chylothorax following partial resection of mediastinal lymphangioma: Report of a case

Daisuke Matsuzoe, Akinori Iwasaki, Teru Hideshima, Yasuteru Yoshinaga, Kan Okabayashi, Takayuki Shirakusa

Journal:

Year:

1995

Language:

english

File:

PDF, 638 KB

english, 1995