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51

Stem cells in the treatment of diabetes

Otonkoski, Timo, Gao, Ru, Lundin, Karolina

Journal:

Annals of Medicine

Year:

2005

Language:

english

File:

PDF, 243 KB

english, 2005

52

Dedifferentiation for Replication of Human -Cells: A Division Between Mice and Men?

Billestrup, N., Otonkoski, T.

Journal:

Year:

2008

Language:

english

File:

PDF, 43 KB

english, 2008

53

Activin A and Wnt-dependent specification of human definitive endoderm cells

Toivonen, Sanna, Lundin, Karolina, Balboa, Diego, Ustinov, Jarkko, Tamminen, Kaisa, Palgi, Jaan, Trokovic, Ras, Tuuri, Timo, Otonkoski, Timo

Journal:

Experimental Cell Research

Year:

2013

Language:

english

File:

PDF, 7.00 MB

english, 2013

54

Tissue- and cell-type-specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model

Hamalainen, R. H., Manninen, T., Koivumaki, H., Kislin, M., Otonkoski, T., Suomalainen, A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2013

Language:

english

File:

PDF, 1.95 MB

english, 2013

55

MANF Is Indispensable for the Proliferation and Survival of Pancreatic β Cells

Lindahl, Maria, Danilova, Tatiana, Palm, Erik, Lindholm, Päivi, Võikar, Vootele, Hakonen, Elina, Ustinov, Jarkko, Andressoo, Jaan-Olle, Harvey, Brandon K., Otonkoski, Timo, Rossi, Jari, Saarma, Mart

Journal:

Year:

2014

Language:

english

File:

PDF, 3.30 MB

english, 2014

56

Patient-Specific Induced Pluripotent Stem Cell–Derived RPE Cells: Understanding the Pathogenesis of Retinopathy in Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency

Polinati, Padmini P., Ilmarinen, Tanja, Trokovic, Ras, Hyotylainen, Tuulia, Otonkoski, Timo, Suomalainen, Anu, Skottman, Heli, Tyni, Tiina

Journal:

Investigative Opthalmology & Visual Science

Year:

2015

Language:

english

File:

PDF, 808 KB

english, 2015

57

Nicotinamide and sodium butyratye for the induction of fetal porcine $beta;-cell differentiation prior to transplantation

Journal:

Cell Transplantation

Year:

1996

Language:

english

File:

PDF, 117 KB

english, 1996

58

In vivo activation of the PI3K–Akt pathway in mouse beta cells by theEGFRmutation L858R protects against diabetes

Hakonen, Elina, Ustinov, Jarkko, Eizirik, Décio L., Sariola, Hannu, Miettinen, Päivi J., Otonkoski, Timo

Journal:

Year:

2014

Language:

english

File:

PDF, 4.01 MB

english, 2014

59

Advanced Feeder-Free Generation of Induced Pluripotent Stem Cells Directly From Blood Cells

Trokovic, R., Weltner, J., Nishimura, K., Ohtaka, M., Nakanishi, M., Salomaa, V., Jalanko, A., Otonkoski, T., Kyttala, A.

Journal:

Stem Cells Translational Medicine

Year:

2014

Language:

english

File:

PDF, 1.77 MB

english, 2014

60

Ontogeny and Tissue Distribution of Human GAD Expression

Mally, M. I., Cirulli, V., Otonkoski, T., Soto, G., Hayek, A.

Journal:

Year:

1996

Language:

english

File:

PDF, 2.53 MB

english, 1996

61

Culture of Adult Human Islet Preparations With Hepatocyte Growth Factor and 804G Matrix Is Mitogenic for Duct Cells but Not for -Cells

Lefebvre, V. H., Otonkoski, T., Ustinov, J., Huotari, M.-A., Pipeleers, D. G., Bouwens, L.

Journal:

Year:

1998

Language:

english

File:

PDF, 2.60 MB

english, 1998

62

cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)

Bondestam, J., Huotari, M.-A., Mor&eacute, n, A., Ustinov, J., Kaivo-oja, N., Kallio, J., Horelli-Kuitunen, N., Aaltonen, J., Fujii, M., Moustakas, A., ten Dijke, P., Otonkoski, T., Ritvos, O.

Journal:

Cytogenetic and Genome Research

Year:

2001

Language:

english

File:

PDF, 191 KB

english, 2001

63

IL-17 Immunity in Human Type 1 Diabetes

Honkanen, J., Nieminen, J. K., Gao, R., Luopajarvi, K., Salo, H. M., Ilonen, J., Knip, M., Otonkoski, T., Vaarala, O.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 576 KB

english, 2010

64

Severe Transient Neonatal Hyperinsulinism Associated with Hyperlactataemia in Non-asphyxiated Infants

Hussain, K., Thornton, P.S., Otonkoski, T., Aynsley-Green, A.

Journal:

Journal of Pediatric Endocrinology and Metabolism

Year:

2004

Language:

english

File:

PDF, 1.39 MB

english, 2004

65

Opposite Effects of -cell Differentiation and Growth on Reg Expression in Human Fetal Pancreatic Cells

Otonkoski, T., Mally, M. I., Hayek, A.

Journal:

Year:

1994

Language:

english

File:

PDF, 473 KB

english, 1994

66

Induced Pluripotent Stem Cell Clones Reprogrammed via Recombinant Adeno-Associated Virus-Mediated Transduction Contain Integrated Vector Sequences

Weltner, J., Anisimov, A., Alitalo, K., Otonkoski, T., Trokovic, R.

Journal:

Journal of Virology

Year:

2012

Language:

english

File:

PDF, 1.43 MB

english, 2012

67

Maturation of Insulin Response to Glucose During Human Fetal and Neonatal Development: Studies with Perifusion of Pancreatic Isletlike Cell Clusters

Otonkoski, T., Andersson, S., Knip, M., Simell, O.

Journal:

Year:

1988

Language:

english

File:

PDF, 777 KB

english, 1988

68

Physical Exercise-Induced Hyperinsulinemic Hypoglycemia Is an Autosomal-Dominant Trait Characterized by Abnormal Pyruvate-Induced Insulin Release

Otonkoski, T., Kaminen, N., Ustinov, J., Lapatto, R., Meissner, T., Mayatepek, E., Kere, J., Sipila, I.

Journal:

Year:

2003

Language:

english

File:

PDF, 116 KB

english, 2003

69

Carriers of an Inactivating -Cell ATP-Sensitive K+ Channel Mutation Have Normal Glucose Tolerance and Insulin Sensitivity and Appropriate Insulin Secretion

Huopio, H., Vauhkonen, I., Komulainen, J., Niskanen, L., Otonkoski, T., Laakso, M.

Journal:

Year:

2002

Language:

english

File:

PDF, 130 KB

english, 2002

70

Functional -Cell Mass After Transplantation of Human Fetal Pancreatic Cells: Differentiation or Proliferation?

Beattie, G. M., Otonkoski, T., Lopez, A. D., Alberto, H.

Journal:

Year:

1997

Language:

english

File:

PDF, 1.40 MB

english, 1997

71

Integrative genomics and transcriptomics analysis of human embryonic and induced pluripotent stem cells

Laurila, Kirsti, Autio, Reija, Kong, Lingjia, Närvä, Elisa, Hussein, Samer, Otonkoski, Timo, Lahesmaa, Riitta, Lähdesmäki, Harri

Journal:

Year:

2014

Language:

english

File:

PDF, 1.40 MB

english, 2014

72

Noninvasive Diagnosis of Focal Hyperinsulinism of Infancy With [18F]-DOPA Positron Emission Tomography

Otonkoski, T., Nanto-Salonen, K., Seppanen, M., Veijola, R., Huopio, H., Hussain, K., Tapanainen, P., Eskola, O., Parkkola, R., Ekstrom, K., Guiot, Y., Rahier, J., Laakso, M., Rintala, R., Nuutila, P.

Journal:

Year:

2006

Language:

english

File:

PDF, 335 KB

english, 2006

73

Severe Persistent Hyperinsulinemic Hypoglycemia due to a De Novo Glucokinase Mutation

Cuesta-Munoz, A. L., Huopio, H., Otonkoski, T., Gomez-Zumaquero, J. M., Nanto-Salonen, K., Rahier, J., Lopez-Enriquez, S., Garcia-Gimeno, M. A., Sanz, P., Soriguer, F. C., Laakso, M.

Journal:

Year:

2004

Language:

english

File:

PDF, 300 KB

english, 2004

74

Stimulated Endocrine Cell Proliferation and Differentiation in Transplanted Human Pancreatic Islets: Effects of the ob Gene and Compensatory Growth of the Implantation Organ

Tyrberg, B., Ustinov, J., Otonkoski, T., Andersson, A.

Journal:

Year:

2001

Language:

english

File:

PDF, 183 KB

english, 2001

75

A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1

Shimomura, K., Tusa, M., Iberl, M., Brereton, M. F., Kaizik, S., Proks, P., Lahmann, C., Yaluri, N., Modi, S., Huopio, H., Ustinov, J., Otonkoski, T., Laakso, M., Ashcroft, F. M.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.17 MB

english, 2013

76

Lack of Association of PAX4 Gene With Type 1 Diabetes in the Finnish and Hungarian Populations

Hermann, R., Mantere, J., Lipponen, K., Veijola, R., Soltesz, G., Otonkoski, T., Simell, O., Knip, M., Ilonen, J.

Journal:

Year:

2005

Language:

english

File:

PDF, 65 KB

english, 2005

77

Proposal for a Standardized Protocol for 18F-DOPA-PET (PET/CT) in Congenital Hyperinsulinism

Mohnike, K., Blankenstein, O., Christesen, H.T., De Lonlay, J., Hussain, K., Koopmans, K.P., Minn, H., Mohnike, W., Mutair, A., Otonkoski, T., Rahier, J., Ribeiro, M., Schoenle, E., F&eacute, k&eacute,

Journal:

Hormone Research

Year:

2006

Language:

english

File:

PDF, 71 KB

english, 2006

78

The binding specificity of the marker antibodies Tra-1-60 and Tra-1-81 reveals a novel pluripotency-associated type 1 lactosamine epitope

Natunen, S., Satomaa, T., Pitkanen, V., Salo, H., Mikkola, M., Natunen, J., Otonkoski, T., Valmu, L.

Journal:

Year:

2011

Language:

english

File:

PDF, 218 KB

english, 2011

79

Rapid Genetic Analysis in Congenital Hyperinsulinism

Christesen, Henrik B.T., Brusgaard, Klaus, Alm, Jan, Sj&ouml, blad, Sture, Hussain, Khalid, Fenger, Claus, Rasmussen, Lars, Hovendal, Claus, Otonkoski, Timo, Jacobsen, Bendt Brock

Journal:

Hormone Research

Year:

2007

Language:

english

File:

PDF, 108 KB

english, 2007

80

[18F]-DOPA Positron Emission Tomography for Preoperative Localization in Congenital Hyperinsulinism

Mohnike, K., Blankenstein, O., Minn, H., Mohnike, W., Fuchtner, F., Otonkoski, T.

Journal:

Hormone Research

Year:

2008

Language:

english

File:

PDF, 219 KB

english, 2008

81

Downregulation of EGF Receptor Signaling in Pancreatic Islets Causes Diabetes Due to Impaired Postnatal -Cell Growth

Miettinen, P. J., Ustinov, J., Ormio, P., Gao, R., Palgi, J., Hakonen, E., Juntti-Berggren, L., Berggren, P.-O., Otonkoski, T.

Journal:

Year:

2006

Language:

english

File:

PDF, 774 KB

english, 2006

82

Clinical Heterogeneity in Monogenic Diabetes Caused by Mutations in the Glucokinase Gene (GCK-MODY)

Cuesta-Munoz, A. L., Tuomi, T., Cobo-Vuilleumier, N., Koskela, H., Odili, S., Stride, A., Buettger, C., Otonkoski, T., Froguel, P., Grimsby, J., Garcia-Gimeno, M., Matschinsky, F. M.

Journal:

Year:

2010

Language:

english

File:

PDF, 63 KB

english, 2010

83

Constitution of a biphasic insulin response to glucose in human fetal pancreatic beta-cells with glucagon-like peptide 1.

Otonkoski, T, Hayek, A

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

1995

Language:

english

File:

PDF, 491 KB

english, 1995

84

A Novel Feeder-Free Culture System for Human Pluripotent Stem Cell Culture and Induced Pluripotent Stem Cell Derivation

Vuoristo, Sanna, Toivonen, Sanna, Weltner, Jere, Mikkola, Milla, Ustinov, Jarkko, Trokovic, Ras, Palgi, Jaan, Lund, Riikka, Tuuri, Timo, Otonkoski, Timo, Shioda, Toshi

Journal:

Year:

2013

Language:

english

File:

PDF, 3.85 MB

english, 2013

85

mtDNA Mutagenesis Disrupts Pluripotent Stem Cell Function by Altering Redox Signaling

Hämäläinen, Riikka H., Ahlqvist, Kati J., Ellonen, Pekka, Lepistö, Maija, Logan, Angela, Otonkoski, Timo, Murphy, Michael P., Suomalainen, Anu

Journal:

Year:

2015

Language:

english

File:

PDF, 3.01 MB

english, 2015

86

Effects of Growth Hormone and Insulin-Like Growth Factor I on Endocrine Function of Human Fetal Islet-Like Cell Clusters During Long-Term Tissue Culture

Otonkoski, T., Knip, M., Wong, I., Simell, O.

Journal:

Year:

1988

Language:

english

File:

PDF, 746 KB

english, 1988

87

Characterization of Endocrine Progenitor Cells and Critical Factors for Their Differentiation in Human Adult Pancreatic Cell Culture

Gao, R., Ustinov, J., Pulkkinen, M.-A., Lundin, K., Korsgren, O., Otonkoski, T.

Journal:

Year:

2003

Language:

english

File:

PDF, 473 KB

english, 2003

88

A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in Finland

Otonkoski, T., Ammala, C., Huopio, H., Cote, G. J., Chapman, J., Cosgrove, K., Ashfield, R., Huang, E., Komulainen, J., Ashcroft, F. M., Dunne, M. J., Kere, J., Thomas, P. M.

Journal:

Year:

1999

Language:

english

File:

PDF, 310 KB

english, 1999

89

Insulin and Glucagon Secretory Responses to Arginine, Glue agon, and Theophylline During Perifusion of Human Fetal Islet-Like Cell Clusters*

OTONKOSKI, TIMO

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

1988

Language:

english

File:

PDF, 867 KB

english, 1988

90

Generation of iPSC line HEL47.2 from healthy human adult fibroblasts

Trokovic, Ras, Weltner, Jere, Otonkoski, Timo

Journal:

Stem Cell Research

Year:

2015

Language:

english

File:

PDF, 464 KB

english, 2015

91

Congenital hyperinsulinism, neonatal diabetes and the risk of malignancies: an international collaborative study. Preliminary communication

Makov, M., Chodick, G., Mohnike, K., Otonkoski, T., Huopio, H., Banerjee, I., Cave, H., Polak, M., Christesen, H. T., Hussain, K., Deleon, D., Stanley, C., Cappa, M., Ramos, O., Zangen, D., Laron, Z.

Journal:

Diabetic Medicine

Year:

2015

Language:

english

File:

PDF, 55 KB

english, 2015

92

Notch signaling regulates the differentiation of neural crest from human pluripotent stem cells

Noisa, P., Lund, C., Kanduri, K., Lund, R., Lahdesmaki, H., Lahesmaa, R., Lundin, K., Chokechuwattanalert, H., Otonkoski, T., Tuuri, T., Raivio, T.

Journal:

Journal of Cell Science

Year:

2014

Language:

english

File:

PDF, 6.17 MB

english, 2014

93

Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation

Balboa, Diego, Weltner, Jere, Eurola, Solja, Trokovic, Ras, Wartiovaara, Kirmo, Otonkoski, Timo

Journal:

Stem Cell Reports

Year:

2015

Language:

english

File:

PDF, 4.22 MB

english, 2015

94

Generation of iPSC line HEL24.3 from human neonatal foreskin fibroblasts

Trokovic, Ras, Weltner, Jere, Otonkoski, Timo

Journal:

Stem Cell Research

Year:

2015

Language:

english

File:

PDF, 430 KB

english, 2015

95

Mechanisms of Coxsackievirus-Induced Damage to Human Pancreaticβ -Cells 1

Roivainen, Merja, Rasilainen, Suvi, Ylipaasto, Petri, Nissinen, Riikka, Ustinov, Jarkko, Bouwens, Luc, Eizirik, Décio L., Hovi, Tapani, Otonkoski, Timo

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2000

Language:

english

File:

PDF, 1.65 MB

english, 2000

96

Massive Insulin Secretion in Response to Anaerobic Exercise in Exercise-induced Hyperinsulinism

Meissner, T., Friedmann, B., Okun, J. G., Schwab, M. A., Otonkoski, T., Bauer, T., Bärtsch, P., Mayatepek, E.

Journal:

Hormone and Metabolic Research

Year:

2005

Language:

english

File:

PDF, 159 KB

english, 2005

97

Developmental Gene Expression in the Human Fetal Pancreas

Mally, Martin I, Otonkoski, Timo, Lopez, Ana D, Hayek, Alberto

Journal:

Pediatric Research

Year:

1994

Language:

english

File:

PDF, 6.75 MB

english, 1994

98

Growth Factor-Mediated Proliferation and Differentiation of Insulin-Producing INS-1 and RINm5F Cells: Identification of Betacellulin as a Novel β-Cell Mitogen 1

Huotari, Mari-Anne, Palgi, Jaan, Otonkoski, Timo

Journal:

Year:

1998

Language:

english

File:

PDF, 212 KB

english, 1998

99

Acute Insulin Response Tests for the Differential Diagnosis of Congenital Hyperinsulinism

Huopio, H., Jääskeläinen, J., Komulainen, J., Miettinen, R., Kärkkäinen, P., Laakso, M., Tapanainen, P., Voutilainen, R., Otonkoski, T.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2002

Language:

english

File:

PDF, 80 KB

english, 2002

100

EGF- and TGF-α-Like Peptides in Human Fetal Gut

Miettinen, Paivi J, Perheentupa, Jaakko, Otonkoski, Timo, Lahteenmaki, Antti, Panula, Pertti

Journal:

Pediatric Research

Year:

1989

Language:

english

File:

PDF, 648 KB

english, 1989