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51

Evolved Stereoselective Hydrolases for Broad-Spectrum G-Type Nerve Agent Detoxification

Moshe Goldsmith, Yacov Ashani, Yair Simo, Moshe Ben-David, Haim Leader, Israel Silman, Joel L. Sussman, Dan S. Tawfik

Journal:

Chemistry & Biology

Year:

2012

Language:

english

File:

PDF, 593 KB

english, 2012

52

Do viral proteins possess unique biophysical features?

Nobuhiko Tokuriki, Christopher J. Oldfield, Vladimir N. Uversky, Igor N. Berezovsky, Dan S. Tawfik

Journal:

Trends in Biochemical Sciences

Year:

2009

Language:

english

File:

PDF, 591 KB

english, 2009

53

Conformational diversity and protein evolution – a 60-year-old hypothesis revisited

Leo C. James, Dan S. Tawfik

Journal:

Trends in Biochemical Sciences

Year:

2003

Language:

english

File:

PDF, 1.18 MB

english, 2003

54

Efficient and Selective P-nitrophenyl-ester-hydrolyzing Antibodies Elicited by a P-nitrobenzyl Phosphonate Hapten

Dan S. Tawfik, Ariel B. Lindner, Rachel Chap, Zelig Eshhar, Bernard S. Green

Journal:

Year:

1997

Language:

english

File:

PDF, 939 KB

english, 1997

55

The Latent Promiscuity of Newly Identified Microbial Lactonases Is Linked to a Recently Diverged Phosphotriesterase†

Roodveldt, Cintia, Manco, Giuseppe, Tawfik, Dan S., Afriat, Livnat

Journal:

Year:

2006

Language:

english

File:

PDF, 685 KB

english, 2006

56

Directed Evolution of Protein Inhibitors of DNA-nucleases by in Vitro Compartmentalization (IVC) and Nano-droplet Delivery

Kalia Bernath, Shlomo Magdassi, Dan S. Tawfik

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 481 KB

english, 2005

57

Reconstruction of Functional β-Propeller Lectins via Homo-oligomeric Assembly of Shorter Fragments

Itamar Yadid, Dan S. Tawfik

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 842 KB

english, 2007

58

The Stability Effects of Protein Mutations Appear to be Universally Distributed

Nobuhiko Tokuriki, Francois Stricher, Joost Schymkowitz, Luis Serrano, Dan S. Tawfik

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 1.11 MB

english, 2007

59

Intense Neutral Drifts Yield Robust and Evolvable Consensus Proteins

Shimon Bershtein, Korina Goldin, Dan S. Tawfik

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.22 MB

english, 2008

60

Evolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the KE07 Series

Olga Khersonsky, Daniela Röthlisberger, Orly Dym, Shira Albeck, Colin J. Jackson, David Baker, Dan S. Tawfik

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 5.60 MB

english, 2010

61

Optimization of the In-Silico-Designed Kemp Eliminase KE70 by Computational Design and Directed Evolution

Olga Khersonsky, Daniela Röthlisberger, Andrew M. Wollacott, Paul Murphy, Orly Dym, Shira Albeck, Gert Kiss, K.N. Houk, David Baker, Dan S. Tawfik

Journal:

Journal of Molecular Biology

Year:

2011

Language:

english

File:

PDF, 1.77 MB

english, 2011

62

Directed Evolution of Sulfotransferases and Paraoxonases by Ancestral Libraries

Uria Alcolombri, Mikael Elias, Dan S. Tawfik

Journal:

Journal of Molecular Biology

Year:

2011

Language:

english

File:

PDF, 1.30 MB

english, 2011

63

Catalytic Versatility and Backups in Enzyme Active Sites: The Case of Serum Paraoxonase 1

Moshe Ben-David, Mikael Elias, Jean-Jacques Filippi, Elisabet Duñach, Israel Silman, Joel L. Sussman, Dan S. Tawfik

Journal:

Journal of Molecular Biology

Year:

2012

Language:

english

File:

PDF, 1.67 MB

english, 2012

64

In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases

Yacov Ashani, Moshe Goldsmith, Haim Leader, Israel Silman, Joel L. Sussman, Dan S. Tawfik

Journal:

Toxicology Letters

Year:

2011

Language:

english

File:

PDF, 254 KB

english, 2011

65

Microbead display by in vitro compartmentalisation: selection for binding using flow cytometry

Armin Sepp, Dan S Tawfik, Andrew D Griffiths

Journal:

Year:

2002

Language:

english

File:

PDF, 256 KB

english, 2002

66

Esterolytic Antibodies as Mechanistic and Structural Models of Hydrolases—A Quantitative Analysis

Ariel B Lindner, Se Ho Kim, Dan G Schindler, Zelig Eshhar, Dan S Tawfik

Journal:

Journal of Molecular Biology

Year:

2002

Language:

english

File:

PDF, 870 KB

english, 2002

67

Expression and characterization of recombinant single-chain Fv and Fv fragments derived from a set of catalytic antibodies

Se-Ho Kim, Daniel G. Schindler, Ariel B. Lindner, Dan S. Tawfik, Zelig Eshhar

Journal:

Molecular Immunology

Year:

1997

Language:

english

File:

PDF, 1.80 MB

english, 1997

68

Directed enzyme evolution: beyond the low-hanging fruit

Moshe Goldsmith, Dan S Tawfik

Journal:

Current Opinion in Structural Biology

Year:

2012

Language:

english

File:

PDF, 295 KB

english, 2012

69

Catalytic Metal Ion Rearrangements Underline Promiscuity and Evolvability of a Metalloenzyme

Ben-David, Moshe, Wieczorek, Grzegorz, Elias, Mikael, Silman, Israel, Sussman, Joel L., Tawfik, Dan S.

Journal:

Journal of Molecular Biology

Year:

2013

Language:

english

File:

PDF, 879 KB

english, 2013

70

Conformational changes affect binding and catalysis by ester-hydrolysing antibodies

Ariel B Lindner, Zelig Eshhar, Dan S Tawfik

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 222 KB

english, 1999

71

Differences in the biochemical properties of esterolytic antibodies correlate with structural diversity

Romy Zemel, Daniel G. Schindler, Dan S. Tawfik, Zelig Eshhar, Bernard S. Green

Journal:

Molecular Immunology

Year:

1994

Language:

english

File:

PDF, 2.13 MB

english, 1994

72

The specificity of cross-reactivity: Promiscuous antibody binding involves specific hydrogen bonds rather than nonspecific hydrophobic stickiness

Leo C. James, Dan S. Tawfik

Journal:

Protein Science

Year:

2003

Language:

english

File:

PDF, 442 KB

english, 2003

73

Book Review

Journal:

Protein Science

Year:

2004

Language:

english

File:

PDF, 40 KB

english, 2004

74

Determinants of cofactor binding to DNA methyltransferases: insights from a systematic series of structural variants of S-adenosylhomocysteine

Cohen, Helen M., Griffiths, Andrew D., Tawfik, Dan S., Loakes, David

Journal:

Organic & Biomolecular Chemistry

Year:

2005

Language:

english

File:

PDF, 254 KB

english, 2005

75

Arsenate Replacing Phosphate: Alternative Life Chemistries and Ion Promiscuity

Tawfik, Dan S., Viola, Ronald E.

Journal:

Year:

2011

Language:

english

File:

PDF, 1.74 MB

english, 2011

76

Structure−Reactivity Studies of Serum Paraoxonase PON1 Suggest that Its Native Activity Is Lactonase †

Khersonsky, Olga, Tawfik, Dan S.

Journal:

Year:

2005

Language:

english

File:

PDF, 272 KB

english, 2005

77

Directed Evolution of Serum Paraoxonase PON3 by Family Shuffling and Ancestor/Consensus Mutagenesis, and Its Biochemical Characterization

Khersonsky, Olga, Rosenblat, Mira, Toker, Lilly, Yacobson, Shiri, Hugenmatter, Adrian, Silman, Israel, Sussman, Joel L., Aviram, Michael, Tawfik, Dan S.

Journal:

Year:

2009

Language:

english

File:

PDF, 3.30 MB

english, 2009

78

What Makes a Protein Fold Amenable to Functional Innovation? Fold Polarity and Stability Trade-offs

Dellus-Gur, Eynat, Toth-Petroczy, Agnes, Elias, Mikael, Tawfik, Dan S.

Journal:

Journal of Molecular Biology

Year:

2013

Language:

english

File:

PDF, 1.19 MB

english, 2013

79

Reconstructing a Missing Link in the Evolution of a Recently Diverged Phosphotriesterase by Active-Site Loop Remodeling

Afriat-Jurnou, Livnat, Jackson, Colin J., Tawfik, Dan S.

Journal:

Year:

2012

Language:

english

File:

PDF, 408 KB

english, 2012

80

ApoE Induces Serum Paraoxonase PON1 Activity and Stability Similar to ApoA-I

Gaidukov, Leonid, R. I, Viji, Yacobson, Shiri, Rosenblat, Mira, Aviram, Michael, Tawfik, Dan S.

Journal:

Year:

2010

Language:

english

File:

PDF, 1018 KB

english, 2010

81

High Affinity, Stability, and Lactonase Activity of Serum Paraoxonase PON1 Anchored on HDL with ApoA-I †

Gaidukov, Leonid, Tawfik, Dan S.

Journal:

Year:

2005

Language:

english

File:

PDF, 166 KB

english, 2005

82

Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme

Tokuriki, Nobuhiko, Jackson, Colin J., Afriat-Jurnou, Livnat, Wyganowski, Kirsten T., Tang, Renmei, Tawfik, Dan S.

Journal:

Nature Communications

Year:

2012

Language:

english

File:

PDF, 985 KB

english, 2012

83

Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro

Worek, Franz, Seeger, Thomas, Goldsmith, Moshe, Ashani, Yacov, Leader, Haim, Sussman, Joel S., Tawfik, Dan, Thiermann, Horst, Wille, Timo

Journal:

Archives of Toxicology

Year:

2014

Language:

english

File:

PDF, 631 KB

english, 2014

84

pH on–off switching of antibody-hapten binding by site-specific chemical modification of tyrosine

Tawfik, Dan S., Chap, Rachel, Eshhar, Zelig, Green, Bernard S.

Journal:

Protein Engineering Design and Selection

Year:

1994

Language:

english

File:

PDF, 2.04 MB

english, 1994

85

Erratum to: “The universality of enzymatic rate–temperature dependency”

Elias, Mikael, Wieczorek, Grzegorz, Rosenne, Shaked, Tawfik, Dan S.

Journal:

Trends in Biochemical Sciences

Year:

2014

Language:

english

File:

PDF, 97 KB

english, 2014

86

Hopeful (Protein InDel) Monsters?

Tóth-Petróczy, Ágnes, Tawfik, Dan S.

Journal:

Year:

2014

Language:

english

File:

PDF, 163 KB

english, 2014

87

Efficient Catalysis of Proton Transfer by Synzymes

Hollfelder, Florian, Kirby, Anthony J., Tawfik, Dan S.

Journal:

Journal of the American Chemical Society

Year:

1997

Language:

english

File:

PDF, 110 KB

english, 1997

88

Accuracy-rate tradeoffs: how do enzymes meet demands of selectivity and catalytic efficiency?

Journal:

Current Opinion in Chemical Biology

Year:

2014

Language:

english

File:

PDF, 638 KB

english, 2014

89

The robustness and innovability of protein folds

Tóth-Petróczy, Ágnes, Tawfik, Dan S

Journal:

Current Opinion in Structural Biology

Year:

2014

Language:

english

File:

PDF, 812 KB

english, 2014

90

DddD Is a CoA-Transferase/Lyase Producing Dimethyl Sulfide in the Marine Environment

Alcolombri, Uria, Laurino, Paola, Lara-Astiaso, Pedro, Vardi, Assaf, Tawfik, Dan S.

Journal:

Year:

2014

Language:

english

File:

PDF, 178 KB

english, 2014

91

Flow Cytometry: A New Method To Investigate the Properties of Water-in-Oil-in-Water Emulsions

Hai, Mingtan, Bernath, Kalia, Tawfik, Dan, Magdassi, Shlomo

Journal:

Year:

2004

Language:

english

File:

PDF, 132 KB

english, 2004

92

Shared Promiscuous Activities and Evolutionary Features in Various Members of the Amidohydrolase Superfamily †

Roodveldt, Cintia, Tawfik, Dan S.

Journal:

Year:

2005

Language:

english

File:

PDF, 253 KB

english, 2005

93

Engineering V-Type Nerve Agents Detoxifying Enzymes Using Computationally Focused Libraries

Cherny, Izhack, Greisen, Per, Ashani, Yacov, Khare, Sagar D., Oberdorfer, Gustav, Leader, Haim, Baker, David, Tawfik, Dan S.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 4.21 MB

english, 2013

94

Role of Chemistry versus Substrate Binding in Recruiting Promiscuous Enzyme Functions

Khersonsky, Olga, Malitsky, Sergey, Rogachev, Ilana, Tawfik, Dan S.

Journal:

Year:

2011

Language:

english

File:

PDF, 1.21 MB

english, 2011

95

Directed Evolution of the Promiscuous Esterase Activity of Carbonic Anhydrase II †

Gould, Stephen McQ., Tawfik, Dan S.

Journal:

Year:

2005

Language:

english

File:

PDF, 116 KB

english, 2005

96

Simple method for selecting catalytic monoclonal antibodies that exhibit turnover and specificity

Tawfik, Dan S., Zemel, Romy R., Arad-Yellin, Rina, Green, Bernard S., Eshhar, Zelig

Journal:

Year:

1990

Language:

english

File:

PDF, 759 KB

english, 1990

97

Characterization of Proton-Transfer Catalysis by Serum Albumins

Hollfelder, Florian, Kirby, Anthony J., Tawfik, Dan S., Kikuchi, Kazuya, Hilvert, Donald

Journal:

Journal of the American Chemical Society

Year:

2000

Language:

english

File:

PDF, 107 KB

english, 2000

98

On the Magnitude and Specificity of Medium Effects in Enzyme-like Catalysts for Proton Transfer

Hollfelder, Florian, Kirby, Anthony J., Tawfik, Dan S.

Journal:

Journal of Organic Chemistry

Year:

2001

Language:

english

File:

PDF, 106 KB

english, 2001

99

Latent evolutionary potentials under the neutral mutational drift of an enzyme

Amitai, Gil, Gupta, Rinkoo Devi, Tawfik, Dan S.

Journal:

Year:

2007

Language:

english

File:

PDF, 660 KB

english, 2007

100

Protein Promiscuity: Drug Resistance and Native Functions—HIV-1 Case

Fernández, Ariel, Tawfik, Dan S., Berkhout, Ben, Sanders, Rogier, Kloczkowski, Andrzej, Sen, Taner, Jernigan, Bob, Tawfik, Dan S., Berkhout, Ben, Sanders, Rogier W., Kloczkowski, Andrzej, Sen, Taner Z

Journal:

Journal of Biomolecular Structure and Dynamics

Year:

2005

Language:

english

File:

PDF, 458 KB

english, 2005