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51

Elevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: implications for prostate cancer progressioan

Mikhail G Dozmorov, Joseph T Azzarello, Jonathan D Wren, Kar-Ming Fung, Qing Yang, Jeffrey S Davis, Robert E Hurst, Daniel J Culkin, Trevor M Penning, Hsueh-Kung Lin

Journal:

Year:

2010

Language:

english

File:

PDF, 932 KB

english, 2010

52

On the Number of Steroid-Binding Sites of Δ5-3-Oxosteroid Isomerase

Trevor M. PENNING, Edwin M. WESTBROOK, Paul TALALAY

Journal:

Year:

1980

Language:

english

File:

PDF, 832 KB

english, 1980

53

Role of Quinones in Toxicology†

Bolton, Judy L., Trush, Michael A., Penning, Trevor M., Dryhurst, Glenn, Monks, Terrence J.

Journal:

Chemical Research in Toxicology

Year:

2000

Language:

english

File:

PDF, 838 KB

english, 2000

54

Selective Inhibitors of Aldo-Keto Reductases AKR1C1 and AKR1C3 Discovered by Virtual Screening of a Fragment Library

Brožič, Petra, Turk, Samo, Adeniji, Adegoke O., Konc, Janez, Janežič, Dušanka, Penning, Trevor M., Lanišnik Rižner, Tea, Gobec, Stanislav

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 624 KB

english, 2012

55

Synthesis of Phenol and Quinone Metabolites of Benzo[a]pyrene, a Carcinogenic Component of Tobacco Smoke Implicated in Lung Cancer

Xu, Daiwang, Penning, Trevor M., Blair, Ian A., Harvey, Ronald G.

Journal:

Journal of Organic Chemistry

Year:

2009

Language:

english

File:

PDF, 249 KB

english, 2009

56

p53 Mutagenesis by Benzo[ a ]pyrene Derived Radical Cations

Sen, Sushmita, Bhojnagarwala, Pratik, Francey, Lauren, Lu, Ding, Penning, Trevor M., Field, Jeffrey

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.80 MB

english, 2012

57

Prostaglandin dehydrogenase activity of purified rat liver 3α-hydroxysteroid dehydrogenase

Trevor M. Penning, Robert B. Sharp

Journal:

Biochemical and Biophysical Research Communications

Year:

1987

Language:

english

File:

PDF, 841 KB

english, 1987

58

Indomethacin-sensitive 3α-hydroxysteroid dehydrogenase in rat tissues

Thomas E. Smithgall, Trevor M. Penning

Journal:

Biochemical Pharmacology

Year:

1985

Language:

english

File:

PDF, 402 KB

english, 1985

59

Indomethacin and glucocorticoid metabolism in rat liver cytosol

Trevor M. Penning

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 513 KB

english, 1986

60

Hormonal regulation of 3α-hydroxysteroid/dihydrodiol dehydrogenase in rat liver cytosol

Trevor M. Penning, Keith Isaacson, C. Richard Lyttle

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 476 KB

english, 1992

61

Inactivation of Δ5-3-ketosteroid isomerase(s) from beef adrenal cortex by acetylenic ketosteroids

Trevor M. Penning, Douglas F. Covey

Journal:

Journal of Steroid Biochemistry

Year:

1982

Language:

english

File:

PDF, 1.06 MB

english, 1982

62

Inhibition of progesterone synthesis in normal and transformed human placental cells by tight binding inhibitors of 3β-hydroxysterioid dehydrogenase

Robert B. Sharp, Trevor M. Penning

Journal:

Year:

1988

Language:

english

File:

PDF, 949 KB

english, 1988

63

Clues to the development of mechanism-based inactivators of 3α-hydroxysteroid dehydrogenase: comparison of steroidal and nonsteroidal Michael acceptors and epoxides

Trevor M. Penning, Rosemary Thornton, Joseph W. Ricigliano

Journal:

Year:

1991

Language:

english

File:

PDF, 947 KB

english, 1991

64

Human aldo–keto reductases: Function, gene regulation, and single nucleotide polymorphisms

Trevor M. Penning, Jason E. Drury

Journal:

Archives of Biochemistry and Biophysics

Year:

2007

Language:

english

File:

PDF, 360 KB

english, 2007

65

Non-stereo-selective cytosolic human brain tissue 3-ketosteroid reductase is refractory to inhibition by AKR1C inhibitors

Stephan Steckelbroeck, Dieter Lütjohann, David R. Bauman, Michael Ludwig, Anke Friedl, Volkmar H.J. Hans, Trevor M. Penning, Dietrich Klingmüller

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2010

Language:

english

File:

PDF, 1.27 MB

english, 2010

66

Liquid chromatography–mass spectrometry (LC–MS) of steroid hormone metabolites and its applications

Trevor M. Penning, Seon-Hwa Lee, Yi Jin, Alejandro Gutierrez, Ian A. Blair

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2010

Language:

english

File:

PDF, 406 KB

english, 2010

67

Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer

Michael C. Byrns, Ling Duan, Seon Hwa Lee, Ian A. Blair, Trevor M. Penning

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2010

Language:

english

File:

PDF, 1.30 MB

english, 2010

68

Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): Overview and structural insights

Michael C. Byrns, Yi Jin, Trevor M. Penning

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2011

Language:

english

File:

PDF, 629 KB

english, 2011

69

Human hydroxysteroid dehydrogenases and pre-receptor regulation: Insights into inhibitor design and evaluation

Trevor M. Penning

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2011

Language:

english

File:

PDF, 584 KB

english, 2011

70

Integration of steroid research: Perspectives on environment factors, homeostasis in health, and disease treatment

Trevor M. Penning, Jerzy Adamski

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2011

Language:

english

File:

PDF, 107 KB

english, 2011

71

Targeted Inhibitors for Steroid Transforming Enzymes

Muhammad Akhtar, Trevor M. Penning

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2011

Language:

english

File:

PDF, 55 KB

english, 2011

72

Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride

Michael C. Byrns, Rebekka Mindnich, Ling Duan, Trevor M. Penning

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2012

Language:

english

File:

PDF, 1.15 MB

english, 2012

73

Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo–keto reductase superfamily

Yi Jin, Ling Duan, Mo Chen, Trevor M. Penning, Helenius J. Kloosterboer

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2012

Language:

english

File:

PDF, 635 KB

english, 2012

74

AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer

Tea Lanišnik Rižner, Tina Šmuc, Ruth Rupreht, Jasna Šinkovec, Trevor M. Penning

Journal:

Molecular and Cellular Endocrinology

Year:

2006

Language:

english

File:

PDF, 510 KB

english, 2006

75

Deoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissues

Kamalesh K. Sharma, Annika Lindqvist, Xin J. Zhou, Richard J. Auchus, Trevor M. Penning, Stefan Andersson

Journal:

Molecular and Cellular Endocrinology

Year:

2006

Language:

english

File:

PDF, 531 KB

english, 2006

76

Aldo-keto reductase (AKR) 1C3: Role in prostate disease and the development of specific inhibitors

Trevor M. Penning, Stephan Steckelbroeck, David R. Bauman, Meredith W. Miller, Yi Jin, Donna M. Peehl, Kar-Ming Fung, Hseuh-Kung Lin

Journal:

Molecular and Cellular Endocrinology

Year:

2006

Language:

english

File:

PDF, 578 KB

english, 2006

77

Identification of the molecular switch that regulates access of 5α-DHT to the androgen receptor

Trevor M. Penning, David R. Bauman, Yi Jin, Tea Lanisik Rizner

Journal:

Molecular and Cellular Endocrinology

Year:

2007

Language:

english

File:

PDF, 218 KB

english, 2007

78

Pre-receptor regulation of the androgen receptor

Trevor M. Penning, Yi Jin, Tea Lanisnik Rizner, David R. Bauman

Journal:

Molecular and Cellular Endocrinology

Year:

2008

Language:

english

File:

PDF, 1.06 MB

english, 2008

79

Structure and catalytic mechanism of human steroid 5β-reductase (AKR1D1)

Luigi Di Costanzo, Jason E. Drury, David W. Christianson, Trevor M. Penning

Journal:

Molecular and Cellular Endocrinology

Year:

2009

Language:

english

File:

PDF, 1.63 MB

english, 2009

80

Estrogen biosynthesis in human H295 adrenocortical carcinoma cells

Moira R. Nicol, Georgia Papacleovoulou, Dean B. Evans, Trevor M. Penning, Mark W.J. Strachan, Andrew Advani, Sarah J. Johnson, Richard Quinton, J. Ian Mason

Journal:

Molecular and Cellular Endocrinology

Year:

2009

Language:

english

File:

PDF, 769 KB

english, 2009

81

Characterization of a monoclonal antibody for human aldo-keto reductase AKR1C3 (type 2 3α-hydroxysteroid dehydrogenase/type 5 17β-hydroxysteroid dehydrogenase); immunohistochemical detection in breast and prostate

Hsueh-Kung Lin, Stephan Steckelbroeck, Kar-Ming Fung, Amy N. Jones, Trevor M. Penning

Journal:

Year:

2004

Language:

english

File:

PDF, 512 KB

english, 2004

82

Molecular docking simulations of steroid substrates into human cytosolic hydroxysteroid dehydrogenases (AKR1C1 and AKR1C2): Insights into positional and stereochemical preferences

Yi Jin, Trevor M. Penning

Journal:

Year:

2006

Language:

english

File:

PDF, 583 KB

english, 2006

83

Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1)

Mo Chen, Jason E. Drury, Trevor M. Penning

Journal:

Year:

2011

Language:

english

File:

PDF, 662 KB

english, 2011

84

Synthesis of 13C4-labelled oxidized metabolites of the carcinogenic polycyclic aromatic hydrocarbon benzo[a]pyrene

Anhui Wu, Daiwang Xu, Ding Lu, Trevor M. Penning, Ian A. Blair, Ronald G. Harvey

Journal:

Year:

2012

Language:

english

File:

PDF, 806 KB

english, 2012

85

Multidrug resistance protein (MRP) 4 attenuates benzo[a]pyrene-mediated DNA-adduct formation in human bronchoalveolar H358 cells

Stacy L. Gelhaus, Oren Gilad, Wei-Ting Hwang, Trevor M. Penning, Ian A. Blair

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 796 KB

english, 2012

86

Developmental Evaluation of Aldo-keto Reductase 1C3 Expression in the Cryptorchid Testis

Richard A. Ashley, Zhongxin Yu, Kar-Ming Fung, Dominic Frimberger, Bradley P. Kropp, Trevor M. Penning, Hsueh-Kung Lin

Journal:

Year:

2010

Language:

english

File:

PDF, 1.38 MB

english, 2010

87

Mammalian 3α-hydroxysteroid dehydrogenases

Trevor M. Penning, John E. Pawlowski, Brian P. Schlegel, Joseph M. Jez, Hseuh-Kung Lin, Susan S. Hoog, Melanie J. Bennett, Mitchell Lewis

Journal:

Year:

1996

Language:

english

File:

PDF, 1.55 MB

english, 1996

88

Structure and function of 3α-hydroxysteroid dehydrogenase

Trevor M. Penning, Melanie J. Bennett, Susan Smith-Hoog, Brian P. Schlegel, Joseph M. Jez, Mitchell Lewis

Journal:

Year:

1997

Language:

english

File:

PDF, 1021 KB

english, 1997

89

Structure-function aspects and inhibitor design of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3)

Trevor M. Penning, Michael E. Burczynski, Joseph M. Jez, Hseuh-Kung Lin, Haiching Ma, Margaret Moore, Kapila Ratnam, Nisha Palackal

Journal:

Molecular and Cellular Endocrinology

Year:

2001

Language:

english

File:

PDF, 480 KB

english, 2001

90

Structure–function relationships in 3α-hydroxysteroid dehydrogenases: a comparison of the rat and human isoforms

Trevor M Penning, Yi Jin, Vladi V Heredia, Mitchell Lewis

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2003

Language:

english

File:

PDF, 234 KB

english, 2003

91

Genomic structure of rat 3α-hydroxysteroid/dihydrodiol dehydrogenase (3α-HSD/DD, AKR1C9)

Hsueh-Kung Lin, Chien-Fu Hung, Margaret Moore, Trevor M. Penning

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

1999

Language:

english

File:

PDF, 211 KB

english, 1999

92

N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo–keto reductase AKR1C3

Sinreih, Maša, Sosič, Izidor, Beranič, Nataša, Turk, Samo, Adeniji, Adegoke O., Penning, Trevor M., Rižner, Tea Lanišnik, Gobec, Stanislav

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 348 KB

english, 2012

93

Crystal Structure of Human Type III 3α-Hydroxysteroid Dehydrogenase/Bile Acid Binding Protein Complexed with NADP + and Ursodeoxycholate †,‡

Jin, Yi, Stayrook, Steven E., Albert, Ross H., Palackal, Nisha T., Penning, Trevor M., Lewis, Mitchell

Journal:

Year:

2001

Language:

english

File:

PDF, 366 KB

english, 2001

94

Chemical Carcinogenesis || p53 and Ras Mutations in Cancer and Experimental Carcinogenesis

Penning, Trevor M.

Year:

2011

Language:

english

File:

PDF, 1.82 MB

english, 2011

95

Inactivation of Δ5-3-ketosteroid isomerase(s) from beef adrenal cortex by β,γ-acetylenic ketosteroids

Trevor M. Penning

Journal:

Year:

1982

Language:

english

File:

PDF, 558 KB

english, 1982

96

Rat liver 3α-hydroxysteroid dehydrogenase

Trevor M Penning, Thomas E Smithgall, Leslie J Askonas, Robert B Sharp

Journal:

Year:

1986

Language:

english

File:

PDF, 3.62 MB

english, 1986

97

Initiation of chemical carcinogenesis and the ‘aspirin-like’ drugs

Trevor M. Penning

Journal:

Trends in Pharmacological Sciences

Year:

1984

Language:

english

File:

PDF, 315 KB

english, 1984

98

A new approach to drug development: inhibitors of steroid hormone biosynthesis

Trevor M. Penning

Journal:

Trends in Pharmacological Sciences

Year:

1985

Language:

english

File:

PDF, 301 KB

english, 1985

99

A new nomenclature for the aldo-keto reductase superfamily

Joseph M Jez, T.Geoffrey Flynn, Trevor M Penning

Journal:

Biochemical Pharmacology

Year:

1997

Language:

english

File:

PDF, 1010 KB

english, 1997

100

Steroid 5α-reductases and 3α-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism

Yi Jin, Trevor M. Penning

Journal:

Best Practice & Research Clinical Endocrinology & Metabolism

Year:

2001

Language:

english

File:

PDF, 292 KB

english, 2001