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101

Other Malignancies in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Tsimberidou, A.-M., Wen, S., McLaughlin, P., O'Brien, S., Wierda, W. G., Lerner, S., Strom, S., Freireich, E. J, Medeiros, L. J., Kantarjian, H. M., Keating, M. J.

Journal:

Journal of Clinical Oncology

Year:

2009

Language:

english

File:

PDF, 255 KB

english, 2009

102

Personalized Medicine in a Phase I Clinical Trials Program: The MD Anderson Cancer Center Initiative

Tsimberidou, A.-M., Iskander, N. G., Hong, D. S., Wheler, J. J., Falchook, G. S., Fu, S., Piha-Paul, S., Naing, A., Janku, F., Luthra, R., Ye, Y., Wen, S., Berry, D., Kurzrock, R.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 603 KB

english, 2012

103

Farnesyltransferase inhibitors: where are we now?

Tsimberidou, Apostolia Maria, Chandhasin, Chandtip, Kurzrock, Razelle

Journal:

Expert Opinion on Investigational Drugs

Year:

2010

Language:

english

File:

PDF, 321 KB

english, 2010

104

Dual antiangiogenic inhibition: a phase I dose escalation and expansion trial targeting VEGF-A and VEGFR in patients with advanced solid tumors

Falchook, Gerald S., Wheler, Jennifer J., Naing, Aung, Piha-Paul, Sarina A., Fu, Siqing, Tsimberidou, Apostolia M., Hong, David S., Janku, Filip, Zinner, Ralph, Jiang, Yunfang, Huang, Mei, Lin, Quan,

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 652 KB

english, 2015

105

Phase I study of pazopanib and vorinostat: a therapeutic approach for inhibiting mutant p53-mediated angiogenesis and facilitating mutant p53 degradation

Fu, S., Hou, M. M., Naing, A., Janku, F., Hess, K., Zinner, R., Subbiah, V., Hong, D., Wheler, J., Piha-Paul, S., Tsimberidou, A., Karp, D., Araujo, D., Kee, B., Hwu, P., Wolff, R., Kurzrock, R., Meri

Journal:

Annals of Oncology

Year:

2015

Language:

english

File:

PDF, 183 KB

english, 2015

106

Combining Erlotinib and Cetuximab Is Associated with Activity in Patients with Non-Small Cell Lung Cancer (Including Squamous Cell Carcinomas) and Wild-Type EGFR or Resistant Mutations

Wheler, J. J., Tsimberidou, A. M., Falchook, G. S., Zinner, R. G., Hong, D. S., Fok, J. Y., Fu, S., Piha-Paul, S. A., Naing, A., Kurzrock, R.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 527 KB

english, 2013

107

Advance Care Planning in Patients With Cancer Referred to a Phase I Clinical Trials Program: The MD Anderson Cancer Center Experience

Fu, S., Barber, F. D., Naing, A., Wheler, J., Hong, D., Falchook, G., Piha-Paul, S., Tsimberidou, A., Howard, A., Kurzrock, R.

Journal:

Journal of Clinical Oncology

Year:

2012

Language:

english

File:

PDF, 176 KB

english, 2012

108

Risk of serious toxicity in 1181 patients treated in phase I clinical trials of predominantly targeted anticancer drugs: the M. D. Anderson Cancer Center experience

Wheler, J. J., Tsimberidou, A. M., Hong, D. S., Naing, A., Falchook, G. S., Fu, S., Moulder, S., Stephen, B., Wen, S., Kurzrock, R.

Journal:

Annals of Oncology

Year:

2012

Language:

english

File:

PDF, 116 KB

english, 2012

109

A phase I trial of combination trastuzumab, lapatinib, and bevacizumab in patients with advanced cancer

Falchook, Gerald S., Moulder, Stacy, Naing, Aung, Wheler, Jennifer J., Hong, David S., Piha-Paul, Sarina A., Tsimberidou, Apostolia M., Fu, Siqing, Zinner, Ralph, Janku, Filip, Jiang, Yunfang, Huang,

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 362 KB

english, 2015

110

Clinical Outcomes and Prognostic Factors in Patients With Richter's Syndrome Treated With Chemotherapy or Chemoimmunotherapy With or Without Stem-Cell Transplantation

Tsimberidou, A.-M., O'Brien, S., Khouri, I., Giles, F. J., Kantarjian, H. M., Champlin, R., Wen, S., Do, K.-A., Smith, S. C., Lerner, S., Freireich, E. J., Keating., M. J.

Journal:

Journal of Clinical Oncology

Year:

2006

Language:

english

File:

PDF, 281 KB

english, 2006

111

Biomarker-Directed Therapy of Squamous Carcinomas of the Head and Neck: Targeting PI3K/PTEN/mTOR Pathway

Holsinger, F. C., Piha-Paul, S. A., Janku, F., Hong, D. S., Atkins, J. T., Tsimberidou, A. M., Kurzrock, R.

Journal:

Journal of Clinical Oncology

Year:

2013

Language:

english

File:

PDF, 222 KB

english, 2013

112

Assessment of Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma by Absolute Lymphocyte Counts in 2,126 Patients: 20 Years of Experience at The University of Texas M.D. Anderson Cancer Center

Tsimberidou, A. M., Wen, S., O'Brien, S., McLaughlin, P., Wierda, W. G., Ferrajoli, A., Faderl, S., Manning, J., Lerner, S., Mai, C. V., Rodriguez, A. M., Hess, M., Do, K.-A., Freireich, E. J., Kantar

Journal:

Journal of Clinical Oncology

Year:

2007

Language:

english

File:

PDF, 298 KB

english, 2007

113

Analysis of 1,115 Patients Tested for MET Amplification and Therapy Response in the MD Anderson Phase I Clinic

Jardim, D. L. F., Tang, C., Gagliato, D. D. M., Falchook, G. S., Hess, K., Janku, F., Fu, S., Wheler, J. J., Zinner, R. G., Naing, A., Tsimberidou, A. M., Holla, V., Li, M. M., Roy-Chowdhuri, S., Luth

Journal:

Clinical Cancer Research

Year:

2014

Language:

english

File:

PDF, 285 KB

english, 2014

114

Phase I Study of BIIB028, a Selective Heat Shock Protein 90 Inhibitor, in Patients with Refractory Metastatic or Locally Advanced Solid Tumors

Hong, D., Said, R., Falchook, G., Naing, A., Moulder, S., Tsimberidou, A.-M., Galluppi, G., Dakappagari, N., Storgard, C., Kurzrock, R., Rosen, L. S.

Journal:

Clinical Cancer Research

Year:

2013

Language:

english

File:

PDF, 545 KB

english, 2013

115

Anti-Vascular Endothelial Growth Factor Therapies and Cardiovascular Toxicity: What Are the Important Clinical Markers to Target?

Vaklavas, C., Lenihan, D., Kurzrock, R., Tsimberidou, A. M.

Journal:

Year:

2010

Language:

english

File:

PDF, 571 KB

english, 2010

116

Phase I trial of valproic acid and lenalidomide in patients with advanced cancer

Bilen, Mehmet Asim, Fu, Siqing, Falchook, Gerald S., Ng, Chaan S., Wheler, Jennifer J., Abdelrahim, Maen, Erguvan-Dogan, Basak, Hong, David S., Tsimberidou, Apostolia M., Kurzrock, Razelle, Naing, Aun

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2015

Language:

english

File:

PDF, 359 KB

english, 2015

117

Xilonix, a novel true human antibody targeting the inflammatory cytokine interleukin-1 alpha, in non-small cell lung cancer

Hong, David S., Janku, Filip, Naing, Aung, Falchook, Gerald S., Piha-Paul, Sarina, Wheler, Jennifer J., Fu, Siqing, Tsimberidou, Apostolia M., Stecher, Michael, Mohanty, Prasant, Simard, John, Kurzroc

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 713 KB

english, 2015

118

Next generation sequencing of exceptional responders with BRAF-mutant melanoma: implications for sensitivity and resistance

Wheler, Jennifer, Yelensky, Roman, Falchook, Gerald, Kim, Kevin B, Hwu, Patrick, Tsimberidou, Apostolia M, Stephens, Philip J, Hong, David, Cronin, Maureen T, Kurzrock, Razelle

Journal:

Year:

2015

Language:

english

File:

PDF, 995 KB

english, 2015

119

Phase I study of azacitidine and oxaliplatin in patients with advanced cancers that have relapsed or are refractory to any platinum therapy

Tsimberidou, Apostolia M, Said, Rabih, Culotta, Kirk, Wistuba, Ignacio, Jelinek, Jaroslav, Fu, Siqing, Falchook, Gerald, Naing, Aung, Piha-Paul, Sarina, Zinner, Ralph, Siddik, Zahid H, He, Guangan, He

Journal:

Clinical Epigenetics

Year:

2015

Language:

english

File:

PDF, 1.27 MB

english, 2015

120

Low-dose interleukin-11 in patients with bone marrow failure: update of the M. D. Anderson Cancer Center experience

Tsimberidou, A.-M.

Journal:

Annals of Oncology

Year:

2005

Language:

english

File:

PDF, 69 KB

english, 2005

121

Phase I combination of pazopanib and everolimus inPIK3CAmutation positive/PTEN loss patients with advanced solid tumors refractory to standard therapy

Rodrigues, Heloisa Veasey, Ke, Danxia, Lim, JoAnn, Stephen, Bettzy, Bellido, Jorge, Janku, Filip, Zinner, Ralph, Tsimberidou, Apostolia, Hong, David, Piha-Paul, Sarina, Fu, Siqing, Naing, Aung, Subbia

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 431 KB

english, 2015

122

Myeloid Sarcoma Involving the Gynecologic Tract

Garcia, Mar, Deavers, Michael T., Knoblock, Ronald J., Chen, Weina, Tsimberidou, Apostolia M., Manning, John T., Medeiros, L. Jeffrey

Journal:

American Journal of Clinical Pathology

Year:

2006

Language:

english

File:

PDF, 602 KB

english, 2006

123

Synergy Between VEGF/VEGFR Inhibitors and Chemotherapy Agents in the Phase I Clinic

Tang, C., Hess, K., Jardim, D. L. F., Gagliato, D. D. M., Tsimberidou, A. M., Falchook, G., Fu, S., Janku, F., Naing, A., Piha-Paul, S., Subbiah, V., Wheler, J., Zinner, R. G., Kurzrock, R., Ellis, L.

Journal:

Clinical Cancer Research

Year:

2014

Language:

english

File:

PDF, 512 KB

english, 2014

124

Barriers to Study Enrollment in Patients With Advanced Cancer Referred to a Phase I Clinical Trials Unit

Fu, S., McQuinn, L., Naing, A., Wheler, J. J., Janku, F., Falchook, G. S., Piha-Paul, S. A., Tu, D., Howard, A., Tsimberidou, A., Zinner, R., Hong, D. S., Kurzrock, R.

Journal:

Year:

2013

Language:

english

File:

PDF, 424 KB

english, 2013

125

Challenges in initiating and conducting personalized cancer therapy trials: perspectives from WINTHER, a Worldwide Innovative Network (WIN) Consortium trial

Rodon, J., Soria, J. C., Berger, R., Batist, G., Tsimberidou, A., Bresson, C., Lee, J. J., Rubin, E., Onn, A., Schilsky, R. L., Miller, W. H., Eggermont, A. M., Mendelsohn, J., Lazar, V., Kurzrock, R.

Journal:

Annals of Oncology

Year:

2015

Language:

english

File:

PDF, 1019 KB

english, 2015

126

Phase I Clinical Trials in 56 Patients with Thyroid Cancer: The M. D. Anderson Cancer Center Experience

Tsimberidou, Apostolia Maria, Vaklavas, Christos, Wen, Sijin, Hong, David, Wheler, Jennifer, Ng, Chaan, Naing, Aung, Tse, Susan, Busaidy, Naifa, Markman, Maurie, Sherman, Steven I., Kurzrock, Razelle

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2009

Language:

english

File:

PDF, 163 KB

english, 2009

127

Phase I Clinical Trial of MPC-6827 (Azixa), a Microtubule Destabilizing Agent, in Patients with Advanced Cancer

Tsimberidou, A.-M., Akerley, W., Schabel, M. C., Hong, D. S., Uehara, C., Chhabra, A., Warren, T., Mather, G. G., Evans, B. A., Woodland, D. P., Swabb, E. A., Kurzrock, R.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 459 KB

english, 2010

128

A Phase I Clinical Trial of Darinaparsin in Patients with Refractory Solid Tumors

Tsimberidou, A. M., Camacho, L. H., Verstovsek, S., Ng, C., Hong, D. S., Uehara, C. K., Gutierrez, C., Daring, S., Stevens, J., Komarnitsky, P. B., Schwartz, B., Kurzrock, R.

Journal:

Clinical Cancer Research

Year:

2009

Language:

english

File:

PDF, 230 KB

english, 2009

129

Phase I Clinical Trial Outcomes in 93 Patients with Brain Metastases: The MD Anderson Cancer Center Experience

Tsimberidou, A. M., Letourneau, K., Wen, S., Wheler, J., Hong, D., Naing, A., Iskander, N. G., Uehara, C., Kurzrock, R.

Journal:

Clinical Cancer Research

Year:

2011

Language:

english

File:

PDF, 478 KB

english, 2011

130

IS4. Trials in Progress

Naing, A., Falchook, G. S., Fu, S., Amin, H. M., Piha-Paul, S. A., Hong, D. S., Tsimberidou, A. M., Wheler, J. J., Janku, F., Klevesath, M. B., Jego, V., Johne, A., Kurzrock, R., Lannert, H., Heidenre

Journal:

Annals of Oncology

Year:

2012

Language:

english

File:

PDF, 84 KB

english, 2012

131

Electrocardiograms (ECGs) in phase I anticancer drug development: the MD Anderson Cancer Center experience with 8518 ECGs

Naing, A., Veasey-Rodrigues, H., Hong, D. S., Fu, S., Falchook, G. S., Wheler, J. J., Tsimberidou, A. M., Wen, S., Fessahaye, S. N., Golden, E. C., Aaron, J., Ewer, M. S., Kurzrock, R.

Journal:

Annals of Oncology

Year:

2012

Language:

english

File:

PDF, 81 KB

english, 2012

132

Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: an update of The University of Texas M. D. Anderson Cancer Center Series

Tsimberidou, Apostolia-Maria, Tirado-Gomez, Maribel, Andreeff, Michael, O'Brien, Susan, Kantarjian, Hagop, Keating, Michael, Lopez-Berestein, Gabriel, Estey, Elihu

Journal:

Leukemia and Lymphoma

Year:

2006

Language:

english

File:

PDF, 271 KB

english, 2006

133

Salirasib in the treatment of pancreatic cancer

Bustinza-Linares, Ernesto, Kurzrock, Razelle, Tsimberidou, Apostolia-Maria

Journal:

Future Oncology

Year:

2010

Language:

english

File:

PDF, 883 KB

english, 2010

134

Target-Based Therapeutic Matching in Early-Phase Clinical Trials in Patients with Advanced Colorectal Cancer and PIK3CA Mutations

Ganesan, P., Janku, F., Naing, A., Hong, D. S., Tsimberidou, A. M., Falchook, G. S., Wheler, J. J., Piha-Paul, S. A., Fu, S., Stepanek, V. M., Lee, J. J., Luthra, R., Overman, M. J., Kopetz, E. S., Wo

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 434 KB

english, 2013

135

Effects of Patupilone on the Pharmacokinetics and Pharmacodynamics of Warfarin in Patients with Advanced Malignancies: A Phase I Clinical Trial

Tsimberidou, A.-M., Takimoto, C. H. M., Moulder, S., Uehara, C., Mita, M., Mita, A., Urban, P., Tan, E., Wang, Y., Vining, D., Kurzrock, R.

Journal:

Molecular Cancer Therapeutics

Year:

2011

Language:

english

File:

PDF, 465 KB

english, 2011

136

Outcomes of Research Biopsies in Phase I Clinical Trials: The MD Anderson Cancer Center Experience

El-Osta, H., Hong, D., Wheler, J., Fu, S., Naing, A., Falchook, G., Hicks, M., Wen, S., Tsimberidou, A. M., Kurzrock, R.

Journal:

Year:

2011

Language:

english

File:

PDF, 70 KB

english, 2011

137

Survival of 1,181 Patients in a Phase I Clinic: The MD Anderson Clinical Center for Targeted Therapy Experience

Wheler, J., Tsimberidou, A. M., Hong, D., Naing, A., Falchook, G., Piha-Paul, S., Fu, S., Moulder, S., Stephen, B., Wen, S., Kurzrock, R.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 502 KB

english, 2012

138

The Prognostic Significance of Serum 2 Microglobulin Levels in Acute Myeloid Leukemia and Prognostic Scores Predicting Survival: Analysis of 1,180 Patients

Tsimberidou, A.-M., Kantarjian, H. M., Wen, S., O'Brien, S., Cortes, J., Wierda, W. G., Koller, C., Pierce, S., Brandt, M., Freireich, E. J., Keating, M. J., Estey, E. H.

Journal:

Clinical Cancer Research

Year:

2008

Language:

english

File:

PDF, 322 KB

english, 2008

139

Phase I-II Study of Oxaliplatin, Fludarabine, Cytarabine, and Rituximab Combination Therapy in Patients With Richter's Syndrome or Fludarabine-Refractory Chronic Lymphocytic Leukemia

Tsimberidou, A. M., Wierda, W. G., Plunkett, W., Kurzrock, R., O'Brien, S., Wen, S., Ferrajoli, A., Ravandi-Kashani, F., Garcia-Manero, G., Estrov, Z., Kipps, T. J., Brown, J. R., Fiorentino, A., Lern

Journal:

Journal of Clinical Oncology

Year:

2008

Language:

english

File:

PDF, 127 KB

english, 2008

140

The prognostic significance of left ventricular ejection fraction in patients with advanced cancer treated in phase I clinical trials

Said, R., Banchs, J., Wheler, J., Hess, K. R., Falchook, G., Fu, S., Naing, A., Hong, D., Piha-Paul, S., Ye, Y., Yeh, E., Wolff, R. A., Tsimberidou, A. M.

Journal:

Annals of Oncology

Year:

2014

Language:

english

File:

PDF, 177 KB

english, 2014

141

Inhibition of the Ras/Raf/MEK/ERK and RET Kinase Pathways with the Combination of the Multikinase Inhibitor Sorafenib and the Farnesyltransferase Inhibitor Tipifarnib in Medullary and Differentiated Thyroid Malignancies

Hong, David S., Cabanillas, Maria E., Wheler, Jennifer, Naing, Aung, Tsimberidou, Apostolia M., Ye, Lei, Waguespack, Steven G., Hernandez, Mike, El Naggar, Alder K., Bidyasar, Savita, Wright, John, Sh

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2011

Language:

english

File:

PDF, 564 KB

english, 2011

142

Quantitative Real-Time Polymerase Chain Reaction for Detection of Circulating Cells with T(14;18) in Volunteer Blood Donors and Patients with Follicular Lymphoma

Tsimberidou, Apostolia-Maria, Jiang, Yunfang, Ford, Richard J., Lichtiger, Benjamin, Medeiros, L. Jeffrey, McLaughlin, Peter, Cabanillas, Fernando, Sarris, Andreas H.

Journal:

Leukemia and Lymphoma

Year:

2002

Language:

english

File:

PDF, 2.56 MB

english, 2002

143

Targeted therapy in cancer

Tsimberidou, Apostolia-Maria

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2015

Language:

english

File:

PDF, 590 KB

english, 2015

144

Phase II Study of Fludarabine, Cytarabine (Ara-C), Cyclophosphamide, Cisplatin and GM-CSF (FACPGM) in Patients With Richter's Syndrome or Refractory Lymphoproliferative Disorders

Tsimberidou, Apostolia M., O'Brien, Susan M., Cortes, Jorge E., Faderl, Stefan, Andreeff, Michael, Kantarjian, Hagop M., Keating, Michael J., Giles, Francis J.

Journal:

Leukemia and Lymphoma

Year:

2002

Language:

english

File:

PDF, 434 KB

english, 2002

145

Treatment Algorithms Based on Tumor Molecular Profiling: The Essence of Precision Medicine Trials

Le Tourneau, Christophe, Kamal, Maud, Tsimberidou, Apostolia-Maria, Bedard, Philippe, Pierron, Gaëlle, Callens, Céline, Rouleau, Etienne, Vincent-Salomon, Anne, Servant, Nicolas, Alt, Marie, Rouzier,

Journal:

JNCI Journal of the National Cancer Institute

Year:

2016

Language:

english

File:

PDF, 971 KB

english, 2016

146

Essential Thrombocythemia (ET): Moving from Palliation to Cure

Tsimberidou, Apostolia-Maria, Giles, Francis J.

Journal:

Hematology (American Society of Hematology)

Year:

2002

Language:

english

File:

PDF, 252 KB

english, 2002

147

Phase I clinical trial of lenalidomide in combination with 5-fluorouracil, leucovorin, and oxaliplatin in patients with advanced cancer

Said, Rabih, Ye, Yang, Hong, David S., Naing, Aung, Falchook, Gerald, Fu, Siqing, Wheler, Jennifer J., Piha-Paul, Sarina, Tsimberidou, Apostolia-Maria

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2016

Language:

english

File:

PDF, 604 KB

english, 2016

148

Antitumor Response to Combined Antiangiogenic and Cytotoxic Chemotherapy in Recurrent Metastatic Chromophobe Renal Cell Carcinoma: Response Signatures and Proteomic Correlates

Maiti, Abhishek, Brown, Robert E., Corn, Paul G., Murthy, Ravi, Ganeshan, Dhakshina Moorthy, Tsimberidou, Apostolia M., Subbiah, Vivek

Journal:

Clinical Genitourinary Cancer

Year:

2016

Language:

english

File:

PDF, 2.63 MB

english, 2016

149

Precision medicine: lessons learned from the SHIVA trial

Tsimberidou, Apostolia M, Kurzrock, Razelle

Journal:

The Lancet Oncology

Year:

2015

Language:

english

File:

PDF, 46 KB

english, 2015

150

P5.01 * A first in human, dose escalation trial of MSC2363318A - a dual p70S6K/Akt inhibitor, for patients with advanced malignancies

Tsimberidou, A. M., Verschraegen, C., Heestand, G., Kaleta, R., Scheuenpflug, J., Huck, B., Weise, A., Kurzrock, R.

Journal:

Annals of Oncology

Year:

2015

Language:

english

File:

PDF, 60 KB

english, 2015