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51

Tu2047 Acetaldehyde-Derived Advanced Glycation End-Products Promote Alcoholic Liver Disease

George, Joseph, Hayashi, Nobuhiko, Takeuchi, Masayoshi, Arisawa, Tomiyasu, Tsutsumi, Mikihiro

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 153 KB

english, 2013

52

Hepatic aldehyde dehydrogenase isoenzymes: Differences with respect to species

Tsutsumi, Mikihiro, Takada, Akira, Takase, Shujiro, Sugata, Keiko

Journal:

Year:

1988

Language:

english

File:

PDF, 544 KB

english, 1988

53

Determination of aldehyde dehydrogenase isozyme activity in human liver

Sugata, Keiko, Takada, Akira, Takase, Shujiro, Tsutsumi, Mikihiro

Journal:

Year:

1988

Language:

english

File:

PDF, 464 KB

english, 1988

54

Clinical significance of vascular endothelial growth factor (VEGF) level in ascitic fluids

Kawahara, Hiromu, Fukura, Masaryuki, Itoh, Tohru, Tsutsumi, Mikihiro, Takase, Shujiro

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 182 KB

english, 2000

55

Genetic polymorphisms of cytochrome P4502E1 related to the development of alcoholic liver disease

Tsutsumi, Mikihiro, Takada, Akira, Wang, Jian-Song

Journal:

Gastroenterology

Year:

1994

Language:

english

File:

PDF, 556 KB

english, 1994

56

W1956 Analysis of C-Kit and Pdgfrα Gene Mutation in Gastrointestinal Stromal Tumor of the Small Intestine

Yamada, Masayoshi, Shiroeda, Hisakazu, Ozaki, Kazuaki, Tsuchishima, Mutsumi, Tsutsumi, Mikihiro, Arisawa, Tomiyasu

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 54 KB

english, 2009

57

Accelerated progression of hepatocellular carcinoma with cytokeratin 19 expression during treatment with lamivudine for hepatitis B virus-related liver cirrhosis

Yamada, Masayoshi, Shiroeda, Hisakazu, Sato, Katsuaki, Hayashi, Ranji, Nomura, Tomoe, Tsutsumi, Mikihiro, Arisawa, Tomiyasu

Journal:

Scandinavian Journal of Gastroenterology

Year:

2011

Language:

english

File:

PDF, 170 KB

english, 2011

58

Usefulness of a Combined Evaluation of the Serum Adiponectin Level, HOMA-IR, and Serum Type IV Collagen 7S Level to Predict the Early Stage of Nonalcoholic Steatohepatitis

Shimada, Masahiko, Kawahara, Hiromu, Ozaki, Kazuaki, Fukura, Masayuki, Yano, Hirokazu, Tsuchishima, Mutsumi, Tsutsumi, Mikihiro, Takase, Shujiro

Journal:

American Journal of Gastroenterology

Year:

2007

Language:

english

File:

PDF, 138 KB

english, 2007

59

Effects of a new orally active dopamine prodrug, docarpamine, on refractory ascites: a pilot study

Funasaki, Tsutomu, Tsutsumi, Mikihiro, Takase, Shujiro, Tsuchishima, Mutsumi, Ueshima, Yasuhiro, Urashima, Sachio, Shimanaka, Koshi, Itoh, Tohoru, Kawahara, Hiromu

Journal:

American Journal of Gastroenterology

Year:

1999

Language:

english

File:

PDF, 133 KB

english, 1999

60

Irsogladine maleate for the treatment of recurrent aphthous stomatitis in hepatitis C virus patients on pegylated-interferon and ribavirin: A pilot study

Hayashi, Nobuhiko, George, Joseph, Shiroeda, Hisakazu, Saito, Takashi, Toshikuni, Nobuyuki, Tsuchishima, Mutsumi, Arisawa, Tomiyasu, Tsutsumi, Mikihiro

Journal:

Journal of Gastroenterology and Hepatology

Year:

2013

Language:

english

File:

PDF, 178 KB

english, 2013

61

Su1468 Mural Nodule of 10mm or Larger As Predictor of Malignancy for Intraductal Papillary Mucinous Neoplasm of the Pancreas: Pathological and Radiological Validation

Kawada, Natsuko, Hayashi, Nobuhiko, Tsuchishima, Mutsumi, Tsutsumi, Mikihiro, Tomita, Yasuhiko

Journal:

Gastroenterology

Year:

2015

Language:

english

File:

PDF, 537 KB

english, 2015

62

Imaging morphological changes of intraductal papillary mucinous neoplasm of the pancreas was associated with its malignant transformation but not with development of pancreatic ductal adenocarcinoma

Kawada, Natsuko, Uehara, Hiroyuki, Nagata, Shigenori, Tsuchishima, Mutsumi, Tsutsumi, Mikihiro, Tomita, Yasuhiko

Journal:

Year:

2015

Language:

english

File:

PDF, 824 KB

english, 2015

63

Mural nodule of 10 mm or larger as predictor of malignancy for intraductal papillary mucinous neoplasm of the pancreas: Pathological and radiological evaluations

Kawada, Natsuko, Uehara, Hiroyuki, Nagata, Shigenori, Tsuchishima, Mutsumi, Tsutsumi, Mikihiro, Tomita, Yasuhiko

Journal:

Year:

2015

Language:

english

File:

PDF, 1.27 MB

english, 2015

64

Mouse Hepatic Portal Venoconstrictive Response to Vasoconstrictors Is Much Weaker Than That in Rat

Zhao, Zhan-Sheng, Shibamoto, Toshishige, Tsutsumi, Mikihiro, Cui, Sen, Zhang, Wei M, Takano, Hiromichi, Kurata, Yasutaka

Journal:

Journal of Cardiovascular Pharmacology

Year:

2009

Language:

english

File:

PDF, 286 KB

english, 2009

65

Immunohistochemical localization of ethanol-inducible P450IIE1 in the rat alimentary tract

Shimizu, Masanori, Lasker, Jerome M., Tsutsumi, Mikihiro, Lieber, Charles S.

Journal:

Gastroenterology

Year:

1990

Language:

english

File:

PDF, 1.89 MB

english, 1990

66

Differentially Expressed Genes in the Nucleus Accumbens from Chronically Ethanol-Administered Rat.

Leng, Shuangying, Tsutsumi, Mikihiro, Takase, Shujiro, Abe, Shuntaro, Yamamoto, Yuki, Fukunaga, Tatsushige, Tanii, Hideji, Saijho, Kiyofumi

Journal:

JOURNAL OF HEALTH SCIENCE

Year:

2001

Language:

english

File:

PDF, 275 KB

english, 2001

67

Cholangiocarcinoma Producing Parathyroid Hormone-related Peptide Treated with Chemoradiation Using Gemcitabine and S-1

Yamada, Masayoshi, Shiroeda, Hisakazu, Shiroeda, Shoko, Sato, Katsuaki, Arisawa, Tomiyasu, Tsutsumi, Mikihiro

Journal:

Internal Medicine

Year:

2009

Language:

english

File:

PDF, 511 KB

english, 2009

68

Colon Cancer Arising in an Ulcer Scar due to Intestinal Behçet's Disease

Yamada, Masayoshi, Shiroeda, Hisakazu, Nomura, Tomoe, Hayashi, Ranji, Sato, Katsuaki, Tsutsumi, Mikihiro, Arisawa, Tomiyasu

Journal:

Internal Medicine

Year:

2011

Language:

english

File:

PDF, 1.11 MB

english, 2011

69

GGsTop, a novel and specific γ-glutamyl transpeptidase inhibitor, protects hepatic ischemia-reperfusion injury in rats

Tamura, Kaneto, Hayashi, Nobuhiko, George, Joseph, Toshikuni, Nobuyuki, Arisawa, Tomiyasu, Hiratake, Jun, Tsuchishima, Mutsumi, Tsutsumi, Mikihiro

Journal:

American Journal of Physiology - Gastrointestinal and Liver Physiology

Year:

2016

Language:

english

File:

PDF, 3.13 MB

english, 2016

70

The Effects of Moderate Drinking on Liver Fibrosis Progression in Subjects with Fatty Liver Disease

Kinoshita, Kaori, Toshikuni, Nobuyuki, Tsuchishima, Mutsumi, Tsutsumi, Mikihiro

Journal:

Gastroenterology

Year:

2017

Language:

english

File:

PDF, 325 KB

english, 2017

71

MMP-13 deletion decreases profibrogenic molecules and attenuates N -nitrosodimethylamine-induced liver injury and fibrosis in mice

George, Joseph, Tsutsumi, Mikihiro, Tsuchishima, Mutsumi

Journal:

Journal of Cellular and Molecular Medicine

Year:

2017

Language:

english

File:

PDF, 2.36 MB

english, 2017

72

Type IV Collagen and Laminin Contents of Livers from Patients with Alcoholic Liver Disease

Tsutsumi, Mikihiro, Urashima, Sachio, Nakase, Katsunori, Takase, Shujiro, Takada, Akira

Journal:

Alcohol and Alcoholism

Year:

1993

Language:

english

File:

PDF, 2.15 MB

english, 1993

73

Su1462 - Targeted Delivery of Epigallocatechin Gallate and Antimir221 Regressed Intrahepatic Tumors in Athymic Mice

George, Joseph, Hayashi, Nobuhiko, Tsutsumi, Mikihiro, Tsuchishima, Mutsumi

Journal:

Gastroenterology

Year:

2018

Language:

english

File:

PDF, 147 KB

english, 2018

74

Acetaldehyde-Derived Advanced Glycation End-Products Promote Alcoholic Liver Disease

Hayashi, Nobuhiko, George, Joseph, Takeuchi, Masayoshi, Fukumura, Atsushi, Toshikuni, Nobuyuki, Arisawa, Tomiyasu, Tsutsumi, Mikihiro, Choi, Jinah

Journal:

Year:

2013

Language:

english

File:

PDF, 15.50 MB

english, 2013

75

Associations of Fatty Liver Disease with Hypertension, Diabetes, and Dyslipidemia: Comparison between Alcoholic and Nonalcoholic Steatohepatitis

Toshikuni, Nobuyuki, Tsuchishima, Mutsumi, Fukumura, Atsushi, Arisawa, Tomiyasu, Tsutsumi, Mikihiro

Journal:

Gastroenterology Research and Practice

Year:

2017

Language:

english

File:

PDF, 1.32 MB

english, 2017

76

Toxic AGE (TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD

Takeuchi, Masayoshi, Takino, Jun-ichi, Sakasai-Sakai, Akiko, Takata, Takanobu, Tsutsumi, Mikihiro

Journal:

Year:

2017

Language:

english

File:

PDF, 1.11 MB

english, 2017

77

Serum Endocan as a Novel Prognostic Biomarker in Patients with Hepatocellular Carcinoma

Ozaki, Kazuaki, Toshikuni, Nobuyuki, George, Joseph, Minato, Takahiro, Matsue, Yasuhiro, Arisawa, Tomiyasu, Tsutsumi, Mikihiro

Journal:

Journal of Cancer

Year:

2014

Language:

english

File:

PDF, 644 KB

english, 2014

78

Elevated Serum Gamma-glutamyl Transpeptidase Levels and Fatty Liver Strongly Predict the Presence of Carotid Plaque

Toshikuni, Nobuyuki, Asaji, Takayoshi, Nakanishi, Yumiko, Nagasawa, Shin-ya, Uenishi, Hiroaki, Tsutsumi, Mikihiro

Journal:

Journal of Atherosclerosis and Thrombosis

Year:

2015

Language:

english

File:

PDF, 98 KB

english, 2015

79

Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosis

George, Joseph, Tsuchishima, Mutsumi, Tsutsumi, Mikihiro

Journal:

Cell Death and Disease

Year:

2019

Language:

english

File:

PDF, 1.85 MB

english, 2019

80

Alteration of Trace Elements during Pathogenesis of N-Nitrosodimethylamine Induced Hepatic Fibrosis

George, Joseph, Tsutsumi, Mikihiro, Tsuchishima, Mutsumi

Journal:

Scientific Reports

Year:

2019

File:

PDF, 2.78 MB

2019

81

Alteration of Trace Elements during Pathogenesis of N-Nitrosodimethylamine Induced Hepatic Fibrosis

George, Joseph, Tsutsumi, Mikihiro, Tsuchishima, Mutsumi

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 2.78 MB

english, 2019

82

Immunohistochemical Study of Hyaluronate Receptor (CD44) in Alcoholic Liver Disease

Urashima, Sachio, Tsutsumi, Mikihiro, Ozaki, Kazuaki, Tsuchishima, Mutsumi, Shimanaka, Koshi, Ueshima, Yasuhiro, Takase, Shujiro

Journal:

Alcoholism: Clinical and Experimental Research

Year:

2000

Language:

english

File:

PDF, 1.79 MB

english, 2000

83

Comparison of the relationships of alcoholic and nonalcoholic fatty liver with hypertension, diabetes mellitus, and dyslipidemia

Toshikuni, Nobuyuki, Fukumura, Atsushi, Hayashi, Nobuhiko, Nomura, Tomoe, Tsuchishima, Mutsumi, Arisawa, Tomiyasu, Tsutsumi, Mikihiro

Journal:

Journal of Clinical Biochemistry and Nutrition

Year:

2013

File:

PDF, 500 KB

2013

84

Comparison of the relationships of alcoholic and nonalcoholic fatty liver with hypertension, diabetes mellitus, and dyslipidemia

Toshikuni, Nobuyuki, Fukumura, Atsushi, Hayashi, Nobuhiko, Nomura, Tomoe, Tsuchishima, Mutsumi, Arisawa, Tomiyasu, Tsutsumi, Mikihiro

Journal:

Journal of Clinical Biochemistry and Nutrition

Year:

2013

Language:

english

File:

PDF, 500 KB

english, 2013

85

Management of gastroesophageal varices in cirrhotic patients: current status and future directions

Toshikuni, Nobuyuki, Takuma, Yoshitaka, Tsutsumi, Mikihiro

Journal:

Annals of Hepatology

Year:

2016

Language:

english

File:

PDF, 292 KB

english, 2016

86

A New Genetic Variant in the Sp1 Binding Cis-Element of Cholecystokinin Gene Promoter Region and Relationship to Alcoholism

Harada, Shoji, Okubo, Takehito, Tsutsumi, Mikihiro, Takase, Shinjiro, Muramatsu, Taro

Journal:

Alcoholism: Clinical and Experimental Research

Year:

1998

File:

PDF, 436 KB

1998

87

Mo1459 – Diagnostic and Prognostic Implication of Mir-27A-3P in Human Hepatocellular Carcinoma with Different Etiology

George, Joseph, Fukumura, Atsushi, Ozaki, Kazuaki, Toshikuni, Nobuyuki, Tsuchishima, Mutsumi, Tsutsumi, Mikihiro

Journal:

Gastroenterology

Year:

2019

Language:

english

File:

PDF, 357 KB

english, 2019

88

THU-076-SPP1 gene knockout in human hepatic stellate cells decreased profibrogenic cytokines and collagen gene expression

George, Joseph, Saito, Takashi, Hayashi, Nobuhiko, Ozaki, Kazuaki, Tsutsumi, Mikihiro, Tsuchishima, Mutsumi

Journal:

Journal of Hepatology

Year:

2019

Language:

english

File:

PDF, 61 KB

english, 2019

89

THU-076-SPP1 gene knockout in human hepatic stellate cells decreased profibrogenic cytokines and collagen gene expression

George, Joseph, Saito, Takashi, Hayashi, Nobuhiko, Ozaki, Kazuaki, Tsutsumi, Mikihiro, Tsuchishima, Mutsumi

Journal:

Journal of Hepatology

Year:

2019

File:

PDF, 61 KB

2019

90

Recombinant thrombomodulin prevented hepatic ischemia-reperfusion injury by inhibiting high-mobility group box 1 in rats

Hirakawa, Yuki, Tsuchishima, Mutsumi, Fukumura, Atsushi, Kinoshita, Kaori, Hayashi, Nobuhiko, Saito, Takashi, George, Joseph, Toshikuni, Nobuyuki, Ueda, Yoshimichi, Tsutsumi, Mikihiro

Journal:

European Journal of Pharmacology

Year:

2019

Language:

english

File:

PDF, 9.01 MB

english, 2019

91

The combination of fatty liver and increased gamma-glutamyl transpeptidase levels as a risk factor for atherosclerotic plaque development in apparently healthy people

KINOSHITA, Kaori, TOSHIKUNI, Nobuyuki, SAITO, Takashi, HAYASHI, Nobuhiko, MINATO, Takahiro, MATSUE, Yasuhiro, UEDA, Yoshimichi, TSUCHISHIMA, Mutsumi, TSUTSUMI, Mikihiro

Journal:

TURKISH JOURNAL OF MEDICAL SCIENCES

Year:

2019

Language:

english

File:

PDF, 212 KB

english, 2019

92

Metabolism of N-nitrosodimethylamine, methylation of macromolecules, and development of hepatic fibrosis in rodent models

George, Joseph, Tsuchishima, Mutsumi, Tsutsumi, Mikihiro

Journal:

Journal of Molecular Medicine

Year:

2020

File:

PDF, 2.47 MB

2020

93

Inhibition of Î³âglutamyl transpeptidase ameliorates ischemiaâ reoxygenation tissue damage in rats with hepatic steatosis

Kubota, Ryuichi, Hayashi, Nobuhiko, Kinoshita, Kaori, Saito, Takashi, Ozaki, Kazuaki, Ueda, Yoshimichi, Tsuchishima, Mutsumi, Tsutsumi, Mikihiro, George, Joseph

Journal:

British Journal of Pharmacology

Year:

2020

File:

PDF, 2.42 MB

2020

94

Study of Cytochrome P4502E1 mRNA Level of Mononuclear Cells in Patients With Alcoholic Liver Disease

Yano, Hirokazu, Tsutsumi, Mikihiro, Fukura, Masayuki, Chen, Wun-Bil, Shimanaka, Koshi, Tsuchishima, Mutsumi, Takase, Shujiro, Imaoka, Susumu, Funae, Yoshihiko

Journal:

Alcoholism: Clinical and Experimental Research

Year:

2001

File:

PDF, 4.10 MB

2001