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1

The significance of circulating tumour cells in breast cancer: A review

Castle, J., Shaker, H., Morris, K., Tugwood, J.D., Kirwan, C.C.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.16 MB

english, 2014

2

A peroxisome proliferator-activated receptor-alpha (PPARα) cDNA cloned from guinea-pig liver encodes a protein with similar properties to the mouse PPARα: implications for species differences in responses to peroxisome proliferators

Jonathan D. Tugwood, Peter R. Holden, Neil H. James, Rebecca A. Prince, Ruth A. Roberts

Journal:

Archives of Toxicology

Year:

1998

Language:

english

File:

PDF, 634 KB

english, 1998

3

Immediate-Early Gene Expression during Regenerative and Mitogen-Induced Liver Growth in the Rat

P. R. Holden, J. Odum, A. R. Soames, J. R. Foster, C. R. Elcombe, J. D. Tugwood

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

1998

Language:

english

File:

PDF, 115 KB

english, 1998

4

A role for the pregnane X receptor in flucloxacillin-induced liver injury

Elise Andrews, Martin Armstrong, Jonathan Tugwood, Dan Swan, Philip Glaves, Munir Pirmohamed, Guruprasad P. Aithal, Matthew C. Wright, Christopher P. Day, Ann K. Daly

Journal:

Year:

2010

Language:

english

File:

PDF, 224 KB

english, 2010

5

Identification and characterisation of hepatotoxicants using microarray analysis of gene expression

P.R. Holden, J.D. Tugwood, G. Orphanides, I. Kimber, W.D. Pennie

Journal:

Year:

2000

Language:

english

File:

PDF, 86 KB

english, 2000

6

An epitope-tagging system for studying regulation of the peroxisome proliferator activated receptor alpha (PPARα)

J. M. Owens, J. D. Tugwood, G. G. Gibson

Journal:

European Journal of Drug Metabolism and Pharmacokinetics

Year:

1997

Language:

english

File:

PDF, 704 KB

english, 1997

7

Microarray analysis of gene expression of mouse hepatocytes of different ploidy

Pin Lu, Sandrine Prost, Helen Caldwell, Jonathan D. Tugwood, Graham R. Betton, David J. Harrison

Journal:

Mammalian Genome

Year:

2007

Language:

english

File:

PDF, 302 KB

english, 2007

8

Preclinical investigation of fibrodysplasia and its relevance to human musculo-skeletal syndrome

Michelle Coulson, Russell Westwood, Jonathan D. Tugwood, Rose A. Maciewicz, Jonathan Bowyer, Bob C. Scott

Journal:

Year:

2008

Language:

english

File:

PDF, 48 KB

english, 2008

9

Peroxisome Proliferator-activated Receptors: Stuctures and Function

JONATHAN D. TUGWOOD, THOMAS C. ALDRIDGE, KEVIN G. LAMBE, NEIL MACDONALD, NICOLA J. WOODYATT

Journal:

Annals of the New York Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 801 KB

english, 1996

10

Identification of a Novel Peroxisome Proliferator Responsive cDNA Isolated from Rat Hepatocytes as the Zinc-Finger Protein ZFP-37

John P. Vanden Heuvel, Peter Holden, Jonathan Tugwood, Christine Ingle, Weiyi Yen, Niels Galjart, William F. Greenlee

Journal:

Toxicology and Applied Pharmacology

Year:

1998

Language:

english

File:

PDF, 527 KB

english, 1998

11

Establishment of an HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions

Catherine Bell, Klara Martinsson, Lee Faulkner, Ana Alfirevic, Neil French, Jonathan Tugwood, Ina Schuppe-Koistinen, Karin Cederbrant, Munir Pirmohamed, Dean Naisbitt, B. Kevin Park

Journal:

Year:

2011

Language:

english

File:

PDF, 107 KB

english, 2011

12

Dexamethasone and Insulin Demonstrate Marked and Opposite Regulation of the Steady-State mRNA Level of the Peroxisomal Proliferator-Activated Receptor (PPAR) in Hepatic Cells : Hormonal Modulation of Fatty-Acid-Induced Transcription

Hilde Hermansen Steineger, Hilde Nebb Sørensen, Jonathan D. Tugwood, Steinar Skrede, Øystein Spydevold, Kaare M. Gautvik

Journal:

Year:

1994

Language:

english

File:

PDF, 901 KB

english, 1994

13

A Human Peroxisome-Proliferator-Activated Receptor-γ is Activated by Inducers of Adipogenesis, Including Thiazolidinedione Drugs

Kevin G. Lambe, Jonathan D. Tugwood

Journal:

Year:

1996

Language:

english

File:

PDF, 802 KB

english, 1996

14

Amino Acid Residues in both the DNA-Binding and Ligand-Binding Domains Influence Transcriptional Activity of the Human Peroxisome Proliferator-Activated Receptor Alpha

Kevin A. Myers, Kevin G. Lambe, Thomas C. Aldridge, Neil Macdonald, Jonathan D. Tugwood

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 191 KB

english, 1997

15

Do Peroxisome Proliferating Compounds Pose a Hepatocarcinogenic Hazard to Humans?

Russell C. Cattley, John DeLuca, Cliff Elcombe, Penelope Fenner-Crisp, Brian G. Lake, Daniel S. Marsman, Timothy A. Pastoor, James A. Popp, Denise E. Robinson, Bernard Schwetz, Jonathan Tugwood, Walte

Journal:

Regulatory Toxicology and Pharmacology

Year:

1998

Language:

english

File:

PDF, 202 KB

english, 1998

16

The application of Next Generation Sequencing to the detection and analysis of miRNAs

Daniel Paul Tonge, Jonathan Tugwood, Timothy Gant

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 40 KB

english, 2012

17

The retinoid X receptor enhances the function of the peroxisome proliferator activated receptor

I. Issemann, R.A. Prince, J.D. Tugwood, S. Green

Journal:

Year:

1993

Language:

english

File:

PDF, 977 KB

english, 1993

18

Peroxisome proliferator-activated receptor (PPAR) alpha-regulated growth responses and their importance to hepatocarcinogenesis

N.H James, J.H Gill, R Brindle, N.J Woodyatt, N Macdonald, M Rolfe, S.C Hasmall, J.D Tugwood, P.R Holden, R.A Roberts

Journal:

Toxicology Letters

Year:

1998

Language:

english

File:

PDF, 453 KB

english, 1998

19

S3/L3 - PPARα-Regulated growth responses and their importance to hepatocarcinogenesis

N.H. James, N.J. Woodyatt, N. Macdonald, M. Rolfe, S.C. Hasmall, P.R. Holden, J.D. Tugwood, R.A. Roberts

Journal:

Toxicology Letters

Year:

1998

Language:

english

File:

PDF, 131 KB

english, 1998

20

T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms

Bell, Catherine C., Faulkner, Lee, Martinsson, Klara, Farrell, John, Alfirevic, Ana, Tugwood, Jonathan, Pirmohamed, Munir, Naisbitt, Dean J., Park, B. Kevin

Journal:

Chemical Research in Toxicology

Year:

2013

Language:

english

File:

PDF, 3.01 MB

english, 2013

21

Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells

Bell, Catherine C., Santoyo Castelazo, Anahi, Yang, Emma L., Maggs, James L., Jenkins, Rosalind E., Tugwood, Jonathan, O’Neill, Paul M., Naisbitt, Dean J., Park, B. Kevin

Journal:

Chemical Research in Toxicology

Year:

2013

Language:

english

File:

PDF, 760 KB

english, 2013

22

The role of microRNAs in the pathogenesis of MMPi-induced skin fibrodysplasia

Daniel P Tonge, Jonathan D Tugwood, Janet Kelsall, Timothy W Gant

Journal:

Year:

2013

Language:

english

File:

PDF, 998 KB

english, 2013

23

Genomics and the search for novel biomarkers in toxicology

Tugwood, Jonathan D., Hollins, Laura E., Cockerill, Mark J.

Journal:

Year:

2003

Language:

english

File:

PDF, 226 KB

english, 2003

24

TESTING TASTE

Green, Stephen, Tugwood, Jonathan D., Issemann, Isabelle

Journal:

Year:

1987

Language:

english

File:

PDF, 331 KB

english, 1987

25

The molecular mechanism of peroxisome proliferator action: a model for species differences and mechanistic risk assessment

Green, Stephen, Tugwood, Jonathan D., Issemann, Isabelle

Journal:

Toxicology Letters

Year:

1992

Language:

english

File:

PDF, 588 KB

english, 1992

26

Circulating biomarkers in hepatocellular carcinoma

Morris, Karen L., Tugwood, Jonathan D., Khoja, Leila, Lancashire, Matthew, Sloane, Robert, Burt, Debbie, Shenjere, Patrick, Zhou, Cong, Hodgson, Clare, Ohtomo, Toshihiko, Katoh, Atsuhiko, Ishiguro, Ta

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2014

Language:

english

File:

PDF, 696 KB

english, 2014

27

[IEEE 2006 IEEE EIC Climate Change Conference - Ottawa, ON, Canada (2006.05.10-2006.05.12)] 2006 IEEE EIC Climate Change Conference - Planning for Atmospheric Hazards and Disaster Management Under Changing Climate Conditions

Auld, Heather, Maclver, Don, Klaassen, Joan, Comer, Neil, Tugwood, Bryan

Year:

2006

Language:

english

File:

PDF, 9.22 MB

english, 2006

28

Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury

Cross, M J, Berridge, B R, Clements, P J M, Cove-Smith, L, Force, T L, Hoffmann, P, Holbrook, M, Lyon, A R, Mellor, H R, Norris, A A, Pirmohamed, M, Tugwood, J D, Sidaway, J E, Park, B K

Journal:

British Journal of Pharmacology

Year:

2015

Language:

english

File:

PDF, 902 KB

english, 2015

29

1: Circulating tumour cells from small cell lung cancer patients are tumourigenic

Hodgkinson, C., Morrow, C., Tugwood, J., Li, Y., Metcalf, R., Rothwell, D., Trapani, F., Burt, D., Simpson, K., Morris, K., Pepper, S., Nonaka, D., Greystoke, A., Kelly, P., Bola, B., Polanski, R., Kr

Journal:

Year:

2015

Language:

english

File:

PDF, 173 KB

english, 2015

30

Tesaglitazar, a Dual PPAR- / Agonist, Hamster Carcinogenicity, Investigative Animal and Clinical Studies

Lindblom, P., Berg, A.-L., Zhang, H., Westerberg, R., Tugwood, J., Lundgren, H., Marcusson-Stahl, M., Sjogren, N., Blomgren, B., Ohman, P., Skanberg, I., Evans, J., Hellmold, H.

Journal:

Toxicologic Pathology

Year:

2012

Language:

english

File:

PDF, 1.01 MB

english, 2012

31

Fibrodysplasia Induced in Dog Skin by a Matrix Metalloproteinase (MMP) Inhibitor--A Mechanistic Analysis

Tugwood, J. D., Kelsall, J., Coverley, L. C., Westwood, F. R., Haque, K., Huby, R. D. J.

Journal:

Toxicological Sciences

Year:

2012

Language:

english

File:

PDF, 721 KB

english, 2012

32

Orphans await real purpose in life: Differential activation of peroxisome proliferator activated receptors by eicosanoids Yu K, Bayona W, Kallens CB, Harding HP, Ravera CP, McMahon G, Brown M and Lazar MA The Journal of Biological Chemistry, 1995; 270: 23975-23983

Journal:

Human & Experimental Toxicology

Year:

1996

Language:

english

File:

PDF, 219 KB

english, 1996

33

Mechanistically-based Human Hazard Assessment of Peroxisome Proliferator-induced Hepatocarcinogenesis

Ashby, J., Brady, A., Elcombe, C.R., Elliott, B.M., Ishmael, J., Odum, J., Tugwood, J.D., Kettle, S., Purchase, I.F.H.

Journal:

Human & Experimental Toxicology

Year:

1994

Language:

english

File:

PDF, 7.04 MB

english, 1994

34

Epstein-Barr Virus-specific Transcription in Normal and Malignant Nasopharyngeal Biopsies and in Lymphocytes from Healthy Donors and Infectious Mononucleosis Patients

Tugwood, J. D., Lau, W.-H., Sai-Kio,, Tsao, S.-Y., Martin, W. M. C., Shiu, W., Desgranges, C., Jones, P. H., Arrand, J. R.

Journal:

Journal of General Virology

Year:

1987

Language:

english

File:

PDF, 4.04 MB

english, 1987

35

Optimisation of immunofluorescence methods to determine MCT1 and MCT4 expression in circulating tumour cells

Kershaw, Stephen, Cummings, Jeffrey, Morris, Karen, Tugwood, Jonathan, Dive, Caroline

Journal:

Year:

2015

Language:

english

File:

PDF, 2.13 MB

english, 2015

36

Biology and toxicology of PPARγ ligands

Tugwood, JD, Montague, CT

Journal:

Human & Experimental Toxicology

Year:

2002

Language:

english

File:

PDF, 231 KB

english, 2002

37

The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs

Faulkner, L., Martinsson, K., Santoyo-Castelazo, A., Cederbrant, K., Schuppe-Koistinen, I., Powell, H., Tugwood, J., Naisbitt, D. J., Park, B. K.

Journal:

Toxicological Sciences

Year:

2012

Language:

english

File:

PDF, 609 KB

english, 2012

38

Predictive models of hepatotoxicity using gene expression data from primary rat hepatocytes

Hultin-Rosenberg, L., Jagannathan, S., Nilsson, K. C., Matis, S. A., Sjögren, N., Huby, R. D. J., Salter, A. H., Tugwood, J. D.

Journal:

Year:

2006

Language:

english

File:

PDF, 1.14 MB

english, 2006

39

The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs

Issemann, I, Prince, R A, Tugwood, J D, Green, S

Journal:

Journal of Molecular Endocrinology

Year:

1993

Language:

english

File:

PDF, 2.96 MB

english, 1993

40

Tesaglitazar, a PPAR / Agonist, Induces Interstitial Mesenchymal Cell DNA Synthesis and Fibrosarcomas in Subcutaneous Tissues in Rats

Hellmold, H., Zhang, H., Andersson, U., Blomgren, B., Holland, T., Berg, A.-L., Elebring, M., Sjogren, N., Bamberg, K., Dahl, B., Westerberg, R., Dillner, B., Tugwood, J., Tugwood, J., Roberts, R., Lu

Journal:

Toxicological Sciences

Year:

2007

Language:

english

File:

PDF, 887 KB

english, 2007

41

Aortic Binding of AZD5248: Mechanistic Insight and Reactivity Assays To Support Lead Optimzation

Bragg, Ryan A., Brocklehurst, Simon, Gustafsson, Frida, Goodman, James, Hickling, Kevin, MacFaul, Philip A., Swallow, Steve, Tugwood, Jonathan

Journal:

Chemical Research in Toxicology

Year:

2015

Language:

english

File:

PDF, 6.60 MB

english, 2015

42

Gene expression profiling for pharmaceutical safety assessment

Huby, Russell, Tugwood, Jonathan D

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2005

Language:

english

File:

PDF, 1.28 MB

english, 2005

43

Circulating tumor cell eXplants (CDX) to advance small cell lung cancer (SCLC) research and drug development

Dive, Caroline, Frese, Kris, Brady, Ged, Tugwood, Jonathan, Miller, Crispin, Blackhall, Fiona

Journal:

Journal of Thoracic Oncology

Year:

2016

Language:

english

File:

PDF, 65 KB

english, 2016

44

The alpha1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family.

Galarneau, L, Paré, J F, Allard, D, Hamel, D, Levesque, L, Tugwood, J D, Green, S, Bélanger, L

Journal:

Molecular and Cellular Biology

Year:

1996

Language:

english

File:

PDF, 1.50 MB

english, 1996

45

Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity

Carr, Daniel F., Alfirevic, Ana, Tugwood, Jonathan D., Barratt, Bryan J., Sherwood, James, Smith, John, Pirmohamed, Munir, Kevin Park, B.

Journal:

Pharmacogenetics and Genomics

Year:

2007

Language:

english

File:

PDF, 156 KB

english, 2007

46

An Automated Synoptic Typing Procedure to Predict Freezing Rain: An Application to Ottawa, Ontario, Canada

Cheng, Chad Shouquan, Auld, Heather, Li, Guilong, Klaassen, Joan, Tugwood, Bryan, Li, Qian

Journal:

Weather and Forecasting

Year:

2004

Language:

english

File:

PDF, 507 KB

english, 2004

47

Tacrine-induced liver damage: an analysis of 19 candidate genes

Alfirevic, Ana, Mills, Tracy, Carr, Daniel, Barratt, Bryan J., Jawaid, Ansar, Sherwood, James, Smith, John C., Tugwood, Jonathan, Hartkoorn, Ruben, Owen, Andrew, Park, Kevin B., Pirmohamed, Munir

Journal:

Pharmacogenetics and Genomics

Year:

2007

Language:

english

File:

PDF, 226 KB

english, 2007

48

A brief report: Circulating tumour cells detected in the tumour-draining pulmonary vein are associated with disease recurrence after surgical resection of non-small cell lung cancer

Crosbie, P.A.J., Shah, R., Krysiak, P., Zhou, C., Morris, K., Tugwood, J., Booton, R., Blackhall, F., Dive, C.

Journal:

Journal of Thoracic Oncology

Year:

2016

Language:

english

File:

PDF, 412 KB

english, 2016

49

Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription

Aldridge, T C, Tugwood, J D, Green, S

Journal:

Biochemical Journal

Year:

1995

Language:

english

File:

PDF, 1.83 MB

english, 1995

50

The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human

MAINWARING, Guy W, WILLIAMS, Sally M, FOSTER, John R, TUGWOOD, Jonathan, GREEN, Trevor

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 683 KB

english, 1996