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51

Brief Report: Anti-Tumor Necrosis Factor α Targets Protein Kinase B/c-Akt-Induced Resistance of Effector Cells to Suppression in Juvenile Idiopathic Arthritis

Wehrens, Ellen J., Vastert, Sebastiaan J., Mijnheer, Gerdien, Meerding, Jenny, Klein, Mark, Wulffraat, Nico M., Prakken, Berent J., van Wijk, Femke

Journal:

Arthritis & Rheumatism

Year:

2013

Language:

english

File:

PDF, 276 KB

english, 2013

52

Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis

Vastert, S. J., van Wijk, R., D'Urbano, L. E., de Vooght, K. M. K., de Jager, W., Ravelli, A., Magni-Manzoni, S., Insalaco, A., Cortis, E., van Solinge, W. W., Prakken, B. J., Wulffraat, N. M., de Ben

Journal:

Year:

2010

Language:

english

File:

PDF, 180 KB

english, 2010

53

Evaluation of anakinra for the treatment of systemic juvenile idiopathic arthritis

Vastert, Sebastiaan J, Swart, Joost F, Wulffraat, Nico M

Journal:

Expert Opinion on Orphan Drugs

Year:

2014

Language:

english

File:

PDF, 155 KB

english, 2014

54

Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression

Peeters, Janneke G.C., Vervoort, Stephin J., Tan, Sander C., Mijnheer, Gerdien, de Roock, Sytze, Vastert, Sebastiaan J., Nieuwenhuis, Edward E.S., van Wijk, Femke, Prakken, Berent J., Creyghton, Menno

Journal:

Year:

2015

Language:

english

File:

PDF, 3.35 MB

english, 2015

55

THU0333 Effectiveness and long-term follow up of recombinant IL-1RA as first line therapy in newly onset juvenile idiopathic arthritis

Vastert, S., De Jager, W., Noordman, B. J., Holzinger, D., Kuis, W., Prakken, B., Wulffraat, N.

Journal:

Annals of the Rheumatic Diseases

Year:

2012

Language:

english

File:

PDF, 217 KB

english, 2012

56

FRI0271 Final Evidence-Based Recommendations for Diagnosis and Treatment of Paediatric Vasculitides

De Graeff, N., Groot, N., Kamphuis, S., Avcin, T., Bader-Meunier, B., Dolezalova, P., Kone-Paut, I., Lahdenne, P., McCann, L., Pilkington, C., Ravelli, A., Van Royen, A., Vastert, B., Wulffraat, N., O

Journal:

Annals of the Rheumatic Diseases

Year:

2015

Language:

english

File:

PDF, 152 KB

english, 2015

57

Autoimmune disease-associated gene expression is reduced by BET-inhibition

Peeters, Janneke G.C., Vervoort, Stephin J., Mijnheer, Gerdien, de Roock, Sytze, Vastert, Sebastiaan J., Nieuwenhuis, Edward E.S., van Wijk, Femke, Prakken, Berent J., Mokry, Michal, van Loosdregt, Jo

Journal:

Year:

2016

Language:

english

File:

PDF, 771 KB

english, 2016

58

REGULATORY T-CELLS CONTROL THE IMMUNE RESPONSE FOLLOWING CARDIAC SURGERY IN CHILDREN

Schadenberg, A W.L., Vastert, S J., de Kleer, I M., Evens, F C.M., Kuis, W, van Vught, A J., Prakken, B J., Jansen, N J.G.

Journal:

Pediatric Critical Care Medicine

Year:

2005

Language:

english

File:

PDF, 112 KB

english, 2005

59

DYNAMICS OF PRO-INFLAMMATORY MONOCYTES IN SYSTEMIC INFLAMMATION AFTER CARDIAC SURGERY IN CHILDREN

Schadenberg, A W.L., Vastert, S J., Hitchcock, J F., Kuis, W, van Vught, A J., Prakken, B J., Jansen, N J.G.

Journal:

Pediatric Critical Care Medicine

Year:

2005

Language:

english

File:

PDF, 112 KB

english, 2005

60

Evidence-based diagnosis and treatment of macrophage activation syndrome in systemic juvenile idiopathic arthritis

Boom, V., Anton, J., Lahdenne, P., Quartier, P., Ravelli, A., Wulffraat, N.M., Vastert, S.J.

Journal:

Pediatric Rheumatology

Year:

2015

Language:

english

File:

PDF, 547 KB

english, 2015

61

The Right Circumscript Populations

Schadenberg, A W.L., Vastert, S J., Jansen, N J.G., Prakken, B J.

Journal:

Critical Care Medicine

Year:

2005

Language:

english

File:

PDF, 401 KB

english, 2005

62

15th Paediatric Rheumatology European Society Congress

Vastert, SJ, Swart, Joost F, Prakken, Berent J

Journal:

Future Rheumatology

Year:

2008

Language:

english

File:

PDF, 229 KB

english, 2008

63

Self-Sustained Resistance to Suppression of CD8+ Teff Cells at the Site of Autoimmune Inflammation Can Be Reversed by Tumor Necrosis Factor and Interferon-γ Blockade

Petrelli, Alessandra, Wehrens, Ellen J., Scholman, Rianne C., Prakken, Berent J., Vastert, Sebastian J., van Wijk, Femke

Journal:

Arthritis & Rheumatology

Year:

2016

Language:

english

File:

PDF, 292 KB

english, 2016

64

The human microbiome and juvenile idiopathic arthritis

Verwoerd, Anouk, Ter Haar, Nienke M., de Roock, Sytze, Vastert, Sebastiaan J., Bogaert, Debby

Journal:

Pediatric Rheumatology

Year:

2016

Language:

english

File:

PDF, 516 KB

english, 2016

65

Enhancers in autoimmune arthritis: Implications and therapeutic potential

Peeters, Janneke G.C., Vastert, Sebastiaan J., van Wijk, Femke, van Loosdregt, Jorg

Journal:

Arthritis & Rheumatology

Year:

2017

Language:

english

File:

PDF, 977 KB

english, 2017

66

OP0055 IL-1 receptor antagonist restores IL-18 nk cell axis in systemic JIA

De Jager, W., Vastert, S.J., Noordman, B.J., Prakken, B.J., Wulffraat, N.M.

Journal:

Annals of the Rheumatic Diseases

Year:

2013

Language:

english

File:

PDF, 87 KB

english, 2013

67

Recommendations for collaborative paediatric research including biobanking in Europe: a Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) initiative

Kuemmerle-Deschner, Jasmin B, Hansmann, Sandra, Wulffraat, Nico M, Vastert, Sebastiaan J, Hens, Kristien, Anton, Jordi, Avcin, Tadej, Martini, Alberto, Koné-Paut, Isabelle, Uziel, Yosef, Ravelli, Ange

Journal:

Annals of the Rheumatic Diseases

Year:

2017

Language:

english

File:

PDF, 778 KB

english, 2017

68

Toward personalized treatment for systemic juvenile idiopathic arthritis

Vastert, Sebastiaan J., Nigrovic, Peter A.

Journal:

Arthritis & Rheumatology

Year:

2018

Language:

english

File:

PDF, 162 KB

english, 2018

69

A1.06 Phagocyte involvement in systemic onset juvenile idiopathic arthritis

ter Haar, NM, de Jager, W, Scholman, RS, Meerding, J, Tak, T, Leliefeld, PHC, Vastert, SJ, de Roock, S

Journal:

Annals of the Rheumatic Diseases

Year:

2016

Language:

english

File:

PDF, 87 KB

english, 2016

70

Update on research and clinical translation on specific clinical areas from biology to bedside: Unpacking the mysteries of juvenile idiopathic arthritis pathogenesis

van Loosdregt, Jorg, van Wijk, Femke, Prakken, Berent, Vastert, Bas

Journal:

Best Practice & Research Clinical Rheumatology

Year:

2018

Language:

english

File:

PDF, 499 KB

english, 2018

71

The safety of live-attenuated vaccines in patients using IL-1 or IL-6 blockade: an international survey

Jeyaratnam, Jerold, ter Haar, Nienke M., Lachmann, Helen J., Kasapcopur, Ozgur, Ombrello, Amanda K., Rigante, Donato, Dedeoglu, Fatma, Baris, Ezgi H., Vastert, Sebastiaan J., Wulffraat, Nico M., Frenk

Journal:

Pediatric Rheumatology

Year:

2018

Language:

english

File:

PDF, 337 KB

english, 2018

72

The Dutch version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR)

Wulffraat, Nico, Kamphuis, Sylvia, Swart, Joost F., Vastert, Sebastiaan, Van Dijkhuizen, Pieter, van Pelt, Philomine, van Dijk-Hummelman, Annette, Consolaro, Alessandro, Bovis, Francesca, Ruperto, Nic

Journal:

Rheumatology International

Year:

2018

Language:

english

File:

PDF, 631 KB

english, 2018

73

OP0196 The Role of Neutrophils in the Inflammatory Cascade of Systemic Onset Juvenile Idiopathic Arthritis

Ter Haar, N., Tak, T., Vastert, B., de Roock, S.

Journal:

Annals of the Rheumatic Diseases

Year:

2015

Language:

english

File:

PDF, 68 KB

english, 2015

74

A2.7 Interleukin-18 production upon S100 stimulation is reduced in systemic-onset juvenile idiopathic arthritis

Ter Haar, NM, De Jager, W, Scholman, RC, Vastert, SJ, De Roock, S

Journal:

Annals of the Rheumatic Diseases

Year:

2015

Language:

english

File:

PDF, 71 KB

english, 2015

75

Contradictory and weak evidence on the effectiveness of anti-emetics for MTX-intolerance in JIA-patients

Schoemaker, Casper G., van Dijkhuizen, E. H. Pieter, Vastert, Sebastiaan J.

Journal:

Pediatric Rheumatology

Year:

2018

Language:

english

File:

PDF, 300 KB

english, 2018

76

OP0297 Trends in Prescription of Biologics and Outcomes of Juvenile Idiopathic Arthritis; Results of the Dutch National Arthritis and Biologicals in Children Register

Otten, M. H., Anink, J., Prince, F. H., Twilt, M., Vastert, S. J., ten Cate, R., Hoppenreijs, E. P., Armbrust, W., Gorter, S. L., van Pelt, P. A., Kamphuis, S., Dolman, K. M., Swart, J. F., van den Be

Journal:

Annals of the Rheumatic Diseases

Year:

2013

Language:

english

File:

PDF, 217 KB

english, 2013

77

Patient’s experiences with the care for juvenile idiopathic arthritis across Europe

van Dijkhuizen, E. H. Pieter., Egert, Tsipi, Egert, Yona, Costello, Wendy, Schoemaker, Casper, Fernhout, Marlous, Kepic, Mirjam, Martini, Alberto, Scala, Silvia, Rotstein-Grein, Ingrid, Vastert, Sebas

Journal:

Pediatric Rheumatology

Year:

2018

Language:

english

File:

PDF, 394 KB

english, 2018

78

OP0057 Anti-TNFΑ Therapy Targets PKB/C-AKT Induced Resistance of Effector Cells to Suppression in Juvenile Idiopathic Arthritis

Wehrens, E. J., Vastert, S. J., Mijnheer, G., Meerding, J. M., Klein, M., Wulffraat, N. M., Prakken, B. J., van Wijk, F.

Journal:

Annals of the Rheumatic Diseases

Year:

2013

Language:

english

File:

PDF, 297 KB

english, 2013

79

S100A12 as diagnostic tool in the differential diagnosis of sJIA associated MAS vs. hereditary or acquired HLH

Holzinger, D, Fall, N, Grom, A, de Jager, W, Vastert, S, Strippoli, R, Bracaglia, C, Sundberg, E, Horne, A, Ehl, S, De Benedetti, F, Beutel, K, Foell, D

Journal:

Pediatric Rheumatology

Year:

2015

Language:

english

File:

PDF, 268 KB

english, 2015

80

Prediction of inactive disease in juvenile idiopathic arthritis: a multicentre observational cohort study

van Dijkhuizen, Evert H Pieter, Aidonopoulos, Orfeas, ter Haar, Nienke M, Pires Marafon, Denise, Magni-Manzoni, Silvia, Ioannidis, Yannis E, Putignani, Lorenza, Vastert, Sebastiaan J, Malattia, Clara,

Journal:

Year:

2018

Language:

english

File:

PDF, 375 KB

english, 2018

81

Autophagy Is a Tolerance-Avoidance Mechanism that Modulates TCR-Mediated Signaling and Cell Metabolism to Prevent Induction of T Cell Anergy

Mocholi, Enric, Dowling, Samuel D., Botbol, Yair, Gruber, Ross C., Ray, Alex K., Vastert, Sebastiaan, Shafit-Zagardo, Bridget, Coffer, Paul J., Macian, Fernando

Journal:

Year:

2018

Language:

english

File:

PDF, 3.76 MB

english, 2018

82

Transcription factor motif enrichment in whole transcriptome analysis identifies STAT4 and BCL6 as the most prominent binding motif in systemic juvenile idiopathic arthritis

Hügle, Boris, Schippers, Anastasia, Fischer, Nadine, Ohl, Kim, Denecke, Bernd, Ticconi, Fabio, Vastert, Bas, Costa, Ivan G., Haas, Johannes-Peter, Tenbrock, Klaus

Journal:

Arthritis Research & Therapy

Year:

2018

Language:

english

File:

PDF, 1.19 MB

english, 2018

83

Transcriptional and epigenetic profiling of nutrient-deprived cells to identify novel regulators of autophagy

Peeters, J.G.C., Picavet, L.W., Coenen, S.G.J.M., Mauthe, M., Vervoort, S.J., Mocholi, E., de Heus, C., Klumperman, J., Vastert, S.J., Reggiori, F., Coffer, P.J., Mokry, M., van Loosdregt, J.

Journal:

Year:

2018

Language:

english

File:

PDF, 1.51 MB

english, 2018

84

Dutch juvenile idiopathic arthritis patients, carers and clinicians create a research agenda together following the James Lind Alliance method: a study protocol

Schoemaker, Casper G., Armbrust, Wineke, Swart, Joost F., Vastert, Sebastiaan J., van Loosdregt, Jorg, Verwoerd, Anouk, Whiting, Caroline, Cowan, Katherine, Olsder, Wendy, Versluis, Els, van Vliet, Re

Journal:

Pediatric Rheumatology

Year:

2018

Language:

english

File:

PDF, 542 KB

english, 2018

85

Microbiome analytics of the gut microbiota in juvenile idiopathic arthritis patients: an observational, longitudinal cohort study

van Dijkhuizen, E.H. Pieter, Del Chierico, Federica, Malattia, Clara, Russo, Alessandra, Pires Marafon, Denise, ter Haar, Nienke M., Magni-Manzoni, Silvia, Vastert, Sebastiaan J., Dallapiccola, Bruno,

Journal:

Arthritis & Rheumatology

Year:

2018

Language:

english

File:

PDF, 1.15 MB

english, 2018

86

Restoring T Cell Tolerance, Exploring the Potential of Histone Deacetylase Inhibitors for the Treatment of Juvenile Idiopathic Arthritis

Nijhuis, Lotte, Peeters, Janneke G. C., Vastert, Sebastiaan J., van Loosdregt, Jorg

Journal:

Frontiers in Immunology

Year:

2019

Language:

english

File:

PDF, 1.20 MB

english, 2019

87

Juvenile Arthritis Patients Suffering from Chronic Inflammation Have Increased Activity of Both IDO and GTP-CH1 Pathways But Decreased BH4 Efficacy: Implications for Well-Being, Including Fatigue, Cognitive Impairment, Anxiety, and Depression

Korte-Bouws, Gerdien A. H., Albers, Eline, Voskamp, Marije, Hendriksen, Hendrikus, De Leeuw, Lidewij R., Güntürkün, Onur, De Roock, Sytze, Vastert, Sebastiaan J., Korte, S. Mechiel

Journal:

Pharmaceuticals

Year:

2019

File:

PDF, 2.06 MB

2019

88

Anakinra in children and adults with Still’s disease

Vastert, Sebastiaan J, Jamilloux, Yvan, Quartier, Pierre, Ohlman, Sven, Osterling Koskinen, Lisa, Kullenberg, Torbjörn, Franck-Larsson, Karin, Fautrel, Bruno, de Benedetti, Fabrizio

Journal:

Year:

2019

File:

PDF, 210 KB

2019

89

The patient and parent perspective on methotrexate in recent Juvenile Idiopathic Arthritis guidelines

Schoemaker, Casper G, Wulffraat, Nico M, Vastert, Sebastiaan J

Journal:

Arthritis & Rheumatology

Year:

2020

Language:

english

File:

PDF, 2.55 MB

english, 2020

90

How autoinflammation may turn into autoimmune inflammation: Insights from monogenetic and complex IL-1 mediated auto-inflammatory diseases

ter Haar, N.M., Jansen, M.H.A., Frenkel, J.F., Vastert, S.J.

Journal:

Clinical Immunology

Year:

2020

File:

PDF, 832 KB

2020

91

Aiming high: quantifying inflammation in systemic onset juvenile idiopathic arthritis (sJIA), a multi-faceted and complex inflammatory disease

Murray, Grainne M, Vastert, Sebastiaan J, Ramanan, Athimalaipet V

Journal:

Year:

2020

File:

PDF, 139 KB

2020

92

Whole Transcriptome Analysis Reveals Heterogeneity in B Cell Memory Populations in Patients With Juvenile Idiopathic Arthritis-Associated Uveitis

Wennink, Roos A. W., Pandit, Aridaman, Haasnoot, Anne-Mieke J. W., Hiddingh, Sanne, Kalinina Ayuso, Viera, Wulffraat, Nico M., Vastert, Bas J., Radstake, Timothy R. D. J., de Boer, Joke H., Kuiper, Jo

Journal:

Frontiers in Immunology

Year:

2020

File:

PDF, 6.78 MB

2020

93

[BMJ Publishing Group Ltd and European League Against Rheumatism Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12â15 June 2019 - ()] SATURDAY, 15 JUNE 2019 - SAT0031âVITAMIN B3 (NAM) SUPPRESSES T CELL ACTIVATION IN AND PRODUCTION OF PRO-INFLAMMATORY CYTOKINES IN VITRO IN A DOSE DEPENDENT MANNER INDICATING THERAPEUTIC POTENTIAL FOR THE TREATMENT OF JIA

Nijhuis, Lotte, Wetering, Renee van de, Houtzager, Isabelle, Lalmohamed, Arief, Vastert, Sebastian, Loosdregt, Jurg van

Year:

2019

File:

PDF, 49 KB

2019

94

[BMJ Publishing Group Ltd and European League Against Rheumatism Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12â15 June 2019 - ()] Poster Presentations - THU0525âDEVELOPMENT OF A PREDICTIVE TOOL FOR RESPONSE TO ANTI-TNF-ALPHA THERAPY IN JIA USING GENE EXPRESSION PROFILES IN PERIPHERAL DERIVED MONONUCLEAR CELLS

Baaij, Jedidja, Scholman, Rianne, Yeung, Rae, Duong, Trang, Wulffraat, Nico, Swart, Joost F., Vastert, Sebastian, Roock, Sytze De

Year:

2019

File:

PDF, 55 KB

2019

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