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1

Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans

Andrew P. Landstrom, Noah Weisleder, Karin B. Batalden, J. Martijn Bos, David J. Tester, Steve R. Ommen, Xander H.T. Wehrens, William C. Claycomb, Jae-Kyun Ko, Moonsun Hwang, Zui Pan, Jianjie Ma, Mich

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2007

Language:

english

File:

PDF, 1.10 MB

english, 2007

2

K + C HANNEL S TRUCTURE -A CTIVITY R ELATIONSHIPS AND M ECHANISMS OF D RUG -I NDUCED QT P ROLONGATION

Clancy, Colleen E., Kurokawa, Junko, Tateyama, Michihiro, Wehrens, Xander H.T., Kass, Robert S.

Journal:

Annual Review of Pharmacology

Year:

2003

Language:

english

File:

PDF, 637 KB

english, 2003

3

Long-term simulated microgravity causes cardiac RyR2 phosphorylation and arrhythmias in mice

Respress, Jonathan L., Gershovich, Pavel M., Wang, Tiannan, Reynolds, Julia O., Skapura, Darlene G., Sutton, Jeffrey P., Miyake, Christina Y., Wehrens, Xander H.T.

Journal:

International Journal of Cardiology

Year:

2014

Language:

english

File:

PDF, 980 KB

english, 2014

4

The mitochondrial uniporter controls fight or flight heart rate increases

Wu, Yuejin, Rasmussen, Tyler P., Koval, Olha M, Joiner, Mei-ling A., Hall, Duane D., Chen, Biyi, Luczak, Elizabeth D., Wang, Qiongling, Rokita, Adam G., Wehrens, Xander H.T., Song, Long-Sheng, Anderso

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 2.88 MB

english, 2015

5

Corrigendum: The mitochondrial uniporter controls fight or flight heart rate increases

Wu, Yuejin, Rasmussen, Tyler P., Koval, Olha M., Joiner, Mei-ling A., Hall, Duane D., Chen, Biyi, Luczak, Elizabeth D., Wang, Qiongling, Rokita, Adam G., Wehrens, Xander H. T., Song, Long-Sheng, Ander

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 258 KB

english, 2015

6

Oxidized CaMKII (Ca 2+ /Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy

Wang, Qiongling, Quick, Ann P., Cao, Shuyi, Reynolds, Julia, Chiang, David Y., Beavers, David, Li, Na, Wang, Guoliang, Rodney, George G., Anderson, Mark E., Wehrens, Xander H.T.

Journal:

Circulation Arrhythmia and Electrophysiology

Year:

2018

Language:

english

File:

PDF, 1.38 MB

english, 2018

7

CRISPR‐Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias

Pang, Paul D., Alsina, Katherina M., Cao, Shuyi, Koushik, Amrita B., Wehrens, Xander H.T., Cooper, Thomas A.

Journal:

Journal of the American Heart Association

Year:

2018

Language:

english

File:

PDF, 1.10 MB

english, 2018

8

A Novel mutation L619F in the cardiac Na+ channel SCN5A associated with long-QT syndrome (LQT3): a role for the I-II linker in inactivation gating

Xander H.T. Wehrens, Tom Rossenbacker, Roselie J. Jongbloed, Marc Gewillig, Hein Heidbüchel, Pieter A. Doevendans, Marc A. Vos, Hein J.J. Wellens, Robert S. Kass

Journal:

Year:

2003

Language:

english

File:

PDF, 327 KB

english, 2003

9

Especially Polymorphonuclear Leukocytes, but also Monomorphonuclear Leukocytes, Roll Spontaneously in Venules of Intact Rat Skin: Involvement of E-Selectin

oude Egbrink, Mirjam G.A., Janssen, Gijsbertus H.G.W., Ookawa, Keiko, Slaaf, Dick W., Reneman, Robert S., Wehrens, Xander H.T., Maaijwee, Kristel J.M., Ohshima, Norio, Struijker Boudier, Harry A.J., T

Journal:

The Journal of Investigative Dermatology

Year:

2002

Language:

english

File:

PDF, 110 KB

english, 2002

10

Ryanodine receptors as pharmacological targets for heart disease

Marco SANTONASTASI, Xander H T WEHRENS

Journal:

Acta Pharmacologica Sinica

Year:

2007

Language:

english

File:

PDF, 565 KB

english, 2007

11

Novel therapeutic approaches for heart failure by normalizing calcium cycling

Wehrens, Xander H. T., Marks, Andrew R.

Journal:

Nature Reviews Drug Discovery

Year:

2004

Language:

english

File:

PDF, 386 KB

english, 2004

12

Stress synchronizes calcium release and promotes SR calcium leak

Wei Wang, Xander H. T. Wehrens

Journal:

The Journal of Physiology

Year:

2010

Language:

english

File:

PDF, 56 KB

english, 2010

13

Cardiac Ryanodine Receptor Function and Regulation in Heart Disease

STEPHAN E. LEHNART, XANDER H. T. WEHRENS, ALEXANDER KUSHNIR, ANDREW R. MARKS

Journal:

Annals of the New York Academy of Sciences

Year:

2004

File:

PDF, 6.88 MB

2004

14

Ryanodine Receptor-Targeted Anti-Arrhythmic Therapy

XANDER H.T. WEHRENS, STEPHAN E. LEHNART, ANDREW R. MARKS

Journal:

Annals of the New York Academy of Sciences

Year:

2005

Language:

english

File:

PDF, 341 KB

english, 2005

15

Ryanodine Receptor Phosphorylation, Calcium/Calmodulin-Dependent Protein Kinase II, and Life-Threatening Ventricular Arrhythmias

Mark D. McCauley, Xander H.T. Wehrens

Journal:

Trends in Cardiovascular Medicine

Year:

2011

Language:

english

File:

PDF, 181 KB

english, 2011

16

Calmodulin Kinase II, Sarcoplasmic Reticulum Ca2+ Leak, and Atrial Fibrillation

Dobromir Dobrev, Xander H.T. Wehrens

Journal:

Trends in Cardiovascular Medicine

Year:

2010

Language:

english

File:

PDF, 243 KB

english, 2010

17

Altered function and regulation of cardiac ryanodine receptors in cardiac disease

Xander H.T Wehrens, Andrew R Marks

Journal:

Trends in Biochemical Sciences

Year:

2003

Language:

english

File:

PDF, 1.48 MB

english, 2003

18

Usefulness of sinus tachycardia and ST-segment elevation in V5 to identify impending left ventricular free wall rupture in inferior wall myocardial infarction

Xander H.T Wehrens, Pieter A Doevendans, Jos W.M.G Widdershoven, Willem R.M Dassen, Kees Prenger, Hein J.J Wellens, Anton P.M Gorgels

Journal:

The American Journal of Cardiology

Year:

2001

Language:

english

File:

PDF, 348 KB

english, 2001

19

Association of systolic blood pressure with mortality in patients with heart failure with reduced ejection fraction: A complex relationship

Sameer Ather, Wenyaw Chan, Annirudha Chillar, David Aguilar, Allison M. Pritchett, Kumudha Ramasubbu, Xander H.T. Wehrens, Anita Deswal, Biykem Bozkurt

Journal:

American Heart Journal

Year:

2011

Language:

english

File:

PDF, 306 KB

english, 2011

20

Calstabin deficiency, ryanodine receptors, and sudden cardiac death

Stephan E. Lehnart, Xander H.T. Wehrens, Andrew R. Marks

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 3.44 MB

english, 2004

21

Calcium/ Calmodulin Dependent Kinase Type II (CaMKIIδ) Phosphorylation of the Cardiac Ryanodine Receptor Is Crucial for the Development of Heart Failure

Jonathan L. Respress, Ralph J. van Oort, Angela C. de Almeida, Na Li, Natale Rolim, Ulrik Wisloff, Xander H.T. Wehrens

Journal:

Journal of Cardiac Failure

Year:

2011

Language:

english

File:

PDF, 59 KB

english, 2011

22

Ca2+/Calmodulin Dependent Protein Kinase II Phosphorylation of RyR2 Alters the Force-Frequency Relationship in Mice

Mark D. McCauley, Tiannan Wang, Sameer Ather, Na Li, Biykem Bozkurt, Xander Wehrens

Journal:

Journal of Cardiac Failure

Year:

2011

Language:

english

File:

PDF, 155 KB

english, 2011

23

Lack of Association of Changes in BNP with Cardiorenal Syndrome during Treatment of Acute Decompensated Heart Failure

Sameer Ather, Mark D. McCauley, Amandeep Dhaliwal, Anita Deswal, Wenyaw Chan, David Aguilar, Allison M. Pritchett, Kumudha Ramasubbu, Xander H.T. Wehrens, Biykem Bozkurt

Journal:

Journal of Cardiac Failure

Year:

2011

Language:

english

File:

PDF, 66 KB

english, 2011

24

Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias

Stephan E. Lehnart, Xander H.T. Wehrens, Steven Reiken, Sunita Warrier, Andriy E. Belevych, Robert D. Harvey, Wito Richter, S.-L. Catherine Jin, Marco Conti, Andrew R. Marks

Journal:

Year:

2005

Language:

english

File:

PDF, 568 KB

english, 2005

25

Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias

Stephan E. Lehnart, Xander H.T. Wehrens, Steven Reiken, Sunita Warrier, Andriy E. Belevych, Robert D. Harvey, Wito Richter, S.-L. Catherine Jin, Marco Conti, Andrew R. Marks

Journal:

Year:

2005

Language:

english

File:

PDF, 95 KB

english, 2005

26

Cardiac rupture complicating myocardial infarction

Xander H.T. Wehrens, Pieter A. Doevendans

Journal:

International Journal of Cardiology

Year:

2004

Language:

english

File:

PDF, 240 KB

english, 2004

27

Mutation-specific effects of lidocaine in Brugada syndrome

Colleen E. Clancy, Xander H.T. Wehrens

Journal:

International Journal of Cardiology

Year:

2007

Language:

english

File:

PDF, 206 KB

english, 2007

28

Digoxin treatment in heart failure — Unveiling risk by cluster analysis of DIG data

Sameer Ather, Leif E. Peterson, Vijay G. Divakaran, Anita Deswal, Kumudha Ramasubbu, Irakli Giorgberidze, Alvin Blaustein, Xander H.T. Wehrens, Douglas L. Mann, Biykem Bozkurt

Journal:

International Journal of Cardiology

Year:

2011

Language:

english

File:

PDF, 342 KB

english, 2011

29

Abnormal ryanodine receptor calcium release induces atrial fibrillation

Subeena Sood, Marco Santonastasi, Haiyun Cheng, Xander H. Wehrens

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2007

Language:

english

File:

PDF, 52 KB

english, 2007

30

Alternative splicing: A key mechanism for ankyrin-B functional diversity?

Ralph J. van Oort, Julio Altamirano, W.J. Lederer, Xander H.T. Wehrens

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2008

Language:

english

File:

PDF, 358 KB

english, 2008

31

A comparison of electrocardiographic changes during reperfusion of acute myocardial infarction by thrombolysis or percutaneous transluminal coronary angioplasty

Xander H.T. Wehrens, Pieter A. Doevendans, Ton J. Oude Ophuis, Hein J.J. Wellens

Journal:

American Heart Journal

Year:

2000

Language:

english

File:

PDF, 4.53 MB

english, 2000

32

Infected sternal fracture hematoma after cardiopulmonary resuscitation initially seen as pericarditis

Xander H.T. Wehrens, Pieter A. Doevendans, Jan Melle van Dantzig, Gabriel Snoep, Hein J. Wellens

Journal:

American Heart Journal

Year:

1996

Language:

english

File:

PDF, 1.73 MB

english, 1996

33

FKBP12.6 Deficiency and Defective Calcium Release Channel (Ryanodine Receptor) Function Linked to Exercise-Induced Sudden Cardiac Death

Xander H.T. Wehrens, Stephan E. Lehnart, Fannie Huang, John A. Vest, Steven R. Reiken, Peter J. Mohler, Jie Sun, Silvia Guatimosim, Long-Sheng Song, Nora Rosemblit, Jeanine M. D'Armiento, Carlo Napoli

Journal:

Year:

2003

Language:

english

File:

PDF, 729 KB

english, 2003

34

Publications from extracurricular research

Xander HT Wehrens, Tim Leiner

Journal:

Year:

2001

Language:

english

File:

PDF, 47 KB

english, 2001

35

CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban

Yiming Wu, Elizabeth D. Luczak, Eun-Jeong Lee, Carlos Hidalgo, Jinying Yang, Zhan Gao, Jingdong Li, Xander H.T. Wehrens, Henk Granzier, Mark E. Anderson

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2012

Language:

english

File:

PDF, 932 KB

english, 2012

36

Nanoscale Organization of Junctophilin-2 and Ryanodine Receptors within Peripheral Couplings of Rat Ventricular Cardiomyocytes

Jayasinghe, Isuru D., Baddeley, David, Kong, Cherrie H.T., Wehrens, Xander H.T., Cannell, Mark B., Soeller, Christian

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 568 KB

english, 2012

37

Mechanisms of heart failure: emerging molecular targets

Xander H.T. Wehrens, Andrew R. Marks

Journal:

Drug Discovery Today: Disease Mechanisms

Year:

2004

Language:

english

File:

PDF, 265 KB

english, 2004

38

Computational and experimental models of Ca2+-dependent arrhythmias

Eric A. Sobie, Xander H.T. Wehrens

Journal:

Drug Discovery Today: Disease Models

Year:

2009

Language:

english

File:

PDF, 111 KB

english, 2009

39

Ryanodine receptors as drug targets for heart failure and cardiac arrhythmias

Stephan E. Lehnart, Xander H.T. Wehrens, Andrew R. Marks

Journal:

Drug Discovery Today: Therapeutic Strategies

Year:

2005

Language:

english

File:

PDF, 451 KB

english, 2005

40

Impact of Noncardiac Comorbidities on Morbidity and Mortality in a Predominantly Male Population With Heart Failure and Preserved Versus Reduced Ejection Fraction

Sameer Ather, Wenyaw Chan, Biykem Bozkurt, David Aguilar, Kumudha Ramasubbu, Amit A. Zachariah, Xander H.T. Wehrens, Anita Deswal

Journal:

Journal of the American College of Cardiology

Year:

2012

Language:

english

File:

PDF, 700 KB

english, 2012

41

Chronic Exercise

Wehrens, Xander H.T., Chiang, David Y., Li, Na

Journal:

Journal of the American College of Cardiology

Year:

2013

Language:

english

File:

PDF, 114 KB

english, 2013

42

INTRACELLULAR CALCIUM RELEASE AND CARDIAC DISEASE

Wehrens, Xander H.T., Lehnart, Stephan E., Marks, Andrew R.

Journal:

Annual Review of Physiology

Year:

2005

Language:

english

File:

PDF, 427 KB

english, 2005

43

Alterations in ryanodine receptors and related proteins in heart failure

Ather, Sameer, Respress, Jonathan L., Li, Na, Wehrens, Xander H.T.

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2013

Language:

english

File:

PDF, 732 KB

english, 2013

44

[Developments in Cardiovascular Medicine] Ryanodine Receptors Volume 254 || Cytosolic Calcium Regulation of Single Ryanodine Receptor Channels

Wehrens, Xander H. T., Marks, Andrew R.

Year:

2005

Language:

english

File:

PDF, 823 KB

english, 2005

45

Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy

Ather, Sameer, Wang, Wei, Wang, Qiongling, Li, Na, Anderson, Mark E., Wehrens, Xander H.T.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.08 MB

english, 2013

46

Sudden Unexplained Death Caused by Cardiac Ryanodine Receptor (RyR2) Mutations

Wehrens, Xander H.T., Marks, Andrew R.

Journal:

Mayo Clinic Proceedings

Year:

2004

Language:

english

File:

PDF, 96 KB

english, 2004

47

Nanoscale Changes in the Organisation of Junctional Proteins in JPH2 Transgenic Mice

Munro, Michelle, Wang, Wei, Baddeley, David, Wehrens, Xander, Soeller, Christian

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 84 KB

english, 2014

48

The junctophilin family of proteins: from bench to bedside

Landstrom, Andrew P., Beavers, David L., Wehrens, Xander H.T.

Journal:

Trends in Molecular Medicine

Year:

2014

Language:

english

File:

PDF, 809 KB

english, 2014

49

CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome

DeGrande, Sean, Nixon, Derek, Koval, Olha, Curran, Jerald W., Wright, Patrick, Wang, Qiongling, Kashef, Farshid, Chiang, David, Li, Na, Wehrens, Xander H.T., Anderson, Mark E., Hund, Thomas J., Mohler

Journal:

Year:

2012

Language:

english

File:

PDF, 1.45 MB

english, 2012

50

Extinguishing intracellular calcium leak: A promising antiarrhythmic approach

Li, Na, Wehrens, Xander H.T.

Journal:

Year:

2013

Language:

english

File:

PDF, 62 KB

english, 2013

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