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51

Tailoring cells for clinical needs: Meeting report from the Advanced Therapy in Healthcare symposium (October 28–29 2017, Doha, Qatar)

Deola, Sara, Guerrouahen, Bella S., Sidahmed, Heba, Al-Mohannadi, Anjud, Elnaggar, Muhammad, Elsadig, Ramaz, Abdelalim, Essam M., Petrovski, Goran, Gadina, Massimo, Thrasher, Adrian, Wels, Winfried S.

Journal:

Journal of Translational Medicine

Year:

2018

Language:

english

File:

PDF, 995 KB

english, 2018

52

Retargeting of natural killerâcell cytolytic activity to ErbB2-expressing cancer cells results in efficient and selective tumor cell destruction

Uherek, Christoph, Tonn, Torsten, Uherek, Barbara, Becker, Sven, Schnierle, Barbara, Klingemann, Hans-Georg, Wels, Winfried

Journal:

Year:

2002

File:

PDF, 218 KB

2002

53

In vivo tracking of genetically engineered, anti-HER2/neu directed natural killer cells to HER2/neu positive mammary tumors with magnetic resonance imaging

Heike E. Daldrup-Link, Reinhardt Meier, Martina Rudelius, Guido Piontek, Morand Piert, Stephan Metz, Marcus Settles, Christoph Uherek, Winfried Wels, Jürgen Schlegel, Ernst J. Rummeny

Journal:

European Radiology

Year:

2005

Language:

english

File:

PDF, 542 KB

english, 2005

54

Disialoganglioside-specific human natural killer cells are effective against drug-resistant neuroblastoma

Seidel, Diana, Shibina, Anastasia, Siebert, Nikolai, Wels, Winfried S., Reynolds, C. Patrick, Huebener, Nicole, Lode, Holger N.

Journal:

Cancer Immunology, Immunotherapy

Year:

2015

Language:

english

File:

PDF, 566 KB

english, 2015

55

The Bacillus subtilis spore inner membrane proteome

Zheng, Linli, Abhyankar, Wishwas, Ouwerling, Natasja, Dekker, Henk L., van Veen, Henk, van der Wel, Nicole N, Roseboom, Winfried, de Koning, Leo J, Brul, Stanley, de Koster, Chris G

Journal:

Journal of Proteome Research

Year:

2016

Language:

english

File:

PDF, 835 KB

english, 2016

56

A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma

Wagner, Juliane, Pfannenstiel, Viktoria, Waldmann, Anja, Bergs, Judith W. J., Brill, Boris, Huenecke, Sabine, Klingebiel, Thomas, Rödel, Franz, Buchholz, Christian J., Wels, Winfried S., Bader, Peter,

Journal:

Frontiers in Immunology

Year:

2017

Language:

english

File:

PDF, 3.76 MB

english, 2017

57

Recombinant antibody toxins specific for ErbB2 and EGF receptor inhibit the in vitro growth of human head and neck cancer cells and cause rapid tumor regression in vivo

Marc Azemar, Mathias Schmidt, Friederike Arlt, Pierre Kennel, Burkhard Brandt, Apollon Papadimitriou, Bernd Groner, Winfried Wels

Journal:

International Journal of Cancer

Year:

2000

Language:

english

File:

PDF, 130 KB

english, 2000

58

Inhibition of signaling from Type 1 receptor tyrosine kinases via intracellular expression of single-chain antibodies

Roger R. Beerli, Winfried Wels, Nancy E. Hynes

Journal:

Breast Cancer Research and Treatment

Year:

1996

Language:

english

File:

PDF, 563 KB

english, 1996

59

Surface Charge-Modification Prevents Sequestration and Enhances Tumor-Cell Specificity of a Recombinant Granzyme B–TGFα Fusion Protein

Jabulowsky, Robert A., Oberoi, Pranav, Bähr-Mahmud, Hayat, Dälken, Benjamin, Wels, Winfried S.

Journal:

Bioconjugate Chemistry

Year:

2012

Language:

english

File:

PDF, 3.02 MB

english, 2012

60

Chimeric Antigen Receptors for the Retargeting of Cytotoxic Effector Cells

Uherek, Christoph, Groner, Bernd, Wels, Winfried

Journal:

Journal of Hematotherapy & Stem Cell Research

Year:

2001

Language:

english

File:

PDF, 244 KB

english, 2001

61

766. Immunotherapy for Her2-Positive Medulloblastoma: Regression of Experimental Tumors by Transfer of Her2-Redirected T Cells In Vivo

Ahmed, Nabil M., Ratnayake, Maheshika K., Savoldo, Barbara, Perlaky, Laszlo, Dotti, Gianpietro, Wels, Winfried, Bhattacharjee, Meenakshi B., Shine, H. David, Rooney, Cliona M., Heslop, Helen E., Gotts

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 90 KB

english, 2006

62

Biotechnological and gene therapeutic strategies in cancer treatment

Winfried Wels, Dirk Moritz, Mathias Schmidt, Margit Jeschke, Nancy E. Hynes, Bernd Groner

Journal:

Year:

1995

Language:

english

File:

PDF, 792 KB

english, 1995

63

Selective Induction of Cancer Cell Death by Targeted Granzyme B

Oberoi, Pranav, Jabulowsky, Robert, Wels, Winfried

Journal:

Year:

2013

Language:

english

File:

PDF, 759 KB

english, 2013

64

Directed Differentiation of Mobilized Hematopoietic Stem and Progenitor Cells into Functional NK Cells with Enhanced Antitumor Activity

Oberoi, Pranav, Kamenjarin, Kathrina, Villena Ossa, Jose Francisco, Uherek, Barbara, BÃ¶nig, Halvard, Wels, Winfried S.

Journal:

Year:

2020

File:

PDF, 3.64 MB

2020

65

Construction, Bacterial Expression and Characterization of a Bifunctional Single–Chain Antibody–Phosphatase Fusion Protein Targeted to the Human ERBB–2 Receptor

Wels, Winfried, Harwerth, Ina-Maria, Zwickl, Marcus, Hardman, Norman, Groner, Bernd, Hynes, Nancy E.

Journal:

Year:

1992

File:

PDF, 927 KB

1992

66

Comparison of mRNA and lentiviral based transfection of natural killer cells with chimeric antigen receptors recognizing lymphoid antigens

Boissel, Laurent, Betancur, Monica, Lu, Weiquan, Wels, Winfried S., Marino, Teresa, Van Etten, Richard A., Klingemann, Hans

Journal:

Leukemia and Lymphoma

Year:

2012

Language:

english

File:

PDF, 541 KB

english, 2012

67

Targeted therapy of Schwannoma cells in immunocompetent rats with an erbB2-specific antibody-toxin

Uwe Altenschmidt, Mathias Schmidt, Bernd Groner, Winfried Wels

Journal:

International Journal of Cancer

Year:

1997

Language:

english

File:

PDF, 166 KB

english, 1997

68

3D model for CAR‐mediated cytotoxicity using patient‐derived colorectal cancer organoids

Schnalzger, Theresa E, de Groot, Marnix HP, Zhang, Congcong, Mosa, Mohammed H, Michels, Birgitta E, Röder, Jasmin, Darvishi, Tahmineh, Wels, Winfried S, Farin, Henner F

Journal:

The EMBO Journal

Year:

2019

Language:

english

File:

PDF, 2.25 MB

english, 2019

69

Intra-tumoral application of a heregulin-exotoxin-A fusion protein causes rapid tumor regression without adverse systemic or local effects

Bernd Groner, Bettina Wick, Margit Jeschke, Heinz-Herbert Fiebig, Wolfgang Dengler, Tatiana Runau, Michael Mihatsch, Ralf Kahl, Mathias Schmidt, Winfried Wels, Elisabeth Stöcklin

Journal:

International Journal of Cancer

Year:

1997

Language:

english

File:

PDF, 357 KB

english, 1997

70

DNA-carrier proteins for targeted gene delivery

Christoph Uherek, Winfried Wels

Journal:

Advanced Drug Delivery Reviews

Year:

2000

Language:

english

File:

PDF, 536 KB

english, 2000

71

Optimization and validation of processes related to the GMP compliant manufacture of genetically modified CAR expressing NK-92 cells

Nowakowska, Paulina, Odendahl, Marcus, Bönig, Halvard, Zhang, Congcong, Naundorf, Sonja, Becker, Petra, Seifried, Erhard, Grez, Manuel, Wels, Winfried S., Tonn, Torsten

Journal:

Year:

2015

Language:

english

File:

PDF, 49 KB

english, 2015

72

Targeted inhibition of tumor-cell growth by recombinant heregulin-toxin fusion proteins

Margit Jeschke, Winfried Wels, Wolfgang Dengler, Roland Imber, Elisabeth Stöcklin, Bernd Groner

Journal:

International Journal of Cancer

Year:

1995

Language:

english

File:

PDF, 1.74 MB

english, 1995

73

Highly efficient selection of phage antibodies mediated by display of antigen as Lpp-OmpA′ fusions on live bacteria

Itai Benhar, Ronit Azriel, Limor Nahary, Shelly Shaky, Yevgeny Berdichevsky, Aviva Tamarkin, Winfried Wels

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 274 KB

english, 2000

74

Arming Cytotoxic Lymphocytes for Cancer Immunotherapy by Means of the NKG2D/NKG2D-Ligand System

Lazarova, Mariya, Wels, Winfried S., Steinle, Alexander

Journal:

Expert Opinion on Biological Therapy

Year:

2020

File:

PDF, 1.71 MB

2020

75

Expression of an oncogenic mutant EGF receptor markedly increases the sensitivity of cells to an EGF-receptor-specific antibody-toxin

Mathias Schmidt, Pia Reiser, David Hills, William J. Gullick, Winfried Wels

Journal:

International Journal of Cancer

Year:

1998

Language:

english

File:

PDF, 134 KB

english, 1998

76

Replacement of N-terminal portions of TGF-α with corresponding heregulin sequences affects ligand-induced receptor signaling and intoxication of tumor cells by chimeric growth-factor toxins

Mathias Schmidt, Winfried Wels

Journal:

International Journal of Cancer

Year:

2002

Language:

english

File:

PDF, 259 KB

english, 2002

77

Retargeting NK-92 cells by means of CD19- and CD20-specific chimeric antigen receptors compares favorably with antibody-dependent cellular cytotoxicity

Boissel, Laurent, Betancur, Monica, Lu, Weiquan, Krause, Daniela, Van Etten, Richard, Wels, Winfried, Klingemann, Hans

Journal:

Year:

2013

Language:

english

File:

PDF, 562 KB

english, 2013

78

Chimeric Antigen Receptor-Engineered NK-92 Cells: An Off-the-Shelf Cellular Therapeutic for Targeted Elimination of Cancer Cells and Induction of Protective Antitumor Immunity

Zhang, Congcong, Oberoi, Pranav, Oelsner, Sarah, Waldmann, Anja, Lindner, Aline, Tonn, Torsten, Wels, Winfried S.

Journal:

Frontiers in Immunology

Year:

2017

Language:

english

File:

PDF, 1.80 MB

english, 2017

79

Suppression of metastasis formation by a recombinant single chain antibody-toxin targeted to full-length and oncogenic variant EGF receptors

Schmidt, Mathias, Maurer-Gebhard, Martina, Groner, Bernd, Köhler, Gabriele, Brochmann-Santos, Gesa, Wels, Winfried

Journal:

Year:

1999

Language:

english

File:

PDF, 628 KB

english, 1999

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