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51

Worsening renal function is not associated with response to treatment in acute heart failure

Ather, Sameer, Bavishi, Chirag, McCauley, Mark D., Dhaliwal, Amandeep, Deswal, Anita, Johnson, Sarah, Chan, Wenyaw, Aguilar, David, Pritchett, Allison M., Ramasubbu, Kumudha, Wehrens, Xander H.T., Boz

Journal:

International Journal of Cardiology

Year:

2013

Language:

english

File:

PDF, 288 KB

english, 2013

52

Enhanced impact of SCN5A mutation associated with long QT syndrome in fetal splice isoform

Wang, Tiannan, Wehrens, Xander H.T.

Journal:

Year:

2012

Language:

english

File:

PDF, 117 KB

english, 2012

53

Ca SR Leak is Modulated by CaMKII Phosphorylation on RyR2-S2814

Yang, Yi, Pereira, Laetitia, van Oort, Ralph J., Wehrens, Xander H.T., Bers, Donald M.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 37 KB

english, 2010

54

CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release

Wehrens, Xander H.T.

Journal:

Year:

2011

Language:

english

File:

PDF, 117 KB

english, 2011

55

Atrial Identity Is Determined by a COUP-TFII Regulatory Network

Wu, San-pin, Cheng, Chiang-Min, Lanz, Rainer B., Wang, Tiannan, Respress, Jonathan L., Ather, Sameer, Chen, Wen, Tsai, Shaw-Jenq, Wehrens, Xander H.T., Tsai, Ming-Jer, Tsai, Sophia Y.

Journal:

Developmental Cell

Year:

2013

Language:

english

File:

PDF, 1.92 MB

english, 2013

56

PROGNOSTIC SIGNIFICANCE OF CHANGE IN HEMOGLOBIN DURING ACUTE HEART FAILURE ADMISSION

Ather, Sameer, Bavishi, Chirag, Deswal, Anita, Ramasubbu, Kumudha, Aguilar, David, Chan, Wenyaw, Vemuri, Srinath, Pritchett, Allison, Wehrens, Xander, Bozkurt, Biykem

Journal:

Journal of the American College of Cardiology

Year:

2012

Language:

english

File:

PDF, 149 KB

english, 2012

57

Inhibition of PKA Phosphorylation of RyR2 Improves Excitation-Contraction Coupling in Dystrophic Cardiomyopathy

Li, Na, Sarma, Satyam, van Oort, Ralph J., Skapura, Darlene, Wehrens, Xander H.T.

Journal:

Year:

2009

Language:

english

File:

PDF, 98 KB

english, 2009

58

Using Multi-Color Super-Resolution Microscopy to Probe the Organization of Dyadic Proteins within Rat Cardiac Myocytes

Baddeley, David, Jayasinghe, Isuru D., Kong, Cherrie H.T., Wehrens, Xander H.T., Cannell, Mark B., Soeller, Christian

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 38 KB

english, 2012

59

Inhibition of RyR2-S2814 Phosphorylation Prevents Heart Failure by Reducing SR Ca Leak

van Oort, Ralph J., Li, Na, Respress, Jonathan L., DeAlmeida, Angela, Wehrens, Xander H.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 37 KB

english, 2010

60

The molecular basis of catecholaminergic polymorphic ventricular tachycardia: What are the different hypotheses regarding mechanisms?

Wehrens, Xander H.T.

Journal:

Year:

2007

Language:

english

File:

PDF, 85 KB

english, 2007

61

Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation

Sood, Subeena, Chelu, Mihail G., van Oort, Ralph J., Skapura, Darlene, Santonastasi, Marco, Dobrev, Dobromir, Wehrens, Xander H.T.

Journal:

Year:

2008

Language:

english

File:

PDF, 873 KB

english, 2008

62

Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development

Giudice, Jimena, Xia, Zheng, Wang, Eric T., Scavuzzo, Marissa A., Ward, Amanda J., Kalsotra, Auinash, Wang, Wei, Wehrens, Xander H. T., Burge, Christopher B., Li, Wei, Cooper, Thomas A.

Journal:

Nature Communications

Year:

2014

Language:

english

File:

PDF, 2.32 MB

english, 2014

63

Molecular determinants of altered contractility in heart failure

Wehrens, Xander, Marks, Andrew

Journal:

Annals of Medicine

Year:

2004

Language:

english

File:

PDF, 280 KB

english, 2004

64

Oxidative Stress and Ca2+ Release Events in Mouse Cardiomyocytes

Shirokova, Natalia, Kang, Chifei, Fernandez-Tenorio, Miguel, Wang, Wei, Wang, Qiongling, Wehrens, Xander H.T., Niggli, Ernst

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 2.55 MB

english, 2014

65

[Developments in Cardiovascular Medicine] Ryanodine Receptors Volume 254 || Regulation of Sarcoplasmic Reticulum Calcium Release by Luminal Calcium

Wehrens, Xander H. T., Marks, Andrew R.

Year:

2005

Language:

english

File:

PDF, 377 KB

english, 2005

66

GW25-e5168 Impaired Post-Transcriptional Regulation of RyR2 by microRNA-106b-25 Cluster Promotes Atrial Fibrillation

Li, Na, Chiang, David Y., Voigt, Niels, Martin, James F., Dobrev, Dobromir, Wehrens, Xander H.T.

Journal:

Journal of the American College of Cardiology

Year:

2014

Language:

english

File:

PDF, 58 KB

english, 2014

67

Alterations in the Interactome of Serine/Threonine Protein Phosphatase Type-1 in Atrial Fibrillation Patients

Chiang, David Y., Lebesgue, Nicolas, Beavers, David L., Alsina, Katherina M., Damen, J. Mirjam A., Voigt, Niels, Dobrev, Dobromir, Wehrens, Xander H.T., Scholten, Arjen

Journal:

Journal of the American College of Cardiology

Year:

2015

Language:

english

File:

PDF, 3.83 MB

english, 2015

68

Identification of microRNA–mRNA dysregulations in paroxysmal atrial fibrillation

Chiang, David Y., Zhang, Min, Voigt, Niels, Alsina, Katherina M., Jakob, Heinz, Martin, James F., Dobrev, Dobromir, Wehrens, Xander H.T., Li, Na

Journal:

International Journal of Cardiology

Year:

2015

Language:

english

File:

PDF, 1.90 MB

english, 2015

69

NFATc2 Is a Necessary Mediator of Calcineurin-dependent Cardiac Hypertrophy and Heart Failure

Bourajjaj, Meriem, Armand, Anne-Sophie, da Costa Martins, Paula A., Weijts, Bart, van der Nagel, Roel, Heeneman, Sylvia, Wehrens, Xander H., De Windt, Leon J.

Journal:

Journal of Biological Chemistry

Year:

2008

Language:

english

File:

PDF, 1.12 MB

english, 2008

70

[Developments in Cardiovascular Medicine] Ryanodine Receptors Volume 254 || Knockout Mice Lacking RYR and Junctophilin Subtypes

Wehrens, Xander H. T., Marks, Andrew R.

Year:

2005

Language:

english

File:

PDF, 324 KB

english, 2005

71

CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca2+ leak and the pathophysiological response to chronic β-adrenergic stimulation

Grimm, Michael, Ling, Haiyun, Willeford, Andrew, Pereira, Laetitia, Gray, Charles B.B., Erickson, Jeffrey R., Sarma, Satyam, Respress, Jonathan L., Wehrens, Xander H.T., Bers, Donald M., Brown, Joan H

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2015

Language:

english

File:

PDF, 1.35 MB

english, 2015

72

Hrd1 and ER-Associated Protein Degradation, ERAD, Are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes

Doroudgar, Shirin, Völkers, Mirko, Thuerauf, Donna J, Khan, Mohsin, Mohsin, Sadia, Respress, Jonathan L, Wang, Wei, Gude, Natalie A, Müller, Oliver J, Wehrens, Xander H, Sussman, Mark A, Glembotski, C

Journal:

Circulation Research

Year:

2015

Language:

english

File:

PDF, 18.61 MB

english, 2015

73

It’s not the Heart: Autonomic Nervous System Predisposition to Lethal Ventricular Arrhythmias

Landstrom, Andrew P., Sun, Jenny J., Ray, Russell S., Wehrens, Xander H.T.

Journal:

Year:

2015

Language:

english

File:

PDF, 458 KB

english, 2015

74

Loss-of-Function SCN5A Mutations Associated with Sinus Node Dysfunction, Atrial Arrhythmias, and Poor Pacemaker Capture

Chiang, David Y., Kim, Jeffrey J., Valdes, Santiago O., de la Uz, Caridad, Fan, Yuxin, Orcutt, Jeffrey, Domino, Melissa, Smith, Melissa, Wehrens, Xander H.T., Miyake, Christina Y.

Journal:

Circulation Arrhythmia and Electrophysiology

Year:

2015

Language:

english

File:

PDF, 2.27 MB

english, 2015

75

Cardiac Rupture

Wehrens, Xander H., Doevendans, Pieter A.

Journal:

Boston Medical and Surgical Journal

Year:

2003

Language:

english

File:

PDF, 55 KB

english, 2003

76

CaMKII-Dependent Phosphorylation of RyR2 Causes Domain Unzipping and Reduced Calmodulin Binding, But Dantrolene Reverses These Effects

Uchinoumi, Hitoshi, Yang, Yi, Puglisi, Jose L., Chen-Izu, Ye, Cornea, Razvan L., Wehrens, Xander H.T., Bers, Donald M.

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 69 KB

english, 2015

77

Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification

Jun Wang, Elzbieta Klysik, Subeena Sood, Randy L. Johnson, Xander H. T. Wehrens, James F. Martin and Eric N. Olson

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.76 MB

english, 2010

78

Emerging role of junctophilin-2 as a regulator of calcium handling in the heart

Garbino, Alejandro, Wehrens, Xander HT

Journal:

Acta Pharmacologica Sinica

Year:

2010

Language:

english

File:

PDF, 774 KB

english, 2010

79

Targeting ryanodine receptors for anti-arrhythmic therapy

McCauley, Mark D, Wehrens, Xander H T

Journal:

Acta Pharmacologica Sinica

Year:

2011

Language:

english

File:

PDF, 1.71 MB

english, 2011

80

Junctophilin-2 at the Intersection of Arrhythmia and Pathologic Cardiac Remodeling

Quick, Ann P., Landstrom, Andrew P., Wehrens, Xander H.T.

Journal:

Year:

2015

Language:

english

File:

PDF, 668 KB

english, 2015

81

The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: A critical analysis

Heijman, Jordi, Algalarrondo, Vincent, Voigt, Niels, Melka, Jonathan, Wehrens, Xander H.T., Dobrev, Dobromir, Nattel, Stanley

Journal:

Cardiovascular Research

Year:

2015

Language:

english

File:

PDF, 1.45 MB

english, 2015

82

Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy

Wang, Qiongling, Wang, Wei, Wang, Guoliang, Rodney, George G., Wehrens, Xander H.T.

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2015

Language:

english

File:

PDF, 1.03 MB

english, 2015

83

A Single Protein Kinase A or Calmodulin Kinase II Site Does Not Control the Cardiac Pacemaker Ca 2+ Clock

Wu, Yuejin, Valdivia, Héctor H., Wehrens, Xander H.T., Anderson, Mark E.

Journal:

Circulation Arrhythmia and Electrophysiology

Year:

2016

Language:

english

File:

PDF, 2.14 MB

english, 2016

84

[Developments in Cardiovascular Medicine] Ryanodine Receptors Volume 254 || Evolution of the Ryanodine Receptor Gene Family

Wehrens, Xander H. T., Marks, Andrew R.

Year:

2005

Language:

english

File:

PDF, 469 KB

english, 2005

85

In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia

Yang, Pei-Chi, Moreno, Jonathan D., Miyake, Christina Y., Vaughn-Behrens, Steven B., Jeng, Mao-Tsuen, Grandi, Eleonora, Wehrens, Xander H. T., Noskov, Sergei Y., Clancy, Colleen E.

Journal:

The Journal of Physiology

Year:

2016

Language:

english

File:

PDF, 2.55 MB

english, 2016

86

Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy

Satyam Sarma, Na Li, Ralph J. van Oort, Corey Reynolds, Darlene G. Skapura, Xander H. T. Wehrens and David E. Clapham

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.56 MB

english, 2010

87

Crosstalk between RyR2 Oxidation and Phosphorylation Contributes to Cardiomyopathy in Mice with Duchenne Muscular Dystrophy

Rodney, George G., Wang, Qiongling, Wang, Guoliang, Wehrens, Xander H.T.

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 49 KB

english, 2015

88

CaMKII and Heart Failure Promote a Pathological Ryanodine Receptor Conformation that Reduces Calmodulin Binding and Enhances SR Ca2+ Leak

Uchinoumi, Hitoshi, Yang, Yi, Oda, Tetsuro, Puglisi, Jose L., Chen-Izu, Ye, Cornea, Razvan L., Wehrens, Xander H.T., Bers, Donald M.

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 49 KB

english, 2016

89

Novel Compounds Inhibit Calmodulin Deficient RyR2 Activity and Arrhythmias in a CPVT Mouse Model

Klipp, Robert C., Li, Na, Wang, Qiongling, Sibrian-Vazquez, Martha, Strongin, Robert M., Wehrens, Xander H.T., Abramson, Jonathan J.

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 48 KB

english, 2016

90

Intracellular Signaling Pathway of Cardiac Apoptosis in the Prediabetic Heart

Sommese, Leandro, Federico, Marilen, Zanuzzi, Carolina, Portiansky, Enrique L., Dedman, John, Kaetzel, Marcia, Xander, Wehrens H., Mattiazzi, Alicia, Palomeque, Julieta

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 41 KB

english, 2015

91

The Ca2+ Clock is Not Governed by a Single CaMKII or PKA Phosphorylation Site for Fight or Flight Responses

Wu, Yuejin, Kutschke, William J., Valdivia, Hector H., Wehrens, Xander H.T., Anderson, Mark E.

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 48 KB

english, 2015

92

PITX2: a master regulator of cardiac channelopathy in atrial fibrillation?

Li, Na, Dobrev, Dobromir, Wehrens, Xander H.T.

Journal:

Cardiovascular Research

Year:

2016

Language:

english

File:

PDF, 195 KB

english, 2016

93

Increased reliance on muscle based thermogenesis upon acute minimization of brown adipose tissue function

Bal, Naresh C., Maurya, Santosh K., Singh, Sushant, Wehrens, Xander H.T., Periasamy, Muthu

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 1.64 MB

english, 2016

94

184

Lai, Yi-Chen, Li, Na, Lawrence, William, Wehrens, Xander, Anderson, Anne

Journal:

Critical Care Medicine

Year:

2013

Language:

english

File:

PDF, 1.50 MB

english, 2013

95

CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift

Uchinoumi, Hitoshi, Yang, Yi, Oda, Tetsuro, Li, Na, Alsina, Katherina M., Puglisi, Jose L., Chen-Izu, Ye, Cornea, Razvan L., Wehrens, Xander H.T., Bers, Donald M.

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2016

Language:

english

File:

PDF, 4.05 MB

english, 2016

96

Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death

Aiba, Isamu, Wehrens, Xander H. T., Noebels, Jeffrey L.

Journal:

Proceedings of the National Academy of Sciences

Year:

2016

Language:

english

File:

PDF, 3.76 MB

english, 2016

97

Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart

Becerra, Romina, Román, Bárbara, Di Carlo, Mariano N., Mariangelo, Juan Ignacio, Salas, Margarita, Sanchez, Gina, Donoso, Paulina, Schinella, Guillermo R., Vittone, Leticia, Wehrens, Xander H., Mundiñ

Journal:

American Journal of Physiology - Heart and Circulatory Physiology

Year:

2016

Language:

english

File:

PDF, 932 KB

english, 2016

98

Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome

Chiang, David Y., Heck, Albert J.R., Dobrev, Dobromir, Wehrens, Xander H.T.

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2016

Language:

english

File:

PDF, 712 KB

english, 2016

99

Methyl-CpG binding-protein 2 function in cholinergic neurons mediates cardiac arrhythmogenesis

Herrera, José A., Ward, Christopher S., Wehrens, Xander H.T., Neul, Jeffrey L.

Journal:

Human Molecular Genetics

Year:

2016

Language:

english

File:

PDF, 3.33 MB

english, 2016

100

Reply from Pei-Chi Yang, Jonathan D. Moreno, Mao-Tsuen Jeng, Xander H. T. Wehrens, Sergei Noskov and Colleen E. Clancy

Yang, Pei-Chi, Moreno, Jonathan D., Jeng, Mao-Tsuen, Wehrens, Xander H. T., Noskov, Sergei, Clancy, Colleen E.

Journal:

The Journal of Physiology

Year:

2016

Language:

english

File:

PDF, 69 KB

english, 2016

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