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51

LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal

Shaikh, Lalarukh Haris, Zhou, Junhua, Teo, Ada E. D., Garg, Sumedha, Neogi, Sudeshna Guha, Figg, Nichola, Yeo, Giles S., Yu, Haixiang, Maguire, Janet J., Zhao, Wanfeng, Bennett, Martin R., Azizan, Ele

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2015

Language:

english

File:

PDF, 1.48 MB

english, 2015

52

An Alu Element–Associated Hypermethylation Variant of the POMC Gene Is Associated with Childhood Obesity

Kuehnen, Peter, Mischke, Mona, Wiegand, Susanna, Sers, Christine, Horsthemke, Bernhard, Lau, Susanne, Keil, Thomas, Lee, Young-Ae, Grueters, Annette, Krude, Heiko, Yeo, Giles S. H.

Journal:

Year:

2012

Language:

english

File:

PDF, 1.14 MB

english, 2012

53

Proopiomelanocortin and Energy Balance: Insights from Human and Murine Genetics

Coll, Anthony P., Farooqi, I. Sadaf, Challis, Benjamin G., Yeo, Giles S. H., O’Rahilly, Stephen

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2004

Language:

english

File:

PDF, 212 KB

english, 2004

54

Serotonin 5-HT 2C Receptor Agonist Promotes Hypophagia via Downstream Activation of Melanocortin 4 Receptors

Lam, Daniel D., Przydzial, Magdalena J., Ridley, Simon H., Yeo, Giles S. H., Rochford, Justin J., O’Rahilly, Stephen, Heisler, Lora K.

Journal:

Year:

2008

Language:

english

File:

PDF, 312 KB

english, 2008

55

Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats

Tung, Yi-Chun Loraine, Ayuso, Eduard, Shan, Xiaoye, Bosch, Fatima, O'Rahilly, Stephen, Coll, Anthony P., Yeo, Giles S. H., Bartolomucci, Alessandro

Journal:

Year:

2010

Language:

english

File:

PDF, 490 KB

english, 2010

56

Functional Characterization and Structural Modeling of Obesity Associated Mutations in the Melanocortin 4 Receptor

Tan, Karen, Pogozheva, Irina D., Yeo, Giles S. H., Hadaschik, Dirk, Keogh, Julia M., Haskell-Leuvano, Carrie, O'Rahilly, Stephen, Mosberg, Henry I., Farooqi, I. Sadaf

Journal:

Year:

2009

Language:

english

File:

PDF, 666 KB

english, 2009

57

Magel2 Is Required for Leptin-Mediated Depolarization of POMC Neurons in the Hypothalamic Arcuate Nucleus in Mice

Mercer, Rebecca E., Michaelson, Sheldon D., Chee, Melissa J. S., Atallah, Tanya A., Wevrick, Rachel, Colmers, William F., Yeo, Giles S. H.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.04 MB

english, 2013

58

Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse

McMurray, Fiona, Church, Chris D., Larder, Rachel, Nicholson, George, Wells, Sara, Teboul, Lydia, Tung, Y. C. Loraine, Rimmington, Debra, Bosch, Fatima, Jimenez, Veronica, Yeo, Giles S. H., O'Rahilly,

Journal:

Year:

2013

Language:

english

File:

PDF, 969 KB

english, 2013

59

DEFLATE Compression Algorithm Corrects for Overestimation of Phylogenetic Diversity by Grantham Approach to Single-Nucleotide Polymorphism Classification

Schlosberg, Arran, Lam, Brian, Yeo, Giles, Clifton-Bligh, Roderick

Journal:

International Journal of Molecular Sciences

Year:

2014

Language:

english

File:

PDF, 578 KB

english, 2014

60

PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism

Medina-Gomez, Gema, Gray, Sarah L., Yetukuri, Laxman, Shimomura, Kenju, Virtue, Sam, Campbell, Mark, Curtis, R. Keira, Jimenez-Linan, Mercedes, Blount, Margaret, Yeo, Giles S. H., Lopez, Miguel, Seppä

Journal:

Year:

2007

Language:

english

File:

PDF, 792 KB

english, 2007

61

Minireview: Human Obesity—Lessons from Monogenic Disorders

O’Rahilly, Stephen, Farooqi, I. Sadaf, Yeo, Giles S. H., Challis, Benjamin G.

Journal:

Year:

2003

Language:

english

File:

PDF, 220 KB

english, 2003

62

TCR usage, gene expression and function of two distinct FOXP3+Treg subsets within CD4+CD25hi T cells identified by expression of CD39 and CD45RO

Ye, Lingying, Goodall, Jane C, Zhang, Libin, Putintseva, Ekaterina V, Lam, Brian, Jiang, Lei, Liu, Wei, Yin, Jian, Lin, Li, Li, Ting, Wu, Xin, Yeo, Giles, Shugay, Mikhail, Chudakov, Dmitriy M, Gaston,

Journal:

Immunology & Cell Biology

Year:

2015

Language:

english

File:

PDF, 5.11 MB

english, 2015

63

Deletion of Codons 88–92 of the Melanocortin-4 Receptor Gene: A Novel Deleterious Mutation in an Obese Female

Donohoue, Patricia A., Tao, Ya-Xiong, Collins, Malia, Yeo, Giles S. H., O’Rahilly, Stephen, Segaloff, Deborah L.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2003

Language:

english

File:

PDF, 157 KB

english, 2003

64

The Effects of Proopiomelanocortin Deficiency on Murine Adrenal Development and Responsiveness to Adrenocorticotropin

Coll, Anthony P., Challis, Benjamin G., Yeo, Giles S. H., Snell, Katherine, Piper, Sarah J., Halsall, David, Thresher, Rosemary R., O’Rahilly, Stephen

Journal:

Year:

2004

Language:

english

File:

PDF, 420 KB

english, 2004

65

FTO is necessary for the induction of leptin resistance by high-fat feeding

Tung, Y.C. Loraine, Gulati, Pawan, Liu, Che-Hsiung, Rimmington, Debra, Dennis, Rowena, Ma, Marcella, Saudek, Vladimir, O'Rahilly, Stephen, Coll, Anthony P., Yeo, Giles S.H.

Journal:

Molecular Metabolism

Year:

2015

Language:

english

File:

PDF, 2.46 MB

english, 2015

66

Functional responses of human ??1 adrenoceptors with defined haplotypes for the common 389R>G and 49S>G polymorphisms

Sandilands, Alastair, Yeo, Giles, Brown, Morris J, O'Shaughnessy, Kevin M

Journal:

Pharmacogenetics

Year:

2004

Language:

english

File:

PDF, 122 KB

english, 2004

67

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

Adriaenssens, Alice E., Svendsen, Berit, Lam, Brian Y. H., Yeo, Giles S. H., Holst, Jens J., Reimann, Frank, Gribble, Fiona M.

Journal:

Year:

2016

Language:

english

File:

PDF, 667 KB

english, 2016

68

Melanocortin receptors and energy homeostasis

Coll, Anthony P, Challis, Benjamin G, Yeo, Giles S. H, Farooqi, I Sadaf, O??Rahilly, Stephen

Journal:

Current Opinion in Endocrinology & Diabetes

Year:

2005

Language:

english

File:

PDF, 90 KB

english, 2005

69

Maternal obesity in pregnancy developmentally programs adipose tissue inflammation in young, lean male mice offspring

Alfaradhi, Maria Z., Kusinski, Laura C., Fernandez-Twinn, Denise S., Pantaleão, Lucas C., Carr, Sarah K., Ferland-McCollough, David, Yeo, Giles S.H., Bushell, Martin, Ozanne, Susan E.

Journal:

Year:

2016

Language:

english

File:

PDF, 2.31 MB

english, 2016

70

Characterization of the human, mouse and rat PGC1beta (peroxisome-proliferator-activated receptor-gamma co-activator 1beta) gene in vitro and in vivo

MEIRHAEGHE, Aline, CROWLEY, Vivion, LENAGHAN, Carol, LELLIOTT, Christopher, GREEN, Kath, STEWART, Abigail, HART, Kevin, SCHINNER, Sven, SETHI, Jaswinder K., YEO, Giles, BRAND, Martin D., CORTRIGHT, Ro

Journal:

Biochemical Journal

Year:

2003

Language:

english

File:

PDF, 332 KB

english, 2003

71

Attractin' more attention – new pieces in the obesity puzzle?

YEO, Giles S. H., SIDDLE, Kenneth

Journal:

Biochemical Journal

Year:

2003

Language:

english

File:

PDF, 56 KB

english, 2003

72

Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues

Zhou, Junhua, Lam, Brian, Neogi, Sudeshna G., Yeo, Giles S.H., Azizan, Elena A.B., Brown, Morris J.

Journal:

Year:

2016

Language:

english

File:

PDF, 712 KB

english, 2016

73

ISH ADA-04 TRANSCRIPTOME PATHWAY ANALYSIS OF AUTONOMOUS AND PHYSIOLOGICAL ALDOSTERONE-PRODUCING HUMAN TISSUE

Zhou, Junhua, Lam, Brian, Neogi, Sudeshna, Yeo, Giles, Azizan, Elena, Brown, Morris

Journal:

Journal of Hypertension

Year:

2016

Language:

english

File:

PDF, 170 KB

english, 2016

74

Adult-onset hyperinsulinaemic hypoglycaemia in clinical practice: diagnosis, aetiology and management

Challis, Ben George, Powlson, Andrew S, Casey, Ruth T, Pearson, Carla, Lam, Brian, Ma, Marcella, Pitfield, Deborah, Yeo, Giles, Godfrey, Edmund, Cheow, Heok, Chatterjee, V. Krishna, Carroll, Nicholas,

Journal:

Endocrine Connections

Year:

2017

Language:

english

File:

PDF, 1001 KB

english, 2017

75

Selective rab11 transport and the intrinsic regenerative ability of CNS axons

Koseki, Hiroaki, Donegá, Matteo, Lam, Brian YH, Petrova, Veselina, van Erp, Susan, Yeo, Giles SH, Kwok, Jessica CF, ffrench-Constant, Charles, Eva, Richard, Fawcett, James W

Journal:

Year:

2017

Language:

english

File:

PDF, 6.24 MB

english, 2017

76

Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery

Larraufie, Pierre, Roberts, Geoffrey P., McGavigan, Anne K., Kay, Richard G., Li, Joyce, Leiter, Andrew, Melvin, Audrey, Biggs, Emma K., Ravn, Peter, Davy, Kathleen, Hornigold, David C., Yeo, Giles S.

Journal:

Year:

2019

File:

PDF, 2.52 MB

2019

77

Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake

Adriaenssens, Alice E., Biggs, Emma K., Darwish, Tamana, Tadross, John, Sukthankar, Tanmay, Girish, Milind, Polex-Wolf, Joseph, Lam, Brain Y., Zvetkova, Ilona, Pan, Warren, Chiarugi, Davide, Yeo, Gile

Journal:

Cell Metabolism

Year:

2019

Language:

english

File:

PDF, 3.11 MB

english, 2019

78

Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice – Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells

Billing, Lawrence J., Larraufie, Pierre, Lewis, Jo, Leiter, Andrew, Li, Joyce, Lam, Brian, Yeo, Giles SH., Goldspink, Deborah A., Kay, Richard G., Gribble, Fiona M., Reimann, Frank

Journal:

Molecular Metabolism

Year:

2019

Language:

english

File:

PDF, 2.62 MB

english, 2019

79

Neurochemical characterization of brainstem Pro-opiomelanocortin cells

Georgescu, Teodora, Lyons, David, Doslikova, Barbora, Garcia, Ana Paula, Marston, Oliver, Burke, Luke K, Chianese, Raffaella, Lam, Brian Y H, Yeo, Giles S H, Rochford, Justin J, Garfield, Alastair S,

Journal:

Year:

2020

Language:

english

File:

PDF, 12.06 MB

english, 2020

80

[BMJ Publishing Group Ltd and British Cardiovascular Society British Cardiovascular Society Annual Conference âHigh Performing Teamsâ, 4â6 June 2018, Manchester, UK - ()] Basic Science - 129âThe CHR9P21 risk locus affects IL-1/TLR signalling in VSMC

Basatemur, Gemma, Ackers-Johnson, Matthew, Schoonejans, Josca, Kazachenka, Anastasiya, Lam, Brian, Ma, Marcella, Brimpari, Minodora, Patel, Meghana, Saleh, Nada, Murphy, Deirdre, Zhao, Tian, Yeo, Gile

File:

PDF, 60 KB

81

SUN-LB107 Functional Characterisation of Human Heterozygous Non-Synonymous MC3R Variants

Melvin, Audrey, Cowan, Ceili, Lam, Brian, Buller, Sophie, Rainbow, Kara, Yeo, Giles S, OâRahilly, Stephen

Journal:

Journal of the Endocrine Society

Year:

2020

File:

PDF, 90 KB

2020