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1

Modulation of fluoropyrimidines by leucovorin: Rational and status

Youcef M. Rustum

Journal:

Journal of Surgical Oncology

Year:

1991

Language:

english

File:

PDF, 679 KB

english, 1991

2

Enhancement of the antitumor effects of 5-fluorouracil by folinic acid

Enrico Mini, Fabio Trave, Youcef M. Rustum, Joseph R. Bertino

Journal:

Pharmacology & Therapeutics

Year:

1990

Language:

english

File:

PDF, 1.71 MB

english, 1990

3

A unique human ovarian carcinoma cell line expressing CD34 in association with selection for multidrug resistance

Hans Minderman, Udo Vanhoefer, Karoly Toth, M. Denice Minderman, Youcef M. Rustum

Journal:

Year:

1996

Language:

english

File:

PDF, 857 KB

english, 1996

4

Involvement of cyclin d1-cdk5 overexpression and mcm3 cleavage in bax-associated spontaneous apoptosis and differentiation in an a253 human head and neck carcinoma xenograft model

Ming-Biao Yin, Károly Tóth, Shousong Cao, Bin Guo, Cheryl Frank, Harry K. Slocum, Youcef M. Rustum

Journal:

International Journal of Cancer

Year:

1999

Language:

english

File:

PDF, 350 KB

english, 1999

5

DiOC2(3) is not a substrate for multidrug resistance protein (MRP)-mediated drug efflux

Hans Minderman, Udo Vanhoefer, Karoly Toth, Ming-Biao Yin, M. Denice Minderman, Carol Wrzosek, Marilyn L. Slovak, Youcef M. Rustum

Journal:

Cytometry Part A

Year:

1996

Language:

english

File:

PDF, 636 KB

english, 1996

6

Cell cycle: Molecular targets for diagnosis and therapy: Tumor suppressor genes and cell cycle progression in cancer

Antonio Giordano, Youcef M. Rustum, Charles E. Wenner

Journal:

Journal of Cellular Biochemistry

Year:

1998

Language:

english

File:

PDF, 55 KB

english, 1998

7

Flow cytometric analysis of DNA content in human bladder tumors and irrigation fluids

Joseph L. Chin, Robert P. Huben, Enriquetta Nava, Youcef M. Rustum, Joseph M. Greco, J. Edson Pontes, Oskar S. Frankfurt

Journal:

Year:

1985

Language:

english

File:

PDF, 492 KB

english, 1985

8

Toxicity and antitumor activity of 5-fluorouracil in combination with leucovorin. Role of dose schedule and route of administration of leucovorin

Youcef M. Rustum

Journal:

Year:

1989

Language:

english

File:

PDF, 440 KB

english, 1989

9

A phase II trial of 5-fluorouracil, doxorubicin, mitomycin C, and leucovorin in advanced gastric carcinoma

Susan G. Arbuck, Yusuf Silk Md, Harold O. Douglass Jr., Hector Nava, Youcef M. Rustum, Suzanne Milliron

Journal:

Year:

1990

Language:

english

File:

PDF, 363 KB

english, 1990

10

Bowel rest, intravenous hydration, and continuous high-dose infusion of octreotide acetate for the treatment of chemotherapy-induced diarrhea in patients with colorectal carcinoma

Nicholas J. Petrelli, Miguel Rodriguez-Bigas, Youcef Rustum, Lemuel Herrera, Patrick Creaven

Journal:

Year:

1993

Language:

english

File:

PDF, 458 KB

english, 1993

11

Time-lapse video reveals immediate heterogeneity and heritable damage among human ileocecal carcinoma HCT-8 cells treated with raltitrexed (ZD1694)

Harry K. Slocum, John C. Parsons, Elva O. Winslow, Lori Broderick, Hans Minderman, Károly Tóth, William R. Greco, Youcef M. Rustum

Journal:

Cytometry Part A

Year:

2000

Language:

english

File:

PDF, 170 KB

english, 2000

12

The determination of growth rates of individual colonies in agarose using high-resolution automated image analysisx

Harry K. Slocum, Martin Malmberg, William R. Greco, John C. Parsons, Youcef M. Rustum

Journal:

Cytometry Part A

Year:

1990

Language:

english

File:

PDF, 1.09 MB

english, 1990

13

Methods for the separation and identification of ribonucleotides on DEAE-cellulose

Youcef M. Rustum, Herbert S. Schwartz

Journal:

Analytical Biochemistry

Year:

1973

Language:

english

File:

PDF, 578 KB

english, 1973

14

High-pressure liquid chromatography: I. Quantitative separation of purine and pyrimidine nucleosides and bases

Youcef M. Rustum

Journal:

Analytical Biochemistry

Year:

1978

Language:

english

File:

PDF, 547 KB

english, 1978

15

A Phase I study of weekly intravenous oxaliplatin in combination with oral daily capecitabine and radiation therapy in the neoadjuvant treatment of rectal adenocarcinoma

Marwan G. Fakih, Ashwani Rajput, Gary Y. Yang, Lakshmi Pendyala, Karoly Toth, Judy L. Smith, David D. Lawrence, Youcef M. Rustum

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2006

Language:

english

File:

PDF, 123 KB

english, 2006

16

Phase II Study of Weekly Intravenous Oxaliplatin Combined With Oral Daily Capecitabine and Radiotherapy With Biologic Correlates in Neoadjuvant Treatment of Rectal Adenocarcinoma

Marwan G. Fakih, Kelli BullardDunn, Gary Y. Yang, Lakshmi Pendyala, Karoly Toth, Chris Andrews, Youcef M. Rustum, Mary Ellen Ross, Charles LeVea, Ajithkumar Puthillath, Young-Mee Park, Ashwani Rajput

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2008

Language:

english

File:

PDF, 161 KB

english, 2008

17

The soft agar clonogenicity and characterization of cells obtained from human solid tumors by mechanical and enzymatic means

Harry K. Slocum, Zlatko P. Pavelic, Peter M. Kanter, Norma J. Nowak, Youcef M. Rustum

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1981

Language:

english

File:

PDF, 596 KB

english, 1981

18

Combination chemotherapy of cisplatin and 5-fluorouracil for advanced colorectal adenocarcinoma

Nicholas J. Petrelli, Stephan Madejewicz, Youcef Rustum, Lemuel Herrera, Patrick J. Creaven, John Plager, Joan Soloman, Arnold Mittelman

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1989

Language:

english

File:

PDF, 417 KB

english, 1989

19

A combination of 5-fluorouracil and thymidine in advanced colorectal carcinoma

Ahud Sternberg, Nicholas J. Petrelli, Jesse Au, Youcef Rustum, Arnold Mittelman, Patrick Creaven

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1984

Language:

english

File:

PDF, 457 KB

english, 1984

20

Relationship between cytotoxicity, drug accumulation, DNA damage and repair of human ovarian cancer cells treated with doxorubicin: modulation by the tiapamil analog RO11-2933

M. Abdellah Alaoui Jamali, Ming-biao Yin, Alessandra Mazzoni, Issam Bankusli, Youcef M. Rustum

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1989

Language:

english

File:

PDF, 778 KB

english, 1989

21

A phase II and pharmacokinetic study of 6S-leucovorin plus 5-fluorouracil in patients with colorectal carcinoma

Neal J. Meropol, Nicholas J. Petrelli, Youcef M. Rustum, Miguel Rodriguez-Bigas, Leslie E. Blumenson, Cheryl Frank, Elmer Berghorn, Patrick J. Creaven

Journal:

Investigational New Drugs

Year:

1995

Language:

english

File:

PDF, 529 KB

english, 1995

22

Mechanism of action of the dual topoisomerase-I and -II inhibitor TAS-103 and activity against (multi)drug resistant cells

Hans Minderman, Carol Wrzosek, Shousong Cao, Teruhiro Utsugi, Takashi Kobunai, Yuji Yamada, Youcef M. Rustum

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2000

Language:

english

File:

PDF, 129 KB

english, 2000

23

A Phase I and pharmacokinetic study of selenomethionine in combination with a fixed dose of irinotecan in solid tumors

Marwan G. Fakih, Lakshmi Pendyala, William Brady, Patrick F. Smith, Mary E. Ross, Patrick J. Creaven, Vladimir Badmaev, Joshua D. Prey, Youcef M. Rustum

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2008

Language:

english

File:

PDF, 344 KB

english, 2008

24

Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1α

Sreenivasulu Chintala, Károly Tόth, Shousong Cao, Farukh A. Durrani, Mary M. Vaughan, Randy L. Jensen, Youcef M. Rustum

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2010

Language:

english

File:

PDF, 629 KB

english, 2010

25

Oral uracil and Ftorafur plus leucovorin: pharmacokinetics and toxicity in patients with metastatic cancer

Dah H. Ho, Wendy Covington, Nita Brown, San N. Lin, Richard Pazdur, Yuang-Yi Huo, Patrick J. Creaven, Youcef M. Rustum, Neal J. Meropol, Yvonne Lassere, Jun Kuritani, Tomohisa Hayakawa

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2000

Language:

english

File:

PDF, 99 KB

english, 2000

26

Tumor size and origin determine the antitumor activity of cisplatin or 5-fluorouracil and its modulation by leucovorin in murine colon carcinomas

J. A. M. Van Laar, Youcef M. Rustum, C. L. Van der Wilt, Kees Smid, Catharina M. Kuiper, Herbert M. Pinedo, G. J. Peters, J. A. M. Van Laar

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1996

Language:

english

File:

PDF, 2.05 MB

english, 1996

27

Combined action of paclitaxel and cisplatin against wildtype and resistant human ovarian carcinoma cells

Laurence M. Levasseur, William R. Greco, Youcef M. Rustum, Harry K. Slocum

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1997

Language:

english

File:

PDF, 383 KB

english, 1997

28

The Chk1-Cdc25C regulation is involved in sensitizing A253 cells to a novel topoisomerase I inhibitor BNP1350 by bax gene transfer

Yin, Ming-biao, Hapke, Gunnar, Guo, Bin, Azrak, Rami G, Frank, Cheryl, Rustum, Youcef M

Journal:

Year:

2001

Language:

english

File:

PDF, 311 KB

english, 2001

29

Preclinical Development of Eniluracil: Enhancing the Therapeutic Index and Dosing Convenience of 5-Fluorouracil

Melanie T. Paff, David P. Baccanari, Stephen T. Davis, Shousong Cao, Robert L. Tansik, Youcef M. Rustum, Thomas Spector

Journal:

Investigational New Drugs

Year:

2000

Language:

english

File:

PDF, 70 KB

english, 2000

30

Targeting Molecular Signals in Chk1 Pathways as a New Approach for Overcoming Drug Resistance

Gunnar Hapke, Ming-biao Yin, Youcef M. Rustum

Journal:

Cancer and Metastasis Reviews

Year:

2001

Language:

english

File:

PDF, 80 KB

english, 2001

31

Ugt1a is required for the protective effect of selenium against irinotecan-induced toxicity

Shousong Cao, Farukh A. Durrani, Youcef M. Rustum, Y. Eugene Yu

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 199 KB

english, 2012

32

Long-term passage of human tissues in vitro as three-dimensional histolines

Harry K. Slocum, Kàroly Tòth, Lingna Li, Sung-Goo Chang, Robert M. Hoffman, Youcef M. Rustum

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

1992

Language:

english

File:

PDF, 1013 KB

english, 1992

33

Growth of human renal cortical tissue on collagen gel

Sung-Goo Chang, Károly Tóth, Jennifer D. Black, Harry K. Slocum, Scott D. Perrapato, Robert P. Huben, Youcef M. Rustum

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

1992

Language:

english

File:

PDF, 1.19 MB

english, 1992

34

Glucose consumption end point in primary histoculture indicates recovery of human tumors from drug treatment

Sung-Goo Chang, Scott D. Perrapato, Harry K. Slocum, Robert P. Huben, Kàroly Tòth, Youcef Rustum, Robert M. Hoffman

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

1992

Language:

english

File:

PDF, 218 KB

english, 1992

35

Biochemical and clinical studies of chronic lymphocytic leukemia

Youcef M. Rustum, Donald J. Higby

Journal:

European Journal of Cancer (1965)

Year:

1965

Language:

english

File:

PDF, 811 KB

english, 1965

36

Friend leukemia cells: Relationship between differentiation, clonogenicity and malignancy

Harvey D. Preisler, Gregory Christoff, Peter Reese, Paul Pavelic, Youcef Rustum

Journal:

Cell Differentiation

Year:

1978

Language:

english

File:

PDF, 859 KB

english, 1978

37

Efficacy of increasing the therapeutic index of irinotecan, plasma and tissue selenium concentrations is methylselenocysteine dose dependent

Rami G. Azrak, Shousong Cao, Lakshmi Pendyala, Farukh A. Durrani, Marwan Fakih, Gerald F. Combs Jr., Joshua Prey, Patrick F. Smith, Youcef M. Rustum

Journal:

Biochemical Pharmacology

Year:

2007

Language:

english

File:

PDF, 468 KB

english, 2007

38

Bevacizumab enhances the therapeutic efficacy of Irinotecan against human head and neck squamous cell carcinoma xenografts

Shousong Cao, Farukh A. Durrani, Karoly Toth, Youcef M. Rustum, Mukund Seshadri

Journal:

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

39

Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-Amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin-6-yl)-(S)-ethyl]-2,5-thienoylamino-l-glutamic acid (AG2034): Comparison across sensitive and resistant human tumor cell lines

Hélène M. Faessel, Harry K. Slocum, Youcef M. Rustum, William R. Greco

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 380 KB

english, 1999

40

α-Fluoro-β-alanine: Effects on the antitumor activity and toxicity of 5-fluorouracil

Shousong Cao, David P Baccanari, Youcef M Rustum, Stephen T Davis, Robert L Tansik, David J.T Porter, Thomas Spector

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 362 KB

english, 2000

41

Rational basis for the metabolic modulation of 5-fluorouracil by leucovorin and interferon alpha

Youcef M. Rustum

Journal:

British Journal of Haematology

Year:

1991

Language:

english

File:

PDF, 440 KB

english, 1991

42

Cyclin E–Cdk2 Activation Is Associated with Cell Cycle Arrest and Inhibition of DNA Replication Induced by the Thymidylate Synthase Inhibitor Tomudex

Ming-biao Yin, Bin Guo, Angeles Panadero, Cheryl Frank, Carol Wrzosek, Harry K. Slocum, Youcef M. Rustum

Journal:

Experimental Cell Research

Year:

1999

Language:

english

File:

PDF, 313 KB

english, 1999

43

Metabolism of N6-(Δ2-isopentenyl)adenosine in rat liver

Youcef M. Rustum, Herbert S. Schwartz

Journal:

Biochemical Pharmacology

Year:

1974

Language:

english

File:

PDF, 329 KB

english, 1974

44

Organ-specific differences in the metabolism of N6-(Δ2-isopentenyl)-adenosine

Youcef M. Rustum, Herbert S. Schwartz

Journal:

Biochemical Pharmacology

Year:

1976

Language:

english

File:

PDF, 601 KB

english, 1976

45

Differential selectivity of 5-fluorouracil and 5′-deoxy-5-fluorouridine in cultured human B lymphocytes and mouse L1210 leukemia

J. Lai-Sim Au, Youcef M. Rustum, Jun Minowada, B.I. Sahai Srivastava

Journal:

Biochemical Pharmacology

Year:

1983

Language:

english

File:

PDF, 572 KB

english, 1983

46

Isolation and characterization of a human ileocecal carcinoma cell line (HCT-8) subclone resistant to fluorodeoxyuridine

Zhang Zheng-Gang, Martin Malmberg, M.-B. Yin, Harry K. Slocum, Youcef M. Rustum

Journal:

Biochemical Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.08 MB

english, 1993

47

Down-regulation of c-myc gene expression with induction of high molecular weight DNA fragments by fluorodeoxyuridine

Li Zhan-Rong, Yin Ming-Biao, Mark A. Arredondo, Christoph Schöber, Youcef M. Rustum

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 910 KB

english, 1994

48

Cellular heterogeneity in DNA damage and growth inhibition induced by ICI D1694, thymidylate synthase inhibitor, using single cell assays

Christoph Schöber, John F. Gibbs, Ming-Biao Yin, Harry K. Slocum, Youcef M. Rustum

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 565 KB

english, 1994

49

Mechanisms of resistance to N-[5-[N-(3, 4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line

Kun Lu, Ming-Biao Yin, John J. McGuire, Enzo Bonmassar, Youcef M. Rustum

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 990 KB

english, 1995

50

Augmented therapeutic efficacy of irinotecan is associated with enhanced drug accumulation

Rami G. Azrak, Shousong Cao, Farukh A. Durrani, Karoly Toth, Arup Bhattacharya, Youcef M. Rustum

Journal:

Year:

2011

Language:

english

File:

PDF, 1.33 MB

english, 2011

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