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51

Selectivity Filter Region, Tetrodotoxin and Local Anesthetics in the NavAb-based Model of the Nav1.4 Channel

Tikhonov, Denis B., Zhorov, Boris S.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 37 KB

english, 2012

52

Interaction of Local Anesthetics with KcsA K+ Channel: Tetramer Stability and Docking Simulations

Gray, Noel W., Zhorov, Boris S., Moczydlowski, Edward

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 40 KB

english, 2013

53

State-dependent inter-repeat contacts of exceptionally conserved asparagines in the inner helices of sodium and calcium channels

Tikhonov, Denis B., Bruhova, Iva, Garden, Daniel P., Zhorov, Boris S.

Journal:

Pflügers Archiv European Journal of Physiology

Year:

2015

Language:

english

File:

PDF, 2.03 MB

english, 2015

54

Mapping of Steroids Binding to 17β-Hydroxysteroid Dehydrogenase Type 1 Using Monte Carlo Energy Minimization Reveals Alternative Binding Modes †

Blanchet, Jonathan, Lin, Sheng-Xiang, Zhorov, Boris S.

Journal:

Year:

2005

Language:

english

File:

PDF, 1013 KB

english, 2005

55

Interaction of local anesthetics with the K + channel pore domain

Gray, Noel W., Zhorov, Boris S., Moczydlowski, Edward G.

Journal:

Year:

2013

Language:

english

File:

PDF, 2.09 MB

english, 2013

56

Conformational Analysis of Free and Ca 2+ -bound forms of Verapamil and Methoxyverapamil

Zhorov, Boris S., Ananthanarayanan, Vettai S.

Journal:

Journal of Biomolecular Structure and Dynamics

Year:

1993

Language:

english

File:

PDF, 1.34 MB

english, 1993

57

Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids

Rinkevich, Frank D., Du, Yuzhe, Tolinski, Josh, Ueda, Atsushi, Wu, Chun-Fang, Zhorov, Boris S., Dong, Ke

Journal:

NeuroToxicology

Year:

2015

Language:

english

File:

PDF, 7.05 MB

english, 2015

58

Conformational Analysis of the Ca 2+ -Bound Opioid Peptides: Implications for Ligand-Receptor Interaction

Zhorov, Boris S., Ananthanarayanan, Vettai S.

Journal:

Journal of Biomolecular Structure and Dynamics

Year:

1995

Language:

english

File:

PDF, 1.14 MB

english, 1995

59

Conformational and Electrostatic Similarity Between Polyprotonated and Ca 2+ -Boundμ-Opioid Peptides

Zhorov, Boris S., Ananthanarayanan, Vettai S.

Journal:

Journal of Biomolecular Structure and Dynamics

Year:

1996

Language:

english

File:

PDF, 1.10 MB

english, 1996

60

Mapping of dihydropyridine binding residues in a less sensitive invertebrate L-type calcium channel (LCa v 1)

Senatore, Adriano, Boone, Adrienne, Lam, Stanley, Dawson, Taylor F., Zhorov, Boris, Spafford, JDavid

Journal:

Year:

2011

Language:

english

File:

PDF, 1.36 MB

english, 2011

61

Interaction of the BK Ca channel gating ring with dendrotoxins

Takacs, Zoltan, Imredy, John P, Bingham, Jon-Paul, Zhorov, Boris S, Moczydlowski, Edward G

Journal:

Year:

2014

Language:

english

File:

PDF, 1.10 MB

english, 2014

62

Rotational Symmetry of Two Pyrethroid Receptor Sites in the Mosquito Sodium Channel

Du, Yuzhe, Nomura, Yoshiko, Dong, Ke, Zhorov, Boris S.

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 43 KB

english, 2015

63

Evidence for dual binding sites for DDT in Insect Sodium Channels

Du, Yuzhe, Nomura, Yoshiko, Zhorov, Boris S., Dong, Ke

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 2.50 MB

english, 2015

64

Irreversible Block of Cardiac Mutant Na + Channels by Batrachotoxin

Wang, Sho-Ya, Tikhonov, Denis B., Mitchell, Jane, Zhorov, Boris, Wang, Ging Kuo

Journal:

Year:

2007

Language:

english

File:

PDF, 885 KB

english, 2007

65

Modeling interactions between blocking and permeant cations in the NavMs channel

Korkosh, Vyacheslav S., Zhorov, Boris S., Tikhonov, Denis B.

Journal:

European Journal of Pharmacology

Year:

2016

Language:

english

File:

PDF, 671 KB

english, 2016

66

Alanine to valine substitutions in the pore helix IIIP1 and linker-helix IIIL45 confer cockroach sodium channel resistance to DDT and pyrethroids

Chen, Mengli, Du, Yuzhe, Nomura, Yoshiko, Zhu, Guonian, Zhorov, Boris S., Dong, Ke

Journal:

NeuroToxicology

Year:

2016

Language:

english

File:

PDF, 1.51 MB

english, 2016

67

Side chain flexibility and the pore dimensions in the GABAAreceptor

Rossokhin, Alexey V., Zhorov, Boris S.

Journal:

Journal of Computer-Aided Molecular Design

Year:

2016

Language:

english

File:

PDF, 3.12 MB

english, 2016

68

Elucidation of Pyrethroid and DDT Receptor Sites in the Voltage-gated Sodium Channel

Zhorov, Boris S., Dong, Ke

Journal:

NeuroToxicology

Year:

2016

Language:

english

File:

PDF, 1.72 MB

english, 2016

69

Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides

Du, Yuzhe, Lee, Jung-Eun, Nomura, Yoshiko, Zhang, Tianxiang, Zhorov, Boris S., Dong, Ke

Journal:

Biochemical Journal

Year:

2009

Language:

english

File:

PDF, 830 KB

english, 2009

70

The Receptor Site and Mechanism of Action of Sodium Channel Blocker Insecticides

Zhang, Yongqiang, Du, Yuzhe, Jiang, Dingxin, Behnke, Caitlyn, Nomura, Yoshiko, Zhorov, Boris S., Dong, Ke

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 1.92 MB

english, 2016

71

Phenotypic Variability from Benign Infantile Epilepsy to Ohtahara Syndrome Associated with a Novel Mutation in SCN2A

Syrbe, Steffen, Zhorov, Boris S., Bertsche, Astrid, Bernhard, Matthias K., Hornemann, Frauke, Mütze, Ulrike, Hoffmann, Jessica, Hörtnagel, Konstanze, Kiess, Wieland, Hirsch, Franz W., Lemke, Johannes

Journal:

Molecular Syndromology

Year:

2016

Language:

english

File:

PDF, 2.14 MB

english, 2016

72

Mutations of two acidic residues at the cytoplasmic end of segment IIIS6 of an insect sodium channel have distinct effects on pyrethroid resistance

Chen, Mengli, Du, Yuzhe, Nomura, Yoshiko, Zhu, Guonian, Zhorov, Boris S., Dong, Ke

Journal:

Insect Biochemistry and Molecular Biology

Year:

2017

Language:

english

File:

PDF, 1.76 MB

english, 2017

73

Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants

Tikhonov, Denis B., Zhorov, Boris S.

Journal:

The Journal of General Physiology

Year:

2017

Language:

english

File:

PDF, 2.23 MB

english, 2017

74

The Sodium Ion Binding Region at the Focus of P1 Helices Attracts both Charged and Electroneutral Ligands of Sodium Channels

Tikhonov, Denis B., Zhorov, Boris S.

Journal:

Biophysical Journal

Year:

2017

Language:

english

File:

PDF, 42 KB

english, 2017

75

Conservation and Variability of the Pore-Lining Helices in P-Loop Channels

Tikhonov, Denis B., Zhorov, Boris S.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.51 MB

english, 2017

76

Molecular basis of selective resistance of the bumblebee BiNa v 1 sodium channel to tau-fluvalinate

Wu, Shaoying, Nomura, Yoshiko, Du, Yuzhe, Zhorov, Boris S., Dong, Ke

Journal:

Proceedings of the National Academy of Sciences

Year:

2017

Language:

english

File:

PDF, 1.06 MB

english, 2017

77

Mechanism of Selective Resistance of the Bumble Bee Sodium Channel BiNa V 1 to TAU-Fluvalinate

Dong, Ke, Wu, Shaoying, Nomura, Yoshiko, Du, Yuzhe, Zhorov, Boris

Journal:

Biophysical Journal

Year:

2018

Language:

english

File:

PDF, 45 KB

english, 2018

78

Mutational analysis of state-dependent contacts in the pore module of eukaryotic sodium channels

Du, Yuzhe, Tikhonov, Denis B., Nomura, Yoshiko, Dong, Ke, Zhorov, Boris S.

Journal:

Archives of Biochemistry and Biophysics

Year:

2018

Language:

english

File:

PDF, 2.28 MB

english, 2018

79

Sodium Channel Mutations and Pyrethroid Resistance in Aedes aegypti

Du, Yuzhe, Nomura, Yoshiko, Zhorov, Boris, Dong, Ke

Journal:

Year:

2016

Language:

english

File:

PDF, 1.41 MB

english, 2016

80

Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid

Maleeva, Galyna, Peiretti, Franck, Zhorov, Boris S., Bregestovski, Piotr

Journal:

Frontiers in Molecular Neuroscience

Year:

2017

Language:

english

File:

PDF, 3.78 MB

english, 2017

81

Selectivity filters and cysteine-rich extracellular loops in voltage-gated sodium, calcium, and NALCN channels

Stephens, Robert F., Guan, W., Zhorov, Boris S., Spafford, J. David

Journal:

Frontiers in Physiology

Year:

2015

Language:

english

File:

PDF, 3.06 MB

english, 2015

82

Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies

Tikhonov, Denis B., Zhorov, Boris S.

Journal:

Frontiers in Pharmacology

Year:

2018

Language:

english

File:

PDF, 7.61 MB

english, 2018

83

Batrachotoxin acts as a stent to hold open homotetrameric prokaryotic voltage-gated sodium channels

Finol-Urdaneta, Rocio K., McArthur, Jeffrey R., Goldschen-Ohm, Marcel P., Gaudet, Rachelle, Tikhonov, Denis B., Zhorov, Boris S., French, Robert J.

Journal:

The Journal of General Physiology

Year:

2018

Language:

english

File:

PDF, 2.54 MB

english, 2018

84

Predicting Variant Pathogenicity in the Cardiac Sodium Channel using Paralogue Annotation

Tarnovskaya, Svetlana, Korkosh, Vyacheslav, Zhorov, Boris S., Frishman, Dmitrij

Journal:

Biophysical Journal

Year:

2019

Language:

english

File:

PDF, 46 KB

english, 2019

85

Timothy Syndrome-Associated Mutations Affect State-Dependent Contacts in L-Type Calcium Channel

Korkosh, Vyacheslav S., Kisilev, Artem M., Mikhaylov, Eugeniy N., Kostareva, Anna A., Zhorov, Boris S.

Journal:

Biophysical Journal

Year:

2019

Language:

english

File:

PDF, 51 KB

english, 2019

86

Timothy Syndrome-Associated Mutations Affect State-Dependent Contacts in L-Type Calcium Channel

Korkosh, Vyacheslav S., Kisilev, Artem M., Mikhaylov, Eugeniy N., Kostareva, Anna A., Zhorov, Boris S.

Journal:

Biophysical Journal

Year:

2019

File:

PDF, 51 KB

2019

87

Characterization of a novel SCN5A genetic variant A1294G associated with mixed clinical phenotype

Zaytseva, Anastasia K., Karpushev, Alexey V., Kiselev, Artem M., Mikhaylov, Evgeny N., Lebedev, Dmitry S., Zhorov, Boris S., Kostareva, Anna A.

Journal:

Biochemical and Biophysical Research Communications

Year:

2019

Language:

english

File:

PDF, 1.22 MB

english, 2019

88

Possible Mechanism of Calcium-Dependent Block of L-Type Calcium Channel by Glacontryphan-M

Korkosh, Vyacheslav S., Tikhonov, Denis B., Zhorov, Boris S.

Journal:

Biophysical Journal

Year:

2019

Language:

english

File:

PDF, 47 KB

english, 2019

89

Molecular evidence of sequential evolution of DDT- and pyrethroid-resistant sodium channel in Aedes aegypti

Chen, Mengli, Du, Yuzhe, Wu, Shaoying, Nomura, Yoshiko, Zhu, Guonian, Zhorov, Boris S., Dong, Ke, Lenhart, Audrey

Journal:

PLoS Neglected Tropical Diseases

Year:

2019

File:

PDF, 3.09 MB

2019

90

Atomic Mechanisms of Timothy Syndrome-Associated Mutations in Calcium Channel Cav1.2

Korkosh, Vyacheslav S., Kiselev, Artem M., Mikhaylov, Evgeny N., Kostareva, Anna A., Zhorov, Boris S.

Journal:

Frontiers in Physiology

Year:

2019

Language:

english

File:

PDF, 8.67 MB

english, 2019

91

Extremely Potent Block of Bacterial Voltage-Gated Sodium Channels by µ-Conotoxin PIIIA

Finol-Urdaneta, Rocio K., McArthur, Jeffrey R., Korkosh, Vyacheslav S., Huang, Sun, McMaster, Denis, Glavica, Robert, Tikhonov, Denis B., Zhorov, Boris S., French, Robert J.

Journal:

Year:

2019

Language:

english

File:

PDF, 6.72 MB

english, 2019

92

Extremely Potent Block of Bacterial Voltage-Gated Sodium Channels by µ-Conotoxin PIIIA

Finol-Urdaneta, Rocio K., McArthur, Jeffrey R., Korkosh, Vyacheslav S., Huang, Sun, McMaster, Denis, Glavica, Robert, Tikhonov, Denis B., Zhorov, Boris S., French, Robert J.

Journal:

Year:

2019

File:

PDF, 6.72 MB

2019

93

Predicting novel disease mutations in the cardiac sodium channel

Tarnovskaya, Svetlana I., Korkosh, Vyacheslav S., Zhorov, Boris S., Frishman, Dmitrij

Journal:

Biochemical and Biophysical Research Communications

Year:

2019

Language:

english

File:

PDF, 1.57 MB

english, 2019

94

Chronology of sodium channel mutations associated with pyrethroid resistance in Aedes aegypti

Chen, Mengli, Du, Yuzhe, Nomura, Yoshiko, Zhorov, Boris S., Dong, Ke

Journal:

Archives of Insect Biochemistry and Physiology

Year:

2020

File:

PDF, 813 KB

2020

95

Phenylalkylamines in calcium channels: computational analysis of experimental structures

Tikhonov, Denis B., Lin, Lianyun, Yang, Daniel S. C., Yuchi, Zhiguang, Zhorov, Boris S.

Journal:

Journal of Computer-Aided Molecular Design

Year:

2020

File:

PDF, 2.19 MB

2020

96

Mutations in transmembrane proteins: diseases, evolutionary insights, prediction and comparison with globular proteins

Zaucha, Jan, Heinzinger, Michael, Kulandaisamy, A, Kataka, Evans, SalvÃ¡dor, Ãscar Llorian, Popov, Petr, Rost, Burkhard, Gromiha, M Michael, Zhorov, Boris S, Frishman, Dmitrij

Journal:

Briefings in Bioinformatics

Year:

2020

File:

PDF, 1.64 MB

2020

97

The pore domain in glutamate-gated ion channels: Structure, drug binding and similarity with potassium channels

Tikhonov, Denis B., Zhorov, Boris S.

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

2020

File:

PDF, 2.04 MB

2020

98

Phenylakylamines in Calcium Channels. Experimental Structures and Computational Models

Tikhonov, Denis B., Lin, Lianyun, Yang, Daniel S., Yuchi, Zhiguang, Zhorov, Boris S.

Journal:

Biophysical Journal

Year:

2020

File:

PDF, 49 KB

2020

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