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101

Mechanisms of Nongenotoxic Carcinogenesis and Assessment of the Human Hazard

Beatriz Silva Lima, Jan Willem Van der Laan

Journal:

Regulatory Toxicology and Pharmacology

Year:

2000

Language:

english

File:

PDF, 88 KB

english, 2000

102

The in Vivo Rodent Test Systems for Assessment of Carcinogenic Potential

Jan-Willem van der Laan, Per Spindler

Journal:

Regulatory Toxicology and Pharmacology

Year:

2002

Language:

english

File:

PDF, 74 KB

english, 2002

103

Testing Therapeutic Potency of Anticancer Drugs in Animal Studies: A Commentary

Willem Den Otter, Peter A. Steerenberg, Jan Willem Van der Laan

Journal:

Regulatory Toxicology and Pharmacology

Year:

2002

Language:

english

File:

PDF, 95 KB

english, 2002

104

Release of outer membrane fragments from normally growing Escherichia coli

Dick Hoekstra, Jan Willem van der Laan, Loe de Leij, Bernard Witholt

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1976

Language:

english

File:

PDF, 775 KB

english, 1976

105

Effects of inhibitors of GABA-transaminase on hole-board exploration and on temperature: Relation with effects on quasi-morphine abstinence behaviour induced by sodium dipropylacetate

Jan Willem van der Laan, Gradus Weick, Grada van Bleek

Journal:

Biochemical Pharmacology

Year:

1985

Language:

english

File:

PDF, 664 KB

english, 1985

106

The effects of centrally acting adrenergic agonists on temperature and on explorative and motor behaviour. Relation with effects on quasi-morphine withdrawal behaviour

Jan W. Van Der Laan, Willem Van Veenendaal, Paul Voorthuis, Gradus Weick, Feddo C. Hillen

Journal:

European Journal of Pharmacology

Year:

1985

Language:

english

File:

PDF, 451 KB

english, 1985

107

Dipropylacetate-induced shaking behaviour in the rat: a role of spinal α2-adrenoceptors

Jan Willem Van der Laan, Ris Dirksen

Journal:

European Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 665 KB

english, 1988

108

Functional properties of the isolated domains of Helix pomatia βc-hemocyanin

Ruurd Torensma, Jan M. van der Laan, Ernst F.J. van Bruggen, Constant Gielens, Leen van Paemel, Laurent J. Verschueren, René Lontie

Journal:

Year:

1980

Language:

english

File:

PDF, 226 KB

english, 1980

109

A proinflammatory monocyte response is associated with myocardial injury and impaired functional outcome in patients with ST-segment elevation myocardial infarction: Monocytes and myocardial infarction

Anja M. van der Laan, Alexander Hirsch, Lourens F.H.J. Robbers, Robin Nijveldt, Ingrid Lommerse, Ronak Delewi, Pieter A. van der Vleuten, Bart J. Biemond, Jaap Jan Zwaginga, Wim J. van der Giessen, Fe

Journal:

American Heart Journal

Year:

2012

Language:

english

File:

PDF, 816 KB

english, 2012

110

In vitro cytokine release assays for predicting cytokine release syndrome: The current state-of-the-science. Report of a European Medicines Agency Workshop

Jean-Marc Vidal, Thomas T. Kawabata, Robin Thorpe, Beatriz Silva-Lima, Karin Cederbrant, Stephen Poole, Jan Mueller-Berghaus, Marc Pallardy, Jan-Willem Van der Laan

Journal:

Year:

2010

Language:

english

File:

PDF, 147 KB

english, 2010

111

Structural Basis for the Function of Tim50 in the Mitochondrial Presequence Translocase

Xinguo Qian, Michael Gebert, Jan Höpker, Ming Yan, Jingzhi Li, Nils Wiedemann, Martin van der Laan, Nikolaus Pfanner, Bingdong Sha

Journal:

Journal of Molecular Biology

Year:

2011

Language:

english

File:

PDF, 998 KB

english, 2011

112

Late Pliocene climate variability on Milankovitch to millennial time scales: A high-resolution study of MIS100 from the Mediterranean

Julia Becker, Lucas J. Lourens, Frederik J. Hilgen, Erwin van der Laan, Tanja J. Kouwenhoven, Gert-Jan Reichart

Journal:

Palaeogeography, Palaeoclimatology, Palaeoecology

Year:

2005

Language:

english

File:

PDF, 417 KB

english, 2005

113

An approach to prevent aggregation during the purification and crystallization of wild type acyl coenzyme A: Isopenicillin N acyltransferase from Penicillium chrysogenum

Hiromi Yoshida, Charles M.H. Hensgens, Jan Metske van der Laan, John D. Sutherland, Darren J. Hart, Bauke W. Dijkstra

Journal:

Protein Expression and Purification

Year:

2005

Language:

english

File:

PDF, 941 KB

english, 2005

114

Moral judgment of young sex offenders with and without intellectual disabilities

Eveline van Vugt, Jessica Asscher, Geert Jan Stams, Jan Hendriks, Catrien Bijleveld, Peter van der Laan

Journal:

Research in Developmental Disabilities

Year:

2011

Language:

english

File:

PDF, 198 KB

english, 2011

115

ABO-blood groups and risk of abdominal aortic aneurysm and peripheral obstructive artery disease: Two sides of the same coin

Bakhtawar K. Mahmoodi, Maarten Nijsten, Jan Wijsman, Abigail G. Matthews, Lijckle van der Laan

Journal:

Thrombosis Research

Year:

2012

Language:

english

File:

PDF, 150 KB

english, 2012

116

No association between tumor necrosis factor-α production and gene polymorphisms among inbred rat strains

Michiel C. Warlé, Luc J.W. van der Laan, Johannes G. Kusters, Raymond G.J. Pot, Wim C.J. Hop, Katja C.A. Segeren, Jan N.M. IJzermans, Herold J. Metselaar, Hugo W. Tilanus

Journal:

Transplant Immunology

Year:

2005

Language:

english

File:

PDF, 109 KB

english, 2005

117

Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6

Jan A.M. Langermans, T. Mark Doherty, Richard A.W. Vervenne, Tridia van der Laan, Konstantin Lyashchenko, Rena Greenwald, Else Marie Agger, Claus Aagaard, Horst Weiler, Dick van Soolingen, Wilfried Da

Journal:

Year:

2005

Language:

english

File:

PDF, 564 KB

english, 2005

118

WHO informal consultation on scientific basis for regulatory evaluation of candidate human vaccines from plants, Geneva, Switzerland, 24–25 January 2005

Jan Willem van der Laan, Philip Minor, Richard Mahoney, Charles Arntzen, Jinho Shin, David Wood

Journal:

Year:

2006

Language:

english

File:

PDF, 116 KB

english, 2006

119

TB diagnosis in non-human primates: comparison of two interferon-γ assays and the skin test for identification of Mycobacterium tuberculosis infection

Richard A.W Vervenne, Stephen L Jones, Dick van Soolingen, Tridia van der Laan, Peter Andersen, Peter J Heidt, Alan W Thomas, Jan A.M Langermans

Journal:

Veterinary Immunology and Immunopathology

Year:

2004

Language:

english

File:

PDF, 192 KB

english, 2004

120

Suppression of inflammatory signaling in monocytes from patients with coronary artery disease

Stephan H. Schirmer, Joost O. Fledderus, Anja M. van der Laan, Tineke C.T.M. van der Pouw-Kraan, Perry D. Moerland, Oscar L. Volger, Josefien M. Baggen, Michael Böhm, Jan J. Piek, Anton J.G. Horrevoet

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2009

Language:

english

File:

PDF, 2.30 MB

english, 2009

121

Motor and cognitive development in children with congenital hypothyroidism: A long-term evaluation of the effects of neonatal treatment

Libbe Kooistra, Carleen Laane, Thomas Vulsma, Jan M.H. Schellekens, Jaap J. van der Meere, Alex F. Kalverboer

Journal:

The Journal of Pediatrics

Year:

1994

Language:

english

File:

PDF, 642 KB

english, 1994

122

The effect of pertussis toxin and whole-cell pertussis vaccine on haemodynamics and autonomic responsiveness in the rat depends on route of administration and age

Jan G.C. van Amsterdam, Jan-Dirk te Biesebeek, Ton van de Kuil, Jan-Willem van der Laan, Johan Wemer, Dick J. de Wildt, Wim Vleeming

Journal:

Year:

1998

Language:

english

File:

PDF, 768 KB

english, 1998

123

Repeated administration of whole-cell and acellular pertussis vaccines affects haemodynamics and autonomic responsiveness

Jan G.C. van Amsterdam, Jan-Dirk te Biesebeek, Ton van de Kuil, Jan-Willem van der Laan, Dick J. de Wildt, Wim Vleeming

Journal:

Year:

1998

Language:

english

File:

PDF, 872 KB

english, 1998

124

Local cellular inflammation as a result of elective standardized vascular surgery

Namkje van der Laan, Lou de Leij, Henk Jan ten Duis

Journal:

Acta Histochemica

Year:

2001

Language:

english

File:

PDF, 281 KB

english, 2001

125

Chronic exposure to morphine and naltrexone induces changes in catecholaminergic neurotransmission in rat brain without altering μ-opioid receptor sensitivity

Taco J. De Vries, Guno H.K. Tjon Tien Ril, Jan Willem Van der Laan, Arie H. Mulder, Anton N.M. Schoffelmeer

Journal:

Year:

1993

Language:

english

File:

PDF, 612 KB

english, 1993

126

A meta-analysis of intensive family preservation programs: Placement prevention and improvement of family functioning

Channa M.W. Al, Geert Jan J.M. Stams, Miranda S. Bek, Esther M. Damen, Jessica J. Asscher, Peter H. van der Laan

Journal:

Children and Youth Services Review

Year:

2012

Language:

english

File:

PDF, 224 KB

english, 2012

127

Oseltamivir and breastfeeding

Netteke Wentges-van Holthe, Marion van Eijkeren, Jan Willem van der Laan

Journal:

International Journal of Infectious Diseases

Year:

2008

Language:

english

File:

PDF, 90 KB

english, 2008

128

Q-WAVE REGRESSION AFTER MYOCARDIAL INFARCTION IS ASSOCIATED WITH INCREASED IMPROVEMENT OF LEFT VENTRICULAR EJECTION FRACTION

Ronak Delewi, Georges Ijff, Tim van de Hoef, Alexander Hirsch, Lourens Robbers, Robin Nijveldt, Anja Van Der Laan, Pieter van der Vleuten, Albert van Rossum, Felix Zijlstra, Jan Piek

Journal:

Journal of the American College of Cardiology

Year:

2012

Language:

english

File:

PDF, 172 KB

english, 2012

129

MYOCARDIAL INFARCT HETEROGENEITY ASSESSED BY LATE GADOLINIUM-ENHANCED CARDIOVASCULAR MAGNETIC RESONANCE (LGE-CMR) IS ASSOCIATED WITH THE DEVELOPMENT OF VENTRICULAR TACHYCARDIAS AFTER ACUTE MYOCARDIAL INFARCTION

Lourens Robbers, Ronak Delewi, Michiel Kemme, Robin Nijveldt, Aernout Beek, Alexander Hirsch, Anja Van Der Laan, Pieter van der Vleuten, Jan Piek, Felix Zijlstra, Albert van Rossum

Journal:

Journal of the American College of Cardiology

Year:

2012

Language:

english

File:

PDF, 91 KB

english, 2012

130

Mitochondrial protein import: Common principles and physiological networks

Jan Dudek, Peter Rehling, Martin van der Laan

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2013

Language:

english

File:

PDF, 701 KB

english, 2013

131

PET/MRI of Inflammation in Myocardial Infarction

Won Woo Lee, Brett Marinelli, Anja M. van der Laan, Brena F. Sena, Rostic Gorbatov, Florian Leuschner, Partha Dutta, Yoshiko Iwamoto, Takuya Ueno, Mark P.V. Begieneman, Hans W.M. Niessen, Jan J. Piek,

Journal:

Journal of the American College of Cardiology

Year:

2012

Language:

english

File:

PDF, 4.80 MB

english, 2012

132

TCT-514 Intracoronary Infusion Of Mononuclear Cells Compared With Standard Therapy After Acute Myocardial Infarction: 2 Year Magnetic Resonance Imaging Results Of The Randomized Controlled Hebe Trial

Ronak Delewi, Anja van der Laan, Lourens Robbers, Alexander Hirsch, Robin Nijveldt, Pieter van der Vleuten, Jan Tijssen, René Tio, Johannes Waltenberger, Jurrien Ten Berg, Pieter Doevendans, Wim Aenge

Journal:

Journal of the American College of Cardiology

Year:

2012

Language:

english

File:

PDF, 74 KB

english, 2012

133

Testing strategies for assessment of carcinogenic risk of drugs: Current developments

Jan Willem Van der Laan

Journal:

Toxicology Letters

Year:

2007

Language:

english

File:

PDF, 72 KB

english, 2007

134

Regulatory view on the relevance of the TDAR in immunotoxicity testing

Jan-Willem van der Laan

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 54 KB

english, 2009

135

New perspectives for alternative approaches to carcinogenicity testing: a regulator viewpoint

Jan Willem van der Laan

Journal:

Toxicology Letters

Year:

1998

Language:

english

File:

PDF, 63 KB

english, 1998

136

W8/L3 - New perspectives for alternative approaches to carcinogenicity testing: A regulator viewpoint

Jan Willem van der Laan

Journal:

Toxicology Letters

Year:

1998

Language:

english

File:

PDF, 242 KB

english, 1998

137

Current status and use of short/medium-term models for assessment of carcinogenicity of human pharmaceuticals: regulatory perspectives

Jan Willem van der Laan

Journal:

Toxicology Letters

Year:

2000

Language:

english

File:

PDF, 67 KB

english, 2000

138

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || Toxicokinetics: A Guidance for Assessing Systemic Exposure in Toxicology Studies, Where Are We Now; An S3A/S3B Update (1995–2011)

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 582 KB

english, 2013

139

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || The Value and Benefits of the International Conference on Harmonisation (ICH) to Drug Regulatory Authorities: Advancing Harmonization for Better Public Health

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 109 KB

english, 2013

140

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || EU Perspective on ICH

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 200 KB

english, 2013

141

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || The International Conference on Harmonisation: History of Safety Guidelines

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 199 KB

english, 2013

142

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || Toward More Scientific Relevance in Carcinogenicity Testing

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 344 KB

english, 2013

143

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || A Japanese Perspective on Implementation of the Three Rs: Incorporating Best Scientific Practices into Regulatory Process

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 305 KB

english, 2013

144

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || Why and How Did Reproduction Toxicity Testing Make Its Early Entry into and Rapid Success in ICH?

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 555 KB

english, 2013

145

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || Duration of Acute and Chronic Toxicity Testing in Animals (ICH S4A and S4B)

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 425 KB

english, 2013

146

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || The Evolution, Scientific Reasoning and Use of ICH S2 Guidelines for Genotoxicity Testing of Pharmaceuticals

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 564 KB

english, 2013

147

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || Non-clinical Safety Studies for the Conduct of Human Clinical Trials for Pharmaceuticals: ICH M3 and M3(R2)

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 146 KB

english, 2013

148

Optical simulation of monolithic scintillator detectors using GATE/GEANT4

van der Laan, D J (Jan), Schaart, Dennis R, Maas, Marnix C, Beekman, Freek J, Bruyndonckx, Peter, van Eijk, Carel W E

Journal:

Physics in Medicine and Biology

Year:

2010

Language:

english

File:

PDF, 479 KB

english, 2010

149

Limits on the spatial resolution of monolithic scintillators read out by APD arrays

van der Laan, D J (Jan), Maas, Marnix C, Bruyndonckx, Peter, Schaart, Dennis R

Journal:

Physics in Medicine and Biology

Year:

2012

Language:

english

File:

PDF, 373 KB

english, 2012

150

Development of the ICH Guidelines for Immunotoxicology Evaluation of Pharmaceuticals Using a Survey of Industry Practices

Weaver, James L., Tsutsui, Naohisa, Hisada, Shigeru, Vidal, Jean-Marc, Spanhaak, Steven, Sawada, Jun-ichi, Hastings, Kenneth L., van der Laan, Jan Willem, van Loveren, Henk, Kawabata, Thomas T., Sims,

Journal:

Journal of Immunotoxicology

Year:

2005

Language:

english

File:

PDF, 206 KB

english, 2005