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51

Paramagnetic Ligand Tagging to Identify Protein Binding Sites

Brath, Ulrika, Swamy, Shashikala I., Veiga, Alberte X., Tung, Ching-Chieh, Van Petegem, Filip, Erdelyi, Mate

Journal:

Journal of the American Chemical Society

Year:

2015

Language:

english

File:

PDF, 594 KB

english, 2015

52

Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant

Yuchi, Zhiguang, Yuen, Siobhan M. Wong King, Lau, Kelvin, Underhill, Ainsley Q., Cornea, Razvan L., Fessenden, James D., Van Petegem, Filip

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 2.97 MB

english, 2015

53

Common allosteric mechanisms between ryanodine and inositol-1,4,5-trisphosphate receptors

Yuchi, Zhiguang, Van Petegem, Filip

Journal:

Year:

2011

Language:

english

File:

PDF, 803 KB

english, 2011

54

Identification of avian corticosteroid-binding globulin (SerpinA6) reveals the molecular basis of evolutionary adaptations in SerpinA6 structure and function as a steroid-binding protein

Vashchenko, Ganna, Das, Samir, Moon, Kyung-Mee, Rogalski, Jason C., Taves, Matthew D., Soma, Kiran K., Van Petegem, Filip, Foster, Leonard J., Hammond, Geoffrey L.

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 2.60 MB

english, 2016

55

Binary Architecture of the Nav1.2-β2 Signaling Complex

Gilchrist, John M., Das, Samir, Van Petegem, Filip, Bosmans, Frank

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 45 KB

english, 2016

56

Structural Insights into Ryanodine Receptor-FKBP12 Interactions in Wild-Type and Mutated States

Yuchi, Zhiguang, Wong King Yuen, Siobhan M., Lau, Kelvin, Underhill, Ainsley, Cornea, Razvan, Fessenden, James, Petegem, Filip Van

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 48 KB

english, 2016

57

Structural Insights into the Nature of the Unique Anion Binding Site within the Cardiac Ryanodine Receptor N-Terminal Region and Associated Disease Mutations

Wong, Siobhan, Bedin, Michele, Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 39 KB

english, 2015

58

Identification of Major FKBP12 Binding Determinants in RyR1

Cornea, Razvan L., Van Petegem, Filip, Fessenden, James D.

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 41 KB

english, 2015

59

Crystal Structures of the Ryanodine Receptor SPRY2 Domain

Lau, Kelvin, Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 42 KB

english, 2015

60

A Thermodynamic Analysis of Disease-Causing Mutations in the Nav1.5 C-Terminus

Tung, Ching-Chieh, Rivera-Acevedo, Ricardo E., Gardill, Bernd R., Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 43 KB

english, 2015

61

Structural Comparisons of Immunoglobulin Folds of Human Navβ Subunits

Das, Samir, Gilchrist, John, Bosmans, Frank, Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 62 KB

english, 2016

62

Ryanodine receptors under the magnifying lens: Insights and limitations of cryo-electron microscopy and X-ray crystallography studies

Yuchi, Zhiguang, Van Petegem, Filip

Journal:

Year:

2016

Language:

english

File:

PDF, 8.62 MB

english, 2016

63

Characterization of Zebrafish Cardiac and Slow Skeletal Troponin C Paralogs by MD Simulation and ITC

Stevens, Charles M., Rayani, Kaveh, Genge, Christine E., Singh, Gurpreet, Liang, Bo, Roller, Janine M., Li, Cindy, Li, Alison Yueh, Tieleman, D. Peter, van Petegem, Filip, Tibbits, Glen F.

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 2.86 MB

english, 2016

64

A Novel RYR2 Loss-of-Function Mutation (I4855M) is Associated with Left Ventricular Non-compaction and Atypical Catecholaminergic Polymorphic Ventricular Tachycardia

Roston, Thomas M., Guo, Wenting, Krahn, Andrew D., Wang, Ruiwu, van Petegem, Filip, Sanatani, Shubhayan, Chen, S.R. Wayne, Lehman, Anna

Journal:

Journal of Electrocardiology

Year:

2016

Language:

english

File:

PDF, 1.03 MB

english, 2016

65

Crystallographic insight into the evolutionary origins of xyloglucan endo-transglycosylases and endo-hydrolases

McGregor, Nicholas, Yin, Victor, Tung, Ching-Chieh, Van Petegem, Filip, Brumer, Harry

Journal:

The Plant Journal

Year:

2016

Language:

english

File:

PDF, 1.33 MB

english, 2016

66

The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca 2+ Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor

Søndergaard, Mads Toft, Liu, Yingjie, Larsen, Kamilla Taunsig, Nani, Alma, Tian, Xixi, Holt, Christian, Wang, Ruiwu, Wimmer, Reinhard, Van Petegem, Filip, Fill, Michael, Chen, S. R. Wayne, Overgaard,

Journal:

Journal of Biological Chemistry

Year:

2017

Language:

english

File:

PDF, 3.07 MB

english, 2017

67

On the Integration of Need-related Autobiographical Memories among Late Adolescents and Late Adults: The Role of Depressive Symptoms and Self-congruence

van der Kaap-Deeder, Jolene, Vansteenkiste, Maarten, Van Petegem, Stijn, Raes, Filip, Soenens, Bart

Journal:

European Journal of Personality

Year:

2016

Language:

english

File:

PDF, 720 KB

english, 2016

68

Ligand binding to Ryanodine Receptors revealed through cryo-electron microscopy

Van Petegem, Filip

Journal:

Year:

2017

Language:

english

File:

PDF, 631 KB

english, 2017

69

Piecing together the ryanodine receptor with crystal structures and cryo-EM

Lau, Kelvin, Van Petegem, Filip

Journal:

Acta Crystallographica Section A Foundations and Advances

Year:

2014

Language:

english

File:

PDF, 376 KB

english, 2014

70

The Cardiac Channel Na V 1.5 Inactivation is Modulated by its C-Terminal EF-hand Domain

Gardill, Bernd R., Tung, Ching-Chieh, Rivera-Acevedo, Ricardo E., Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2017

Language:

english

File:

PDF, 44 KB

english, 2017

71

Structural Characterization of Calmodulin Disease Mutations

Wang, Kaiqian, Lu, Jocelyn, Larsen, Kamilla T., Overgaard, Michael T., Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2017

Language:

english

File:

PDF, 47 KB

english, 2017

72

How to open a Ryanodine Receptor

Van Petegem, Filip

Journal:

Year:

2016

Language:

english

File:

PDF, 1.21 MB

english, 2016

73

Catecholaminergic polymorphic ventricular tachycardia

Roston, Thomas M., Van Petegem, Filip, Sanatani, Shubhayan

Journal:

Current Opinion in Cardiology

Year:

2017

Language:

english

File:

PDF, 541 KB

english, 2017

74

Structural insights into binding of STAC proteins to voltage-gated calcium channels

Wong King Yuen, Siobhan M., Campiglio, Marta, Tung, Ching-Chieh, Flucher, Bernhard E., Van Petegem, Filip

Journal:

Proceedings of the National Academy of Sciences

Year:

2017

Language:

english

File:

PDF, 1.95 MB

english, 2017

75

STAC proteins associate to the IQ domain of Ca V 1.2 and inhibit calcium-dependent inactivation

Campiglio, Marta, Costé de Bagneaux, Pierre, Ortner, Nadine J., Tuluc, Petronel, Van Petegem, Filip, Flucher, Bernhard E.

Journal:

Proceedings of the National Academy of Sciences

Year:

2018

Language:

english

File:

PDF, 1.28 MB

english, 2018

76

The voltage-gated sodium channel EF-hands form an interaction with the III-IV linker that is disturbed by disease-causing mutations

Gardill, Bernd R., Rivera-Acevedo, Ricardo E., Tung, Ching-Chieh, Okon, Mark, McIntosh, Lawrence P., Van Petegem, Filip

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 6.75 MB

english, 2018

77

The H29D Mutation Does Not Enhance Cytosolic Ca2+ Activation of the Cardiac Ryanodine Receptor

Xiao, Zhichao, Guo, Wenting, Yuen, Siobhan M. Wong King, Wang, Ruiwu, Zhang, Lin, Van Petegem, Filip, Chen, S. R. Wayne, Beard, Nicole

Journal:

Year:

2015

Language:

english

File:

PDF, 3.91 MB

english, 2015

78

Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel

Wang, Kaiqian, Holt, Christian, Lu, Jocelyn, Brohus, Malene, Larsen, Kamilla Taunsig, Overgaard, Michael Toft, Wimmer, Reinhard, Van Petegem, Filip

Journal:

Proceedings of the National Academy of Sciences

Year:

2018

Language:

english

File:

PDF, 2.34 MB

english, 2018

79

Structural Insights into the STAC Adaptor Protein and Voltage-Gated Calcium Channel Interaction

Wong King Yuen, Siobhan, Campiglio, Marta, Tung, Ching-Chieh, Flucher, Bernhard, Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2018

Language:

english

File:

PDF, 46 KB

english, 2018

80

Ca 2+ dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains

Brohus, Malene, Søndergaard, Mads Toft, Chen, S.R. Wayne, Van Petegem, Filip, Overgaard, Michael Toft

Journal:

Biochemical Journal

Year:

2018

Language:

english

File:

PDF, 9.30 MB

english, 2018

81

Subtle changes in the combining site of the Chlamydiaceae-specific mAb S25-23 increase antibody-carbohydrate binding affinity by an order of magnitude

Haji-Ghassemi, Omid, Müller-Loennies, Sven, Brooks, Cory L., MacKenzie, Colin Roger, Caveney, Nathanael, Van Petegem, Filip, Brade, Lore, Kosma, Paul, Brade, Helmut, Evans, Stephen V.

Journal:

Year:

2018

Language:

english

File:

PDF, 5.13 MB

english, 2018

82

Binding of calcium and magnesium to cardiac Troponin C assessed through Isothermal Titration Calorimetry (ITC)

Rayani, Kaveh, Muñoz, Eva, Spuches, Anne, Van Petegem, Filip, Tibbits, Glen

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2018

Language:

english

File:

PDF, 50 KB

english, 2018

83

Structural Insights into Recognition of Ryanodine Receptors by PKA

Haji-Ghassemi, Omid, Yuchi, Zhiguang, Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2019

Language:

english

File:

PDF, 73 KB

english, 2019

84

In vitro analyses of suspected arrhythmogenic thin filament variants as a cause of sudden cardiac death in infants

Shafaattalab, Sanam, Li, Alison Yueh, Lin, Eric, Stevens, Charles M., Dewar, Laura J., Lynn, Francis C., Sanatani, Shubhayan, Laksman, Zachary, Morin, Ryan D., van Petegem, Filip, Hove-Madsen, Leif, T

Journal:

Proceedings of the National Academy of Sciences

Year:

2019

File:

PDF, 1.98 MB

2019

85

Crystal structures of Ca 2+ –calmodulin bound to Na V C-terminal regions suggest role for EF-hand domain in binding and inactivation

Gardill, Bernd R., Rivera-Acevedo, Ricardo E., Tung, Ching-Chieh, Van Petegem, Filip

Journal:

Proceedings of the National Academy of Sciences

Year:

2019

Language:

english

File:

PDF, 2.30 MB

english, 2019

86

Slaying a giant: Structures of calmodulin and protein kinase a bound to the cardiac ryanodine receptor

Van Petegem, Filip

Journal:

Year:

2019

Language:

english

File:

PDF, 749 KB

english, 2019

87

Binding and structural asymmetry governs ligand sensitivity in a cyclic nucleotide–gated ion channel

Ng, Leo C.T., Zhuang, Meiying, Van Petegem, Filip, Li, Yue Xian, Accili, Eric A.

Journal:

The Journal of General Physiology

Year:

2019

Language:

english

File:

PDF, 3.62 MB

english, 2019

88

Characterization of Arrhythmia Mutations in Calmodulin and their Interactions with the Voltage-Gated Calcium Channel

Wang, Kaiqian, Holt, Christian, Lu, Jocelyn, Brohus, Malene, Larsen, Kamilla T., Overgaard, Michael T., Wimmer, Reinhard, Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2019

Language:

english

File:

PDF, 51 KB

english, 2019

89

Characterization of Arrhythmia Mutations in Calmodulin and their Interactions with the Voltage-Gated Calcium Channel

Wang, Kaiqian, Holt, Christian, Lu, Jocelyn, Brohus, Malene, Larsen, Kamilla T., Overgaard, Michael T., Wimmer, Reinhard, Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2019

File:

PDF, 51 KB

2019

90

Molecular interactions between sex hormone-binding globulin and non-steroidal ligands that enhance androgen action

Round, Phillip, Das, Samir, Wu, Tsung-Sheng, Wähälä, Kristiina, Van Petegem, Filip, Hammond, Geoffrey L.

Journal:

Journal of Biological Chemistry

Year:

2019

File:

PDF, 4.83 MB

2019

91

Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca 2+ binding and cause misfolding

Wang, Kaiqian, Brohus, Malene, Holt, Christian, Overgaard, Michael Toft, Wimmer, Reinhard, Van Petegem, Filip

Journal:

The Journal of Physiology

Year:

2020

File:

PDF, 1.41 MB

2020

92

Cardiac arrest in a mother and daughter and the identification of a novel RYR2 variant, predisposing to low penetrant catecholaminergic polymorphic ventricular tachycardia in a fourâgeneration Canadian family

Tung, Matthew, Van Petegem, Filip, Lauson, Samantha, Collier, Ashley, Hodgkinson, Kathy, Fernandez, Bridget, Connors, Sean, Leather, Rick, Sanatani, Shubhayan, Arbour, Laura

Journal:

Molecular Genetics & Genomic Medicine

Year:

2020

Language:

english

File:

PDF, 1.05 MB

english, 2020

93

Nanodisc technology facilitates identification of monoclonal antibodies targeting multi-pass membrane proteins

Gardill, Bernd, Huang, Jerry, Tu, Lawrence, Van Petegem, Filip, Oxenoid, Kirill, Thomson, Christy A.

Journal:

Scientific Reports

Year:

2020

Language:

english

File:

PDF, 3.22 MB

english, 2020

94

A rare CACNA1H variant associated with amyotrophic lateral sclerosis causes complete loss of Cav3.2âT-type channel activity

Stringer, Robin N., Jurkovicova-Tarabova, Bohumila, Huang, Sun, Haji-Ghassemi, Omid, Idoux, Romane, Liashenko, Anna, Souza, Ivana A., Rzhepetskyy, Yuriy, Lacinova, Lubica, Van Petegem, Filip, Zamponi,

Journal:

Molecular Brain

Year:

2020

File:

PDF, 2.31 MB

2020

95

Human Cardiac Voltage-Gated Calcium Channel Phosphorylation by cAMP-Dependent Protein Kinase A

Haji-Ghassemi, Omid, Xu, Jiaming, Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2020

Language:

english

File:

PDF, 57 KB

english, 2020

96

Synergy between Cell Surface Glycosidases and Glycan-Binding Proteins Dictates the Utilization of Specific Beta(1,3)-Glucans by Human Gut Bacteroides

DÃ©jean, Guillaume, Tamura, Kazune, Cabrera, Adriana, Jain, Namrata, Pudlo, Nicholas A., Pereira, Gabriel, Viborg, Alexander Holm, Van Petegem, Filip, Martens, Eric C., Brumer, Harry, Comstock, Laurie

Journal:

Year:

2020

File:

PDF, 3.34 MB

2020

97

Reply to Pitt and Lee: Occupancies of Ca 2+ in complexes of calmodulin with voltage-gated sodium channels

Van Petegem, Filip, Gardill, Bernd R.

Journal:

Proceedings of the National Academy of Sciences

Year:

2019

File:

PDF, 480 KB

2019

98

The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor

Holt, Christian, Hamborg, Louise, Lau, Kelvin, Brohus, Malene, SÃ¸rensen, Anders Bundgaard, Larsen, Kamilla Taunsig, Sommer, Cordula, Van Petegem, Filip, Overgaard, Michael Toft, Wimmer, Reinhard

Journal:

Journal of Biological Chemistry

Year:

2020

File:

PDF, 1.69 MB

2020

99

Crystal Structures of Calcium-Loaded Calmodulin in Complex with C-Terminal Domains of Voltage-Gated Sodium Channels

Van Petegem, Filip, Tung, Ching-Chieh, Gardill, Bernd, Rivera-Acevedo, Ricardo E.

Journal:

Biophysical Journal

Year:

2020

File:

PDF, 45 KB

2020

100

Multiple Sequence Variants in STAC3 Affect Interactions with CaV1.1 and Excitation-Contraction Coupling

Rufenach, Britany, Christy, Darren, Flucher, Bernhard E., Bui, Jennifer M., Gsponer, JÃ¶rg, Campiglio, Marta, Van Petegem, Filip

Journal:

Year:

2020

File:

PDF, 3.05 MB

2020