The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme's stability and conformational transitions linked to Na+ binding
Raimondo De Cristofaro, Andrea Carotti, Sepideh Akhavan, Roberta Palla, Flora Peyvandi, Cosimo Altomare, Pier Mannuccio MannucciVolume:
273
Year:
2006
Language:
english
Pages:
11
DOI:
10.1111/j.1742-4658.2005.05052.x
File:
PDF, 311 KB
english, 2006